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Search Results: 1 - 10 of 1115 matches for " Isamu Okamoto "
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Practical Use of Gemcitabine and Cisplatin Combination Therapy as First-Line Treatment for Japanese Patients with Advanced Biliary Tract Cancer  [PDF]
Hisato Kawakami, Isamu Okamoto, Wataru Okamoto, Masayuki Takeda, Shinya Ueda, Toshihiro Kudo, Shin-ichi Nishina, Yasuhito Fujisaka, Masaki Miyazaki, Junji Tsurutani, Takayasu Kurata, Kazuhiko Nakagawa
Journal of Cancer Therapy (JCT) , 2013, DOI: 10.4236/jct.2013.46121

Gemcitabine and cisplatin combination therapy (GC) is accepted as a standard treatment for advanced biliary tract cancer (BTC). However, little information is available regarding such treatment in the clinical practice setting in Japan. We retrospectively examined the clinical data of patients with unresectable or recurrent BTC who received GC as first-line treatment. The regimen consisted of cisplatin (25 mg/m2) and gemcitabine (1000 mg/m2) administered intravenously on days 1 and 8 of repeated 3-week cycles. Twenty patients were analyzed. A total of 148 cycles of GC was administered, with a median of 8 and a range of 1 to 18 cycles. Treatment delay and dose reduction were noted in 35 (24%) and 41 (28%) of the 148 cycles, respectively. The major adverse events of grade 3 or 4 included neutropenia (50%), leukopenia (45%), anemia (30%), and thrombocytopenia (15%). Nonhematologic toxicities included nausea (10%), appetite loss (10%), and fatigue (10%). Median progression-free and overall survival times were 6.9 and 12.3 months, respectively. Gallbladder cancer showed a significantly higher response rate than did other types of BTC (chi-squaretest, P = 0.002). GC was thus effective and well tolerated as first-line chemotherapy for Japanese patients with advanced BTC in the clinical practice setting.

Impact of treatment with bevacizumab beyond disease progression: a randomized phase II study of docetaxel with or without bevacizumab after platinum-based chemotherapy plus bevacizumab in patients with advanced nonsquamous non–small cell lung cancer (WJOG 5910L)
Takeda Masayuki,Okamoto Isamu,Yamanaka Takeharu,Nakagawa Kazuhiko
BMC Cancer , 2012, DOI: 10.1186/1471-2407-12-327
Abstract: Background Bevacizumab, a humanized antibody to vascular endothelial growth factor (VEGF), shows clinical activity against human cancer, with its addition to standard chemotherapy having been found to improve outcome in patients with advanced nonsquamous non–small cell lung cancer (NSCLC). However, there have been no evidence-based studies to support the continued use of bevacizumab beyond disease progression in such patients treated with the drug in first-line therapy. We have now designed a randomized phase II trial to examine the clinical benefit and safety of continued bevacizumab treatment in patients with advanced nonsquamous NSCLC whose disease has progressed after first-line treatment with bevacizumab plus a platinum-based doublet. Methods/Design WJOG 5910L was designed as a multicenter, open-label, randomized, phase II trial by the West Japan Oncology Group of docetaxel (arm A) versus docetaxel plus bevacizumab (arm B) in patients with recurrent or metatstatic nonsquamous NSCLC whose disease has progressed after first-line treatment with bevacizumab plus a platinum-based doublet. Patients in arm A will receive docetaxel at 60 mg/m2 and those in arm B will receive docetaxel at 60 mg/m2 plus bevacizumab at 15 mg/kg, with each drug administered on day 1 every 21 days until progression or unacceptable toxicity. The primary endpoint of the study is progression-free survival, with secondary endpoints including response rate, overall survival, and safety, for patients treated in either arm. Trial registration UMIN (University Hospital Medical Information Network in Japan) 000004715
Modified Cp Criterion for Optimizing Ridge and Smooth Parameters in the MGR Estimator for the Nonparametric GMANOVA Model  [PDF]
Isamu Nagai
Open Journal of Statistics (OJS) , 2011, DOI: 10.4236/ojs.2011.11001
Abstract: Longitudinal trends of observations can be estimated using the generalized multivariate analysis of variance (GMANOVA) model proposed by [10]. In the present paper, we consider estimating the trends nonparametrically using known basis functions. Then, as in nonparametric regression, an overfitting problem occurs. [13] showed that the GMANOVA model is equivalent to the varying coefficient model with non-longitudinal covariates. Hence, as in the case of the ordinary linear regression model, when the number of covariates becomes large, the estimator of the varying coefficient becomes unstable. In the present paper, we avoid the overfitting problem and the instability problem by applying the concept behind penalized smoothing spline regression and multivariate generalized ridge regression. In addition, we propose two criteria to optimize hyper parameters, namely, a smoothing parameter and ridge parameters. Finally, we compare the ordinary least square estimator and the new estimator.
Simple Prediction Formula for Proportion Installment Interest Rate in a Private Finance Initiative Project  [PDF]
Takanori Inoue, Isamu Yoshitake
Journal of Service Science and Management (JSSM) , 2013, DOI: 10.4236/jssm.2013.63022

Private Finance Initiative (PFI) projects aim to develop public facilities using private funds. Installment interest payments must be predominant in PFI project costs. The proportion of installment interest depends upon the business period, payment method, interest rate, and other factors. However, prediction of the installment interest is not simple. Cost simulation based on various assumptions has been required for planning PFI finance project. A simplified estimation formula for installment interest rate based on cost evaluations using wide range of comparable conditions is proposed in this paper. The applicability of the proposed formula is also discussed and verified. The proportion of installment interest of a PFI project can be estimated to sufficient accuracy using the proposed formula.

Production Smoothing in Developed Countries  [PDF]
Isamu Ginama, Mitsuhiro Odaki
Journal of Mathematical Finance (JMF) , 2017, DOI: 10.4236/jmf.2017.72018
Abstract: This paper extends the method of regressing production and sales variables on a set of seasonal dummy variables and a linear trend for empirical tests on the production smoothing hypothesis of inventory investment. Unit root testing procedures form the basis for constructing the bootstrap confidence intervals for the ratio of the variance of production to the variance of sales. Models used to test for a unit root when there are structural breaks in the linear time trend are converted to equations comprising deterministic and stochastic components. A limiting distribution of the test statistic is derived. Bootstrap resampling is conducted over deterministic parts of the converted equations to construct confidence intervals for the relative variance ratio for G7 countries. Primary findings for these countries are production-counter smoothing phenomena.
Attentional Modulation of Temporal Contrast Sensitivity in Human Vision
Isamu Motoyoshi
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019303
Abstract: Recent psychophysical studies have shown that attention can alter contrast sensitivities for temporally broadband stimuli such as flashed gratings. The present study examined the effect of attention on the contrast sensitivity for temporally narrowband stimuli with various temporal frequencies. Observers were asked to detect a drifting grating of 0–40 Hz presented gradually in the peripheral visual field with or without a concurrent letter identification task in the fovea. We found that removal of attention by the concurrent task reduced the contrast sensitivity for gratings with low temporal frequencies much more profoundly than for gratings with high temporal frequencies and for flashed gratings. The analysis revealed that the temporal contrast sensitivity function had a more band-pass shape with poor attention. Additional experiments showed that this was also true when the target was presented in various levels of luminance noise. These results suggest that regardless of the presence of external noise, attention extensively modulates visual sensitivity for sustained retinal inputs.
"Intermediate Mass Higgs Study at $γγ$ Colliders"
Isamu Watanabe
Physics , 1995,
Abstract: We present the efficient technique to extract the signal of the intermediate mass Higgs boson from the backgrounds at future $\gamma \gamma$ colliders. For a clear Higgs detection, it is important to fit the original electron accelerator energy depending on the Higgs mass, to set the polarization of the photon beams and to apply the efficient $b$ quark tagging method. We demonstrate the extraction of information of Higgs parameters and the new physics from the observable physical quantities. It is clearly shown that a future $\gamma \gamma$ collider will have a rich potential for study on the new physics, as well as the Higgs physics.
Logarithmic geometry, minimal free resolutions and toric algebraic stacks
Isamu Iwanari
Mathematics , 2007,
Abstract: In this paper we will introduce a certain type of morphisms of log schemes (in the sense of Fontaine, Illusie, and Kato) and investigate their moduli. Then by applying this we define a notion of toric algebraic stacks over arbitrary schemes, which may be regarded as torus embeddings within the framework of algebraic stacks, and study some basic properties. Furthermore, we study the stack-theoretic analogue of toroidal embeddings.
Integral Chow rings of toric stacks
Isamu Iwanari
Mathematics , 2007,
Abstract: The purpose of this paper is to prove that integral Chow rings of toric stacks are naturally isomorphic to Stanley-Reisner rings.
Stable points on algebraic stacks
Isamu Iwanari
Mathematics , 2010,
Abstract: This paper is largely concerned with constructing coarse moduli spaces for Artin stacks. The main purpose of this paper is to introduce the notion of stability on an arbitrary Artin stack and construct a coarse moduli space for the open substack of stable points. Also, we present an application to coherent cohomology of Artin stacks.
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