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Search Results: 1 - 10 of 212 matches for " Ikuko Ogino "
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Comparing Lifestyle Convenience of Multiple Daily Injection and Continuous Subcutaneous Insulin Infusion  [PDF]
Ikuko Nishio
Open Journal of Nursing (OJN) , 2017, DOI: 10.4236/ojn.2017.712098
Abstract:

Aim: This study investigated the lifestyle convenience of Insulin therapy for adult women patients with type 1 diabetes. Methods: Participants were type 1 diabetes adult women patients who switched from multiple daily injection (MDI) therapy to Continuous Subcutaneous Insulin Infusion (CSII) therapy. We conducted semi-structured interviews with participants. To analyze, we referenced the classification table of Hamada’s study comparing the usefulness of both the NovoPen? and CSII. Semi-structured interviews were conducted with the research subjects. The questions focused mainly on diabetes management, instrument operation, everyday life, and social, psychological and lifestyle convenience aspects during MDI and CSII. Results: Research subjects were 4 women patients with type 1 diabetes. The average age was 35.3 ± 6.24 (SE) years old. Participants were undergoing MDI therapy; however, in the middle, they switched to CSII therapy. CSII therapy is convenient in terms of diabetes management, social and psychological. MDI therapy is convenient in terms of instrument operation and daily life. Compared to MDI therapy, CSII therapy is less convenient in terms of instrument operation and everyday life. However, since CSII therapy has more stable HbA1c and blood glucose levels compared to MDI therapy, it is more convenient in terms of social and psychological aspects and reduces those burdens. About economy CSII therapy, patients paid about 5000 yen more per month compared to MDI therapy. Conclusion: It is believed that patients prioritize therapeutic effects, and choose CSII, which is stable in psychological and social aspects, even though it is inconvenient with life.

Leucine-Rich α2-Glycoprotein Is a Novel Biomarker of Neurodegenerative Disease in Human Cerebrospinal Fluid and Causes Neurodegeneration in Mouse Cerebral Cortex
Masakazu Miyajima, Madoka Nakajima, Yumiko Motoi, Masao Moriya, Hidenori Sugano, Ikuko Ogino, Eri Nakamura, Norihiro Tada, Miyuki Kunichika, Hajime Arai
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074453
Abstract: Leucine-rich α2-glycoprotein (LRG) is a protein induced by inflammation. It contains a leucine-rich repeat (LRR) structure and easily binds with other molecules. However, the function of LRG in the brain during aging and neurodegenerative diseases has not been investigated. Here, we measured human LRG (hLRG) concentration in the cerebrospinal fluid (CSF) and observed hLRG expression in post-mortem human cerebral cortex. We then generated transgenic (Tg) mice that over-expressed mouse LRG (mLRG) in the brain to examine the effects of mLRG accumulation. Finally, we examined protein-protein interactions using a protein microarray method to screen proteins with a high affinity for hLRG. The CSF concentration of hLRG increases with age and is significantly higher in patients with Parkinson’s disease with dementia (PDD) and progressive supranuclear palsy (PSP) than in healthy elderly people, idiopathic normal pressure hydrocephalus (iNPH) patients, and individuals with Alzheimer’s disease (AD). Tg mice exhibited neuronal degeneration and neuronal decline. Accumulation of LRG in the brains of PDD and PSP patients is not a primary etiological factor, but it is thought to be one of the causes of neurodegeneration. It is anticipated that hLRG CSF levels will be a useful biomarker for the early diagnosis of PDD and PSP.
Fabrication of Microspheres Based on Poly(4-butyltriphenylamine) Blends with Poly(methyl methacrylate) and Block Copolymer by Solvent Evaporation Method  [PDF]
Hossein Taherzadeh, Kenji Ogino
Open Journal of Organic Polymer Materials (OJOPM) , 2015, DOI: 10.4236/ojopm.2015.52004
Abstract: Micron-sized polymer particles from single poly(4-butyltriphenylamine) (PBTPA) homopolymer, binary polymer blend [PBTPA/poly(methyl methacrylate) (PMMA)], and ternary polymer blend (PBTPA/PBTPA-b-PMMA/PMMA) via a solvent evaporation method, and the surface morphologies and inside structure of resulting particles were investigated. Spherical homopolymer particles with smooth surface were resulted from PBTPA with low molecular weight. In the case of binary blends (PBTPA/PMMA = 1/1), Janus (low molecular weight) and dumbbell (high molecular weight) type morphologies were observed. The particles based on ternary blends containing PBTPA-b-PMMA showed core-shell type morphologies (PMMA; core, PBTPA; shell). Degree of engulfment of PMMArich domain increased with the content of the block copolymer. The decrease of domain size was not observed although the block copolymer had a suitable structure as a compatibilizer for the blend. It was also found that the initial concentration of polymer solution had an effect on the final morphology.
Synthesis of Polyfluorene-Polytriarylamine Block Copolymer with Emitting Part at Junction Point for Light Emitting Applications  [PDF]
Mehdi Jahanfar, Kenta Suwa, Kousuke Tsuchiya, Kenji Ogino Ogino
Open Journal of Organic Polymer Materials (OJOPM) , 2013, DOI: 10.4236/ojopm.2013.32008
Abstract: A block copolymer consisting of polyfluorene (PF) and polytriarylamine (PTAA) functionalized with green emitting phenoxazine moiety at the junction point of two blocks was designed and prepared for electroluminescent application. PF homopolymer was synthesized by Suzuki coupling polymerization, and was reacted with brominated phenoxazine. In the presence of the resulting PF functionalized with phenoxazine, C-N coupling polymerization of 4-(4’-bromophenyl)-4’’-butyldiphenylamine was carried out to afford a triblock copolymer, PTAA-phenoxazine-PF-phenoxazine-PTAA (PF-Ph-PTAA). Two types of random copolymers were also synthesized with fluorene and phenoxazine (PF2) by Suzuki coupling polymerization for comparison. All the polymers were soluble in common organic solvents and readily formed thin films by a solution processing. Prepared polymers exhibited similar UV absorption and PL emission in chloroform solutions. In a film state, the existence of phenoxazine unit drastically changed PL spectra. Although the content of phenoxazine unit in PF-Ph-PTAA was relatively high (13 mol%), it showed similar PL spectrum to that of PF2(phenoxazine content, 0.2 mol%) indicating that phenoxazine unit is isolated in single polymer chain nevertheless the high content. EL device based on PF-Ph-PTAA showed green-emission, suggesting that emission sites predominantly located in the vicinity of phenoxazine moiety because of its shallow HOMO level.
The Myth of an 'Invisible Mediator': An Australian Case Study of English-Japanese Police Interpreting
Ikuko Nakane
PORTAL : Journal of Multidisciplinary International Studies , 2009,
Abstract: Recent studies have challenged the assumption that the interpreter is an ‘invisible’ mediator and have demonstrated a departure from the ‘conduit’ role often assigned to interpreters in their professional ethics guidelines (e.g. Russell 2000, Wadensj 1998, 2004; Yoshida 2007). In this paper, I address the issue of interpreter’s role as an invisible mediator through an examination of interactional ‘repairs’, one of the key aspects of interaction management mechanisms in the tradition of Conversation Analysis. The context of interpreting is Australian Federal Police interviews mediated by Japanese-English interpreters. While some repair sequences in interpreter-mediated police interviews followed common patterns of monolingual police interviews, there were also some features of repairs specific to interpreter-mediated discourse. In particular, due to the interpreting of each turn, in some cases, it is not always possible to ascertain whether it was the primary speaker’s turn or the interpreted version that was the source of ‘trouble’ leading to an interactional repair. The paper demonstrates interpreters’ vulnerability to being identified as the ‘troublemaker’ in repair sequences and consequential face-saving strategies. These strategies included modifying the primary speaker’s utterances or providing explanations for why a need to repair was perceived or why a repair sequence failed to rectify a problem. It is demonstrated that in engaging in these types of problem solving activities, interpreters at times shift roles, sometimes pushing the boundaries of their professional ethics. The paper argues that, while interpreters are often viewed as operating within a third ‘invisible’ space between interlocutors, this invisibility needs to be questioned. It is suggested that the expectation of a completely invisible, or neutral, third space is unrealistic, and that interpreters as cultural and linguistic mediators, and as social beings, continuously negotiate their identity with their clients while interpreting.
Interpretation of Coulomb breakup of 31Ne in terms of deformation
Ikuko Hamamoto
Physics , 2009, DOI: 10.1103/PhysRevC.81.021304
Abstract: The recent experimental data on Coulomb breakup of the nucleus $^{31}$Ne are interpreted in terms of deformation. The measured large one-neutron removal cross-section indicates that the ground state of $^{31}$Ne is either s- or p-halo. The data can be most easily interpreted as the spin of the ground state being 3/2$^-$ coming from either the Nilsson level [330 1/2] or [321 3/2] depending on the neutron separation energy $S_n$. However, the possibility of 1/2$^{+}$ coming from [200 1/2] is not excluded. It is suggested that if the large ambiguity in the measured value of $S_n$ of $^{31}$Ne, 0.29$\pm1.64$ MeV, can be reduced by an order of magnitude, say to be $\pm$100 keV, one may get a clear picture of the spin-parity of the halo ground state.
One-particle properties of deformed N $\approx$ 28 odd-N nuclei with weakly-bound or resonant neutrons
Ikuko Hamamoto
Physics , 2008, DOI: 10.1103/PhysRevC.79.014307
Abstract: Possible deformation of odd-N nuclei with N $\approx$ 28 towards the neutron drip line is investigated using the Nilsson diagram based on deformed Woods-Saxon potentials. Both weakly-bound and resonant one-particle levels are properly obtained by directly solving the Schr\"{o}dinger equation in mesh of space coordinate with the correct boundary condition. If we use the same diffuseness of the potential as that of $\beta$-stable nuclei, the energy difference between the neutron 2p$_{3/2}$ and 1f$_{7/2}$ levels becomes very small or the N=28 energy gap almost disappears, as the binding energies of those levels approach zero. This suggests that the ground states of those neutron drip line nuclei are likely to be deformed. In particular, the spin-parity and the magnetic moment of the ground state of odd-N nuclei, $^{43}_{16}$S$_{27}$ and $^{45}_{16}$S$_{29}$, are examined. Moreover, it is suggested that in $^{39}_{12}$Mg$_{27}$ lying outside the drip line the lowest resonant state may have 5/2$^{-}$, if the N=28 energy gap almost vanishes.
Nilsson diagrams for light neutron-rich nuclei with weakly-bound neutrons
Ikuko Hamamoto
Physics , 2007, DOI: 10.1103/PhysRevC.76.054319
Abstract: Using Woods-Saxon potentials and the eigenphase formalism for one-particle resonances, one-particle bound and resonant levels for neutrons as a function of quadrupole deformation are presented, which are supposed to be useful for the interpretation of spectroscopic properties of some light neutron-rich nuclei with weakly-bound neutrons. Compared with Nilsson diagrams in text books which are constructed using modified oscillator potentials, we point out a systematic change of the shell structure in connection with both weakly-bound and resonant one-particle levels related to small orbital angular momenta $\ell$. Then, it is seen that weakly-bound neutrons in nuclei such as $^{15-19}$C and $^{33-37}$Mg may prefer to being deformed as a result of Jahn-Teller effect, due to the near degeneracy of the 1d$_{5/2}$-2s$_{1/2}$ levels and the 1f$_{7/2}$-2p$_{3/2}$ levels in the spherical potential, respectively. Furthermore, the absence of some one-particle resonant levels compared with the Nilsson diagrams in text books is illustrated.
Change of shell structure and magnetic moments of odd-N deformed nuclei towards neutron drip line
Ikuko Hamamoto
Physics , 2010, DOI: 10.1088/0954-3899/37/5/055102
Abstract: Examples of the change of neutron shell-structure in both weakly-bound and resonant neutron one-particle levels in nuclei towards the neutron drip line are exhibited. It is shown that the shell-structure change due to the weak binding may lead to the deformation of those nuclei with the neutron numbers $N \approx$ 8, 20, 28 and 40, which are known to be magic numbers in stable nuclei. Nuclei in the "island of inversion" are most easily and in a simple manner understood in terms of deformation. As an example of spectroscopic properties other than single-particle energies, magnetic moments of some weakly-bound possibly deformed odd-N nuclei with neutron numbers close to those traditional magic numbers are given, which are calculated using the wave function of the last odd particle in deformed Woods-Saxon potentials.
Neutron shell structure and deformation in neutron-drip-line nuclei
Ikuko Hamamoto
Physics , 2012, DOI: 10.1103/PhysRevC.85.064329
Abstract: Neutron shell-structure and the resulting possible deformation in the neighborhood of neutron-drip-line nuclei are systematically discussed, based on both bound and resonant neutron one-particle energies obtained from spherical and deformed Woods-Saxon potentials. Due to the unique behavior of weakly-bound and resonant neutron one-particle levels with smaller orbital angular-momenta $\ell$, a systematic change of the shell structure and thereby the change of neutron magic-numbers are pointed out, compared with those of stable nuclei expected from the conventional j-j shell-model. For spherical shape with the operator of the spin-orbit potential conventionally used, the $\ell_{j}$ levels belonging to a given oscillator major shell with parallel spin- and orbital-angular-momenta tend to gather together in the energetically lower half of the major shell, while those levels with anti-parallel spin- and orbital-angular-momenta gather in the upper half. The tendency leads to a unique shell structure and possible deformation when neutrons start to occupy the orbits in the lower half of the major shell. Among others, the neutron magic-number N=28 disappears and N=50 may disappear, while the magic number N=82 may presumably survive due to the large $\ell =5$ spin-orbit splitting for the $1h_{11/2}$ orbit. On the other hand, an appreciable amount of energy gap may appear at N=16 and 40 for spherical shape, while neutron-drip-line nuclei in the region of neutron number above N=20, 40 and 82, namely N $\approx$ 21-28, N $\approx$ 41-54, and N $\approx$ 83-90, may be quadrupole-deformed though the possible deformation depends also on the proton number of respective nuclei.
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