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Search Results: 1 - 10 of 966 matches for " Indian eyes "
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In-Vivo Slit Scanning Confocal Microscopy of Normal Corneas in Indian Eyes
Vanathi Murugesan,Tandon Radhika,Sharma Namrata,Titiyal Jeewan
Indian Journal of Ophthalmology , 2003,
Abstract: Objective: To study the cellular populations of healthy corneas of Indian eyes using confocal microscopy and to evaluate the correlation with age, gender and laterality. Methods: The central corneas of 100 eyes of 50 healthy subjects were examined using an i n-vivo slit scanning confocal microscope (Confoscan 2). Images were analysed for cell densities of the epithelium, stroma and endothelium. Results: Good quality images enabling analysis of all cell layer populations were obtained in 74 eyes of 43 healthy subjects (22 males and 21 females) with a mean age of 31.89 ± 13.47 (range 19-71 years). The basal epithelial cell density was 3601.38 ± 408.19 cells/mm2 (range 3017.3 -4231.1cells/mm2). The mean keratocyte nuclei density in the anterior stroma was 1005.02 ± 396.86 cells/mm2 (range 571.6 - 1249.6 cells/mm2) and in the posterior stroma was 654.32 ± 147.09 cells/mm2 (range 402.6 - 1049.1 cells/mm2). Posterior keratocyte nuclei density was 30.76% less than the anterior stromal keratocyte nuclei density. The difference in keratocyte nuclei density was statistically significant (P=0.001). The mean endothelial cell density was 2818.1 ± 361.03 cells/mm2 (range 2118.9 - 4434 cells/mm2) and the mean endothelial cell area was found to be 385.44 ± 42.66 mm2 (range 268.9 - 489.2 mm2). Hexagonal cells formed 22.5 - 69.4% of the endothelial cell populations (mean 42.04 ± 11.81%). Mean coefficient of cell size variation was 32.29 ± 3.06 (range 27.2 - 39.2). No statistically significant differences were found in cell densities of any corneal layer either between female and male patients or between right and left eyes. Basal epithelial cell density, anterior stromal keratocyte nuclei and posterior stromal keratocyte nuclei density were unaffected by age (r= 0.12, 0.07, - 0.12 respectively) (P= 0.001). There was a statistically significant negative correlation between mean endothelial cell density and increase in age (r= - 0.42, P=0.001). Coefficient of cell size variation and age were positively correlated (r=0.73, P=0.001). Conclusion: In-vivo slit scanning confocal microscopy is useful for the study of corneal cell populations. Our study provides normative data of these cell populations.
Efficacy and Safety of Latanoprost for Glaucoma Treatment: A Three-Month Multicentric Study in India
Thomas Ravi,Parikh Rajul,Sood Devendra,Vijaya L
Indian Journal of Ophthalmology , 2005,
Abstract: PURPOSE: To evaluate the short-term efficacy and safety of 0.005% topical latanoprost in Indian eyes. DESIGN: Prospective non-randomised open-label multicentric trial. METHODS: One hundred and fifty patients with ocular hypertension (OHT), primary open-angle, pseudoexfoliation or pigmentary glaucoma were enrolled at four centers. Each center contributed at least 20 patients. Following baseline measurements, 0.005% latanoprost was applied topically once daily in the evening for three months. Patients were examined at 2, 6 and 12 weeks. The primary outcome measure was mean intraocular pressure (IOP) reduction. The mean diurnal variation of IOP (difference between highest and lowest IOP) at baseline and at 12-weeks was compared. RESULTS: One hundred and thirty of 150 enrolled patients completed the study. One randomly selected eye of each patient was included for analysis. At three months, latanoprost reduced the mean IOP from 24.9 (± 3.16) mmHg at baseline to 16.10 (± 2.7) mmHg, a reduction of 35.25%. 83% had a reduction in IOP of > 25%. The IOP reduction was maintained throughout the study period, and was not affected by gender or age of the patient. One eye did not show any response to the drug. Daytime diurnal variation of IOP was reduced from 4.5 to 2.9 mmHg. 20 patients had conjunctival hyperemia. Six patients had side effects requiring withdrawal from the study. CONCLUSIONS: In this short-term multicentric study, latanoprost effectively reduced IOP and stabilised the diurnal curve in Indian eyes. There were no clinically significant ocular or systemic adverse effects.
Optic disc topography of normal Indian eyes: An assessment using optical coherence tomography
Dacosta Shaun,Bilal Sheena,Rajendran Babu,Janakiraman P
Indian Journal of Ophthalmology , 2008,
Abstract: Purpose: To study the optic disc topographic measurements of normal Indian eyes using optical coherence tomography (OCT). Materials and Methods: One hundred and fifty eyes selected randomly from 150 normal Indian subjects of both sex and various age groups underwent optic disc imaging with the OCT using the fast optic disc protocol. Results: Mean ± standard deviation of the optic disc topographic measurements were: disc area 2.63 ± 0.55 mm 2 , cup area 0.87 ± 0.45 mm 2 , neuroretinal rim area 1.78 ± 0.55 mm 2 and cup to disc area ratio 0.33 ± 0.15. There was no significant difference in the measurements between males and females. There was no significant correlation with respect to age and refractive errors ranging from -5.0 to +3.0 diopters of spherical equivalent. Conclusion: Our study provides a normative database for the various optic disc topographic measurements and its variations with age, sex and refractive error in normal Indian eyes using OCT.
Verteporfin therapy for myopic choroidal neovascularisation in Indian eyes (one year results).
Hussain Nazimul,Das Taraprasad,Vashist Urvish,Sumashri Kallukuri
Indian Journal of Ophthalmology , 2004,
Abstract: PURPOSE: To investigate the 12 months′ follow-up outcome of photodynamic therapy (PDT) with verteporfin for CNV in pathologic myopia in pigmented eyes of patients from the Indian subcontinent. METHODS: Nine eyes of 9 consecutive patients were included in the study. Patients with a spherical equivalent of - 6 diopter or more and baseline visual acuity of 6/60 or better were included. All patients received ETDRS visual acuity test (including letter acuity) and fluorescein angiography both before and after PDT. All patients had at least 12 months of follow up. RESULTS: The final visual acuity was unchanged 8 eyes (88.8% had VA of 6/30 or better) at the end of 12 months. Six eyes (66.7%) lost < or = 8 letters and three eyes (33.3%) lost < or = 15 letters at the end of 12 months from the baseline. CONCLUSION: Photodynamic therapy with verteporfin for subfoveal choroidal neovascularisation secondary to high myopia tends to stabilise the vision at 12 months follow up in Indian eyes. Longer follow up is necessary to understand the natural history of CNV treated with PDT in high myopia in Indian eyes.
Assessment of anterior segment parameters under photopic and scotopic conditions in Indian eyes using anterior segment optical coherence tomography
Dacosta Shaun,Fernandes Gitanjali,Rajendran Babu,Janakiraman P
Indian Journal of Ophthalmology , 2008,
Abstract: Purpose: To compare the anterior segment parameters in photopic and scotopic conditions using anterior segment optical coherence tomography (AS OCT) in Indian eyes. Materials and Methods: One hundred eyes of 100 normal subjects of both sexes, aged 19 to 76 years, underwent anterior segment evaluation by AS OCT (VisanteTM OCT). Central corneal thickness (CCT), central anterior chamber depth (ACD), pupil diameter (PD) and the temporal and nasal peripheral irido-corneal angles were assessed in photopic and scotopic conditions. These anterior segment parameters were stratified for age, sex and refractive error. Results: Mean values of the parameters measured in photopic and scotopic conditions respectively were as follows: ACD (mm) 2.88 ± 0.32, 2.89 ± 0.32 (P = 0.10); nasal angle (degrees) 28.80 ± 5.91, 22.28 ± 7.50 (P < 0.001); temporal angle (degrees) 29.95 ± 6.74, 22.82 ± 8.43 (P < 0.001); pupil diameter (mm) 4.08 ± 0.91, 4.68 ± 0.92 (P < 0.001); CCT (μm) 519 ± 33.88, 519 ± 33.88. Conclusions: There was no significant difference in the ACD in photopic and scotopic conditions. While the nasal and temporal angles showed a significant decrease, the pupil diameter showed a significant increase in scotopic conditions. Mean central ACD decreased with age and was shallower in females than in males. It was highest in myopes and lowest in hypermetropes. CCT was not influenced by photopic and scotopic conditions.
Quantification of the retinal nerve fibre layer thickness in normal Indian eyes with optical coherence tomography.
Sony Parul,Sihota Ramanjit,Tewari Hem,Venkatesh Pradeep
Indian Journal of Ophthalmology , 2004,
Abstract: PURPOSE: To quantitatively assess the normative values for peripapillary retinal nerve fibre layer (RNFL) thickness with Optical Coherence Tomography (OCT 3) in Indian subjects. METHODS: The peripapillary retinal nerve fibre layer of 146 normal subjects was imaged on OCT 3 in this cross-sectional study. Thickness of the RNFL around the disc was determined with three 3.4 mm diameter circle OCT scan. The RNFL thickness was measured in four quadrants; superior, nasal, inferior and temporal. The data was analysed using SAS commercial statistical software. Influence of age and gender was evaluated on various measured parameters using unpaired t test, one-way analysis variance (ANOVA) and Pearson′s correlation coefficient. RESULTS: One hundred and forty six eyes of 146 patients, 84 males and 62 females were studied. The average RNFL thickness in the sample population under study was 104.27 +/- 8.51 (95% CI 87.25-121). The RNFL was thickest in the inferior quadrant, followed by the superior quadrant, and progressively less in nasal and temporal quadrant. The difference between inferior and superior quadrants was not statistically significant. Age had a significant negative correlation with average RNFL thickness (r = -0.321, P = 0.000) and with average superior (r = -0.233, P = 0.005) and average inferior RNFL thickness (r = -0.234, P = 0.004). There was no effect of gender on various RNFL thickness parameters. CONCLUSIONS: RNFL thickness is significantly correlated with age, but not with gender. This normative database of RNFL thickness with OCT in Indian eyes is similar to previously reported values in normal Asian eyes.
Optic disc topography in normal Indian eyes using spectral domain optical coherence tomography
Mansoori Tarannum,Viswanath Kalluri,Balakrishna Nagalla
Indian Journal of Ophthalmology , 2011,
Abstract: Purpose: The aim was to study optic nerve head (ONH) parameters in normal Indian eyes using spectral domain optical coherence tomography (OCT)/scanning laser ophthamoscope (SLO). Materials and Methods: One hundred and fifty-seven eyes of 157 normal subjects of various age groups underwent ONH imaging with spectral OCT/SLO and the parameters obtained were correlated with disc size. The effect of age, gender, and refractive error on various ONH parameters were also studied. Results: The mean optic disc area was 3.36 ± 0.64 mm 2 (range, 2.13-5.08 mm 2 ), mean rim area was 2.49 ± 0.58 mm 2 (range, 1.20-3.62 mm 2 ), and mean cup area was 1.10 ± 0.75 mm 2 (range, 0-3.07 mm 2 ). The disc area showed significant positive correlation with the rim area, cup area, horizontal cup disc ratio, vertical cup disc ratio, cup disc area ratio, mean cup depth, and maximum cup depth (P < 0.001). Neither gender nor refractive error showed any significant difference in various ONH parameters. ONH parameters did not show significant change with age except for rim area which declined with the advancing age (r = -0.25, P < 0.001). Conclusions: The quantitative measurement of ONH topography obtained with this study provides a normative database for an Indian population with spectral OCT/SLO. As optic disc area influences ONH topography, disc size should to be considered when evaluating optic disc for progressive optic neuropathies such as glaucoma.
Age-related changes in the macula. A histopathological study of fifty Indian donor eyes
Biswas Jyotirmay,Raman Rajiv
Indian Journal of Ophthalmology , 2002,
Abstract: PURPOSE: Age-related macular degeneration (ARMD) is clinically less common in India compared to the West. Therefore, clinicians are unfamiliar with histopathologic evidence of age-related macular changes in the Indian population. METHODS: Fifty consecutive human donor eyes removed for corneal grafting were studied for gross, microscopic and histochemical features of age-related changes in the macula in the Indian population. A horizontal block was cut from the globe including the optic disc, and the macula. Six sections, 6 microns thick, were cut from three levels in the macula at a distance of 140 microns. These were stained with haemotoxylin-eosin, periodic acid-Schiff, Mallory, Masson trichrome, alcian blue and von Kossa stains. The presence of basal laminar deposits, drusen and thickening and calcification of Bruch′s membrane in the macula were assessed at 400 x magnification using a modified version of Sark′s classification. RESULTS: Twenty-four donor eyes (48%) had some form of age-related macular change. These included basal laminar deposits, hard drusen, soft drusen, extensive retinal pigment epithelium atrophy of the macula, and disciform degeneration of macula. A combination of changes was often seen. Age-related changes were more common in the seventh and eighth decade. CONCLUSION: Our study shows that histological changes characteristic of the early stages of age-related macular degeneration are fairly common in the Indian population. However, advanced macular changes are significantly rare.
Contamination of Heavy Metals (Lead, Zinc, Magnesium and Manganese) Concentrations in Human Eyes  [PDF]
Nazar S. Haddad, Salah Z. Alasadi, Hanaa H. Haddad
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.37065
Abstract: The aim of our study is to measure the concentration of Lead, Zinc, Magnesium and manganese, toxic/transition metals in human lens. The analyzed samples were categorized according to their personal habits (smoking, food, drinking and medical history). Demographic and laboratory characteristics of patients, the patients were twenty six males and twenty females. The comparison of trace elements between patients and control revealed significant increase of lead and manganese levels in patients and significant decrease of magnesium while there was few significant difference in zinc concentration among them.
The Effect of Heavy Metals Cadimium, Chromium and Iron Accumulation in Human Eyes  [PDF]
Hanaa H. Haddad
American Journal of Analytical Chemistry (AJAC) , 2012, DOI: 10.4236/ajac.2012.310094
Abstract: The object of the present study is to measure the concentrations of toxic heavy metals in human eyes (cadimium and chromium) and major mineral iron ion. The heavy metals cadimium, chromium and iron were assayed using atomic absorption spectrometry. Metals determination in human eye is the most common application of biological monitoring for screening diagnosis and assessment of metals exposures and their risks. The statistical analysis of the metals (cadimium, chromium and iron) levels in human eyes showed that levels of the three metals in non-smoker were lower than metals contents of the smoker groups. Metals levels in human eyes of males were significantly lower than females. Statistically significant differences (p < 0.001) were observed between persons living in city centre and others who living in outskirt for concentrations of all three metals. Geographical influences are thought to be the main source of variability.
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