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Search Results: 1 - 10 of 30506 matches for " In-Do Song "
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A case of hypereosinophilic syndrome presenting with intractable gastric ulcers
Tae Young Park, Chang Hwan Choi, Suh Yoon Yang, In Soo Oh, In-Do Song, Hyun Woong Lee, Hyung Joon Kim, Jae Hyuk Do, Sae Kyung Chang, Ah Ra Cho, Young Joo Cha
World Journal of Gastroenterology , 2009,
Abstract: We report a rare case of hypereosinophilic syndrome (HES) presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. He underwent Helicobacter pylori (H pylori) eradication therapy followed by proton pump inhibitor (PPI) therapy. However, follow-up endoscopy at 4, 6, 10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement. The proportion of his eosinophil count increased to 43% (total count: 7903/mm3). Abdominal-pelvic and chest computed tomography scans showed multiple small nodules in the liver and both lungs. The endoscopic biopsy specimen taken from the gastric antrum revealed prominent eosinophilic infiltration, and the liver biopsy specimen also showed eosinophilic infiltration in the portal tract and sinusoid. A bone marrow biopsy disclosed eosinophilic hyperplasia as well as increased cellularity of 70%. The patient was finally diagnosed with HES involving the stomach, liver, lung, and bone marrow. When gastric ulcers do not improve despite H pylori eradication and prolonged PPI therapy, infiltrative gastric disorders such as HES should be considered.
Marginal turbid band and light blue crest, signs observed in magnifying narrow-band imaging endoscopy, are indicative of gastric intestinal metaplasia
An Jin,Song Geun,Kim Gwang,Park Do
BMC Gastroenterology , 2012, DOI: 10.1186/1471-230x-12-169
Abstract: Background Gastric intestinal metaplasia (IM) usually appears in flat mucosa and shows few morphologic changes, making diagnosis using conventional endoscopy unreliable. Magnifying narrow-band imaging (NBI) endoscopy enables evaluation of detailed morphological features that correspond with the underlying histology. The aim of this study was to investigate and clarify the diagnostic efficacy of magnifying NBI endoscopic findings for the prediction and diagnosis of IM. Methods Forty-seven patients were prospectively enrolled, and magnifying NBI examinations were performed in the lesser curvature of the midbody and the greater curvature of the upper body. The marginal turbid band (MTB) was defined as an enclosing white turbid band on the epithelial surface/gyri; light blue crest (LBC), as a fine, blue-white line on the crest of the epithelial surface/gyri. Immediately after observation under magnifying endoscopy, biopsy specimens were obtained from the evaluated areas. Results The degree of IM significantly increased with increasing MTB/LBC positivity (MTB-/LBC-, 0.00 ± 0.00; MTB+/LBC-, 0.44 ± 0.51; MTB+/LBC+, 0.94 ± 0.24; p < 0.001). Moderate-to-severe IM was more common in MTB+/LBC+ areas than in MTB+/LBC- areas (p < 0.001). For the diagnosis of IM, MTB had a sensitivity, specificity, and accuracy of 100%, 66.0%, and 81.7%, respectively, and the corresponding values for LBC were 72.1%, 96.0%, and 84.9%. Conclusion MTB and LBC observed in the gastric mucosa with magnifying NBI endoscopy are highly accurate indicators of the presence of IM. MTB likely represents a sign of early gastric IM, while LBC appears with progression to severe IM.
Durability of viral response after off-treatment in HBeAg positive chronic hepatitis B
Myeong Jun Song,Do Seon Song,Hee Yeon Kim,Sun Hong Yoo
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i43.6277
Abstract: AIM: To evaluate the durability in hepatitis B e antigen (HBeAg) positive chronic hepatitis B patients who discontinued antiviral treatment. METHODS: A total of 48 HBeAg positive chronic hepatitis B patients who were administered nucleoside analogues and maintained virological response for ≥ 6 mo [hepatitis B virus (HBV) DNA < 300 copies/mL and HBeAg seroconversion] before cessation of treatment were enrolled between February 2007 and January 2010. The criteria for the cessation of the antiviral treatment were defined as follows: (1) achievement of virological response; and (2) duration of consolidation therapy (≥ 6 mo). After treatment cessation, the patients were followed up at 3-6 mo intervals. The primary endpoint was serologic and virologic recurrence rates after withdrawal of antiviral treatment. Serologic recurrence was defined as reappearance of HBeAg positivity after HBeAg seroconversion. Virologic recurrence was defined as an increase in HBV-DNA level > 104 copies/mL after HBeAg seroconversion with previously undetectable HBV-DNA level. RESULTS: During the median follow-up period of 18.2 mo (range: 5.1-47.5 mo) after cessation of antiviral treatment, the cumulative serological recurrence rate was 15 % at 12 mo. The median duration between the cessation of antiviral treatment and serologic recurrence was 7.2 mo (range: 1.2-10.9 mo). Of the 48 patients with HBeAg positive chronic hepatitis, 20 (41.6%) showed virological recurrence. The cumulative virologic recurrence rates at 12 mo after discontinuing the antiviral agent were 41%. The median duration between off-treatment and virologic recurrence was 7.6 mo (range: 4.3-27.1 mo). The mean age of the virological recurrence group was older than that of the non-recurrence group (46.7 ± 12.1 years vs 38.8 ± 12.7 years, respectively; P = 0.022). Age (> 40 years) and the duration of consolidation treatment (≥ 15 mo) were significant predictive factors for offtreatment durability in the multivariate analysis [P = 0.049, relative risk (RR) 0.31, 95% CI (0.096-0.998) and P = 0.005, RR 11.29, 95% CI (2.054-65.12), respectively]. Patients with age (≤ 40 years) who received consolidation treatment (≥ 15 mo) significantly showed durability in HBeAg positive chronic hepatitis B patients (P = 0.014). These results suggest that additional treatment for more than 15 mo after HBeAg seroconversion in patients who are ≤ 40 years old may be beneficial in providing a sustained virological response. CONCLUSION: Our data suggest that HBeAg seroconversion is an imperfect end point in antiviral treatment. Long-term consol
An Experiment on Power Properties in a Small-Scaled Wind Turbine Generator  [PDF]
Jee-Ho Kim, Hyun-Dai Yang, Kyu-Jin Lee, Sung-Do Song, Sung-Hoon Park, Joong-Ho Shin
Journal of Power and Energy Engineering (JPEE) , 2013, DOI: 10.4236/jpee.2013.17002
Abstract:

This study configures a simple wind tunnel using a blower for generating wind energy, which is equivalent to natural wind, and a test system that measures properties of power. Also, the mechanical and electrical power in a small-scaled wind turbine are empirically measured to analyze the relationship between the mechanical and electrical power.

Characteristics of Mechanical and Electrical Power Transmission for Small-Scaled Wind Turbine  [PDF]
Kyu-Jin Lee, Hyun-Dai Yang, Sung-Hoon Park, Sung-Do Song, Byung-Sun Kim, Joong-Ho Shin
World Journal of Engineering and Technology (WJET) , 2016, DOI: 10.4236/wjet.2016.43D011
Abstract:
Small-scaled wind turbine is converted to mechanical power of windmill to electric power by generator. However almost all studies seems to have overlooked converting relation of mechanical & electric power. It the reason for was very difficult establishing wind turbine system. In this paper, it is define equation of converting relation of mechanical & electric power. And it is verified by experimental methods. Defined equation will be used in developing electric devices such as inverter and controller in wind turbines. In addition this method can be used in the fields that utilize the rotational power into electrical power through generator.
Modeling Camera Image Formation Using a Feedforward Neural Network  [PDF]
Yongtae Do
Open Journal of Applied Sciences (OJAppS) , 2013, DOI: 10.4236/ojapps.2013.31B015
Abstract: One fundamental problem in computer vision and image processing is modeling the image formation of a camera, i.e., mapping a point in three-dimensional space to its projected position on the camera’s image plane. If the relationship between the space and the image plane is assumed to be linear, the relationship can be expressed in terms of a transfor-mation matrix and the matrix is often identified by regression. In this paper, we show that the space-to-image relation-ship in a camera can be modeled by a simple neural network. Unlike most other cases employing neural networks, the structure of the network is optimized so as for each link between neurons to have a physical meaning. This makes it possible to effectively initialize link weights and quickly train the network.
“It’s More than Doing Sports Together, You Know. It’s Deeply Personal”: Preliminary Findings of an Ongoing Qualitative Study on the Relationships between Personal Fitness Trainers and Trainees  [PDF]
Ceren Do?an
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.59008
Abstract: Training at the gym has become, without question, one of the most popular leisure pursuits in contemporary Western societies. In addition to conventional forms of fitness training with free weights, on machines or in exercise-to-music classes, more and more gym members decide to work out with a certified personal trainer on a one-to-one basis, often over long periods of time. The purpose of this ongoing study is to explore the relationship between personal fitness trainers and trainees with a focus on their subjective experiences. Eight semi-structured, indepth interviews were conducted so far and analysed through a thematic analysis. Two central themes have emerged from the data: First, the trainer-trainee relationship is for both sides more than a transactional event but an emotionally significant encounter. Second, trainees describe an occasional reversal of roles where they show interest in and concern about the trainer. Future research should account for possible gender differences, changes of relational dynamics over time and possible negative experiences of both trainers and trainees.
Both Basic and Acidic Amino Acid Residues of Are Involved in Triggering Substate of RyR1
In Ra Seo,Dae Eun Kang,Dong Woo Song,Do Han Kim
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/386384
Abstract: Imperatoxin A (IpTxa) is known to modify the gating of skeletal ryanodine receptor (RyR1). In this paper, the ability of charged aa residues of IpTxa to induce substate of native RyR1 in HSR was examined. Our results show that the basic residues (e.g., Lys19, Lys20, Lys22, Arg23, and Arg24) are important for producing substate of RyR1. In addition, other basic residues (e.g., Lys30, Arg31, and Arg33) near the C-terminus and some acidic residues (e.g., Glu29, Asp13, and Asp2) are also involved in the generation of substate. Residues such as Lys8 and Thr26 may be involved in the self-regulation of substate of RyR1, since alanine substitution of the aa residues led to a drastic conversion to the substate. The modifications of the channel gating by the wild-type and mutant toxins were similar in purified RyR1. Taken together, the specific charge distributions on the surface of IpTxa are essential for regulation of the channel gating of RyR1.
Deep RNA Sequencing Reveals Novel Cardiac Transcriptomic Signatures for Physiological and Pathological Hypertrophy
Hong Ki Song, Seong-Eui Hong, Taeyong Kim, Do Han Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035552
Abstract: Although both physiological hypertrophy (PHH) and pathological hypertrophy (PAH) of the heart have similar morphological appearances, only PAH leads to fatal heart failure. In the present study, we used RNA sequencing (RNA-Seq) to determine the transcriptomic signatures for both PHH and PAH. Approximately 13–20 million reads were obtained for both models, among which PAH showed more differentially expressed genes (DEGs) (2,041) than PHH (245). The expression of 417 genes was barely detectable in the normal heart but was suddenly activated in PAH. Among them, Foxm1 and Plk1 are of particular interest, since Ingenuity Pathway Analysis (IPA) using DEGs and upstream motif analysis showed that they are essential hub proteins that regulate the expression of downstream proteins associated with PAH. Meanwhile, 52 genes related to collagen, chemokines, and actin showed opposite expression patterns between PHH and PAH. MAZ-binding motifs were enriched in the upstream region of the participating genes. Alternative splicing (AS) of exon variants was also examined using RNA-Seq data for PAH and PHH. We found 317 and 196 exon inclusions and exon exclusions, respectively, for PAH, and 242 and 172 exon inclusions and exclusions, respectively for PHH. The AS pattern was mostly related to gains or losses of domains, changes in activity, and localization of the encoded proteins. The splicing variants of 8 genes (i.e., Fhl1, Rcan1, Ndrg2, Synpo, Ttll1, Cxxc5, Egfl7, and Tmpo) were experimentally confirmed. Multilateral pathway analysis showed that the patterns of quantitative (DEG) and qualitative (AS) changes differ depending on the type of pathway in PAH and PHH. One of the most significant changes in PHH is the severe downregulation of autoimmune pathways accompanied by significant AS. These findings revealed the unique transcriptomic signatures of PAH and PHH and also provided a more comprehensive understanding at both the quantitative and qualitative levels.
Patterned thin metal film for the lateral resolution measurement of photoacoustic tomography
Do-Hyun Kim, Dong Ho Shin, Sang-Hun Ryu, Chul-Gyu Song
BioMedical Engineering OnLine , 2012, DOI: 10.1186/1475-925x-11-37
Abstract: A patterned thin metal film deposited on silica glass provides high contrast in optical imaging due to high reflectivity from the metal film and high transmission from the glass. It provides high contrast when it is used for photoacoustic tomography because thin metal film can absorb pulsed laser energy. An US Air Force 1951 resolution target was used to generate patterned photoacoustic signal to measure the lateral resolution. Transducer with 2.25?MHz bandwidth and a sample submerged in water and gelatinous block were tested for lateral resolution measurement.Photoacoustic signal generated from a thin metal film deposited on a glass can propagate along the surface or through the surrounding medium. First, a series of experiments with tilted sample confirmed that the measured photoacoustic signal is what is propagating through the medium. Lateral resolution of the photoacoustic tomography system was successfully measured for water and gelatinous block as media: 0.33?mm and 0.35?mm in water and gelatinous material, respectively, when 2.25?MHz transducer was used. Chicken embryo was tested for biomedical applications.A patterned thin metal film sample was tested for its feasibility of measuring lateral resolution of a photoacoustic tomography system. Lateral resolutions in water and gelatinous material were successfully measured using the proposed method. Measured resolutions agreed well with theoretical values.
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