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Search Results: 1 - 10 of 11249 matches for " Insulin-dependent diabetes "
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Factores de riesgo y prevención en diabetes mellitus tipo I: Actualización
García B.,Hernán;
Revista chilena de pediatría , 2001, DOI: 10.4067/S0370-41062001000400002
Abstract: insulin dependent diabetes mellitus (iddm) or type 1 is the result of a long immunological process resulting in destruction of pancreatic islet beta cells. inspite of medical advances a cure for the disease has not been achieved. this prompts the importance of attempts to prevent the disease in first degree relatives whose risk of developing iddm is 20 times greater than the general population. any attempt to modify the immune system that may alter the disease′s natural history must first identify susceptibles individuals. to this end the presence of anti-islet antibodies is determined. in those who tested positive (35%) it is measured the first phase of insulin secretion in response to an iv glucose load. individuals with a greater risk of developing iddm are those who are antibody positive and a fpir of less than the 10th centile of the reference population. this protocol has been applied to first degree relatives of patients with iddm in 2 controlled prospective multicentre clinical trials taking place at this moment. the european trial (endit) is using nicotinamide and has recluted more than 40,000 subjects, while the american protocol, the diabetes prevention trail of dm type 1 (dpt-1) use oral or subcutaneous insulin according to the risk of developing iddm. in this trial are participating more than 80,000 subjects, the results of which are expected in 2003-4. there are hopes that the results of this trials help to answer the question, if it is possible to alter the biological destiny of a person, and prevent or retard the development of iddm in susceptible individuals.
Reprodutibilidade de informa??es em estudo de fatores de risco para o diabetes mellitus insulino-dependente
Gimeno,Suely Godoy Agostinho; Souza,José Maria Pacheco de;
Revista de Saúde Pública , 1997, DOI: 10.1590/S0034-89101997000600010
Abstract: the reliability of information about mothers' and fathers' education, weight and height at birth, history of diarrhoea, duration of exclusive breast feeding and age of introduction of cows' milk products, selected from a structured questionnaire used in home interviewers was examined in a sample of 38 cases and 38 controls from a study related to the risk factors of insulin-dependent diabetes mellitus. the repetition of the questions was done by telephone. the agreement between the answers of both interviewers was verified using the kappa statistic (categorical variables) and the intra-class correlation coefficient (quantitative variables). the results enable one to conclude that the information is reproducible.
Disfunción ventricular izquierda subclínica en diabéticos tipo 1 con menos de 10 a?os de evolución de la diabetes
Licea Puig,Manuel; Singh Linares,Omar; Martínez García,Rolando; Díaz Féliz,ángel;
Revista Cubana de Endocrinolog?-a , 2001,
Abstract: a cross-sectional study in 32 type l diabetics aged 17-40 with less than 10 years of evolution of the disease was conducted to know the frequency of subclinical left ventricular dysfunction (lvd) and its associated factors. patients with valvulopathies, ischemic heart disease, arterial hypertension and other diseases causing myocardiopathies, were excluded. complete medical histories were obtained and fasting glycemia, hbal, total cholesterol, total triglycerides, hdl-cholesterol, urinary excretion of albumin (usa), velocity of motor and sensitive conduction of the lower limbs, ekg and mode b bidemensional pulsed doppler echocardiography were indicated. the criteria proposed by the american society of echocardiography for the echocardiographic diagnosis of lvd were adopted. lvd was proved in 25 %. the structural cardiac alterations were observed in 6.2 %. peripheral neuropathy was observed in 6 of the 8 patients with lvd. the us levels were significantly higher in those affected with lvd (219.5 ± 170.2 mg/l vs 6.9 ± 86.9 mg/l). it was concluded that lvd appears commonly among diabetics with less than 10 years of evolution and that the us levels may be a risk marker for the development of this complication.
El diabético insulinodependiente: Estrategia terapéutica actual
Carvajal Martínez,Francisco; Herrera Hernández,Elsa;
Revista Cubana de Medicina General Integral , 1998,
Abstract: the present therapeutic estrategy for the insulin-dependent diabetic is analyzed. it is stressed the need of attaining normoglycaemia as a criterion of metabolic control expressed in normal values of glycosylated hemoglobin or hb alc quarterly. emphasis shoud be made on the education received by the diabetic patients in connection with the disease, reinforcing it at every office visit, and reevaluating it periodically. being on a diet is very important, too. we should use highly purified insulin with insulin schemes based mainly on mixtures of insulins or regimes of multiple doses of insulin. it is necessary that the patient attains the glycaemic control. we should try to locate and study the possible risk groups that may develop this disease
Auto-aplica??o de insulina em crian?as portadoras de diabetes mellitus tipo 1
Dall'Antonia, Cristina;Zanetti, Maria Lúcia;
Revista Latino-Americana de Enfermagem , 2000, DOI: 10.1590/S0104-11692000000300008
Abstract: the present descriptive study had the goals of characterizing type 1 diabetic children, according to socio-demographic variables and identifying the difficulties related to insulin self-management and home control. 34 type 1 diabetic children were interviewed at a big hospital. results showed that 82.4% of children were white, 61.8% were female and 54.1% were from nine to eleven years of age, 67.7% were catholic, and 64% had the illness for 3 years. 35.3% of them learned insulin management with their mothers and 32.3% follow a schedule regarding insulin self-administration. difficulties to perform home control are related to the available resources and lack of information. results show the need for a planned work integrated by a multiprofessional team and directed to the children whose characteristics meet the mentioned aspects, considering their interdependence and aiming at achieving a successful careb.
Case-control analysis of the ERAP1 polymorphism rs30187 in Italian type 1 diabetes mellitus patients  [PDF]
Elena Gianchecchi, Antonino Crinò, Alessia Palma, Rosa Luciano, Valentina Perri, Doriana Fruci, Marco Cappa, Alessandra Fierabracci
Health (Health) , 2013, DOI: 10.4236/health.2013.512293
Abstract:

Autoimmune diseases are a heterogeneous group of disorders affecting different organs and tissues whose incidence are increasing worldwide. New tools, such as genome-wide association studies, have provided evidence for new susceptibility loci and candidate genes in the disease process including common susceptibility genes involved in the immunological synapse and T cell activation. Close linkages have been found in a number of diseases, including ankylosing spondylitis, multiple sclerosis, Crohn’s disease and insulin-dependent diabetes mellitus (Type 1 diabetes mellitus). The evidence for some associations with Type 1 diabetes was previously found in the region containing 5q15/ERAP1 (endoplasmic reticulum aminopeptidase 1) (rs30187, ARTS1). Our aim was to conduct the first casecontrol study to test the association between the rs30187 polymorphism of ERAP1 and the development of Type 1 diabetes mellitus in patients selected from continental Italy. All control subjects were matched for the sex, age, ethnic origin and geographical area. Genotyping of the rs30187 polymorphism of ERAP1 was carried out by the allelic discrimination assay on DNA extracted from whole blood. We did not observe a statistically significant prevalence of the rs30187 polymorphism of ERAP1 in our cohort of patients than in controls suggesting a minor contribution of this gene to the pathogenesis of Type 1 diabetes mellitus in

Resultados do transplante pancreático em um centro brasileiro
Nicoluzzi, Jo?o Eduardo Leal;Marmanillo, Carlos Gustavo W. C.;Repka, Jo?o Carlos Domingues;Monteiro, Mauro Roberto Duarte;Santos, Wilson Paulo dos;Caron, Pedro Ernesto;
Revista do Colégio Brasileiro de Cirurgi?es , 2003, DOI: 10.1590/S0100-69912003000600006
Abstract: background: pancreatic transplantation (pt) is the only treatment available to keep long term normoglicemic state and insulin independence in type 1 diabetic patients. we present the results of pt performed in a center at the state of paraná. methods: from january 2001 until april 2003, 24 patients received simultaneous pancreas-kidney transplant (spk) and one isolated pancreatic transplant at hospital angelina caron. results: with a mean follow-up of 8,2 months (range 1-27), the pancreas and kidney success rate was 74%. patient survival was 76%. leading cause of pancreas and kidney losses was thrombosis in three pancreas (12%) and two kidneys (8%). no episode of rejection occurred in any of the transplanted patients. all patients with successful grafts are insulin-free since transplantation. conclusions : this series confirms that spk is a highly successful procedure for diabetic patients with renal failure.
Disfunción ventricular izquierda subclínica en diabéticos tipo 1 con menos de 10 a os de evolución de la diabetes Subclinical left ventricular dysfunction in type 1 diabetics with less than 10 years of evolution of diabetes
Manuel Licea Puig,Omar Singh Linares,Rolando Martínez García,ángel Díaz Féliz
Revista Cubana de Endocrinología , 2001,
Abstract: Se realizó un estudio transversal en 32 diabéticos tipo 1 con menos de 10 a os de evolución de la enfermedad, edades entre 17 y 40 a os, para conocer la frecuencia de disfunción ventricular izquierda (DVI) subclínica y factores asociados a la misma. Se excluyeron los pacientes que presentaron valvulopatías, cardiopatía isquémica, hipertensión arterial y otras enfermedades que provocan miocardiopatías. Se les realizó una historia clínica completa y se les indicó: glucemia en ayunas, HbA1, colesterol total, triglicéridos totales, HDL-colesterol, excreción urinaria de albúmina (EUA), velocidad de conducción motora y sensitiva de los miembros inferiores, electrocardiograma y ecocardiograma modo M, bidimensional y con Doppler pulsado. Se adoptaron los criterios propuestos por la Sociedad Americana de Ecocardiografía para el diagnóstico ecocardiográfico de DVI. Se comprobó DVI en el 25 %. Las alteraciones estructurales cardíacas se observaron en el 6,2 %. La neuropatía periférica se presentó en 6 de 8 pacientes con DVI. Los niveles de EUA fueron significativamente mayores en los afectados de DVI (219,5 ± 170,2 mg/L vs. 66,9 ± 86,9 mg/L). En conclusión, se afirmó que la DVI es de observación relativamente frecuente en los diabéticos con menos de 10 a os de evolución y los niveles de EUA pudieran constituir un marcador de riesgo para el desarrollo de esta complicación. A cross-sectional study in 32 type l diabetics aged 17-40 with less than 10 years of evolution of the disease was conducted to know the frequency of subclinical left ventricular dysfunction (LVD) and its associated factors. Patients with valvulopathies, ischemic heart disease, arterial hypertension and other diseases causing myocardiopathies, were excluded. Complete medical histories were obtained and fasting glycemia, HbAl, total cholesterol, total triglycerides, HDL-cholesterol, urinary excretion of albumin (USA), velocity of motor and sensitive conduction of the lower limbs, EKG and mode B bidemensional pulsed Doppler echocardiography were indicated. The criteria proposed by the American Society of Echocardiography for the echocardiographic diagnosis of LVD were adopted. LVD was proved in 25 %. The structural cardiac alterations were observed in 6.2 %. Peripheral neuropathy was observed in 6 of the 8 patients with LVD. The US levels were significantly higher in those affected with LVD (219.5 ± 170.2 mg/L vs 6.9 ± 86.9 mg/L). It was concluded that LVD appears commonly among diabetics with less than 10 years of evolution and that the US levels may be a risk marker for the development of this com
El diabético insulinodependiente: Estrategia terapéutica actual
Francisco Carvajal Martínez,Elsa Herrera Hernández
Revista Cubana de Medicina General Integral , 1998,
Abstract: Se analiza la estrategia terapéutica actual en el diabético insulinodependiente. Se insiste en la necesidad de lograr la normoglicemia como criterio de control metabólico expresado en valores normales de hemoglobina glicolisada o Hb Alc trimestral. Se debe enfatizar en la educación diabetológica reforzándola en cada consulta y reevaluando cada cierto tiempo. El cumplimiento de la dieta es fundamental. Debemos utilizar insulina altamente purificada con esquemas insulínicos principalmente basados en mezclas de insulinas o regímenes de múltiples dosis de insulina. Es necesario lograr el monitoreo glicémico por el paciente. La práctica sistemática del ejercicio físico diario o tres veces a la semana es importante. Es preciso tratar de localizar y estudiar los posibles grupos de riesgo a desarrollar esta enfermedad The present therapeutic estrategy for the insulin-dependent diabetic is analyzed. It is stressed the need of attaining normoglycaemia as a criterion of metabolic control expressed in normal values of glycosylated hemoglobin or HB Alc quarterly. Emphasis shoud be made on the education received by the diabetic patients in connection with the disease, reinforcing it at every office visit, and reevaluating it periodically. Being on a diet is very important, too. We should use highly purified insulin with insulin schemes based mainly on mixtures of insulins or regimes of multiple doses of insulin. It is necessary that the patient attains the glycaemic control. We should try to locate and study the possible risk groups that may develop this disease
Immunotherapy of type 1 diabetes: lessons for other autoimmune diseases
Jean-Fran?ois Bach
Arthritis Research & Therapy , 2002, DOI: 10.1186/ar554
Abstract: Insulin-dependent diabetes mellitus (IDDM), or type 1 diabetes, is a T-cell-mediated autoimmune disease. Much effort has been devoted over the past two decades to establishing an immunological treatment that could substitute for insulin therapy. In this chapter, I provide an update of the noteworthy preclinical data obtained in the spontaneous animal models of the disease and of clinical trials in progress. These data are presented with particular attention to lessons that could benefit the immunotherapy of other autoimmune diseases, notably rheumatoid arthritis.It is now firmly established that in the vast majority of cases, IDDM has an autoimmune origin [1]. This does not preclude the possible aetiological role of a triggering environmental factor, notably a pancreatotropic virus, but the fact remains that the β-cell lesion is mediated by β-cell-specific autoreactive T cells.No consensus has been reached on the nature of the effector T cell(s). Research on the nonobese diabetic (NOD) mouse has shown that both CD4 and CD8 clones could induce the disease separately, but it is likely that the two cell types cooperate in the β-cell lesion. CD8 T cells could act through a direct cytotoxic mechanism, although this has not been proven. CD4 cells could act either as helper T cells or as effector cells through cytokine production.Increasing importance is given to various subsets of regulatory T cells that have been shown to control the onsets of diabetes in both the NOD mouse and the BioBreeding (BB) rat. Three main types of regulatory T cell have been described [2]: Th2 cells, which appear after administration of soluble β-cell autoantigens, CD4+CD25+ T cells, and natural killer T cells, which probably appear spontaneously during ontogeny. It is not yet clear whether the onset of diabetes results from the decline of T-cell-mediated regulation or, what is more likely, from the overriding of the regulation by activation of β-cell-specific effector T cells. Another major unc
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