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Search Results: 1 - 10 of 27811 matches for " Interstitial Lung Disease "
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Idiopathic Interstitial Pneumonias (IIPs): Review of Clinical, Radiographic and High-Resolution Computed Tomography (HRCT)  [PDF]
Zoheb Gulab Shaikh, Cheng Li, Yiming Li
Advances in Computed Tomography (ACT) , 2016, DOI: 10.4236/act.2016.52002
Abstract: Making a confident diagnosis is a complex task for a specific form of interstitial lung disease and providing appropriate management in an attempt to achieve normalization of the disease can put up an alarming process for the clinicians. A set of diffuse and restrictive lung diseases incorporate with idiopathic interstitial pneumonias, showing inflammation and fibrosis of the interstitium due to parenchymal damage. High-resolution computed tomography (HRCT) has magnified the diagnostic standpoint in stepwise identification and classified various patterns in the evaluation of interstitial lung disease. The aim of our review is to elaborate clinical, radiographic and typical and atypical HRCT findings of idiopathic interstitial pneumonias by correlating with its differential diagnosis. Idiopathic pulmonary fibrosis is the most predominant idiopathic interstitial pneumonias and its diagnosis needs to omit all other well-known causes of interstitial lung diseases. According to the 2011 evidence-based guidelines, usual interstitial pneumonia can be diagnosed by HRCT when all criteria are fulfilled. Non-specific interstitial pneumonia is distinguished by bilateral patchy ground-glass opacities and irregular linear/reticular opacities. Respiratory bronchiolitis associated-interstitial lung disease and desquamative interstitial pneumonia show centrolobular nodules and ground-glass opacities as imaging patterns. Cryptogenic organizing pneumonia consists of patchy peripheral or peribronchial consolidations, while ground-glass opacities with tendency for migration, which is evolving to fibrosis, in acute interstitial pneumonia. Lymphoid interstitial pneumonia and idiopathic pleuro-parenchymal fibroelastosis are classified under rare idiopathic interstitial pneumonias. HRCT images help radiologists in diagnosis and mapping specific patterns of idiopathic interstitial pneumonias. This article reviews the stages of evolution in HRCT features for idiopathic interstitial pneumonias.
Pulmonary rehabilitation outcome of exercise-induced oxygen desaturation in systemic sclerosis with interstitial lung disease  [PDF]
Fujiko Someya, Naoki Mugii
Health (Health) , 2013, DOI: 10.4236/health.2013.56A2001

While exercise capacity in systemic sclerosis with interstitial lung disease could be improved by exercise training, the training outcome of exercise-induced oxygen desaturation has not been examined. The aim of this study was to investigate the effect of pulmonary rehabilitation on exercise-induced oxygen desaturation during the six-minute walk test and to detect the factors affecting outcome retrospectively. Patients showing impaired exercise capacity (≤80% of predicted) and/or exercise-induced oxygen desaturation (≤-4% in SpO2) at the end of the six-minute walk test underwent routine walking exercise. Sixteen patients with stable systemic sclerosis completed exercise training for 55 days on average. The mean six-minute walk distance improved from 467 m to 502 m (P = 0.0012). The improvement in distance was negatively related to baseline distance (R2 = 0.28, P = 0.037), but was not related to parameters from pulmonary function tests and echocardiograms. Oxygen saturation was normal at rest, but was decreased in fifteen patients at the end of the test. Exercise-induced oxygen desaturation was positively related to the diffusion capacity of the lungs for carbon monoxide at baseline (R2 = 0.33, P = 0.026); however, it was not related to any cardiopulmonary parameters after intervention. Seven of sixteen patients ameliorated exercise-induced oxygen desaturation or showed no oxygen desaturation after exercise training, while others deteriorated. No cardiopulmonary parameters affected the training outcome of exercise-induced oxygen desaturation. Exercise train ing was beneficial in improving exercise

Clinical Phenotype of Japanese Patients with Dermatomyositis—Classification Based on Dermatomyositis-Specific Autoantibodies  [PDF]
Shinji Sato, Masataka Kuwana, Michito Hirakata, Shinichi Nogi, Noriko Sasaki, Naofumi Chinen, Kiri Honda, Eiko Saito, Takayuki Wakabayashi, Chiho Yamada, Yasuo Suzuki
Open Journal of Rheumatology and Autoimmune Diseases (OJRA) , 2014, DOI: 10.4236/ojra.2014.42018
Abstract: Objectives: To correlate the precise specificity of autoantibodies in Japanese dermatomyositis (DM) patients with their clinical phenotypes. Methods: Serum samples from 94 adult DM patients (67 with classical DM and 27 with clinically amyopathic dermatomyositis, CADM) were screened for autoantibodies using immunoprecipitation assays. Patients with antibodies against aminoacyl transfer RNA synthetase (ARS), Mi-2 or who had other autoantibodies were assessed for clinical symptoms and laboratory findings. Results: Sera from 27 of 94 DM patients (29%) were found to have anti-ARS antibodies. Nineteen (20%) had anti-CADM-140/MDA5, 5 (5%) had anti-Mi-2, and 8 (6%) had anti-p155/TIF1-γ. Anti-MJ/NXP-2 was not found in our series of adult DM. Seventeen patients with anti-ARS had fever and 22 had arthritis and interstitial lung disease (ILD), compatible with a diagnosis of anti-ARS syndrome. Seventeen of 19 (89%) with anti-CADM-140/MDA5 had ILD, 16 (84%) of whom developed rapidly progressive ILD (RP-ILD). Four of 5 (80%) with anti-Mi-2 had heliotrope rash and/or Gottron’s sign/papules, and 2 (40%) had V-sign and/or shawl-sign rash, whereas no ILD or malignancy was detected. As seen with anti-Mi-2-positive patients, a low frequency of ILD (13%) was found in patients with anti-p155/TIF1-γ but 6 of 8 (75%) had malignancy during their course. The frequency of ILD was significantly higher in patients with anti-ARS or anti-CADM-140/MDA5 compared with anti-Mi-2 or anti-p155/TIF1-γ (81% and 89%, respectively). It should be noted that anti-CADM-140/MDA5-positive patients suffered significantly more RP-ILD compared to patients with anti-ARS (84% vs. 7%, P < 0.0001). On the other hand, anti-p155/TIF1-γ positive patients had a significantly higher rate of malignancy compared with anti-ARS-, anti-CADM-140/MDA5-and anti-Mi-2-positive patients (75% vs. 7%: P = 0.0004, 5%: P = 0.0006, 0%: P = 0.02, respectively). Conclusions: These results indicate that in addition to antibodies previously identified as specific for DM, autoantibodies newly found in these patients are useful for stratifying them into clinical subgroups.
Adenocarcinoma de pulmón simulando una enfermedad pulmonar intersticial en un varón de 30 a?os
Casallo Blanco,S.; Marcos Sánchez,F.; Matías Salces,L. de; Viana Alonso,A.; Celdrán Gil,J.; Nú?ez Cuerda,E.;
Anales de Medicina Interna , 2007, DOI: 10.4321/S0212-71992007000600008
Abstract: a case of a 30-year-old man is presented. he had a past medical history of asthma and presented with cough, shortness of breath, fever and chest pain. the chest x-ray showed cardiomegaly and a interstitial pattern. the echocardiogram revealed a severe pericardial effusion that required performing a pericardiocentesis. a ct scan showed mediastinal adenopathies and reticulonodular intertitial pattern. a bronchoscopy could not be completed because of non-tolerance. finally a lung biopsy allowed us to reach a final diagnosis of lung adenocarcinoma. following, some aspects of lung cancer in young people are commented, especially its incidence, histology, symptoms and a prognosis. a few aspects of the interstitial lung disease are also addressed and the differential diagnosis with lymphangitic carcinomatosis.
Biopsia en enfermedad intersticial pulmonar
Quadrelli,Silvia; Lyons,Gustavo; Ciallella,Lorena; Iotti,Alejandro; Chertcoff,Julio;
Medicina (Buenos Aires) , 2007,
Abstract: the objective of this study was to determine the morbidity, mortality and diagnostic yield of video assisted thoracoscopy (vats) and thoracotomy lung biopsy in interstitial lung disease (ild). clinical records of 71 patients were retrospectively analyzed. there was no difference in mean hospital stay, intensive care unit stay and duration of chest tube drainage in patients with vats (n = 52) compared with those undergoing open thoracotomy (n = 17). complications rate (22.2% vs. 21.0%, p = 1.0000) and operating mortality (9.2 vs. 15.7%, p = 0.2738) were also similar. overall, complications occurred in 16 patients (22.5%). thirty-day mortality rate was 11.2% (n = 8). prevalence of immunosupression (4/8 vs. 9/63, p = 0.0325) was significantly higher in the group of patients who died. no surviving patients had higher values of plasmatic urea (50 ± 20.1 mg/dl vs. 31.2 ± 10.3 mg/dl, p = 0.0013) or lower values of preoperative oxygen saturation (sao2): 82.7 ± 14.8% vs. 92.8 ± 3.4%, (p = 0.0009). eleven patients had an acute illness. those patients did not show a higher complication rate (4/11 vs. 10/45, p = 0.4390) but mortality was significantly higher (4/11, 36.3% vs. 3/45, 7.1%, p = 0.0223). biopsy allowed a specific histologic diagnosis in 100% of patients and changed therapy in 66.7%. we conclude that surgical lung biopsy is a safe and useful procedure in patients with ild. however the higher mortality rate in patients with acute symptoms, immunocompromise, or in respiratory failure must be balanced against potential benefits of altering treatment decisions.
Value of lung biopsy in pulmonary diseases in children
Al-Nassar S,Kadamba P,Habib Z
Journal of Indian Association of Pediatric Surgeons , 2006,
Abstract: Purpose: Open lung biopsy (OLB) is claimed to be a sensitive tool for the diagnosis of interstitial lung disease. It is reported to be associated with significant morbidity and mortality. Aim: Evaluate whether lung biopsy helped us to make a specific diagnosis, it had resulted in change in therapy and assessment of its morbidity and mortality. Materials and Methods: This was a retrospective analysis of 91 lung biopsies performed in 83 patients between January 2000 and December 2003. These children were allocated to three groups: a. Primary pulmonary pathology (22), b. Immunocompromised (49) i. Primary immunodeficiency (10), ii. Postchemotherapy and BMT (39), c. Pulmonary metastases from solid tumors (20) Results: A specific diagnosis was reached in 87/91 children (95%), but this resulted in a change in therapy (excluding lung meet) in only 23/71 (32%). It is lower in those postchemo/BMT 8/39 (20.6%). Postoperative morbidity occurred in 11/91 (12%) but procedure-related morbidity was only (3.2%). Death within a month of the biopsy occurred in six children (6.5%), with one (1.1%) procedure-related. Conclusion: 1. OLB is a safe procedure at our institution. 2. OLB is a sensitive tool to determine the specific cause of pulmonary infiltrate. 3. Change in therapy expected to be only in 32% of patients and even lower in postchemotherapy and BMT children.
Quantitative CT Indexes and CT Visual Score in Interstitial Lung Abnormality as Indicators of Concurrent Lung Cancer  [PDF]
Akihiro Hotta, Kazuhiro Suzuki, Mariko Fukui, Katsutoshi Ando, Kenji Suzuki, Ryohei Kuwatsuru, Kazuya Takamochi
Open Journal of Radiology (OJRad) , 2019, DOI: 10.4236/ojrad.2019.92010
Abstract: Background: The associations between the severity of interstitial lung disease and the stage and histologic type of concurrent lung cancer remain unknown. Purpose: To evaluate whether the severity of interstitial lung abnormality (ILA), as indicated by quantitative computed tomographic (CT) indexes and CT visual score, was correlated with the stage and histological type of concurrent lung cancer. Materials and Methods: Twenty-eight patients with surgically diagnosed lung cancer and ILA on CT were enrolled in this retrospective study. The subjects were allocated to one of three groups by histological type: adenocarcinoma group (13 subjects); squamous cell carcinoma group (10 subjects); and the other histological diagnosis group (5 subjects). Two independent observers evaluated the CT findings to determine the CT visual score, and the kurtosis and skewness of CT-based density histograms were determined. The relationships between severity of ILA and the pathological stage and histological type of concurrent lung cancer were evaluated. Results: There were no significant differences in the CT visual scores and quantitative indexes among the three groups. CT visual score was significantly negatively correlated with pathological stage (r = 0.43, P = 0.025). Conclusion: Patients can have only mild ILA on visual scoring but advanced lung cancer. Therefore, the frequency of follow-up examination should not be based on the severity of ILA on CT.
Chronic eosinophilic pneumonia due to radiographic contrast administration: an orphan disease?
Hohenforst-Schmidt W, Riedel A, Zarogoulidis P, Franke C, Gschwendtner A, Huang H, Machairiotis N, Dramba V, Zarogoulidis K, Brachmann J
Drug Design, Development and Therapy , 2012, DOI: http://dx.doi.org/10.2147/DDDT.S37937
Abstract: onic eosinophilic pneumonia due to radiographic contrast administration: an orphan disease? Case report (1396) Total Article Views Authors: Hohenforst-Schmidt W, Riedel A, Zarogoulidis P, Franke C, Gschwendtner A, Huang H, Machairiotis N, Dramba V, Zarogoulidis K, Brachmann J Published Date December 2012 Volume 2012:6 Pages 385 - 389 DOI: http://dx.doi.org/10.2147/DDDT.S37937 Received: 10 September 2012 Accepted: 06 November 2012 Published: 10 December 2012 Wolfgang Hohenforst-Schmidt,1 Andreas Riedel,1 Paul Zarogoulidis,2,3 Christian Franke,4 Andreas Gschwendtner,5 Haidong Huang,6 Nikolaos Machairiotis,2 Vasiliki Dramba,2 Konstantinos Zarogoulidis,2 Johnannes Brachmann1 1II Medical Clinic, Coburg Clinic, University of Würzburg, Coburg, Germany; 2Pulmonary Department, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 3Pulmonary Department–Interventional Unit, University of Duisburg-Essen, Essen, Germany; 4Pulmonary Department, Sonneberg, Germany; 5Institute for Pathology, Coburg Clinic, University of Würzburg, Coburg, Germany; 6Department of Respiratory Diseases, Changhai Hospital, Second Military Medical University, Shanghai, China Abstract: Pulmonary eosinophilia comprises a heterogeneous group of diseases that are defined by eosinophilia in pulmonary infiltrates or in tissue. Drugs can cause almost all histopathologic patterns of interstitial pneumonias, such as cellular and fibrotic nonspecific interstitial pneumonia, pulmonary infiltrates and eosinophilia, organizing pneumonia, lymphocytic interstitial pneumonia, desquamative interstitial pneumonia, a pulmonary granulomatosis-like reaction, and a usual interstitial pneumonia-like pattern. We present a very rare case of chronic eosinophilic pneumonia due to radiographic contrast infusion diagnosed with video-assisted thoracoscopy. The patient after 1 year is still under corticosteroid treatment with the disease stabilized.
Interstitial Lung Disease in a Patient with Chronic Granulomatous Disease
Mozhgan Moghtaderi,Sara Kashef,Nima Rezaei
Iranian Journal of Pediatrics , 2012,
Abstract: Background: Chronic granulomatous disease (CGD) is an inherited phagocytes defect, characterized by defects of NADPH-oxidase and inability of bacterial killing, which leads to recurrent life-threatening infections. Respiratory problems, which are the major cause of morbidity in CGD, usually result fromrecurrent severe infections; however, vigorous inflammatory response could also cause respiratory diseases.Case Presentation: Herein, an 11 year-old patient with CGD is presented who suffered from chronic cough and dyspnea for 7 years. Considering the results of chest X-ray, high-resolution computedtomography, and pulmonary function test, the diagnosis of interstitial lung disease was made.Conclusion: Early recognition of manifestations associated with CGD and appropriate treatment could prevent further complications and reduce morbidity and mortality in this group of patients.
Diphenylhydantoin (phenytoin)-induced chronic pulmonary disease
Dixit Ramakant,Dixit Kalpana,Nuwal Paras,Banerjee Arunima
Lung India , 2009,
Abstract: Drug-induced respiratory diseases are difficult to diagnose and therefore usually not identified, probably underestimated and under-reported. We report a case of diphenylhydantoin/phenytoin-induced chronic pulmonary disease in a 62-year-old male patient presenting with progressive dyspnea, eosinophilia, and pulmonary abnormalities. The importance of drug history in clinical history-taking and early diagnosis of drug-induced respiratory diseases is emphasized so as to prevent permanent pulmonary damage.
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