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Search Results: 1 - 10 of 2324 matches for " Isabelle Ligi "
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The Intensity of IUGR-Induced Transcriptome Deregulations Is Inversely Correlated with the Onset of Organ Function in a Rat Model
Daniel Vaiman, Géraldine Gascoin-Lachambre, Farid Boubred, Fran?oise Mondon, Jean-Marc Feuerstein, Isabelle Ligi, Isabelle Grandvuillemin, Sandrine Barbaux, Eric Ghigo, Vincent Achard, Umberto Simeoni, Christophe Buffat
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021222
Abstract: A low-protein diet applied during pregnancy in the rat results in intrauterine growth restricted (IUGR) fetuses. In humans, IUGR is associated with increased perinatal morbidity, higher incidence of neuro-developmental defects and increased risk of adult metabolic anomalies, such as diabetes and cardiovascular disease. Development and function of many organs are affected by environmental conditions such as those inducing fetal and early postnatal growth restriction. This phenomenon, termed “fetal programming” has been studied unconnectedly in some organs, but very few studies (if any) have investigated at the same time several organs, on a more comparative basis. However, it is quite probable that IUGR affects differentially most organ systems, with possible persistent changes in gene expression. In this study we address transcriptional alterations induced by IUGR in a multi-organ perspective, by systematic analysis of 20-days rat fetuses. We show that (1) expressional alterations are apparently stronger in organs functioning late in foetal or postnatal life than in organs that are functioning early (2) hierarchical classification of the deregulations put together kidney and placenta in one cluster, liver, lungs and heart in another; (3) the epigenetic machinery is set up especially in the placenta, while its alterations are rather mild in other organs; (4) the genes appear deregulated in chromosome clusters; (5) the altered expression cascades varies from organ to organ, with noticeably a very significant modification of the complement and coagulation cascades in the kidney; (6) we found a significant increase in TF binding site for HNF4 proteins specifically for liver genes that are down-regulated in IUGR, suggesting that this decrease is achieved through the action of HNF transcription factors, that are themselves transcriptionnally induced in the liver by IUGR (x 1.84 fold). Altogether, our study suggests that a combination of tissue-specific mechanisms contributes to bring about tissue-driven modifications of gene cascades. The question of these cascades being activated to adapt the organ to harsh environmental condition, or as an endpoint consequence is still raised.
Asymptotic Expansion of Temperature Close to a Singularity of a Plate  [PDF]
Isabelle Titeux
World Journal of Mechanics (WJM) , 2011, DOI: 10.4236/wjm.2011.13015
Abstract: The thermal conduction in a thin laminated plate is considered here. The lateral surface of the plate is not regular. Consequently, the boundary of the middle plane admits a geometrical singularity. Close to the origin, the lateral edge forms an angle. We shall prove that the classical bidimensional problem associated with the thin plate problem is not valid. In this paper, using the boundary layer theory, we describe the local behavior of the plate, close to the perturbation.
Peri-Orbital Non-Invasive and Painless Skin Tightening-Safe and Highly Effective Use of Multisource Radio-Frequency Treatment Platform  [PDF]
Isabelle Rousseaux
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2015, DOI: 10.4236/jcdsa.2015.53025
Abstract: The periorbital area is the third highest-ranking area for cosmetic surgery. However, surgery in this area presents a number of difficulties and safety concerns. First generation Monopolar RF treatments in this area were usually associated with considerable pain and long downtime. In the present clinical study, we used the iFine handpiece of the EndyMed PRO, multi-source phase-controlled radiofrequency (RF) for Non-invasive, pain free, skin rejuvenation of the periorbital area. The study included eleven (11) subjects, treated for periorbital signs of aging (iFine handpiece, EndyMed PRO platform, EndyMed Medical, Caesarea, Israel). The degree of clinical improvement was assessed by the global aesthetic improvement scale (GAIS) and subjects satisfaction by post treatment questionnaires. 91% of patients showed good to excellent improvement as a result of the treatment. Subjects satisfaction showed that 55% of patients reported that they were very satisfied, 45% were satisfied while none were dissatisfied. There were no incidences of infections, scarring, hypopigmentation, or any other serious complications.
Cutaneous Metastasis In Visceral Malignancy
Mathew Ligi,Kuruvila Maria,Dinesh M
Indian Journal of Dermatology , 2002,
Abstract: Cutaneous metastasis from visceral malignancy is uncommon. We report a 54 year old female operated for adenocarcinoma caecum who developed multiple cutaneous metastatic nodules while on chemotherapy.
Tectonics and seismicity of the ApulianRidge south of Salento peninsula(Southern Italy)
A. Argnani,F. Frugoni,R. Cosi,M. Ligi
Annals of Geophysics , 2001, DOI: 10.4401/ag-3573
Abstract: Multichannel reflection seismic data were acquired south of the Salento peninsula, in an area where crustal seismicity has been recorded. Seismic profiles show the presence of small grabens bounded by extensional faults with NW-SE direction. These grabens are filled with Plio-Quaternary sediments and represent the prolongation of the grabens located onshore in the Salento peninsula. Outer arc extension due to flexuring of the Adriatic-Apulian lithosphere under the double load of the Hellenides and Apennines-Calabrian arc is thought to have originated these grabens. The Adriatic-Apulian continental lithosphere presents a very small radius of curvature and a decoupling between upper crust and mantle lithosphere is expected. Inner arc compression within the upper crust may be responsible for the seismicity recorded in the area.
The operation of VEGA/CHARA : from the scientific idea to the final products
Roxanne Ligi,Denis Mourard,Nicolas Nardetto,Jean-Michel Clausse
Physics , 2014, DOI: 10.1142/S2251171713400035
Abstract: We describe the data flow in the operation of the VEGA/CHARA instrument. After a brief summary of the main characteristics and scientific objectives of the VEGA instrument, we explain the standard procedure from the scientific idea up to the execution of the observation. Then, we describe the different steps done after the observation, from the raw data to the archives and the final products. Many tools are used and we show how the Virtual Observatory principles have been implemented for the interoperability of these software and databases.
Carotid Endothelial VCAM-1 Is an Early Marker of Carotid Atherosclerosis and Predicts Coronary Artery Disease in Swine  [PDF]
Isabelle Masseau, Douglas K. Bowles
Journal of Biomedical Science and Engineering (JBiSE) , 2015, DOI: 10.4236/jbise.2015.811073
Abstract: Objective: The aim was to determine if endothelial VCAM-1 (eVCAM-1) expression in the common carotid artery (CCA) would correlate with predictive markers of atherosclerotic disease, would precede reduction of markers of endothelial cell function and would predict coronary artery disease (CAD). Methods and results: Carotid arterial segments (bifurcation, proximal and distal CCA) were harvested from 14 and 24 month-old male castrated familial hypercholesterolemic (FH) swine, a model of spontaneous atherosclerosis. Quantification of local expression of eVCAM-1, intimal macrophage accumulation, oxidative stress, intima-media (I/M) ratio, intima-media thickness (IMT), endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS (p-eNOS) in selected regions of the carotids revealed a relationship between local inflammation and atherosclerotic plaque progression. Importantly, inflammation was not uniform throughout the CCA. Endothelial VCAM-1 expression was the greatest at the bifurcation and increased with age. Finally, eVCAM-1 best estimated the severity of CAD compared to blood levels of glucose, hypercholesterolemia, carotid IMT, and p-eNOS. Conclusion: Our data suggested that eVCAM-1 was closely associated with atherosclerotic plaque progression and preceded impairment of EDD. Thus, this study supported the use of carotid VCAM-1 targeting agents to estimate the severity of CAD.
Mycobacterium avium Paratuberculosis (MAP) and Cytomegalovirus (CMV) Are Frequently Detected in the Saliva of Patients Recently Diagnosed with Crohn Disease (CD) Whereas Oral Propionibacterium Acnes (PA) or Methylacetate (MA) in Their Breath Is Rare  [PDF]
Donatini Bruno, Le Blaye Isabelle
Journal of Biosciences and Medicines (JBM) , 2015, DOI: 10.4236/jbm.2015.312003

We investigated the presence of MAP, CMV, or Epstein-Barr virus (EBV) in the saliva of patients presenting with periodontal disease, gingivitis or oral aphthosis. We also measured methylacetate in their breath and looked for the presence of PA on their tongue. All patients were prospectively enrolled into a two-year cohort study. We compared the group presenting with CD versus the group without CD. 167 patients were enrolled. 24 patients presented with CD. CMV and MAP were found concomitantly in 67% of CD patients (17 patients) whereas only 1 patient (<0.1%; p < 0.001) has these infectious agents in the comparative group. PA was rare in CD (25% versus 70.6%; p < 0.001). MA was low, especially with an empty stomach (0.59 ppm +/? 1.45 versus 5.14 ppm +/? 8.97; p < 0.001). It was concluded that the association MAP + CMV was frequently found in oral lesions of CD at an early stage. Detection of PA, MAP and CMV, as well as breath test could be easily performed and may participate to the early diagnosis of CD.

O paradoxal estatuto do conhecimento jornalístico: entre a desconsidera??o e o protagonismo do saber produzido pelas notícias nas sociedades modernas
Anchieta, Isabelle;
Intercom: Revista Brasileira de Ciências da Comunica??o , 2011, DOI: 10.1590/S1809-58442011000200009
Abstract: the knowledge of journalism debate produces a paradox: on the one hand, it is the most appropriate way to meet the present and historical events in modern societies, on the other hand, is considered insufficient knowledge, fragmented and ideologically committed to the social reality . in this article we ask: which is, after all the place of knowledge generated for journalism in modern society? let's get into the discussion in the context of the crisis of traditional knowledge and science as truth. its effects reach particularly the form of journalism and creates a dilemma: whether journalism can not be legitimized in scientific terms would then be closer to the knowledge based on common sense? for that, compared two theoretical perspectives on knowledge news: the german tobias peucer, seventeenth century, and the american robert park, of the twentieth century. in this comparison we are interested in observing the changes, but especially that which remains in journalistic practices to finally establish the ethics of journalistic knowledge.
From street to job: integrating juvenile delinquents
Etnográfica , 2010,
Abstract: since the 1970s, given the transformations of the job market and the changes in ?street culture?, professional morals replace ?street morals? less easily than before, and the shop floor is less integrative for juvenile delinquents. in that sense, the importance of the role played by the institutions involved in the process of normalization has grown in proportion. by studying an integration system for juvenile delinquents, in a french banlieue, it is precisely that sort of ambition i wished to apprehend. through the case studies of three young men, i explain the reasons why the young people involved in the system participate in it, and the conditions that need to be met for a street educator?s moral authority to be acknowledged. i underscore the acculturation that takes place at the heart of the system and the type of competences that can be acquired there. i show also, the stigmata linked to a delinquent past can always get in the way of the process and reactivate habits developed in the ?street?.
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