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Search Results: 1 - 10 of 1525 matches for " Ilya Laufer "
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The baboon (Papio anubis) extracranial carotid artery: An anatomical guide for endovascular experimentation
J Mocco, Daniel J Hoh, M Nathan Nair, Tanvir F Choudhri, William J Mack, Ilya Laufer, E Sander Connolly
BMC Cardiovascular Disorders , 2001, DOI: 10.1186/1471-2261-1-4
Abstract: We characterized the extracranial carotid system often male baboons (Papio anubis, range 15.1–28.4 kg) by early post-mortem dissection. Photographic documentation of vessel lengths, lumen diameters, and angles of origin were measured for each segment of the carotid bilaterally.The common carotid arteries averaged 94.7 ± 1.7 mm (left) and 87.1 ± 1.6 mm (right) in length. The average minimal common carotid lumen diameters were 3.0 ± 0.3 mm (left) and 2.9 ± 0.2 mm (right). Each animal had a common brachiocephalic artery arising from the aorta which bifurcated into the left common carotid artery and right braciocephalic artery after 21.5 ± 1.6 mm. The vascular anatomy was found to be consistent among animals despite a wide range of animal weights.The consistency in the Papio anubis extracranial carotid system may promote the use of this species in the preclinical investigation of neuro-interventional therapies.There has been a recent interest in developing aggressive interventional strategies for the treatment of a variety of neurological diseases including stroke, subarachnoid hemorrhage, and head trauma [1-4]. Successful translation of these therapies to the clinical arena, however, is critically dependent on the use of appropriate experimental models [5]. Non-human primate models of neurological diseases currently exist and have the advantage of most closely mimicking human physiology [6]. These models are particularly relevant to neuro-interventional research in that anatomical similarities permit routine vascular access and evaluation of devices designed on a clinically relevant scale.Conducting experimental primate endovascular studies, however, requires a comprehensive understanding of the carotid vascular system. Previous investigations of non-human primate vascular anatomy have focused primarily on the general morphology of the vessels and not on vessel angles, lengths, or lumen diameters which are necessary for guiding endovascular technology [7,8]. To answer
A "bela morte"
Laufer, Laurie;
ágora: Estudos em Teoria Psicanalítica , 2012, DOI: 10.1590/S1516-14982012000100002
Abstract: it is in the hidden visibility, in the modesty and in the shame that the issue of viewing the body of the dead takes shape, going towards the phantasmal aspect (aspect of fantasy) linked to the dead. if sexuality seems less veiled as compared to the classical era, death in itself has become a taboo and withdraws itself into the private sphere, into a psychological intimacy, what ariès calls "the barbarization of death". concerning flaubert, writing about the death of emma bovary, the imagery of the body's decomposition and of death creates a repressed, "halo-ed" imagery. the censor process against madame bovary is, in this respect, symbolic of society's repression of the representation of death.
Editorial: Innovationen in der Herzchirurgie
Laufer G
Journal für Kardiologie , 2002,
The exponential map of GL(N)
Alexander Laufer
Physics , 1996, DOI: 10.1088/0305-4470/30/15/029
Abstract: A finite expansion of the exponential map for a $N\times N$ matrix is presented. The method uses the Cayley-Hamilton theorem for writing the higher matrix powers in terms of the first N-1 ones. The resulting sums over the corresponding coefficients are rational functions of the eigenvalues of the matrix.
Tolerance to Self: Which Cells Kill
Terri M. Laufer
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.0060241
Negative Smad Expression and Regulation in the Developing Chick Limb
Neil Vargesson, Ed Laufer
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005173
Abstract: The inhibitory or negative Smads, Smad6 and Smad7, block TGFβ superfamily signals of both the BMP and TGFβ classes by antagonizing the intracellular signal transduction machinery. We report the cloning of one Smad6 and two Smad7 (Smad7a and Smad7b) chick homologs and their expression and regulation in the developing limb. Smad6 and Smad7a are expressed in dynamic patterns reflecting the domains of BMP gene expression in the limb. Activation and inhibition of the BMP signaling pathway in limb mesenchyme indicates that negative Smad gene expression is regulated, at least in part, by BMP family signals.
Cellular Phone Enabled Non-Invasive Tissue Classifier
Shlomi Laufer, Boris Rubinsky
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005178
Abstract: Cellular phone technology is emerging as an important tool in the effort to provide advanced medical care to the majority of the world population currently without access to such care. In this study, we show that non-invasive electrical measurements and the use of classifier software can be combined with cellular phone technology to produce inexpensive tissue characterization. This concept was demonstrated by the use of a Support Vector Machine (SVM) classifier to distinguish through the cellular phone between heart and kidney tissue via the non-invasive multi-frequency electrical measurements acquired around the tissues. After the measurements were performed at a remote site, the raw data were transmitted through the cellular phone to a central computational site and the classifier was applied to the raw data. The results of the tissue analysis were returned to the remote data measurement site. The classifiers correctly determined the tissue type with a specificity of over 90%. When used for the detection of malignant tumors, classifiers can be designed to produce false positives in order to ensure that no tumors will be missed. This mode of operation has applications in remote non-invasive tissue diagnostics in situ in the body, in combination with medical imaging, as well as in remote diagnostics of biopsy samples in vitro.
Lateral motor column axons execute a ternary trajectory choice between limb and body tissues
Victor Luria, Ed Laufer
Neural Development , 2007, DOI: 10.1186/1749-8104-2-13
Abstract: We determined the spinal cord motor column origin of motor nerves that innervate ventral flank tissues at hindlimb level. We found unexpectedly that a subset of medial LMC axons innervates ventral non-limb mesenchyme at hindlimb level, rather than entering ventral limb mesenchyme. We also found that in a conditional BmprIa mutant where all ventral hindlimb mesenchyme is converted to a dorsal identity, all medial LMC axons are redirected into the ventral flank, while lateral LMC axons innervate the bidorsal limb.We have found that medial LMC neurons innervate both ventral flank and limb targets. While normally only a subset of medial LMC axons innervate the flank, all are capable of doing so. Furthermore, LMC axons execute a ternary, rather than binary, choice at the base of the limb between ventral flank, ventral limb and dorsal limb trajectories. When making this choice, medial and lateral LMC axons exhibit different and asymmetric relative preferences for these three trajectories. These data redefine the LMC as a motor column that innervates both limb and body tissues.The precision of neural circuits requires stereotypic patterns of neuronal connectivity, which are often organized as topographic maps. Studies of how the point-to-point connections between spinal cord motor neurons and their targets are generated have revealed much about how such maps are constructed [1-3]. One principle to emerge from these studies is that functionally related neurons extend axons along shared trajectories that are precisely and accurately subdivided at intermediate choice points [4,5]. Deciphering the logic underlying these trajectory choices is thus critical to understanding how these connectivity patterns are established.The overall map between motor neurons and their peripheral targets is well described [3,6-8]. The motor neurons are organized mediolaterally into medial and lateral motor columns (MMC and LMC) and their divisions. Medial MMC neurons innervate dorsal axial muscle
TENS to the Lateral Aspect of the Knees During Stance Attenuates Postural Sway in Young Adults
Yocheved Laufer,Ruth Dickstein
The Scientific World Journal , 2007, DOI: 10.1100/tsw.2007.279
Tolerance to Self: Which Cells Kill
Terri M Laufer
PLOS Biology , 2008, DOI: 10.1371/journal.pbio.0060241
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