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The Influence of Gonadectomy on Anxiolytic and Antidepressant Effects of Melatonin in Male and Female Wistar Rats: A Possible Implication of Sex Hormones  [PDF]
El Mrabet Fatima Zahra, Lagbouri Ibtissam, Mesfioui Abdelhalim, El Hessni Aboubakr, Ouichou Ali
Neuroscience & Medicine (NM) , 2012, DOI: 10.4236/nm.2012.32021
Abstract: The main objective of this study was to analyze the effects of sex, ovariectomy (Ovx) and orchidectomy (Orx) on antidepressant and anxiolytic effect of melatonin in forced swimming test, open field test and elevated plus maze test. Initially, 4 mg/kg of melatonin was daily administered, at 4:00 pm, to intact male and female rats during 8 weeks. Our results have shown that the effect of chronic injection of Mel is sex dependent in the three behaviors tests. Females rats have responded better than males in behavior test study after administration of melatonin, this difference between the sexes may be related to the action of sex hormones (androgens and estrogens) on behavior in males as well as in females. Secondly, to determine the possible interaction between Melatonin and steroid hormones, Ovx/sham female received Mel at dose of 4mg/kg alone or NaCl (0.9%) alone, and Orx/sham male received Mel at dose of 4 mg/kg alone or NaCl (0.9%) alone daily and during 8 weeks of treatment at 4:00 pm. All animals were tested in the open-field test, elevated plus maze test for anxiety behavior study, and forced swimming test for depression behavior study. Results revealed that Mel exerts an anxiolytic and antidepressant effects in the orchidectomized males and in intact females, confirming that the suppression of androgens by orchidectomy improved anxiolytic and antidepressant effects of melatonin in males. However in females, the suppression of estrogen by ovariectomy masked the antidepressant and anxiolytic effects of melatonin. Our results confirmed that the antidepressant and anxiolytic effects of melatonin are linked to sex hormones.
Melatonin and Diazepam Affect Anxiety-Like and Depression-Like Behavior in Wistar Rats: Possible Interaction with Central GABA Neurotransmission  [PDF]
Sihame Ouakki, Fatima Zahra El Mrabet, Ibtissam Lagbouri, Aboubaker El Hessni, Abdelhalem Mesfioui, Paul Pévet, Etienne Challet, Ali Ouichou
Journal of Behavioral and Brain Science (JBBS) , 2013, DOI: 10.4236/jbbs.2013.37055
Abstract: Recent studies have shown the importance of the GABA-ergic transmission in the pathophysiology of anxiety and depressive disorders in humans. Our present study aims to investigate the interaction of melatonin (MEL) with this system by exploring the effects of MEL with or without a facilitator of GABA-ergic neurotransmission, diazepam (DZ) on the levels of depression and anxiety in Wistar rats. For this purpose, different doses of MEL (2, 4 or 16 mg/kg) or DZ (2 mg/kg) are subchronically administered during 15 days. After pharmacological treatments, anxiety levels are evaluated in behavioral tests of Open Field (OFT) and elevated plus maze (EPM) and depression levels are evaluated by the forced swim test (FST). The results showed that MEL produces anxiolytic-like and antidepressant-like effects in a dose-dependent manner; the maximum effect was obtained at a dose of 16 mg/kg. However, a dose of 4 mg/kg is necessary to induce an effect. The effect of MEL and DZ reported in this study concerns selective modulation of behavioral anxiety and depression since locomotor activity assessed by the OFT and EPM was not affected. The subchronic injection of MEL at 4 mg/kg, DZ at 2 mg/kg or the two combined molecules also induces also anxiety-like and antidepressant-like behavior. In addition, a potentiating effect between MEL and DZ was observed. These effects suggest that psychopharmacological actions of MEL are due, at least in part, to its ability to improve the central GABA-ergic transmission.
Numerical Study of Natural Convection in a Two-Dimensional Enclosure with a Sinusoidal Boundary Thermal Condition Utilizing Nanofluid  [PDF]
Ibtissam El Bouihi, Rachid Sehaqui
Engineering (ENG) , 2012, DOI: 10.4236/eng.2012.48058
Abstract: Nanofluids are considered to offer important advantages over conventional heat transfer fluids. A model is developed to analyze the behavior of nanofluids taking into account the solid fraction χ. The Navier-Stokes equations are solved numerically with Alternating Direct Implicit method (ADI method) for various Grashof numbers 104 and 105; we have an excellent agreement between our numerical code and previously published works. Copper-Water nanofluid is used with Pr = 6.2 and solid volume fraction χ is varied as 0%; 5%; 10%; 15% and 20%. The problem considered is a two-dimensional heat transfer in a square cavity. The vertical walls are differentially heated, the left is maintained at hot con- dition (sinusoidal) when the right one is cold. The horizontal walls are assumed to be insulated, non conducting and impermeable to mass transfer. The nanofluid in the enclosure is Newtonian, incompressible and laminar. The nanopar- ticles are assumed to have a uniform shape and size. Moreover, it is assumed that both the fluid phase and nanoparticles are in thermal equilibrium state and they flow at the same velocity. The thermophysical properties of the nanofluid are assumed to be constant except for the density variation in the buoyancy force, which is based on the Boussinesq approximation. Different correlations are proposed for predicting heat transfer for uniform and sinusoidal boundary thermal conditions.
Négociation de spectre dans les réseaux de radio cognitive
Ibtissam Larbi,Badr Benmammar
Computer Science , 2014,
Abstract: In this report, we propose a technique using negotiation based on multi-agent system (MAS) in the context of cognitive radio network (CRN). The agents are particularly suited to provide responsive solutions to complex problems such as the negotiation of the spectrum in CRN. We have implemented our proposed solution with JADE (Java Agent Development Framework) and we have also evaluate the proposed solution to show its interest.
Burnout among Lebanese nurses: Psychometric properties of the Maslach Burnout Inventory-Human Services Survey (MBI-HSS)  [PDF]
Ibtissam Sabbah, Hala Sabbah, Sanaa Sabbah, Hussein Akoum, Nabil Droubi
Health (Health) , 2012, DOI: 10.4236/health.2012.49101
Abstract: Background: Burnout is a mental condition defined as a result of continuous and long-term stress exposure, particularly related to psychosocial factors at work. This paper aims to examine the psychometric properties of the Maslach Burnout Questionnaire (MBI-HSS) for validation of use in Lebanon, and to describe burnout and associated factors amongst nurses in Lebanon especially the gender and employment sector. Methods: The psychometric properties of the Arabic version of MBI-HSS were studied amongst a sample of 200 nurses. In this descriptive study, survey data were collected from private and public hospitals. The data were analyzed by means of descriptive statistics and multivariate analysis. Results: The results indicated satisfactory reliability through internal consistency for all three scales of the MBI-HSS. The factor analysis was quite satisfactory. Most of staff had scores which indicated they were burnt out. Nearly three quarters (77.5%) reported emotional exhaustion, 36.0% reported depersonalization while almost one third (33.0%) experienced reduced personal accomplishment. Burnout increases for 30-39 years age groups. Married nurses had significantly higher emotional exhaustion. Depersonalization was highest among nurses in private sector, and personal accomplishment was highest among nurses in public sector. Depersonalization proved to be higher in night and rotating shift nurses. Depression, backache, and headache were predictors of burnout. Conclusion: Findings indicate that the main psychometric properties of reliability and validity of the Arabic version of MBI-HSS appear to be satisfactory. Burnout is particularly prominent and severe in the nurses working population. The implications of these findings for interventions that reduce burnout and promote nursing mental health are therefore in the interest of employers, governments and policy makers.
Occupational exposures to blood and body fluids (BBF): Assessment of knowledge, attitude and practice among health care workers in general hospitals in Lebanon  [PDF]
Ibtissam Sabbah, Hala Sabbah, Sanaa Sabbah, Hussein Akoum, Nabil Droubi
Health (Health) , 2013, DOI: 10.4236/health.2013.51010

Healthcare workers (HCWs) who are employed in traditional health care workplaces face a serious danger that may threaten their life; it is their exposure to blood and body fluids (BBF). In Lebanon, the introduction of a hospital accreditation system has put a particular emphasis on staff safety, and on the evaluation of professional practice (EPP) programs. Methods: A cross-sectional survey was conducted amongst 277 HCWs working in 4 general hospitals in South Lebanon. Objective: 1) describe the prevalence and the risk factors for occupational exposure to BBF among HCWs; 2) evaluate knowledge, attitude, and practices of HCW concerning blood-borne pathogens and adherence to universal safety precautions. Results: The mean age of the respondents was 32.14 years (SD = 10.33), 57.4% were females. 43.3% of HCWs expressed that they use gloves all the time for every activeity of care. 67.1% were aware that needles should not be recapped after use; registered nurses and nursing students were more aware than physicians and nursing assistants (nurse) in this subject. 30% of HCWs declared having had at least one occupational exposure to BBF; 62.7% of all accidental exposure was reported to the department responsible for managing exposures. Percutaneous injuries were the most frequently reported. Vaccination coverage was 88.4% for hepatitis B, and 48.4% against influenza. The source patient was tested in 43.4% of reported BBF exposures. Accidental exposure to BBF was more frequent in older people (OR = 3.42; p = 0.03) and the more experienced. Subjects working in intensive care unit ward reported more exposure to BBF (OR = 3; p = 0.04). Participants incurring exposure to BBF resorted to different measures after the injury suggesting a lack of a uniform policy for post-exposure prophylaxis. Conclusion: Exposure to BBF represents an important and frequently preventable occupational hazard for HCWs in Lebanon that requires continuous EPP of HCWs, and a comprehensive approach for prevention and management.

Central Obesity and Comorbidity Risk in Hemodialysis Patients: A Cross Sectional Study in Lebanon  [PDF]
Ibtissam Sabbah, Hala Sabbah, Sanaa Sabbah, Hussein Akoum, Nabil Droubi
Open Journal of Nephrology (OJNeph) , 2012, DOI: 10.4236/ojneph.2012.24018
Abstract: Introduction: Abdominal deposition of fat has been described as the type of obesity that offers the greatest risk for the health of individuals, and is associated with increased mortality, and morbidity. Conicity index (Ci), Body mass index (BMI), and waist hip ratio (WHR) are used to predict the risk of obesity related diseases. However, it has not been ex amined whether these indicators can predict the comorbidities in hemodialysis subjects in Lebanon. Objective: to determine the effect of central obesity on comorbidities in hemodialysis patients in Lebanon. Material and Method: This is a cross-sectional study of obesity in 60 hemodialysis subjects in Lebanon. A linear regression analysis was used to determine the relationship between BMI, Ci, WHR, and comorbidities measured by Charlson (CCI) and Davies comorbidities indexes. Results: Ci values were significantly associated with age, and CCI; the abdominal fat deposition evaluated by the conicity index and WHR were a predictor of the comorbidities according to CCI (= 2.96; p = 0.01), and Davies comorbidity index (= 1.19; p = 0.05) scores. BMI was a weak predictor of comorbidity. Conclusion: Abdominal obesity by using simple anthropometric measurements e.g. Ci, and WHR values can similarly predict the presence of comorbidities in hemodialysis patients. Maintaining appropriate Ci and WHR values might be important to improve outcome in hemodialysis patients.
Health related quality of life of university students in Lebanon: Lifestyles behaviors and socio-demographic predictors  [PDF]
Ibtissam Sabbah, Hala Sabbah, Rania Khamis, Sanaa Sabbah, Nabil Droubi
Health (Health) , 2013, DOI: 10.4236/health.2013.57A4001

Measuring and monitoring health related quality of life (HRQoL) in youth are important for both researchers and decision makers. During the time that young people are at university, many will encounter a number of academic, as well as social, emotional and psychological difficulties. The aims of this study are to: 1) assess the health related quality of life of youths using SF-36 questionnaire and its factor determinants, and 2) provide an objective basis for a health promotion structure. Methods: This is a cross-sectional study in South Lebanon, in a population of 282 young university students attending a public university which is the largest and most widespread institution of higher education in Lebanon. Socioeconomic and lifestyle behaviors data were collected. Students’ HRQoL was measured using the SF-36 Health Survey. Results: The mean age of the respondents was 18.7 years (SD = 1.16), 80.1% were women, 64.5% were living in rural area. The proportion of current smokers was significantly greater among men than women (26.8% vs. 11.5%, p < 0.01). Water pipe was the main type of smoking. Education of the fathers had negatively influenced HRQoL. Younger age scored higher in Social Functioning and Role-Emotional; the area of residence had no influences on SF-36 scales scores. Females had poorer HRQoL than males especially in mental health scales. Smokers had low Vitality and Mental Health scores. Sedentary lifestyle was linked to a lower score of Physical Functioning (β = -5.16, 95% CI = -7.67 -2.65), and Vitality ( β= -5.85, 95% CI = -10.24

Erratum to “Occupational Exposures to Blood and Body Fluids (BBF): Assessment of Knowledge, Attitude and Practice among Health Care Workers in General Hospitals in Lebanon”  [PDF]
Ibtissam Sabbah, Hala Sabbah, Sanaa Sabbah, Hussein Akoum, Nabil Droubi
Health (Health) , 2016, DOI: 10.4236/health.2016.813138
Abstract: The original online version of this article (Sabbah, I., et al. (2013) Occupational exposures to blood and body fluids (BBF): Assessment of knowledge, attitude and practice among health care workers in general hospitals in Lebanon. Health, 5, Article ID: 26524. doi: 10.4236/health.2013.51010.) unfortunately contains a mistake. The authors wish to correct the errors: in Table 5, page 74: in the column concerning Exp (β). So, in paragraph 3.4., page 74 (Factors Influencing the Accidental Exposure to BBF), there are three numbers that must be changed without any others changes in the content of the manuscript.
Measurement Properties of the Arabic Lebanon Version of the Pediatric Quality of Life Inventory 4.0 Generic Core Scales for Young Child (5 - 7 years), and Child Aged 8 - 12 Years: Quality of Life of in Urban and Rural Children in Lebanon  [PDF]
Ibtissam Sabbah, Hala Sabbah, Sanaa Sabbah, Hussein Akoum, Nabil Droubi, Mariette Mercier
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.326146
Abstract: Background: Health-related quality of life (HRQOL) is recognized as an important health outcome measurement for pediatric patients. HRQOL in children are needed to gain a better understanding of the impact of public policies, interventions, therapies, and the prediction of health and social care need. In view of the lack of reliable HRQOL instruments for children in Arabic, the present study aims to translate the PedsQLTM4.0 self-report and proxy-report for young children (ages 5-7 years), and Children (ages 8-12), evaluate psychometric properties of the Arabic Lebanon version; and to evaluate HRQOL of children in rural and urban areas in Lebanon. Methods: PedsQLTM4.0 was translated and adapted into Arabic using the standard approach provided by Varni JW. The Arabic version was administered to a representative sample of 368 children aged 5-12 years and their parents. The psychometric properties were then evaluated. Results: The rate of missing data for self-report and proxy-report was very low (0.51% and 0.46% of items). All child self-report, and parent proxy-report subscales exceeded the minimum reliability standard of 0.70 for alpha coefficient, except emotional subscale of young child self-report and proxy-report, and, the social subscale of child self-report (alphas ranging from 0.60 to 0.66). Factor analysis yielded patterns of factor correlation comparable to the original version. The emotional functioning of children is low, where most children feel afraid, sad, and angry. Children resident in rural areas had higher social scores than those in urban areas. The HRQOL of girls is higher than boys; Children undergoing treatment for cancer rated their HRQOL as poorer in all dimensions. Conclusions: The results support the validity of the PedsQLTM4.0 self-report and proxy-report Arabic version. Habitat has a minor influence on HRQOL of children. Further psychometric evaluation in a larger sample of children, in other departments of Lebanon is recommended to provide firmer conclusions.
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