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Search Results: 1 - 10 of 4641 matches for " In-Kyung Sung "
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Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy
Jeong Hwan Kim, Sun-Young Lee, Byung Kook Kim, Won Hyeok Choe, So Young Kwon, In-Kyung Sung, Hyung-Seok Park, Choon-Jo Jin
World Journal of Gastroenterology , 2008,
Abstract: AIM: To examine the characteristics of colonic polyps, where it is difficult to distinguish adenomatous polyps from hyperplastic polyps, with the aid of acetic acid chromoendoscopy.METHODS: Acetic acid spray was applied to colonic polyps smaller than 10 mm before complete excision. Endoscopic images were taken before and 15-30 s after the acetic acid spray. Both pre- and post-sprayed images were shown to 16 examiners, who were asked to interpret the lesions as either hyperplastic or adenomatous polyps. Regression analysis was performed to determine which factors were most likely related to diagnostic accuracy.RESULTS: In 50 cases tested by the 16 examiners, the overall accuracy was 62.4% (499/800). Regression analysis demonstrated that surrounding colonic mucosa was the only factor that was significantly related to accuracy in discriminating adenomatous from hyperplastic polyps (P < 0.001). Accuracy was higher for polyps with linear surrounding colonic mucosa than for those with nodular surrounding colonic mucosa (P < 0.001), but was not related to the shape, location, or size of the polyp.CONCLUSION: The accuracy of predicting histology is significantly related to the pattern of colonic mucosa surrounding the polyp. Making a histological diagnosis of colon polyps merely by acetic acid spray is helpful for colon polyps with linear, regularly patterned surrounding colonic mucosa, and less so for those with nodular, irregularly patterned surrounding colonic mucosa.
Investigation of Responsiveness to Thyrotropin-Releasing Hormone in Growth Hormone-Producing Pituitary Adenomas
Sang Ouk Chin,Sang Youl Rhee,Suk Chon,You-Cheol Hwang,In-Kyung Jeong,Seungjoon Oh,Sung-Woon Kim
International Journal of Endocrinology , 2013, DOI: 10.1155/2013/159858
Abstract: Objective. The aim of this study was to investigate how the paradoxical response of GH secretion to TRH changes according to tumor volumes. Methods. Patients with newly diagnosed acromegaly were classified as either TRH responders or nonresponders according to the results of a TRH stimulation test (TST), and their clinical characteristics were compared according to responsiveness to TRH and tumor volumes. Results. A total of 41 acromegalic patients who underwent the TST were included in this study. Between TRH responders and nonresponders, basal GH, IGF-I levels, peak GH levels, and tumor volume were not significantly different, but the between-group difference of GH levels remained near significant over the entire TST time. during the TST were significantly different according to the responsiveness to TRH. Peak GH levels and during the TST showed significantly positive correlations with tumor volume with higher levels in macroadenomas than in microadenomas. GH levels over the entire TST time also remained significantly higher in macroadenomas than in microadenomas. Conclusion. Our data demonstrated that the paradoxical response of GH secretion to TRH in GH-producing pituitary adenomas was not inversely correlated with tumor volumes. 1. Introduction Abnormal responsiveness of growth hormone- (GH-) producing pituitary adenomas to hypothalamic hormones has been previously described [1]. This paradoxical response of GH to thyrotropin-releasing hormone (TRH) in GH-producing pituitary adenomas was first reported in 1972 [2, 3] and observed in 50~75% of untreated acromegalic patients [4]. However, this response is not specific to acromegaly and was also found in various pathologic conditions such as severe hepatic failure [2], chronic renal failure [5], diabetes mellitus [6], and anorexia nervosa [7]. There have been many studies of the predictive value of the paradoxical response for treatment outcome and prognosis in acromegaly [4, 8–10]. However, the detailed mechanism of the paradoxical response of GH to TRH in acromegaly remains unknown despite a number of possible hypotheses: local production of TRH by adenoma cells [11, 12], TRH-induced release of GH [13], TRH production by anterior pituitary gland [14], and inappropriate expression of TRH receptors at tumor cells [15]. Moreover, only a few studies have attempted to observe how the pattern of paradoxical response changes according to tumor volume [10, 16]. The aim of this study was to investigate how the paradoxical response of GH secretion to TRH changes according to tumor volume in acromegalic
Diabetic factors associated with gastrointestinal symptoms in patients with type 2 diabetes
Jeong Hwan Kim, Hyung Seok Park, Soon Young Ko, Sung Noh Hong, In-Kyung Sung, Chan Sub Shim, Kee-Ho Song, Dong-Lim Kim, Sook Kyung Kim, Jeeyoung Oh
World Journal of Gastroenterology , 2010,
Abstract: AIM: To determine whether gastrointestinal (GI) symptoms are more frequent in type 2 diabetic patients and to examine which diabetic factors are associated with the symptoms.METHODS: Consecutive subjects with diabetes and age-/gender-matched normal controls were recruited for this study. GI symptoms were assessed using a structured questionnaire divided into two GI symptom categories (upper and lower GI symptoms), and consisting of 11 individual symptoms. In the diabetic patient group, diabetic complications including peripheral neuropathy, nephropathy and retinopathy, glycosylated hemoglobin (HbA1c) level and diabetes duration were evaluated.RESULTS: Among the total 190 diabetic patients and 190 controls enrolled, 137 (72%) of the diabetic patients and 116 (62%) of the controls had GI symptoms. In the diabetic patient group, 83 (43%) had upper GI symptoms and 110 (58%) lower GI symptoms; in the control group, 59 (31%) had upper GI symptoms and 104 (55%) lower GI symptoms. This difference between the two groups was significant for only the upper GI symptoms (P = 0.02). Among the diabetic factors, the HbA1c level was the only independent risk factor for upper GI symptoms in the multiple logistic regression analysis (odds ratio = 2.01, 95% confidence interval: 1.02-3.95).CONCLUSION: Type 2 diabetes was associated with an increased prevalence of upper GI symptoms and these symptoms appeared to be independently linked to poor glycemic control, as measured by the HbA1c levels.
RPS3a Over-Expressed in HBV-Associated Hepatocellular Carcinoma Enhances the HBx-Induced NF-κB Signaling via Its Novel Chaperoning Function
Keo-Heun Lim, Kyun-Hwan Kim, Seong Il Choi, Eun-Sook Park, Seung Hwa Park, Kisun Ryu, Yong Kwang Park, So Young Kwon, Sung-Il Yang, Han Chu Lee, In-Kyung Sung, Baik L. Seong
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0022258
Abstract: Hepatitis B virus (HBV) infection is one of the major causes of hepatocellular carcinoma (HCC) development. Hepatitis B virus X protein (HBx) is known to play a key role in the development of hepatocellular carcinoma (HCC). Several cellular proteins have been reported to be over-expressed in HBV-associated HCC tissues, but their role in the HBV-mediated oncogenesis remains largely unknown. Here, we explored the effect of the over-expressed cellular protein, a ribosomal protein S3a (RPS3a), on the HBx-induced NF-κB signaling as a critical step for HCC development. The enhancement of HBx-induced NF-κB signaling by RPS3a was investigated by its ability to translocate NF-κB (p65) into the nucleus and the knock-down analysis of RPS3a. Notably, further study revealed that the enhancement of NF-κB by RPS3a is mediated by its novel chaperoning activity toward physiological HBx. The over-expression of RPS3a significantly increased the solubility of highly aggregation-prone HBx. This chaperoning function of RPS3a for HBx is closely correlated with the enhanced NF-κB activity by RPS3a. In addition, the mutational study of RPS3a showed that its N-terminal domain (1–50 amino acids) is important for the chaperoning function and interaction with HBx. The results suggest that RPS3a, via extra-ribosomal chaperoning function for HBx, contributes to virally induced oncogenesis by enhancing HBx-induced NF-κB signaling pathway.
Sarcopenia Is Independently Associated with Cardiovascular Disease in Older Korean Adults: The Korea National Health and Nutrition Examination Survey (KNHANES) from 2009
Sang Ouk Chin, Sang Youl Rhee, Suk Chon, You-Cheol Hwang, In-Kyung Jeong, Seungjoon Oh, Kyu Jeung Ahn, Ho Yeon Chung, Jeong-taek Woo, Sung-Woon Kim, Jin-Woo Kim, Young Seol Kim, Hong-Yup Ahn
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0060119
Abstract: Background The association between sarcopenia and cardiovascular disease (CVD) in elderly people has not been adequately assessed. The aim of this study was to investigate whether CVD is more prevalent in subjects with sarcopenia independent of other well-established cardiovascular risk factors in older Korean adults. Method This study utilized the representative Korean population data from the Korea National Health and Nutrition Examination Survey (KNHANES) which was conducted in 2009. Subjects older than 65 years of age with appendicular skeletal muscle mass (ASM) determined by dual energy X-ray absorptiometry were selected. The prevalence of sarcopenia in the older Korean adults was investigated, and it was determined whether sarcopenia is associated with CVD independent of other well-known risk factors. Results 1,578 subjects aged 65 years and older with the data for ASM were selected, and the overall prevalence of sarcopenia was 30.3% in men and 29.3% in women. Most of the risk factors for CVD such as age, waist circumference, body mass index, fasting plasma glucose and total cholesterol showed significant negative correlations with the ratio between appendicular skeletal muscle mass and body weight. Multiple logistic regression analysis demonstrated that sarcopenia was associated with CVD independent of other well-documented risk factors, renal function and medications (OR, 1.768; 95% CI, 1.075–2.909, P = 0.025). Conclusions Sarcopenia was associated with the presence of CVD independent of other cardiovascular risk factors after adjusting renal function and medications.
Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy
Scott J. Dylla, Lucia Beviglia, In-Kyung Park, Cecile Chartier, Janak Raval, Lucy Ngan, Kellie Pickell, Jorge Aguilar, Sasha Lazetic, Stephanie Smith-Berdan, Michael F. Clarke, Tim Hoey, John Lewicki, Austin L. Gurney
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0002428
Abstract: Background Patients generally die of cancer after the failure of current therapies to eliminate residual disease. A subpopulation of tumor cells, termed cancer stem cells (CSC), appears uniquely able to fuel the growth of phenotypically and histologically diverse tumors. It has been proposed, therefore, that failure to effectively treat cancer may in part be due to preferential resistance of these CSC to chemotherapeutic agents. The subpopulation of human colorectal tumor cells with an ESA+CD44+ phenotype are uniquely responsible for tumorigenesis and have the capacity to generate heterogeneous tumors in a xenograft setting (i.e. CoCSC). We hypothesized that if non-tumorigenic cells are more susceptible to chemotherapeutic agents, then residual tumors might be expected to contain a higher frequency of CoCSC. Methods and Findings Xenogeneic tumors initiated with CoCSC were allowed to reach ~400 mm3, at which point mice were randomized and chemotherapeutic regimens involving cyclophosphamide or Irinotecan were initiated. Data from individual tumor phenotypic analysis and serial transplants performed in limiting dilution show that residual tumors are enriched for cells with the CoCSC phenotype and have increased tumorigenic cell frequency. Moreover, the inherent ability of residual CoCSC to generate tumors appears preserved. Aldehyde dehydrogenase 1 gene expression and enzymatic activity are elevated in CoCSC and using an in vitro culture system that maintains CoCSC as demonstrated by serial transplants and lentiviral marking of single cell-derived clones, we further show that ALDH1 enzymatic activity is a major mediator of resistance to cyclophosphamide: a classical chemotherapeutic agent. Conclusions CoCSC are enriched in colon tumors following chemotherapy and remain capable of rapidly regenerating tumors from which they originated. By focusing on the biology of CoCSC, major resistance mechanisms to specific chemotherapeutic agents can be attributed to specific genes, thereby suggesting avenues for improving cancer therapy.
Interpretable Housing for Freedom of the Body: The Next Generation of Flexible Homes  [PDF]
Kyung Wook Seo, Chang Sung Kim
Journal of Building Construction and Planning Research (JBCPR) , 2013, DOI: 10.4236/jbcpr.2013.13011
Abstract: If we have gone through the first generation of housing design that pursued functional optimization, ergonomics, and circulation efficiency during the last century, now we are living in the second generation where more advanced goals, such as universal design, ubiquitous design, sustainable design, and environment-friendly design, are emphasized. Although this second generation of design focuses upon the wellness of humans in accordance with environment, it still has the attitude that a more precisely designed home can guarantee a better life. What lacks in this approach is the freedom of the body; it needs to make its own choice as to how to use a space. Thus, it is suggested in this paper that what is important in designing a home is to provide alternatives in daily lives so as to make a full exploration of a given space. These alternatives can be made by offering residents an interpretable space where they can figure out space usages and routs in a constantly changing context. Two spatial devices are discussed in depths as a way to realize this interpretable house: room-to-room enfilade and ring spatial structure. By investigating some existing house plans, it is illustrated how they can guarantee the freedom of the body, and thus alternatives for the flexible domestic life.
The Architectural Expression of Space and Form Created by the Light in the Works of Alvaro Siza  [PDF]
Chang Sung Kim, Kyung Wook Seo
Journal of Building Construction and Planning Research (JBCPR) , 2014, DOI: 10.4236/jbcpr.2014.22011
Abstract: The light is an important element which helps people perceive objects. Therefore, it is important for architects to make the light and space be in harmony with each other. In this study, we analyzed the works of Alvaro Siza with a view to understand the conceptual value of the light expressed in his works and his principles in controlling it. According to the results of the study, the Siza’s architecture is not a mere theoretical one trapped inside formality, but is a sensual and experiential one based on the locality. He was willing to use void spaces to invite the light in free-flowing plans, in order to invigorate and extend architectural spatiality to create deeper visual effect. In addition, the refined light in his works helped visitors experience the continuous forms and spaces by their own movements, while using the changes of the light to stimulate the interest of visitors and highlight the sequence of spaces.
Minimal-Drift Heading Measurement using a MEMS Gyro for Indoor Mobile Robots
Sung Kyung Hong,Sungsu Park
Sensors , 2008, DOI: 10.3390/s8117287
Abstract: To meet the challenges of making low-cost MEMS yaw rate gyros for the precise self-localization of indoor mobile robots, this paper examines a practical and effective method of minimizing drift on the heading angle that relies solely on integration of rate signals from a gyro. The main idea of the proposed approach is consists of two parts; 1) self-identification of calibration coefficients that affects long-term performance, and 2) threshold filter to reject the broadband noise component that affects short-term performance. Experimental results with the proposed phased method applied to Epson XV3500 gyro demonstrate that it effectively yields minimal drift heading angle measurements getting over major error sources in the MEMS gyro output.
Angular Rate Estimation Using a Distributed Set of Accelerometers
Sungsu Park,Sung Kyung Hong
Sensors , 2011, DOI: 10.3390/s111110444
Abstract: A distributed set of accelerometers based on the minimum number of 12 accelerometers allows for computation of the magnitude of angular rate without using the integration operation. However, it is not easy to extract the magnitude of angular rate in the presence of the accelerometer noises, and even worse, it is difficult to determine the direction of a rotation because the angular rate is present in its quadratic form within the inertial measurement system equations. In this paper, an extended Kalman filter scheme to correctly estimate both the direction and magnitude of the angular rate through fusion of the angular acceleration and quadratic form of the angular rate is proposed. We also provide observability analysis for the general distributed accelerometers-based inertial measurement unit, and show that the angular rate can be correctly estimated by general nonlinear state estimators such as an extended Kalman filter, except under certain extreme conditions.
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