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Search Results: 1 - 10 of 467300 matches for " Isabel A. Perillo "
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1H- and 13C-NMR Analysis of a Series of 1,2-Diaryl-1H-4,5-dihydroimidazoles
Alejandra Salerno,Isabel A. Perillo
Molecules , 2005, DOI: 10.3390/10020435
Abstract: An analysis of the 1H- and 13C-NMR spectra of a series of 1,2-diaryl-1H-4,5-dihydroimidazoles and comparisons with 4,5-dihydroimidazoles having differentsubstitution patterns are presented. The influence of different 1-aryl and 2-aryl groupsubstituents on spectroscopic parameters of the heterocyclic ring and on the contributionsof possible mesomeric structures in the system was determined. Spectroscopic featuresare coherent with the presence of two conjugated systems (Ar1-N and Ar2-C=N) whichcompete with the delocalization characteristics of the amidine system.
1H and 13C-NMR Spectroscopic Study of Some 1H-4,5-Dihydroimidazolium Salts
Alejandra Salerno,Isabel A. Perillo
Molecules , 2000, DOI: 10.3390/50300479
Abstract: The 1H y 13C-NMR spectra of some 1,3 and 1,2,3-trisubstituted 1H-4,5-dihydroimidazolium salts are analyzed.
New Green Synthesis and Antineoplastic Activity of Bis (3-Arylimidazolidinyl-1) Methanes  [PDF]
María Cristina Caterina, Isabel A. Perillo, Ximena Villalonga, Nicolás Amiano, Cristian Payés, Mercedes L. Sanchez, Alejandra Salerno
Open Journal of Medicinal Chemistry (OJMC) , 2013, DOI: 10.4236/ojmc.2013.34014
Abstract: A new green synthesis and anti-tumor activity of the series of bis (3-arylimidazolidinyl-1) methanes 1 - 6 are described.
The compounds were synthesized from the corresponding N-arylethylenediamine and trioxane as sources of formaldehyde
and the reactions were performed in heterogeneous phase catalyzed by an acidic ion-exchange resin (Amberlyst
15). The compounds were tested with the Sulforhodamine B assay according to the protocol of the National Cancer Institute
for several cell lines. The results were expressed as percentage inhibition of growth cell in comparison with the
full growth of the cells without treatment. Cytotoxicity on normal cells using the Annexing-PI staining and flow cytometry
has been evaluated. The parent compound, bis(3-phenylimidazolidinyl-1)methane 1 and the monohalogenated
derivatives 4-chlorophenyl 3 and 3-bromophenyl 5 showed antineoplastic activity, 60%, 82% and 89% inhibition
growth cell respectively on the human colon cell line (HCT116). The 4-tolyl derivative 6 presented inhibitory activity (73%
inhibition of growth cell) on human lung adenocarcinoma cell line (A549) and 62% on human mammary cell line MCF-7.
Conformational Analysis of Seven Membered Nitrogen Heterocycles Employing Molecular Modeling. Part II: 1-(ONitrophenyl)-2-Phenyl-1h-4,5,6,7-Tetrahydro-1,3-Diazepine
Mónica E. Hedrera,Adriana Robinsohn,Isabel A. Perillo
Molecules , 2000, DOI: 10.3390/50300483
Abstract: Geometry optimization of 1-(o-nitrophenyl)-2-phenyl-1H-4,5,6,7-tetrahydro-1,3-diazepine is performed by means of molecular modeling. Results are correlated with theoretical and experimental UV spectra.
Simple and Efficient Microwave Assisted N-Alkylation of Isatin
María Sol Shmidt,Ana María Reverdito,Lautaro Kremenchuzky,Isabel Amalia Perillo,María Mercedes Blanco
Molecules , 2008, DOI: 10.3390/molecules13040831
Abstract: We present herein the results of microwave promoted N-alkylations of isatin (1)with different alkyl, benzyl and functionalized alkyl halides. Reactions were carried outunder different conditions, always employing methodologies compatible with MW assistedchemistry. Generation of isatin anion employing diverse bases and solvents or using thepreformed isatin sodium salt was tested. The best results were achieved using K2CO3 orCs2CO3 and a few drops of N,N-dimethylformamide or N-methyl-2-pyrrolidinone. Thesereactions present noteworthy advantages over those carried out employing conventionalheating.
Effects of Gabaergic Phenols on Phospholipid Bilayers as Evaluated by 1H-NMR  [PDF]
Gabriela N. Reiner, Leonardo Fernandes Fraceto, Eneida de Paula, María A. Perillo, Daniel A. García
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.43A004

The phenols propofol and thymol, and lately carvacrol, eugenol and chlorothymol, have been shown to act as positive allosteric modulators on GABAA receptor, which is the main inhibitory receptor of the central nervous system. GABAA receptor is an intrinsic membrane protein which activity may be affected by surface-active compounds and by physical changes in the membrane. Recently, we demonstrated that these phenols interacted with the lipid membrane phase, suggesting their anesthetic activity could be the combined result of their specific (with receptor proteins) as well as nonspecific (with surrounding lipid molecules) interaction modulating the supramolecular organization of the receptor environment. In the current study, by using 1H-NMR spectroscopy, we have investigated the effects of the insertion and the possible preferential location of the five phenol derivatives with GABAergic activity on EPC membranes. The results indicate that all compounds are able to insert in EPC phospholipid vesicles and to locate in the region between the polar group (choline molecule), the glycerol and the first atoms of the acyl chains, being the more lipophilic compounds (propofol and chlorothymol) that seem to prefer a deeper bilayer insertion. The location of the phenol molecules would reduce the repulsive forces among phospholipids head groups allowing closer molecular packing and finally diminishing the mobility of the hydrocarbon chains, as revealed by 1H spin relaxation times.

Lesions associated with mineral deposition in the lymph nodes and lungs of cattle: a case-control study of environmental health hazard.
A Perillo,O Paciello,A Tinelli,A Morelli
Folia Histochemica et Cytobiologica , 2010, DOI: 10.5603/4300
Abstract: This report focuses on the state of health of the cattle raised in the district of Taranto - city of Italy rated as environmentally at risk. Representative samples of lungs, bronchial and mediastinal lymph nodes of cattle from district of Taranto's slaughterhouses were collected. After a macroscopic examination, samples with marked lesions were processed for light microscopy. Samples were also observed with polarized light microscopy, scanning electron microscopy and with microanalysis. The macroscopic examination revealed that 60 out of 183 samples showed marked lesions. Lung alterations were characterized by thickening of the alveolar septa and by the latter's modifying action on the alveolar spaces, foci of fibrosis and bronchopulmonary inflammation. For 51 out of the 60 samples observed, the histological examination confirmed the presence of pneumoconiosis and lymph nodal anthracosis. Energy-dispersive X-ray microanalysis of lung samples identified a wide range of elements including silicon, aluminium, titanium, iron, carbon and small amount of the other metals. In the lymph-nodes the same kind of metals with a different levels of distribution was observed. Our survey on cattle farmed in areas at high risk of pollution may be helpful to the estimation of the exposure risk for man to environmental contaminants and to the evaluation of the occurrence of the pathological manifestations as well.
Short-term variability in the phytoplankton and physico-chemical variables in a high-tidal regime, Bahía Blanca Estuary, Argentina
Valeria A. Guinder,Cecilia A. Popovich,Gerardo M. E. Perillo
Brazilian Journal of Oceanography , 2009, DOI: 10.1590/s1679-87592009000300008
Improved Synthesis of N-Substituted Quinolinimides Using Microwave Irradiation
M. M. Blanco,I. A. Perillo,C. B. Schapira
Molecules , 2000, DOI: 10.3390/50300481
Abstract: The synthesis of several quinolinimidoacetic acid derivatives (I) by two different routes, starting from quinolinic anhydride or quinolinimide, is described. In all cases better yields and decreased reaction times were achieved employing microwave irradiation as an alternative source of energy.
Hydrologic response of the drainage basins that intersect Las Grutas town, Argentina
Genchi, Sibila A.;Carbone, María E.;Piccolo, María C.;Perillo, Gerardo M. E.;
Investigaciones geográficas , 2011,
Abstract: the town of las grutas, in a semiarid region on the north west coast of san matías gulf (argentina), is intersected by two drainage basins that are activated immediately after intense rainfall events. these events generate flows capable of producing local flooding, such as the flood of april 2004. the purpose of this study is to establish the hydrologic behavior of these geoforms and the manner in which the land use interacts with them. the lack of hydrometric records necessitates the explanation and prediction of hydrologic responses through empirical approaches such as fluvial morphometry and the usda soil conservation service curve number (1972), supported by geographical information system technology. the study area has characteristics that favor the concentration of runoff into streams during extreme events. first-order segments play an important role in the hydrologic response, showing great potential to receive surface runoff. the effect of urbanization produces an additional runoff of 17.3% and 2.1% in the respective basins. a potential increase in the number of these extreme events in the future due to climate change may lead to more disturbances in the urbanized area. the results of the present study will contribute to the implementation of measures to mitigate the consequences of floods.
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