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Search Results: 1 - 10 of 18810 matches for " Indira U Mysorekar "
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Early Severe Inflammatory Responses to Uropathogenic E. coli Predispose to Chronic and Recurrent Urinary Tract Infection
Thomas J. Hannan,Indira U. Mysorekar,Chia S. Hung,Megan L. Isaacson-Schmid,Scott J. Hultgren
PLOS Pathogens , 2010, DOI: 10.1371/journal.ppat.1001042
Abstract: Chronic infections are an increasing problem due to the aging population and the increase in antibiotic resistant organisms. Therefore, understanding the host-pathogen interactions that result in chronic infection is of great importance. Here, we investigate the molecular basis of chronic bacterial cystitis. We establish that introduction of uropathogenic E. coli (UPEC) into the bladders of C3H mice results in two distinct disease outcomes: resolution of acute infection or development of chronic cystitis lasting months. The incidence of chronic cystitis is both host strain and infectious dose-dependent. Further, development of chronic cystitis is preceded by biomarkers of local and systemic acute inflammation at 24 hours post-infection, including severe pyuria and bladder inflammation with mucosal injury, and a distinct serum cytokine signature consisting of elevated IL-5, IL-6, G-CSF, and the IL-8 analog KC. Mice deficient in TLR4 signaling or lymphocytes lack these innate responses and are resistant, to varying degrees, to developing chronic cystitis. Treatment of C3H mice with the glucocorticoid anti-inflammatory drug dexamethasone prior to UPEC infection also suppresses the development of chronic cystitis. Finally, individuals with a history of chronic cystitis, lasting at least 14 days, are significantly more susceptible to redeveloping severe, chronic cystitis upon bacterial challenge. Thus, we have discovered that the development of chronic cystitis in C3H mice by UPEC is facilitated by severe acute inflammatory responses early in infection, which subsequently are predisposing to recurrent cystitis, an insidious problem in women. Overall, these results have significant implications for our understanding of how early host-pathogen interactions at the mucosal surface determines the fate of disease.
Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception
Lara W Crock, Kristina M Stemler, David G Song, Philip Abbosh, Sherri K Vogt, Chang-Shen Qiu, H Henry Lai, Indira U Mysorekar, Robert W Gereau IV
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-20
Abstract: Using a combination of genetic and pharmacologic approaches, we provide evidence indicating that mGluR5 is necessary for the full expression of VMR in response to bladder distention in the absence of inflammation. Furthermore, we observed that mice infected with a uropathogenic strain of Escherichia coli (UPEC) develop inflammatory hyperalgesia to bladder distention, and that the selective mGluR5 antagonist fenobam [N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl) urea], reduces the VMR to bladder distention in UPEC-infected mice.Taken together, these data suggest that mGluR5 modulates both inflammatory and non-inflammatory bladder nociception, and highlight the therapeutic potential for mGluR5 antagonists in the alleviation of bladder pain.Interstitial cystitis/painful bladder syndrome (IC/PBS) is a serious and painful condition of unknown etiology that affects 3-6% of women in the United States [1,2]. The major clinical symptom of IC/PBS is pain upon bladder filling (distention) leading to urinary frequency and urinary urgency [3]. The current available treatments are often ineffective and do not treat the underlying pathology. Rodent bladder-injury models that induce some of the symptoms observed in IC/PBS have been used to evaluate potential treatments for IC/PBS [4-9]. One injury model, bacterial cystitis (urinary tract infection, UTI) is known to cause a similar constellation of symptoms as observed in IC/PBS (i.e. urinary frequency and urgency [10-12]). In addition, bacterial cystitis can be modeled in rodents through bladder exposure to uropathogenic Escherichia Coli (UPEC) [13,14]. Bladder infections due to UPEC are responsible for approximately 80% of UTIs in otherwise healthy women [15,16]. Understanding the underlying molecular mechanisms of both non-inflammatory bladder pain and inflammatory bladder pain due to UPEC infection could lead to the development of novel treatments for painful bladder infections as well as for IC/PBS and po
The Musical Language of Zeqirja Ballata in His Piano Work Fantasia Rustica  [PDF]
Indira ?ipa
Advances in Anthropology (AA) , 2018, DOI: 10.4236/aa.2018.84013
Abstract: Zeqirja Ballata (1943), a Kosovar composer, is in step with the works of his time, more precisely belonging to the postmodernist period. Throughout his musical opus, he showed consistency to the contemporary stylistic elements of the second half of the twentieth century. Among the 157 musical works by the Kosovar composer Zeqirja Ballata, this paper brings the results of the analysis of the musical language used in Fantasia rustica (for the left hand). The work in question is atonal, with dominant dissonance followed by short consonant bursts. Employing a qualitative research method, or analysis, the work was analysed including the following musical parameters: general and historical data of the piece, structure, linear expression, consonant structures, rhythm and its components, dynamics and synthesis of musical parameters in the process of concretization. The paper also contains notation tables and examples illustrating concretization moments.
Cutaneous sarcoidosis
Mishra R,Indira C,Saxena U,Mukherjee A
Indian Journal of Dermatology, Venereology and Leprology , 1993,
Abstract: Two cases of sarcoidosis with cutaneous lesions as presenting complaints are reported. Clinicians should have a high index of suspicion for sarcoidosis since it mimics other granulomatous skin conditions.
Primary Cutaneous Low Grade Mucinous Adenocarcinoma of Eyelid
Geethalakshmi U,Vijayshankar S,Abhishek MG,Indira CS
Online Journal of Health & Allied Sciences , 2010,
Abstract: Primary cutaneous mucinous adenocarcinoma is a rare adnexal neoplasm, eyelid being the most common site of presentation. Clinically it is mistaken for a benign / cystic lesion. Its morphologic similarity to metastatic deposits from breast, gastrointestinal tract (GIT) or any visceral sites adds to the diagnostic difficulty mandating the role of ancillary techniques in precise diagnosis and hence planning the management. We report a case of primary cutaneous mucinous adenocarcinoma of eyelid with emphasis on pathology along with a brief review of literature.
Cytomegalovirus pneumonia with pulmonary mucormycosis
Mysorekar Vijaya,Rao Saraswati
Indian Journal of Pathology and Microbiology , 2008,
Abstract: Solid organ transplantation is becoming increasingly common in the treatment of end-stage organ failure. However, despite improvements in patient and allograft survival, immunosuppression-induced compromised cell-mediated immunity predisposes transplant recipients to opportunistic infections. We describe a case of mixed opportunistic lung infection in the form of cytomegalovirus pneumonia and mucormycosis in a renal transplant recipient. Prompt recognition and treatment of infection is imperative for successful transplantation.
Study of Heavy Quarkonium with Energy Dependent Potential  [PDF]
Pramila Gupta, Indira Mehrotra
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.310189
Abstract: Heavy quark systems (c and b ) have been studied in the nonrelativistic framework using energy dependent interquark potential of the form harmonic oscillator with a small linear term as energy dependent as perturbation plus a inverse square potential. This potential admits exact analytical solution of the Schrodinger equation. Mass spectra, leptonic decay width, root mean square radii (), the expectation value of the radius (r) and <1/r> have been estimated for different quantum mechanical states for and systems. It is observed that energy dependent term in the potential leads to saturation of the mass spectra and degree of saturation is governed by the magnitude of perturbation. The calculated values of leptonic decay widths for 1s state are in very good agreement with the experimental data both for c and b systems.
Ant Routing Protocol with Location Services in Intermittently Connected MANETs  [PDF]
S. Ramesh, R. Indira
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.77092
Abstract: Wireless and mobile networks seem to deliver tremendous uses. In its way, MANET leads to enormous real world applications. Routing allows us to implement many real world applications. Complete affinity in an infrequent network like ICMANET is highly impossible. Disconnected MANET is also known as ICMANET which is also a DTN (Delay Torrent Network) that supports for higher delays. It is laborious process to execute routing in a diffused network process to execute routing in a diffused network. To deliver the data packets towards the destined node to its best, a new strategy in routing called Ant routing protocol in concoction with storage strategy LoDis has been proposed. Despite of routing, security is still an unsolved problem. To evaluate this situation, this paper presents a methodology called agent technology which yields a secure routing. Hostile node in the network is spotted with the help of agent at each node. A cryptographic algorithm Advanced Encryption Standard (AES) is habituated to improve secure communication in wide range Mobility and total number of nodes in the network act as variables in examining the hostile nodes in the network to judge the standard of security. Improved performance along with the security is the point to be highlighted.
Flood Maps and Bank Shifting of Dharla River in Bangladesh  [PDF]
Indira Bose, Umme Kulsum Navera
Journal of Geoscience and Environment Protection (GEP) , 2017, DOI: 10.4236/gep.2017.59008
Abstract: Bangladesh is prone to severe flooding as being located at the confluence of three mighty rivers named the Ganges, Brahmaputra, and Meghna. As a consequence, river flooding and erosion are common natural disasters that severely affect the landscape, lives and economy of the country. Dharla River, one of the trans-boundary rivers originated in the Himalayas, along with Brahmaputra River has a great influence on the recurring floods and erosion in north-western Bangladesh. Almost in every year, excessive erosion and embankment damages caused by Dharla render a thousand of people homeless with massive loss of crops and poultries. As per the environmentalists, this is a matter of huge concern as development of accurate flood maps and erosion prediction for Dharla River has been very challenging. In this study, the flood map and Dharla River bank shifting study have been developed by using HEC-RAS 4.1.0 hydrodynamic model and Landsat satellite images. In addition, the HEC-GeoRAS was used to establish the river reach for HEC-RAS. The calibration and validation have been performed using the observed and simulated water levels for the years of 2013 and 2014 respectively. The HEC-RAS flood water level output was used in HEC-GeoRAS for raster interpolation followed by overlain onto the land surface elevation of the study area. Then, the difference between water level interpolation and land elevation surfaces has been considered as a depth of inundation which is performed in Arc-Map 10.2. Flood maps have been generated for the years 2010, 2013, and 2014 for highest water level of each year. The erosion prone areas have been indicated by analyzing bank shifting of Dharla River for the years 1987, 1997, 2007, and 2017 by digitizing the satellite images in Arc-GIS 10.2. From the observation it has been found that the course of the Dharla River has been shifted vastly since 1987 to 2017 due to erosion.
Opportunistic infections in a renal transplant recipient
Vijaya V. Mysorekar,Mahesh Eshwarappa,Umesh Lingaraj
Infectious Disease Reports , 2012, DOI: 10.4081/idr.2012.e8
Abstract: With the present progress in transplantation procedures, there is an improvement in patient and allograft survival. However, the immunosuppression necessary to sustain the allograft predisposes these transplant recipients to infection, which is now a significant cause of morbidity and mortality. We describe a case of a 30-year-old renal transplant recipient with two opportunistic infections, namely, primary cutaneous aspergillosis and intestinal tuberculosis, with terminal enterococcal pleuritis and peritonitis. Control of the degree of immunosuppression, and prompt recognition and treatment of infection are vital for successful organ transplantation.
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