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Search Results: 1 - 10 of 1282 matches for " Ichiro Nakachi "
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Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells
Hideo Watanabe, Kenzo Soejima, Hiroyuki Yasuda, Ichiro Kawada, Ichiro Nakachi, Satoshi Yoda, Katsuhiko Naoki, Akitoshi Ishizaka
Cancer Cell International , 2008, DOI: 10.1186/1475-2867-8-15
Abstract: We observed differential HKMT expression in a lung cancer model in which normal human bronchial epithelial (NHBE) cells expressing telomerase, SV40 large T antigen, and Ras were immortal, formed colonies in soft agar, and expressed specific HKMTs for H3 lysine 9 and 27 residues but not for H3 lysine 4 residue. Modifications in the H3 tails affect the binding of proteins to the histone tails and regulate protein function and the position of lysine methylation marks a gene to be either activated or repressed. In the present study, suppression by siRNA of HKMTs (EZH2, G9A, SETDB1 and SUV39H1) that are over-expressed in immortalized and transformed cells lead to reduced cell proliferation and much less anchorage-independent colony growth. We also found that the suppression of H3-K9, G9A and SUV39H1 induced apoptosis and the suppression of H3-K27, EZH2 caused G1 arrest.Our results indicate the potential of these HKMTs in addition to the other targets for epigenetics such as DNMTs and HDACs to be interesting therapeutic targets.Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations involving tumor suppressor genes, oncogenes and DNA stability genes as well as from potentially reversible epigenetic changes leading to modifications in gene function [1,2]. It is well established that epigenetic modifications of nucleosomal histones are central to proper gene expression and aberrant DNA methylation of genes play an important role in tumor progression. However, still relatively little is known about histone modifications, especially methylation, with respect to tumorigenesis. The N-terminus of histone tails is modified by amino-acid phosphorylation, acetylation or methylation to form a code for specifying downstream events and consequently a certain chromatin structure. Tens of histone lysine methyltransferases (HKMTs) have been identified and histone lysine methylation is now considered to be a critical regulator of tra
Bacterial Cells as Model Factories  [PDF]
Ichiro Matsumura
American Journal of Operations Research (AJOR) , 2013, DOI: 10.4236/ajor.2013.31A007

Bacteria, like industrial engineers, must manage processes that convert low value inputs into high value outputs. Bacteria are not intelligent, so they utilize self-organizing production systems to accelerate life-sustaining chemical processes. Here I explore two questions. First, can businesses apply the principles of self-organization? Second, can operations researchers contribute to our understanding of biological systems? I explain biochemical concepts in plain terms, illustrated with a few informative laboratory evolution experiments, and describe the organizing principles that underlie complex biological systems. I describe the new disciplines of synthetic biology and metabolic engineering, which offer opportunities for interdisciplinary collaboration between life scientists and operations researchers.

Niveles de insatisfacción del usuario externo en el Instituto Nacional de Salud del Ni o de Lima, Perú Levels of dissatisfaction of external users of the Instituto Nacional de Salud del Ni o (National Institute of Child Health) in Lima, Peru
Roberto Shimabuku,Luis Huicho,Danitza Fernández,Graciela Nakachi
Revista Peruana de Medicina Experimental y Salud Pública , 2012,
Abstract: Objetivos. Determinar los cambios de los niveles de insatisfacción del usuario externo del Instituto Nacional de Salud del Ni o, Lima, Perú. Materiales y métodos. Estudio observacional basado en un programa para la evaluación de encuestas de usuarios en salud (SEEUS). La población estuvo conformada por todos los acompa antes del usuario externo en consulta ambulatoria, hospitalización y emergencia en los a os 2008, 2009 y 2010. Para el cálculo del tama o muestral se empleó la proporción de usuarios insatisfechos de cada servicio del a o anterior, con un nivel de confianza del 95% y un error estimado del 5%. Resultados. Se obtuvo una muestra de 2051 acompa antes, en la cual se constató una tendencia decreciente de los niveles de insatisfacción en consulta ambulatoria, y un aumento de la insatisfacción en la dimensión capacidades médicas en hospitalización y emergencia. Se encontró además, índices de insatisfacción menores de 0,20 en las dimensiones capacidades médicas en consulta ambulatoria. En contraste, los mayores índices de insatisfacción se encontraron en las dimensiones de higiene durante los a os 2009 (0,25) y 2010 (0,25), y otros en emergencia durante el 2009 (0,25). Conclusiones. Las dimensiones en las que hubo un incremento en el índice de insatisfacción fueron aspectos tangibles, higiene y otros en hospitalización y emergencia. Por otra parte, la dimensión capacidades médicas en consulta ambulatoria mostró una disminución de los niveles de insatisfacción durante el periodo evaluado. Objectives. To determine the changes in the levels of dissatisfaction of the external users of the Instituto Nacional de Salud del Ni o, in Lima, Peru. Materials and methods. Observational study based on a software to evaluate surveys completed by health care users (Software de Evaluación de Encuestas de Usuarios en Salud - SEEUS). The population consisted of every person accompanying external users to outpatient visits, inpatient visits or emergency treatment in the years 2008, 2009 and 2010. To calculate the sample size, last year’s proportion of users dissatisfied with each service was used, with an estimated error of 5% at a 95% confidence level Results. A sample of 2051 people was obtained, which revealed a decreasing trend in the levels of dissatisfaction with outpatient visits, and an increased dissatisfaction in the medical capabilities dimension for hospitalization and emergency services. In addition, a dissatisfaction index lower than 0.20 was registered in the medical capabilities dimension for outpatient visits. In contrast, the highest dissatisfaction
New Neumerical Method to Calculate Time-Dependent Quantum Properties in Finite Temperature Based on the Heisenberg Equation of Motion  [PDF]
Shin-Ichiro Kondo
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.310190
Abstract: For the purpose of computer calculation to evaluate time-dependent quantum properties in finite temperature, we propose new numerical method expressed in the forms of simultaneous differential equations. At first we derive the equation of motion in finite temperature, which is found to be same expression as Heisenberg equation of motion except for the c-number. Based on this equation, we construct numerical method to estimate time-dependent physical properties in finite temperature precisely without using analytical procedures such as Keldysh formalism. Since our approach is so simple and is based on the simultaneous differential equations including no terms related to self-energies, computer programming can be easily performed. It is possible to estimate exact time-dependent physical properties, providing that Hamiltonian of the system is taken to be a one-electron picture. Furthermore, we refer to the application to the many body problem and it is numerically possible to calculate physical properties using Hartree Fock approximation. Our numerical method can be applied to the case even when perturbative Hamiltonians are newly introduced or Hamiltonian shows complex time-dependent behavior. In this article, at first, we derive the equation of motion in finite temperature. Secondly, for the purpose of verification and of exhibiting the usefulness, we show the derivation of gap equation of superconductivity and of sum rule of electrical conductivity and the application to the many body problem. Finally we apply this method to these two cases: the first case is most simplified resonance charge transfer neutralization of an ion and the second is the same process but impurity potential is newly introduced as perturbative Hamiltonian. Through both cases, it is found that neutralization process is not so sensitive to temperature, however, impurity potential as small as 10 meV strongly influences the neutralization of ion.
Exchange Rate and Current Account Dynamics with Habits over Consumption and Money Holdings  [PDF]
Ichiro Gombi, Shinsuke Ikeda
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.47051

Incorporating two independent habits over consumption and money holdings into a small country model, we examine the adjustment dynamics of the current account and the exchange rate to expansionary monetary and fiscal shocks under two alternative policy regimes: (1) the endogenous income transfer regime; and (2) the endogenous fiscal spending regime. In response to the shocks under regime (1), the exchange rate depreciates on impact and in the long run whereas it appreciates (depreciates) in transition if preferences for real money balances exhibit distant (adjacent) complementarity. Under regime (2), the consumption habits and the monetary habits jointly generate possibly non-monotonic current account dynamics. An induced increase in fiscal spending in regime (2) can generate a current account surplus in the case where the monetary habits exhibit strong distant complementarity.

Scientific Catch-Up in Asian Economies: A Case Study for Solar Cell  [PDF]
Ichiro Sakata, Hajime Sasaki
Natural Resources (NR) , 2013, DOI: 10.4236/nr.2013.41A017

A significant structural change in the pattern of economic development in Asian economies has been observed in recent years. We have seen many cases in which the Asian economies became the center of the world-wide production in an extremely short period of time after a new product entered the market. Also in the science, the number of papers written by Asian researchers has been increasing dramatically. In this situation, the existing studies cannot sufficiently explain the driving force and the mechanism of catch-up or economic growth. Therefore, it is now required to model this new type of economic development. In this paper we analyzed their scientific catch-up status using scientific papers on solar cells to clarify the structural change. After mid 1990s, knowledge creation has been accelerated in the field of solar cell. Now more than three thousand papers are published annually. We found as a result that the catch-up process in Asian economies had progressed rapidly, that some economies had a larger share of scientific papers in the frontier field of advanced science than in the matured fields, and that the strategy largely changed from area to area. A parallel-running-type growth model has thus been emerging in Asia. Responding to the significant changes in development model, we have to re-design the framework of economic cooperation. There is a need for further horizontal collaboration among major Asian economies and developed

Oxygen Isotope Study of Silica Sinter from the Osorezan Geothermal Field, Northeast Japan  [PDF]
Ken-ichiro Hayashi
International Journal of Geosciences (IJG) , 2013, DOI: 10.4236/ijg.2013.410141

Silica sinter developed on the northern shore of Lake Usoriyama in the Osorezan geothermal field was examined for the occurrence, texture, crystallinity of silica minerals, and the concentrations of trace elements and oxygen isotopes. The silica sinter consists of a thick eastern mound (layer A) and a thin western part (layer B). Most of the silica sinter is composed of alternating bands of thin layers of silica minerals with colors varying from white to yellow and reddish gray. There is a unique stromatolitic texture, an aggregate of stratified concentric layers that extends upward and is red to reddish gray in color in the middle of layer A. Silica minerals, mainly opal-A and opal-CT, dominate the mineralogical constituents of the sinter. The δ18O of the silica mineral in layer A varies between 13‰ and 26‰, while layer B has higher values, between 19‰ and 33‰. The hydrothermal fluid from which the silica sinter precipitated is dominated by meteoric water is similar to present-day hot spring water.

A New Type of Bridge, Mobilebridge? to Super-Quickly Recover a Bridge  [PDF]
Ichiro Ario, Yuki Chikahiro
World Journal of Engineering and Technology (WJET) , 2015, DOI: 10.4236/wjet.2015.33C025

Many natural disasters cause not only critical situations for facilities and resident’s residents’ life, but also significant damage to economy. It is obvious that quick rescue action must be undertaken and that there are many problems due to the occurrence of secondary disasters at rescue worksite. Basing Based on the previous study of deployable structures and the concept of the multi-folding micro-structures, we propose a new type of foldable bridge in form of scissor structure called the Mobile-bridge?. In this paper, we discuss the vehicle passing test performed on the real-scale Mobile-bridge in order to evaluate its mechanical characteristics and application limits. Moreover, we verified the compatibility between the result of calculations and experiments by means of theoretical modelling. The results show that it is sufficient to treat the load as equivalent nodal forces applied at the joints without including the stiffness of the deck.

Adsorption of CO2 and H2 on Cu and Zn Micro-Cluster Surfaces Studied by Quantum Chemistry and Theory of Absolute Reaction Rates  [PDF]
Hiroaki Kuze, Shin’ichiro Okude
Open Journal of Physical Chemistry (OJPC) , 2011, DOI: 10.4236/ojpc.2011.13015
Abstract: Statistical mechanics and semi-empirical molecular orbital theory (PM6) are used to calculate the surface coverage of CO2 and H2 molecular species chemically adsorbed on the surface of Cu and Zn micro clusters. The calculation shows that CO2 is adsorbed well both on the surface of Cu and Zn micro clusters. Although H2 is adsorbed well on the surface of Zn micro clusters, H2 absorption on the surface of Cu micro clusters is much more limited in the pressure range of 20 - 100 atm and temperature range of 200 - 1000 K. Reaction rates are also estimated for some chemical adsorption process of H2 gas using theory of absolute reaction rates. It is found that the values of the reaction rate calculated in the present paper agree reasonably well with the experimental values.
Ionic Liquids in Tribology
Ichiro Minami
Molecules , 2009, DOI: 10.3390/molecules14062286
Abstract: Current research on room-temperature ionic liquids as lubricants is described. Ionic liquids possess excellent properties such as non-volatility, non-flammability, and thermo-oxidative stability. The potential use of ionic liquids as lubricants was first proposed in 2001 and approximately 70 articles pertaining to fundamental research on ionic liquids have been published through May 2009. A large majority of the cations examined in this area are derived from 1,3-dialkylimidazolium, with a higher alkyl group on the imidazolium cation being beneficial for good lubrication, while it reduces the thermo-oxidative stability. Hydrophobic anions provide both good lubricity and significant thermo-oxidative stability. The anions decompose through a tribochemical reaction to generate metal fluoride on the rubbed surface. Additive technology to improve lubricity is also explained. An introduction to tribology as an interdisciplinary field of lubrication is also provided.
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