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Search Results: 1 - 10 of 19725 matches for " In Youb Chang "
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Immunolocalization of Ephexin-1 in the Developing Canine Cerebellum  [PDF]
Hyun Sik Park, In Youb Chang, Han Yong Kim, Sang Pil Yoon
Neuroscience & Medicine (NM) , 2014, DOI: 10.4236/nm.2014.51002

Ephexin-1 functions as guanine nucleotide exchange factors for the Rho-type GTPases which have important roles in neuronal development including axon guidance, migration, morphogenesis, and plasticity of neurons. As little is known about ephexin-1 in the cerebellum, we investigated the immunolocalization of ephexin-1 in the developing canine cerebellum. While the cellular maturation was followed by the temporal pattern, the calbindin D-28k and ephexin-1 immunoreactivities gradually increased in developing canine cerebellum. When compared to the calbindin D-28k immunoreactivities, belated ephexin-1 immunolocalization was observed in the Purkinje cells which aligned a single layer during cerebellar development. These results suggest that ephexin-1 might play an important role in the development of the Purkinje cells during the first two postnatal weeks based on its immunolocalization in the present study.

Direct Torque Control of Induction Motors with Fuzzy Minimization Torque Ripple
Lecture Notes in Engineering and Computer Science , 2009,
Comparison by Simulation of Various Strategies of Three Level Induction Motor Torque Control Schemes for Electrical Vehicle Application
Lecture Notes in Engineering and Computer Science , 2011,
Identification of TRPM7 channels in human intestinal interstitial cells of Cajal
Byung Joo Kim, Kyu Joo Park, Hyung Woo Kim, Seok Choi, Jae Yeoul Jun, In Youb Chang, Ju-Hong Jeon, Insuk So, Seon Jeong Kim
World Journal of Gastroenterology , 2009,
Abstract: AIM: To investigate the characteristics of slow electrical waves and the presence of transient receptor potential melastatin-type 7 (TRPM7) in the human gastrointestinal (GI) tract.METHODS: Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue. Immunohistochemistry was used to identify TRPM7 channels in interstitial cells of Cajal (ICCs).RESULTS: The human GI tract generated slow electrical waves and had ICCs which functioned as pacemaker cells. Flufenamic acid, a nonselective cation channel blocker, and 2-APB (2-aminoethoxydiphenyl borate) and La3+, TRPM7 channel blockers, inhibited the slow waves. Also, TRPM7 channels were expressed in ICCs in human tissue.CONCLUSION: These results suggest that the human GI tract generates slow waves and that TRPM7 channels expressed in the ICCs may be involved in the generation of the slow waves.
Nonselective Blocking of the Sympathetic Nervous System Decreases Detrusor Overactivity in Spontaneously Hypertensive Rats
Khae-Hawn Kim,Long-Hu Jin,Gwoan-Youb Choo,Hun-Jae Lee,Bo-Hwa Choi,Jiyeon Kwak,Sang-Min Yoon,Chang-Shin Park,Tack Lee
International Journal of Molecular Sciences , 2012, DOI: 10.3390/ijms13045048
Abstract: The involuntary dual control systems of the autonomic nervous system (ANS) in the bladder of awake spontaneously hypertensive rats (SHRs) were investigated through simultaneous registrations of intravesical and intraabdominal pressures to observe detrusor overactivity (DO) objectively as a core symptom of an overactive bladder. SHRs ( n = 6) showed the features of overactive bladder syndrome during urodynamic study, especially DO during the filling phase. After injection of the nonselective sympathetic blocking agent labetalol, DO disappeared in 3 of 6 SHRs (50%). DO frequency decreased from 0.98 ± 0.22 min ?1 to 0.28 ± 0.19 min ?1 ( p < 0.01), and DO pressure decreased from 3.82 ± 0.57 cm H 2O to 1.90 ± 0.86 cm H 2O ( p < 0.05). This suggests that the DO originating from the overactive parasympathetic nervous system is attenuated by the nonselective blocking of the sympathetic nervous system. The detailed mechanism behind this result is still not known, but parasympathetic overactivity seems to require overactive sympathetic nervous system activity in a kind of balance between these two systems. These findings are consistent with recent clinical findings suggesting that patients with idiopathic overactive bladder may have ANS dysfunction, particularly a sympathetic dysfunction. The search for newer and better drugs than the current anticholinergic drugs as the mainstay for overactive bladder will be fueled by our research on these sympathetic mechanisms. Further studies of this principle are required.
The Importance of Edge Effects on the Intrinsic Loss Mechanisms of Graphene Nanoresonators
Sung Youb Kim,Harold S. Park
Physics , 2009, DOI: 10.1021/nl802853e
Abstract: We utilize classical molecular dynamics simulations to investigate the intrinsic loss mechanisms of monolayer graphene nanoresonators undergoing flexural oscillations. We find that spurious edge modes of vibration, which arise not due to externally applied stresses but intrinsically due to the different vibrational properties of edge atoms, are the dominant intrinsic loss mechanism that reduces the Q-factors. We additionally find that while hydrogen passivation of the free edges is ineffective in reducing the spurious edge modes, fixing the free edges is critical to removing the spurious edge-induced vibrational states. Our atomistic simulations also show that the Q-factor degrades inversely proportional to temperature; furthermore, we also demonstrate that the intrinsic losses can be reduced significantly across a range of operating temperatures through the application of tensile mechanical strain.
Kinematic aspects of trunk motion and gender effect in normal adults
Chin Youb Chung, Moon Seok Park, Sang Hyeong Lee, Se Jin Kong, Kyoung Min Lee
Journal of NeuroEngineering and Rehabilitation , 2010, DOI: 10.1186/1743-0003-7-9
Abstract: Kinematic trunk motion data were obtained for 20 healthy subjects (11 men and 9 women; age from 21 to 40 years) during walking a 9 m long lane at a self selected speed, namely, motions in the sagittal (tilt), coronal (obliquity), and transverse (rotation) planes, which were all expressed as motions in global (relative to the ground) and those in pelvic reference frame (relative to pelvis), i.e., tilt (G), obliquity (G), rotation (G), tilt (P), obliquity (P), rotation (P).Range of tilt (G), obliquity (G) and rotation (G) showed smaller motion than that of tilt (P), obliquity (P) and rotation (P), respectively. When genders were compared, female trunks showed a 5 degree more extended posture during gait than male trunks (p = 0.002), which appeared to be caused by different lumbar lordosis. Ranges of coronal and transverse plane motion appeared to be correlated. In gait cycle, the trunk motion appeared to counterbalance the lower extremity during swing phase in sagittal plane, and to reduce the angular velocity toward the contralateral side immediate before the contralateral heel strike in the coronal plane.Men and women showed different lumbar lordosis during normal gait, which might be partly responsible for the different prevalence of lumbar diseases between genders. However, this needs further investigation.Trunk motion has not attracted much attention from those interested in three dimensional gait analysis, because this motion is relatively small and is generally thought to be passive and to depend on lower extremity motion. However, some recent studies have shown that trunk posture and motion can influence gait patterns of the lower extremity [1] and alter energy expenditure in the pathologic gait compared to a normal gait [2]. Moreover, the role of trunk motion in balance and proprioceptive function in gait [3,4] is being investigated by studying pathologic gait in patients with neurological, vestibular, or musculoskeletal diseases [5-7]. However, three dimensi
Collision Avoidance of Moving Obstacles for Underwater Robots
KWON KYOUNG YOUB,Cho Jeongmok,Kwon Sung-Ha,Joh Joongseon
Journal of Systemics, Cybernetics and Informatics , 2006,
Abstract: A fuzzy logic for autonomous navigation of underwater robot is proposed in this paper. The VFF(Virtual Force Field) algorithm, which is widely used in the field of mobile robot, is modified for application to the autonomous navigation of underwater robot. This Modified Virtual Force Field(MVFF) algorithm using the fuzzy logic can be used in either track keeping or obstacle avoidance. Fuzzy logics are devised to handle various situations which can be faced during autonomous navigation of underwater robot. A graphic simulator based on OpenGL for an autonomous navigation has been developed. The good performance of the proposed MVFF algorithm is verified through computer simulations on an underwater robot.
Bayesian Decision Analysis for Recurrent Cervical Cancer  [PDF]
Chi-Chang Chang
Open Journal of Clinical Diagnostics (OJCD) , 2014, DOI: 10.4236/ojcd.2014.42013
Abstract: Risk modeling for recurrent cervical cancer requires the development of new concepts and methodologies. Unlike most daily decisions, many medical decision making have substantial consequences, and involve important uncertainties and trade-offs. The uncertainties may be about the accuracy of available diagnostic tests, the natural history of the cervical cancer, the effects of treatment in a patient or the effects of an intervention in a group or population as a whole. With such complex decisions, it can be difficult to comprehend all options “in our heads”. This study applied Bayesian decision analysis to an inferential problem of recurrent cervical cancer in survival analysis. A formulation is considered where individual was expected to experience repeated events, along with concomitant variables. In addition, the sampling distribution of the observations is modelled through a proportional intensity Nonhomogeneous Poisson process. The proposed decision models can provide decision support techniques not only for taking action in the light of all available relevant information, but also for minimizing expected loss. The decision process is useful in selecting the best alternative when a patient with recurrent cervical cancer, in particular, the proposed decision process can provide more realistic solutions.
Validity of gait parameters for hip flexor contracture in patients with cerebral palsy
Sun Jong Choi, Chin Youb Chung, Kyoung Min Lee, Dae Gyu Kwon, Sang Hyeong Lee, Moon Soek Park
Journal of NeuroEngineering and Rehabilitation , 2011, DOI: 10.1186/1743-0003-8-4
Abstract: Twenty-four patients with cerebral palsy (mean age 6.9 years) and 28 normal children (mean age 7.6 years) were included. Kinematic and kinetic data were obtained by three dimensional gait analysis, and psoas lengths were determined using a musculoskeletal modeling technique. Validity of the hip parameters were evaluated.In discriminant validity, maximum psoas length (effect size r = 0.740), maximum pelvic tilt (0.710), maximum hip flexion in late swing (0.728), maximum hip extension in stance (0.743), and hip flexor index (0.792) showed favorable discriminant ability between the normal controls and the patients. In convergent validity, maximum psoas length was not significantly correlated with maximum hip extension in stance in control group whereas it was correlated with maximum hip extension in stance (r = -0.933, p < 0.001) in the patients group. In responsiveness, maximum pelvic tilt (p = 0.008), maximum hip extension in stance (p = 0.001), maximum psoas length (p < 0.001), and hip flexor index (p < 0.001) showed significant improvement post-operatively.Maximum pelvic tilt, maximum psoas length, hip flexor index, and maximum hip extension in stance were found to be clinically relevant parameters in evaluating hip flexor contracture.Hip flexion deformity or spasticity is a cause of the abnormal gait observed in cerebral palsy patients. Hip flexor spasticity was reported to cause dynamic restriction of hip extension in the terminal stance and become fixed hip flexion contracture with age in those patients [1-3]. The psoas muscle is a primary cause of hip flexion contracture [4,5] and has been known to be associated with increased anterior pelvic tilt, crouch gait, hip instability and lumbar lordosis, which can eventually cause spondylosis and back pain [1,4,6-8]. The psoas muscle plays an important role in advancing the lower leg during normal gait [4], whereas the dysphasic activity of the hip flexor muscle opposes and limits hip extension in patients with cerebr
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