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Search Results: 1 - 10 of 810 matches for " Irena Vlatkovic "
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Correlation of Renal Impairment and Duration of Hemodialysis with Electromyoneurographic Findings in Chronic Kidney Disease
Branislav Gasic,Aleksandra Dominovic-Kovacevic,Irena Balaban,Vlastimir Vlatkovic
Aktuelnosti iz Neurologije, Psihijatrije i Grani?nih Podru?ja , 2010,
Abstract: Uremic polyneuropathy (PN) is a common concomitant sign of chronic kidney disease (CKD). Numerous studies have demonstrated improvement of symptoms and signs of polyneuropathy on hemodialysis. The aim of this study was to evaluate association between duration of hemodialysis(HD)treatment and the type of polyneuropathy, and association between duration of hemodialysis and sensory and motor nerve conduction velocities for the sural and peroneal nerve. We also examined correlation between glomerular fi ltration rate (GFR) as an indicator of renal impairment and the type of polyneuropathy, and the correlation between GFR and sensory and motor nerve conduction velocities of the sural and peroneal nerve in patients with CKD not treated with HD. Th is study was carried out with 30 patients, 12 females and 18 males, average age 62.67 ± 13.2 years. Patients were divided into 3 groups, each consisting of 10 patients: CKD patients with no need for HD; patients on HD for one year; and CKD patients on HD for 2-12 years. Sensory nerve conduction velocity of the sural nerve and motor nerve conduction velocity of the peroneal nerve were measured by electromyoneurography. Twenty patients were treated with HD for an average 3.85 ± 1.5 years (median 1.5, range 1-12 years). Results showed that 19 out of all patients had sensory polyneuropathy, eight patients had sensorimotor polyneuropathy, and three patients had no signs of neuropathy. We found a negative but statistically insignifi cant association between sensory and motor nerve conduction velocities and the degree of renal impairment and duration of HD treatment. Possible explanations for such fi ndings could be the existence of extreme values of studied variables, the older age of study subjects, and an inadequate HD treatment.
Alternative Splicing and Nonsense-Mediated RNA Decay Contribute to the Regulation of SHOX Expression
Claudia Durand,Ralph Roeth,Harsh Dweep,Irena Vlatkovic,Eva Decker,Katja Ute Schneider,Gudrun Rappold
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018115
Abstract: The human SHOX gene is composed of seven exons and encodes a paired-related homeodomain transcription factor. SHOX mutations or deletions have been associated with different short stature syndromes implying a role in growth and bone formation. During development, SHOX is expressed in a highly specific spatiotemporal expression pattern, the underlying regulatory mechanisms of which remain largely unknown. We have analysed SHOX expression in diverse embryonic, fetal and adult human tissues and detected expression in many tissues that were not known to express SHOX before, e.g. distinct brain regions. By using RT-PCR and comparing the results with RNA-Seq data, we have identified four novel exons (exon 2a, 7-1, 7-2 and 7-3) contributing to different SHOX isoforms, and also established an expression profile for the emerging new SHOX isoforms. Interestingly, we found the exon 7 variants to be exclusively expressed in fetal neural tissues, which could argue for a specific role of these variants during brain development. A bioinformatical analysis of the three novel 3′UTR exons yielded insights into the putative role of the different 3′UTRs as targets for miRNA binding. Functional analysis revealed that inclusion of exon 2a leads to nonsense-mediated RNA decay altering SHOX expression in a tissue and time specific manner. In conclusion, SHOX expression is regulated by different mechanisms and alternative splicing coupled with nonsense-mediated RNA decay constitutes a further component that can be used to fine tune the SHOX expression level.
An RNA-Seq Strategy to Detect the Complete Coding and Non-Coding Transcriptome Including Full-Length Imprinted Macro ncRNAs
Ru Huang, Markus Jaritz, Philipp Guenzl, Irena Vlatkovic, Andreas Sommer, Ido M. Tamir, Hendrik Marks, Thorsten Klampfl, Robert Kralovics, Hendrik G. Stunnenberg, Denise P. Barlow, Florian M. Pauler
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027288
Abstract: Imprinted macro non-protein-coding (nc) RNAs are cis-repressor transcripts that silence multiple genes in at least three imprinted gene clusters in the mouse genome. Similar macro or long ncRNAs are abundant in the mammalian genome. Here we present the full coding and non-coding transcriptome of two mouse tissues: differentiated ES cells and fetal head using an optimized RNA-Seq strategy. The data produced is highly reproducible in different sequencing locations and is able to detect the full length of imprinted macro ncRNAs such as Airn and Kcnq1ot1, whose length ranges between 80–118 kb. Transcripts show a more uniform read coverage when RNA is fragmented with RNA hydrolysis compared with cDNA fragmentation by shearing. Irrespective of the fragmentation method, all coding and non-coding transcripts longer than 8 kb show a gradual loss of sequencing tags towards the 3′ end. Comparisons to published RNA-Seq datasets show that the strategy presented here is more efficient in detecting known functional imprinted macro ncRNAs and also indicate that standardization of RNA preparation protocols would increase the comparability of the transcriptome between different RNA-Seq datasets.
Dusan Vlatkovic,Marko Vukovic
Acta Facultatis Medicae Naissensis , 2007,
Abstract: A number of requests for revision of previously fitted prosthesis hasbecome often due to numerous causes and is likely to be more frequent in thefuture. By an intervention we want to remove some of the complications relatedto prosthetic replacement of the hip joint and its application.The causes are often interconnected. Those are biological problemsrelated to prosthesis usage.We think that patient's behaviour leads to a numberof complications as well.What you need for this intervention is an experienced team, wide rangeof fitting appliances and a set of good instruments.We replaced cement prostheses with cement ones in all but one case, andnon-cement with non-cement or cement prostheses. We conducted antithrombosisprophylaxis and put a patient on antibiotics of high dosage for fourdays. Upright position was allowed depending on the general state starting fromthe third to seventh day.
Dusan Vlatkovic,Marko Vukovic,Rada Aleksic
Acta Facultatis Medicae Naissensis , 2007,
Abstract: The treatment of osseous-joint infections presents a problem in all conditions due to the character, duration and consequences of this complication. In the conditions of general surgery ward, there are numerous aggravating factors.Osseous-joint infections belong to the group of nosocomial infections (NI) defined as infections a patient is exposed to during hospitalization. Most infections which manifested 48 hours after the hospitalization are regarded as nosocomial infections. The patient can be affected by nosocomial infection after leaving the hospital if microorganism is passed on during treatment or hospitalization. Postoperative infection of surgical wounds or infection of the site of surgical intervention is an example of such nosocomial infection.In accordance with the aforementioned, we have undertaken the following preventive actions: isolated hospitalization of the patient, early surgical intervention in the isolated operating theatre, administration of antibiotic therapy intraoperatively and four to five days postoperatively. We have paid special attention to surgical technique: removing a tissue of suspicious vitality, cleansing wounds, and avoiding dead tissues in wounds. We have reduced patient's hospitalization to the shortest possible time.
Obsessive-Compulsive Cognitions, Symptoms and Religiousness in an Iranian Population  [PDF]
Giti Shams, Irena Milosevic
International Journal of Clinical Medicine (IJCM) , 2013, DOI: 10.4236/ijcm.2013.411084

Individual differences in obsessive-compulsive (OC) behavior in various cultures appear to be associated with religiosity. The purpose of this study was to evaluate the role of religion in OC symptoms and cognitions in distinctly low and high religious groups from a normal community sample of 119 Iranian Muslims. Specifically, we compared the two groups on OC cognitions and symptoms, and we examined the correlations between the cognitive and symptom measures within each group. There was a trend for the high religious group to produce greater scores than those in the low religious group on the Obsessive Beliefs Questionnaire (OBQ) subscale of threat overestimation and responsibility. Furthermore, participants that were more religious achieved significantly higher scores on the Penn Inventory of Scrupulosity and on its Fear of God subscale. Although a number of significant correlations were observed between OBQ and Padua Inventory total and subscale scores, particularly in the low religious group, there was no conclusive relationship between religiosity and OC behavior and obsessional beliefs. Religion appears to be one more arena where OC symptoms expressed, rather than being a determinant of the disorder.

Interaction of glassy fertilizers and Cd2+ ions in terms of soil pollution neutralization  [PDF]
Irena Wac?awska, Magdalena Szumera
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.38092
Abstract: Immobilization of cadmium contamination in soils by precipitation of nonassimilable for plants Cd-phosphates was considered. Glassy fertilizer of controlled release rate of the nutrients for plants as a source of phosphate anions was applied. The negative role of Cd complexing citric acid solution simulating the natural soil conditions, which inhibits the Cd-phos-phates formation, was stated.
Cerebrospinal Fluid and Blood Biomarkers of Neuroaxonal Damage in Multiple Sclerosis
Irena Dujmovic
Multiple Sclerosis International , 2011, DOI: 10.1155/2011/767083
Abstract: Following emerging evidence that neurodegenerative processes in multiple sclerosis (MS) are present from its early stages, an intensive scientific interest has been directed to biomarkers of neuro-axonal damage in body fluids of MS patients. Recent research has introduced new candidate biomarkers but also elucidated pathogenetic and clinical relevance of the well-known ones. This paper reviews the existing data on blood and cerebrospinal fluid biomarkers of neuroaxonal damage in MS and highlights their relation to clinical parameters, as well as their potential predictive value to estimate future disease course, disability, and treatment response. Strategies for future research in this field are suggested. 1. Introduction Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) characterized by unpredictable clinical relapses and remissions and/or by progression of disability over time [1]. Relapses are considered to be the clinical expression of acute inflammation in the CNS, whereas progression reflects chronic demyelination, gliosis, and axonal loss [2]. Although axonal/neuronal damage has been recognized in MS for more than a century [3], a refocused interest on the role of axonal pathology and neurodegeneration as the cause of permanent neurological disability in MS patients appeared since the 1990s [4–9]. The development of new immunostaining protocols and new magnetic resonance imaging (MRI) techniques has enabled earlier detection of more subtle changes in diffuse neuroaxonal pathology not only within focal white matter [6, 10] and gray matter lesions [11–13], but also within normal appearing white matter (NAWM) [14–16] and normal appearing gray matter in MS [14, 15]. Current evidence suggests that axonal loss occurs at an early stage of MS [6, 17], but because of CNS compensatory mechanisms it remains clinically silent until a threshold level of axonal loss is achieved and the functional reserve capacity is exhausted [9, 18]. Subsequent progressive axonal loss underlies a continuous and irreversible neurological decline [19], causing a transition from initially relapsing remitting (RR) to the secondary-progressive (SP) MS [7, 9]. Since inflammation correlates only poorly with disability and the loss of neurons and axons may be subject to biochemical monitoring [20], biochemical markers of neuroaxonal degeneration gain increasing importance. Such biomarkers could provide tools for development and evaluation of new therapeutic strategies [21] and might serve as prescreening tools and/or cross-sectional surrogate endpoints
Galvanic Wastewater Treatment by Means of Anionic Polymer Enhanced Ultrafiltration
Irena Korus
Ecological Chemistry and Engineering S , 2012, DOI: 10.2478/v10216-011-0002-2
Abstract: This work is focused on polyelectrolyte enhanced ultrafiltration as an effective heavy metal separation technique. Three types of effluents, containing Zn(II), Cu(II) and Ni(II) ions, were subjected to the separation process. Poly(sodium 4-styrenesulfonate) - PSSS, a water soluble anionic polyelectrolyte was used as a metal binding agent. Two Sepa CF (Osmonics) membranes: EW, made of polysulfone and a modified polyacrylonitrile membrane MW, were used in the ultrafiltration process. The preliminary UF tests were carried out on model solutions with target metal ion concentrations of 10, 100 and 250 mg dm-3. The main parameters affecting the metal retention (the polyelectrolyte quantity and solution pH) were examined. The values of pH 6 and polymer : metal concentration ratio CPSSS : CM = 7.5 : 1 (mol of mer unit per mol of metal) were selected to perform the galvanic wastewater ultrafiltration-concentration tests. Three types of wastewater containing Zn(II), Ni(II) and Cu(II) ions within the concentration range of 30÷70 mg dm-3 were used in the investigations. Very high metal retention coefficients, up to > 99%, were achieved. The retentates obtained were subjected to the decomplexation-ultrafiltration (pH = 1) and subsequent diafiltration step, which enabled partial recovery of concentrated metal ions and the polyelectrolyte. The recovered polyelectrolyte was reused toward Ni(II) ions and the high effectiveness of metal separation has been achieved.
Resources and coping styles utilized by Warsaw adolescents
Irena Jelonkiewicz
Polish Psychological Bulletin , 2010, DOI: 10.2478/s10059-010-0002-6
Abstract: The aim of the study was to establish relationships between perceived psychosocial resources and styles of coping with stress utilized by adolescents. A total of 1326 students (aged 15-20, mean age 17.0 years) of 16 randomly selected secondary schools were examined using a set of self-report questionnaires. Personal resources (sense of coherence and optimism), environmental resources (family affluence, family strengths, support from parents, teachers and peers), and styles of coping with stress were measured. Two groups differing significantly in their perceived resources were distinguished. The group with high resources (HR) consisted of 502, while the low-resource group (LR) - of 570 adolescents. The level of perceived resources (high vs. low) turned out to be associated with utilization of specific coping styles. High-resource adolescents as compared to their low-resource counterparts more often utilized task-oriented coping and seeking interpersonal contacts, at the same time less often using emotion- and distraction-oriented coping styles.
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