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Search Results: 1 - 10 of 1292 matches for " Isabela Rosier Olimpio;Damasceno "
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Avalia??o das concentra??es plasmática e urinária de isoflavonas purificadas de soja
Pereira, Isabela Rosier Olimpio;Damasceno, Nágila Raquel Teixeira;Pereira, Edimar Cristiano;Tavares, Leoberto Costa;Abdalla, Dulcineia Saes Parra;
Revista Brasileira de Ciências Farmacêuticas , 2002, DOI: 10.1590/S1516-93322002000300005
Abstract: soy isoflavones show antioxidant and estrogenic effects and have been related to decreased risk of cancer and cardiovascular diseases. the goal of the present study was to standardize the extraction of isoflavones from soy molasses and to evaluate the plasmatic and urinary concentrations of isoflavones in rabbits after consumption of extracted isoflavones. isoflavones were extracted with 90% ethanol and purified with a c18 column. the extraction yield was 81%. the purified isoflavone extract was added to the chow (5 mg isoflavone/ kg body weight/ day) used for feeding rabbits during 6 months. the concentration of isoflavones (genistein and daidzein) in the extracts, chow, blood plasma and urine was determined by high performance liquid chromotagraphy. the mean concentration of isoflavones in blood plasma was 4 mm and the urinary excretion was 22 μmol/24 h. the extraction of isoflavones from soy molasses resulted in a suitable preparation for experimental studies.
Lipid peroxidation and nitric oxide inactivation in postmenopausal women
Pereira Isabela Rosier Olimpio,Bertolami Marcelo Chiara,Faludi André Arpad,Campos Maria Fernanda
Arquivos Brasileiros de Cardiologia , 2003,
Lipid peroxidation and nitric oxide inactivation in postmenopausal women
Pereira, Isabela Rosier Olimpio;Bertolami, Marcelo Chiara;Faludi, André Arpad;Campos, Maria Fernanda;Ferderbar, Simone;Lima, Emersom Silva;Aldrighi, José Mendes;Abdalla, Dulcineia Saes Parra;
Arquivos Brasileiros de Cardiologia , 2003, DOI: 10.1590/S0066-782X2003000400005
Abstract: objective: to assess the effect of endogenous estrogens on the bioavailability of nitric oxide (·no) and in the formation of lipid peroxidation products in pre- and postmenopausal women. methods: nox and s-nitrosothiols were determined by gaseous phase chemiluminescence, nitrotyrosine was determined by elisa, cox (cholesterol oxides) by gas chromatography, and cholesteryl linoleate hydroperoxides (ce18:2-ooh), trilinolein (tg18:2-ooh), and phospholipids (pc-ooh) by hplc in samples of plasma. results: the concentrations of nox, nitrotyrosine, cox, ce18:2-ooh, and pc-ooh were higher in the postmenopausal period (33.8±22.3 mm; 230±130 nm; 55±19 ng/ml; 17±8.7 nm; 2775±460 nm, respectively) as compared with those in the premenopausal period (21.1±7.3 mm; 114±41 nm; 31±13 ng/ml; 6±1.4 nm; 1635±373 nm). in contrast, the concentration of s-nitrosothiols was lower in the postmenopausal period (91±55 nm) as compared with that in the premenopausal p in the premenopausal period (237±197 nm). conclusion: in the postmenopausal period, an increase in nitrotyrosine and a reduction of s-nitrosothiol formation, as well as an increase of cox, ce18:2-ooh and pc-ooh formation occurs. therefore, ?no inactivation and the increase in lipid peroxidation may contribute to endothelial dysfunction and to the greater risk for atherosclerosis in postmenopausal women.
Influência do ciclo lunar no parto: mito ou constata??o científica?
Bueno, Aline;Iessi, Isabela Lovizutto;Damasceno, Débora Cristina;
Revista Brasileira de Enfermagem , 2010, DOI: 10.1590/S0034-71672010000300021
Abstract: superstitions are found everywhere in our lives, and medicine, a profession that is prides itself on an evidence-based approach to treatment, is not exempt. a superstition that pervades the labor and delivery floor is that it is busier during certain phases of the lunar cycle, specifically the full moon. although some studies have demonstrated an increase in deliveries that are related to the lunar cycle, there has been disagreement about when, in the lunar cycle, the peak volume occurs. front to the divergence of the existent results in the literature to relate the events of the lunar cycle with deliveries, the aim of this review was to accomplish the literature in the attempt of explaining this popular culture with base in the results presented by different researchers.
Laurence Rosier
Argumentation et Analyse du Discours , 2012,
Abstract: Au vu de leur importance dans la dynamique sociale des échanges, on ne peut que se réjouir du nombre et de la qualité des travaux consacrés, depuis une vingtaine d’années, à l’insulte/injure et plus largement à la violence verbale , une catégorie qui peut appara tre fourre tout pour certains (Largèche 2011), mais facilement identifiable du point de vue pragmatique et lexical aux yeux de l’institution, et de nature à être contr lée pénalement (Moise & Auger 2003, 2004 notamment). En tém...
Postures de l’érudit-puriste et sociotypifications imaginaires
Laurence Rosier
COnTEXTES : Revue de Sociologie de la Littérature , 2011, DOI: 10.4000/contextes.4724
Abstract: IntroductionAfin de poursuivre notre travail en cours sur les représentations socio-langagières spontanées des locuteurs, leur validité scientifique et leur portée heuristique, nous partirons de quelques définitions en usage d’expressions telles que posture d’érudit et posture de puriste , utilisées dans des productions spontanées d’internautes. Pourquoi ce point de départ ?Nous pensons (et ces positions sont notamment illustrées dans notre ouvrage sur la langue fran aise de 2008 et da...
Chaotic dynamical systems associated with tilings of $\R^N$
Lionel Rosier
Mathematics , 2010,
Abstract: In this chapter, we consider a class of discrete dynamical systems defined on the homogeneous space associated with a regular tiling of $\R^N$, whose most familiar example is provided by the $N-$dimensional torus $\T ^N$. It is proved that any dynamical system in this class is chaotic in the sense of Devaney, and that it admits at least one positive Lyapunov exponent. Next, a chaos-synchronization mechanism is introduced and used for masking information in a communication setup.
Evaluation of neonatally-induced mild diabetes in rats: Maternal and fetal repercussions
Isabela L Iessi, Aline Bueno, Yuri K Sinzato, Kristin N Taylor, Marilza VC Rudge, Débora C Damasceno
Diabetology & Metabolic Syndrome , 2010, DOI: 10.1186/1758-5996-2-37
Abstract: Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia, insufficient insulin secretion, and receptor insensitivity to endogenous insulin. Its incidence is associated with high morbidity and mortality rates [1]. In pregnancies complicated by diabetes, hyperglycemia and alterations in lipid metabolism are associated with both maternal and fetal complications [2,3], causing reproductive abnormalities that enhance spontaneous abortion, congenital anomalies, and neonatal morbidity and mortality [4,5].Congenital anomalies are more common in infants of diabetic women than in children of nondiabetic women. The etiology, pathogenesis and prevention of diabetes-induced anomalies have spurred considerable clinical and basic research efforts. The infant of the diabetic mother also has increased risk for several neonatal complications, such as macrosomia, hypoglycemia, hypocalcemia, polycythemia and hyperbilirubinemia. Up to 25% of such offspring have been reported with these complications. It also appears that early detection and subsequent strict metabolic control of pregnant women with diabetes in pregnancy should decrease the frequency and severity of some of these short- and long-term complications in the offspring of the diabetic mother [4].Despite increased clinical efforts to improve glycemic control during diabetic pregnancy, however, the rate of congenital malformations remains increased in studies of Diabetes mellitus (DM) of type 1 [6-9], DM type 2 [9-12], and gestational diabetes (GDM) [10,13]. The prevalence of major congenital malformations is approximately three to five times higher in infants of diabetic mothers [14-17] and is presently the most common cause of perinatal death among these infants [18,19]. Diabetes is associated with a variety of anomalies, primarily cardiovascular, neurological, and musculoskeletal [20]. The malformation considered to be most pathognomic to the infants of diabetic mothers - caudal regression syndrome or sa
Neonatally Induced Mild Diabetes in Rats and Its Effect on Maternal, Placental, and Fetal Parameters
Yuri Karen Sinzato,Gustavo Tadeu Volpato,Isabela Lovizutto Iessi,Aline Bueno,Iracema de Mattos Paranhos Calderon,Marilza Vieira Cunha Rudge,Débora Cristina Damasceno
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/108163
Abstract: The aim of this study was to assess placental changes and reproductive outcomes in neonatally induced mild diabetic dams and fetal development in their offspring. At birth, female rats were assigned either to control or diabetic group (100 mg of streptozotocin/Kg, subcutaneously). At adulthood, the female rats were mated. During pregnancy, the blood glucose levels and glucose and insulin tolerance tests were performed. At term, maternal reproductive outcomes, fetal and placental weight, and placental morphology were analyzed. Diabetic rats had smaller number of living fetuses, implantations and corpora lutea, and increased rate of embryonic loss. Placenta showed morphometric alterations in decidua area. Our results showed that mild diabetes was sufficient to trigger alterations in maternal organism leading to impaired decidua development contributing to failure in embryonic implantation and early embryonic losses. Regardless placental decidua alteration, the labyrinth, which is responsible for the maternal-fetal exchanges, showed no morphometric changes contributing to an appropriate fetal development, which was able to maintain normal fetal weight at term in mild diabetic rats. Thus, this experimental model of diabetes induction at the day of birth was more effective to reproduce the reproductive alterations of diabetic women.
Evaluation of placental glycogen storage in mild diabetic rats
Bueno, Aline;Iessi, Isabela Lovizutto;Calderon, Iracema de Mattos Paranhos;Rudge, Marilza Vieira Cunha;Santos, Carlos Eduardo Meirelles dos;Damasceno, Débora Cristina;
Acta Cirurgica Brasileira , 2010, DOI: 10.1590/S0102-86502010000200002
Abstract: purpose: to evaluate the placental glycogen storage and fetal development in the pregnancy of neonatally streptozocin-induced diabetic rats and to establish relation with glycemia and insulin levels. methods: at the birth day, 147 female rats were randomly distributed in two experimental groups: 1) non-diabetic group (control, n=45) - received the vehicle; 2) diabetic group (stz, n=102) - received 100 mg streptozocin/kg in neonatal period. at day 0 of pregnancy, adult female rats were included in the control group when presented glycemia below 120 mg/dl and, in the group stz with glycemia between 120 and 300 mg/dl. at day 21 of pregnancy, blood samples were collected for glycemia and insulin determination, and placentas withdrawn for placental glycogen determination. the newborns (nb) were classified in small (sga), appropriate (aga) and large (lga) for gestational age. results: rats stz presented higher glycemia at days 0 and 14 of pregnancy. at end of pregnancy, rats stz showed higher proportion of nb sga and lga; reduced rate of nb aga and unaltered glycemia, insulin and placental glycogen determinations. conclusion: mild diabetes altered the maternal glycemia in the early pregnancy, impairing future fetal development, but it caused no alteration on insulin and placental glycogen determination, confirming that this glycemic intensity was insufficient to change glycogen metabolism.
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