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Search Results: 1 - 10 of 874 matches for " Ingo Fietze "
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Rationale for Treatment of Common Cold and Flu with Multi-Ingredient Combination Products for Multi-Symptom Relief in Adults  [PDF]
Ron Eccles, Ingo Fietze, Uwe-Bernd Rose
Open Journal of Respiratory Diseases (OJRD) , 2014, DOI: 10.4236/ojrd.2014.43011
This up-to-date overview will look at the rationale for the recommendation of combination products for multi-symptom relief of common cold and flu. Common cold and flu are defined by their multi-symptom nature with data showing a variety of symptoms reported simultaneously each day over the first six days of illness. Multi-ingredient combination products for multi-symptom relief are formulated to safely, simply, and simultaneously treat multiple symptoms when used as directed. The rationale for the formulation combination products for common cold and flu is therefore practical, logical and reasonable. No evidence has been found that multi-symptom relief medicines are inherently less safe than single-active ingredient medicines. Multi-symptom relief combination products containing several active ingredients provide a safe, effective, cost-effective, and convenient way of treating the multiple symptoms of common cold and flu, when used as directed. This therapy requires some special information for the patient to be provided by the physician and the pharmacist.
Open-Label Real-World Pharmacy Purchaser Study of Two Fixed-Dose Combination OTC Cold Treatments; Wick MediNait, Wick DayMed Capsules or a Combination of Both  [PDF]
Gillian Phillipson, David Ramsey, Sue Aspley, Ingo Fietze
Open Journal of Respiratory Diseases (OJRD) , 2018, DOI: 10.4236/ojrd.2018.83006
Abstract: Acute upper respiratory tract infections, i.e. common colds cause multiple symptoms and affect adults on average 2 - 4 times a year and children 6 - 8 times per year. Thousands of non-prescription, over-the-counter products are used by sufferers, aimed at relieving the various both er some symptoms such as cough, nasal congestion, sore throat, etc. This study evaluated real-world effectiveness of Wick MediNait or Wick DayMed medicines alone and together in a combination as a day and night treatment regimen. Adult cold sufferers were recruited in pharmacy by pharmacy staff following self-purchase of either Wick MediNait, Wick DayMed capsules, or the combination of DayMed and MediNait. Participants completed online questionnaires before and after product use (evening of the first day for DayMed and the morning after using MediNait at bedtime). For the primary endpoint “Wick MediNait was effective at relieving my symptoms”, there was a statistically significant difference (p < 0.0001) in the users who Strongly Agreed or Agreed vs. Neither Agreed or Disagreed, Disagreed or Strongly Disagreed. Further, all symptoms evaluated (cough, runny nose, nasal congestion, fever, headache, sore throat, muscle aches and pains, sneezing) were statistically improved after MediNait and DayMed alone and when both were used, and users were satisfied with both treatments. All treatments were well tolerated with minimal adverse event reporting. The diurnal use of DayMed capsules combined with the nocturnal use of MediNait allows cold sufferers to efficiently self-manage their symptom relief throughout the day and night.
Association of Sleep Duration with Chronic Diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
Anne von Ruesten, Cornelia Weikert, Ingo Fietze, Heiner Boeing
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030972
Abstract: Background In view of the reduced number of hours devoted to sleep in modern western societies the question arises what effects might result from sleep duration on occurrence of chronic diseases. Methods Data from 23 620 middle-aged participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study, that were recruited between 1994–1998, were analyzed by using Cox proportional hazard regression to examine the association between self-reported sleep duration at baseline and incidence of chronic diseases, such as diabetes, myocardial infarction, stroke, and cancer. Results During a mean follow-up period of 7.8 years 841 incident cases of type 2 diabetes, 197 cases of myocardial infarction, 169 incident strokes, and 846 tumor cases were observed. Compared to persons sleeping 7-<8 h/day, participants with sleep duration of <6 h had a significantly increased risk of stroke (Hazard Ratio (HR) = 2.06, 95% confidence interval (CI): 1.18–3.59), cancer (HR = 1.43, 95% CI: 1.09–1.87), and overall chronic diseases (HR = 1.31, 95% CI: 1.10–1.55) in multivariable adjusted models. Self-reported daytime sleep at baseline was not associated with incident chronic diseases in the overall study sample. However, there had been an effect modification of daytime sleep by hypertension showing that daytime sleep was inversely related to chronic disease risk among non-hypertensive participants but directly related to chronic diseases among hypertensives. Conclusion Sleep duration of less than 6 h is a risky behavior for the development of chronic diseases, particularly stroke and cancer, and should be therefore addressed in public health campaigns.
Blood cis-eQTL Analysis Fails to Identify Novel Association Signals among Sub-Threshold Candidates from Genome-Wide Association Studies in Restless Legs Syndrome
Eva C. Schulte, Katharina Schramm, Claudia Schurmann, Peter Lichtner, Christian Herder, Michael Roden, Christian Gieger, Annette Peters, Claudia Trenkwalder, Birgit H?gl, Birgit Frauscher, Klaus Berger, Ingo Fietze, Nadine Gross, Karin Stiasny-Kolster, Wolfgang Oertel, Cornelius G. Bachmann, Walter Paulus, Alexander Zimprich, Henry V?lzke, Ulf Schminke, Matthias Nauck, Thomas Illig, Thomas Meitinger, Bertram Müller-Myhsok, Holger Prokisch, Juliane Winkelmann
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098092
Abstract: Restless legs syndrome (RLS) is a common neurologic disorder characterized by nightly dysesthesias affecting the legs primarily during periods of rest and relieved by movement. RLS is a complex genetic disease and susceptibility factors in six genomic regions have been identified by means of genome-wide association studies (GWAS). For some complex genetic traits, expression quantitative trait loci (eQTLs) are enriched among trait-associated single nucleotide polymorphisms (SNPs). With the aim of identifying new genetic susceptibility factors for RLS, we assessed the 332 best-associated SNPs from the genome-wide phase of the to date largest RLS GWAS for cis-eQTL effects in peripheral blood from individuals of European descent. In 740 individuals belonging to the KORA general population cohort, 52 cis-eQTLs with pnominal<10?3 were identified, while in 976 individuals belonging to the SHIP-TREND general population study 53 cis-eQTLs with pnominal<10?3 were present. 23 of these cis-eQTLs overlapped between the two cohorts. Subsequently, the twelve of the 23 cis-eQTL SNPs, which were not located at an already published RLS-associated locus, were tested for association in 2449 RLS cases and 1462 controls. The top SNP, located in the DET1 gene, was nominally significant (p<0.05) but did not withstand correction for multiple testing (p = 0.42). Although a similar approach has been used successfully with regard to other complex diseases, we were unable to identify new genetic susceptibility factor for RLS by adding this novel level of functional assessment to RLS GWAS data.
Learn More about Your Data: A Symbolic Regression Knowledge Representation Framework  [PDF]
Ingo Schwab, Norbert Link
International Journal of Intelligence Science (IJIS) , 2012, DOI: 10.4236/ijis.2012.224018
Abstract: In this paper, we propose a flexible knowledge representation framework which utilizes Symbolic Regression to learn and mathematical expressions to represent the knowledge to be captured from data. In this approach, learning algorithms are used to generate new insights which can be added to domain knowledge bases supporting again symbolic regression. This is used for the generalization of the well-known regression analysis to fulfill supervised classification. The approach aims to produce a learning model which best separates the class members of a labeled training set. The class boundaries are given by a separation surface which is represented by the level set of a model function. The separation boundary is defined by the respective equation. In our symbolic approach, the learned knowledge model is represented by mathematical formulas and it is composed of an optimum set of expressions of a given superset. We show that this property gives human experts options to gain additional insights into the application domain. Furthermore, the representation in terms of mathematical formulas (e.g., the analytical model and its first and second derivative) adds additional value to the classifier and enables to answer questions, which sub-symbolic classifier approaches cannot. The symbolic representation of the models enables an interpretation by human experts. Existing and previously known expert knowledge can be added to the developed knowledge representation framework or it can be used as constraints. Additionally, the knowledge acquisition framework can be repeated several times. In each step, new insights from the search process can be added to the knowledge base to improve the overall performance of the proposed learning algorithms.
Why Do Cancer Cells Become “Addicted” to Oncogenic Epidermal Growth Factor Receptor?
Ingo Mellinghoff
PLOS Medicine , 2007, DOI: 10.1371/journal.pmed.0040321
Transatlantic communication in the 19th century aspects of the correspondence between alexander von humboldt and george ticknor
Schwarz, Ingo
Asclepio : Revista de Historia de la Medicina y de la Ciencia , 2004,
Abstract: The Prussian explorer Alexander von Humboldt (1769-1859) and the North American scholar George Ticknor (1791-1871) met in 1817 in Paris, after Ticknor had studied languages, history, and natural sciences at the University of G ttingen. Two years later, he became the first Harvard Professor of the French and Spanish Languages and Literatures. When Ticknor visited Europe in 1836 and 1856, Humboldt was his guide in the Prussian Capital. Both, Humboldt and Ticknor were mediators between the Old World and the New Continent at a time when nationalism was fashionable both in literature and in politics. Humboldt and Ticknor did not agree on all political questions. However, their respect for each other helped them avoid controversial topics in their correspondence, and possibly in their conversations. With their ability to rank the things they had in common higher than their differences they were able to maintain a fruitful transatlantic dialogue over forty years. El explorador prusiano Alexander von Humboldt (1769-1859) y el erudito norteamericano George Ticknor (1791-1871) se conocieron en 1817 en París, después que Ticknor había estudiado idiomas, historia y ciencias naturales en la Universidad de G ttingen. Dos a os más tarde, llegó a ser el primer Profesor Harvard de Lenguas y Literatura francesa y espa ola. Cuando Ticknor visitó Europa en 1836 y 1856, Humboldt fue su guía en la capital prusiana. Humboldt y Ticknor fueron mediadores entre el Viejo Mundo y el Nuevo Continente en una época en que el nacionalismo estaba de moda en la literatura y la política. Humboldt y Ticknor no estaban de acuerdo en todas las cuestiones políticas. Sin embargo, el respecto que existía entre ellos evitó los asuntos controvertibles en su conversación y posiblemente en su correspondencia. Con su habilidad para clasificar las cosas tenían en común por encima de sus diferencias ser capaces de mantener un diálogo fructífero trasatlántico durante cuarenta a os.
Web 2.0 aus Nutzer- und Bibliothekssicht: Vorrang für Kernaufgaben der Bibliothek
Ingo Caesar
Libreas : Library Ideas , 2007,
Abstract: Library 2.0 has become a buzzword in the community of librarians. It seems that increasing political participation is more achievable now than ever. But long lasting processes of institution building of libraries have brought us to the point that it is not useful to negotiate the core tasks of librarianship in the arena of web 2.0 communities. Even though these tasks are dynamically and discussable, libraries have the responsibility to act as culture building, independent authorities with no-go-areas. Anyway, there are different virtual services within the applications of web 2.0 software that are useful for a better support of the customers’ needs in using the library. I present examples and scenarios for mash-ups, forums, voting systems and some other tools and their potential. Finally, it is necessary to ask in how far these tools optimize the contact with the library user. Some basic problems like decreasing resources or the enlargement of catalogues and library networks are more important to solve than just to focus on social software.
Kontinuierliche dozentenbezogene Evaluation des Moduls Pharmakologie & Toxikologie [Teaching in Pharmacology and Toxicology: ongoing lecture-based evaluation]
Just, Ingo
GMS Zeitschrift für Medizinische Ausbildung , 2008,
Quality of life before and after septoplasty and rhinoplasty
Baumann, Ingo
GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery , 2010,
Abstract: Subjective assessment of quality of life (QOL) as an important aspect of outcomes research has received increasing importance during the past decades. QOL is measured with standardized questionnaires which had been tested with regard to reliability, validity, and sensitivity. Surgical procedures of the nasal septum (septoplasty) and the external nose (rhinoplasty) are frequently performed. Since many years subjectively assessed results of these operations have been reported in the literature. However, validated QOL instruments were applied only for one decade. Beforehand, measurements were performed using retrospective assessment of satisfaction or visual analogue scales. Prospective application of validated disease-specific and general measuring instruments has to be demanded for future studies. Most of the septoplasty patients as well as most of the rhinoplasty patients evaluate the operation being successful. However, a relevant number of patients is not satisfied with the result of surgery. In this context, QOL instruments have the potential to identify further factors influencing the outcome. Especially in rhinoplasty patients, special attention has to be drawn on potential psychosocial effects of the operation.
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