oalib

Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99

Submit

Any time

4 ( 1 )

2020 ( 1 )

2019 ( 42 )

2018 ( 65 )

Custom range...

Search Results: 1 - 10 of 24040 matches for " Isabela;Alves-Leon "
All listed articles are free for downloading (OA Articles)
Page 1 /24040
Display every page Item
SPECT cerebral interictal em pacientes com epilepsia do lobo temporal de difícil controle
Andraus, Maria Emilia Cosenza;Cosenza, Carlos Alberto Nunes;Fonseca, Léa Mirian Barbosa da;Andraus, Cesar Fantezia;D'Andrea, Isabela;Alves-Leon, Soniza Vieira;
Arquivos de Neuro-Psiquiatria , 2002, DOI: 10.1590/S0004-282X2002000500019
Abstract: the objective of this study was to evaluate the utility of interictal brain spect in localizing the epileptogenic focus in a population of patients of epilepsy clinic of hospital universitário clementino fraga filho (hucff/ufrj), with medically refractory temporal lobe epilepsy (tle) and normal computed tomography (ct) scans, studying the correlation between spect, electroencephalogram (eeg) and, in 11 cases, brain magnectic resonance imaging (mri), and to compare the results to the other six literatura series. twelve (52.2%) patients presented abnormal spect. among these, five (41.6% of abnormal spects) presented unilateral spect changes at the same side of eeg (hypoperfusion in four and hyperperfusion in one), three (25% of abnormal spects) presented bilateral hypoperfusion and bilateral eeg changes too, and four (33.3%) presented unilateral hypoperfusion and bilateral eeg changes. the statistical analysis was based on fuzzy logic. the correlation index among spect x eeg, spect x mri and spect x eeg x mri were highly significant, with signifcance levels at 0.01, p < 0.0005 and trust interval at 99% in all correlations. the correlation studies between the series presented similar results.
Clinical and electroencephalographic characteristics of a cohort of patients with epilepsy and absence seizures
Alves-Leon, Soniza Vieira;Cardoso, Maria Fátima Bento de Souza;Pereira, Valéria Coelho Santa Rita;Meira, Isabela D'Andrea;
Arquivos de Neuro-Psiquiatria , 2009, DOI: 10.1590/S0004-282X2009000600005
Abstract: background: epileptic syndromes with absence seizures (as) possess unique clinical and electroencephalographic (eeg) characteristics. in typical or atypical as, ictal phenomenology may include various characteristics. vídeo-eeg monitoring enables findings to be correlated with ictal phenomenology. objective: to evaluate the different as in a cohort of patients with drug-resistant epilepsy (dre) based on the international league against epilepsy (ilae)'s 2006 classification, to correlate with ictal phenomenology recorded and to apply the panayiotopoulos criteria. method: this study included patients with criteria of as followed up at the epilepsy clinic. a dual, cross-sectional cohort study was carried out between 2005 and 2008. patients receiving care in the epilepsy program of the hucff-ufrj, who had been investigated by video-eeg and who presented clinical and eeg criteria for absence seizures, typical or atypical, according to the criteria defined by the ilae, were included in the study, independent of age onset, the review of clinical history, age onset, family history, epilepsy onset and evolution, seizures phenomenology, antiepileptic drugs response and neuroimaging studies were used to classify the patients among the different epileptic syndrome associated to absence seizures. results: typical absences were more frequent (71.4%) than atypical absences. cases of juvenile absence epilepsy were the most frequent (19%) in this series, followed by childhood absence epilepsy (14.4%) and juvenile myoclonic epilepsy (4.8%). in 14 patients (66.67%), diagnosis was modified from focal epilepsy to primary generalized epilepsy. clinical and eeg diagnosis of absence epilepsy resulted in a dramatic improvement in the control of seizures following modification of diagnosis and indication of an appropriate antiepileptic drug. conclusion: our results show that typical as are more frequent than atypical. as was successfully defined in 10 patients following application of panayi
Non-epileptiform EEG abnormalities: an overview
Andraus, Maria Emilia Cosenza;Alves-Leon, Soniza Vieira;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000600020
Abstract: more than 80 years after its introduction by hans berger, the electroencephalogram (eeg) remains as an important supplementary examination in the investigation of neurological disorders and gives valuable and accurate information about cerebral function. abnormal eeg findings may include ictal patterns, interictal epileptiform activity and non-epileptiform abnormalities. the aim of this study is to make an overview on the main non-epileptiform eeg abnormalities, emphasizing the pathologic findings and the importance of their recognition, excluding periodic patterns and eeg physiologic changes. scientific articles were selected from medline and pubmed database. the presence of non-epileptiform eeg abnormalities provide evidence of brain dysfunction that are not specific to a particular etiology and may be related to a number of disorders affecting the brain. although these abnormalities are not specific, they can direct attention to the diagnostic possibilities and guide the best treatment choice.
Determination of soluble ICAM-1 and TNFalphaR in the cerebrospinal fluid and serum levels in a population of Brazilian patients with relapsing-remitting multiple sclerosis
Alves-Leon, Soniza Vieira;Batista, Elizabeth;Papais-Alvarenga, Regina;Quírico-Santos, Thereza;
Arquivos de Neuro-Psiquiatria , 2001, DOI: 10.1590/S0004-282X2001000100005
Abstract: cytokines and adhesion molecules have been implicated in the pathogenesis of multiple sclerosis (ms), a chronic inflammatory disease of the central nervous system. in this study we analyzed intrathecal (csf) and serum levels of soluble intercellular adhesion molecule (icam-1) and tnfar (60kd) from 20 patients with clinically definite ms during acute relapse or stable disease. comparing to control groups of healthy individuals and patients with intervertebral herniated disc, ms patients showed increased levels (p< 0.001) of sicam-1 and tnfar in both serum and csf samples. regardless stage of disease there was no significant difference in the levels of sicam-1 during acute relapse (657±124.9 ng/ml) or remission (627±36.2 ng/ml). a steady increase of tnfar (60kd) in both serum and csf, indicate the existence of a continuous inflammatory process within the brain tissue of ms patients despite absence of clinical signs of disease activity.
Study of polymorphisms in the interleukin-4 and IL-4 receptor genes in a population of Brazilian patients with multiple sclerosis
Quirico-Santos, Thereza;Suppiah, Vijayaprakash;Heggarty, Shirley;Caetano, Regina;Alves-Leon, Soniza;Vandenbroeck, Koen;
Arquivos de Neuro-Psiquiatria , 2007, DOI: 10.1590/S0004-282X2007000100005
Abstract: this study aimed to investigate in a population of brazilian patients with multiple sclerosis (ms) single-nucleotide polymorphisms (snp) in the promoter region of il4 (*33c-t) and receptor il4r (*q551r a-g) genes proposed to interfere with disease progression. no significant differences were observed in either of the snps investigated between healthy controls (n=135) and ms patients (n=129). however, the il4+33 tt genotype was significantly (p=0.039) higher in african descendants ms (af-ms= 9.09%) than in caucasian ms (ca-ms= 1.35%). it was also observed a significant (p=0.016) increase for the il4r* q551r cc genotype in af-ms compared to those of caucasian ethnicity (af-ms= 21.62%; ca-ms= 4.35%). these results suggest that il4+33 and il4r*q551 polymorphisms may have a disease-promoting role of th2 mediators in african ms descendants. additionally neither il4 nor il4r genes are susceptibility factors for brazilian ms but may be able to modify ethnicity-dependent disease risk and penetrance of susceptibility factors.
Periodic EEG patterns: importance of their recognition and clinical significance
Andraus, Maria Emilia Cosenza;Andraus, Cesar Fantezia;Alves-Leon, Soniza Vieira;
Arquivos de Neuro-Psiquiatria , 2012, DOI: 10.1590/S0004-282X2012000200014
Abstract: periodic electroencephalographic (eeg) patterns consist of discharges usually epileptiform in appearance, which occur at regular intervals, in critical patients. they are commonly classified as periodic lateralized epileptiform discharges (pleds), bilateral independent pleds or bipleds, generalized epileptiform discharges (gpeds) and triphasic waves. stimulus-induced rhythmic, periodic or ictal discharges (sirpids) are peculiar eeg patterns, which may be present as periodic discharges. the aim of this study is to make a review of the periodic eeg patterns, emphasizing the importance of their recognition and clinical significance. the clinical significance of the periodic eeg patterns is uncertain, it is related to a variety of etiologies, and many authors suggest that these patterns are unequivocally epileptogenic in some cases. their recognition and classification are important to establish an accurate correlation between clinical, neurological, laboratorial and neuroimaging data with the eeg results.
Avalia??o de foco epileptogênico do lobo temporal: correla??o entre SPECT ictal, ressonancia magnética e ressonancia magnética com espectroscopia de prótons
Diegues, Maria Elena Martins;Pellini, Marcos Pinto;Alves-Leon, Soniza Vieira;Domingues, Romeu C?rtes;
Radiologia Brasileira , 2004, DOI: 10.1590/S0100-39842004000100003
Abstract: the purpose of this study was to determine the degree of concordance between radiological and radioisotopic methods and, if positive, to evaluate the usefulness of ictal spect in the localization of the epileptogenic focus. ictal brain spect, magnetic resonance imaging (mri) and magnetic resonance spectroscopy (mrs) were performed on six patients with refractory temporal lobe epilepsy. ictal spect was performed after withdrawal of the anti-epileptogenic drugs during video-eeg monitoring, using 99mtc-ecd, administered to patients at the time of the ictus. mri was performed in t1, t2 and flair sequences and mrs was obtained using the press technique, with a single voxel positioned in both hippocampi. the statistical analysis included the determination of the values of kappa (k), standard error (se) and significance level (p) for the lateralization of the ictal focus. the analysis of all findings was based on eeg localization of the ictal discharge, seizure duration (109-280 s; 152 s average) and time of radiotracer injection (30-262 s; 96 s average). we obtained correlated data in four patients (67%), and values of k = 0.67, se = 0.38, and p = 0.041. we concluded that there is a concordance between ictal spect, mri and mrs data and the usefulness of the radioisotopic procedure is related to a nondiagnostic eeg and when there is a discordant or misleading diagnosis after a comparative analysis of eeg and mrs.
Avalia o de foco epileptogênico do lobo temporal: correla o entre SPECT ictal, ressonancia magnética e ressonancia magnética com espectroscopia de prótons
Diegues Maria Elena Martins,Pellini Marcos Pinto,Alves-Leon Soniza Vieira,Domingues Romeu C?rtes
Radiologia Brasileira , 2004,
Abstract: O objetivo deste trabalho foi determinar a existência de concordancia entre os métodos radioisotópico e radiológico e, em caso positivo, avaliar a utilidade do SPECT ictal na determina o do foco epileptogênico. Foram realizados SPECT ictal, ressonancia magnética (RM) e ressonancia magnética com espectroscopia de prótons (RME) em seis pacientes com epilepsia de lobo temporal refratária. O SPECT ictal foi realizado após a retirada das drogas antiepilépticas durante monitoramento por vídeo-EEG, utilizando-se o 99mTc-ECD, administrado aos pacientes no início da crise. As imagens de RM foram obtidas em T1, T2 e FLAIR, com cortes de 3 e 5 mm de espessura, e a RME foi realizada com técnica PRESS, com voxel único posicionado no hipocampo, bilateralmente. A análise estatística incluiu os valores de Kappa (k), erro-padr o (ep) e o nível de significancia (p) para a lateraliza o do foco. Os achados foram analisados com base na localiza o por EEG da descarga ictal, no tempo de dura o da crise (109-280 s; média: 152 s) e no tempo de administra o do tra ador (30-262 s; média: 96 s). Obtivemos dados correlatos em quatro pacientes (67%), com valores de k = 0,67, ep = 0,38 e p = 0,041. Concluímos que existe concordancia entre SPECT ictal, RM e RME, e a utilidade do procedimento radioisotópico está relacionada aos casos em que o EEG n o é diagnóstico e quando há discordancia ou indefini o diagnóstica na análise comparativa entre EEG, RM e RME.
Determination of soluble ICAM-1 and TNFaR in the cerebrospinal fluid and serum levels in a population of Brazilian patients with relapsing-remitting multiple sclerosis
Alves-Leon Soniza Vieira,Batista Elizabeth,Papais-Alvarenga Regina,Quírico-Santos Thereza
Arquivos de Neuro-Psiquiatria , 2001,
Abstract: Cytokines and adhesion molecules have been implicated in the pathogenesis of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system. In this study we analyzed intrathecal (CSF) and serum levels of soluble intercellular adhesion molecule (ICAM-1) and TNFalphaR (60kD) from 20 patients with clinically definite MS during acute relapse or stable disease. Comparing to control groups of healthy individuals and patients with intervertebral herniated disc, MS patients showed increased levels (p< 0.001) of sICAM-1 and TNFalphaR in both serum and CSF samples. Regardless stage of disease there was no significant difference in the levels of sICAM-1 during acute relapse (657±124.9 ng/ml) or remission (627±36.2 ng/ml). A steady increase of TNFalphaR (60kD) in both serum and CSF, indicate the existence of a continuous inflammatory process within the brain tissue of MS patients despite absence of clinical signs of disease activity.
Clinical and electroencephalographic characteristics of benign occipital epilepsy of childhood in two tertiary Brazilian hospitals
Alves-Leon, Soniza Vieira;Nunes, Renata Gomes;Andraus, Maria Emilia Cosenza;Biagini Junior, José Carlos;Hemb, Marta;Genofre, Maria Alice;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000500014
Abstract: this study intended to investigate the clinical and electroencephalographic benign occipital epilepsy of childhood (boec) characteristics in a population sample of patients from two tertiary brazilian hospitals. we analyzed retrospectively 4912 electroencephalograms (eegs) records, and the included patients were submitted to a new clinical and eeg evaluation. were included 12 (0.92%) patients; 4 (33.3%) with criteria for early boec; 6 (50%) for late form and 2 (16.7%) with superimposed early and late onset forms. after new investigation, 2 (16.7%) had normal eeg; 4 (33.3%) had paroxysms over the occipital region; 3 (25%) over the temporal posterior regions and 3 (25%) over the posterior regions. sharp waves were the predominant change, occurring in 8 (66.6%); spike and slow wave complexes in 1 (8.3%) and sharp and slow wave complexes in 1 (8.3%). vomiting, headache and visual hallucinations were the most common ictal manifestations, presented in 100% of patients with superimposed forms. vomiting were absent in the late form and headache was present in all forms of boec.
Page 1 /24040
Display every page Item


Home
Copyright © 2008-2017 Open Access Library. All rights reserved.