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Search Results: 1 - 10 of 236823 matches for " Ibrahim Helmy El Sayed c "
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Doxorubicin-induced cardiotoxicity in mice; protection by silymarin
Heba Abdelnasser Aniss a, Ashraf El Metwally Said b, Ibrahim Helmy El Sayed c, Camelia AdLy
Egyptian Journal of Hospital Medicine , 2012,
Abstract: Background: despite its vast utility in clinical oncology, the use of doxorubicin is limited by a potentially fatal cardiomyopathy and congestive heart failure. Free radical formation and antioxidants depletion are mechanisms proposed for this cardiomyopathy. The aim of this study is to compare the potential antioxidative protective effect of silymarin on doxorubicin-induced cardiotoxicity in experimental mice. Materials and methods: four groups (ten animals in each group) of experimental mice were used as follows: Group 1, mice received only saline (intraperitoneally) and served as a negative control group; Group 2, mice received doxorubicin (intraperitoneally, 5 mg/kg body weight) in three equal injections over a period of two weeks for a cumulative dose of 15 mg/kg body weight; Group 3, mice orally administrated silymarin (200 mg/day/kg body weight) respectively, through an intragastric feeding tube over a period of three weeks; Group 4, mice treated orally with silymarin plus intraperitoneally doxorubicin administration with the same protocol of groups 3 and 4. Serum lactate dehydrogenase (LDH), creatine phosphokinase (CPK), aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), malondialdehyde (MDA), total nitric oxide (NO), cardiac reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured in all tested groups. Results: doxorubicin elevated the activities of LDH, CPK, AST, ALT, MDA and NO in the cardiac tissue. Cardiac antioxidant enzymes activities SOD and CAT also increased while GPx activity was decreased. Pre-co-treatment with silymarin prevented the changes induced by doxorubicin administration. These findings demonstrate the cardio-protective effect of silymarin on cardiac antioxidant status during doxorubicin induced cardiac damage in mice. Conclusion: silymarin could be recommended for further investigation as potentially new indication for clinical application.
The Products of Regularly Solvable Operators with Their Spectra in Direct Sum Spaces  [PDF]
Sobhy El-Sayed Ibrahim
Advances in Pure Mathematics (APM) , 2013, DOI: 10.4236/apm.2013.34060

In this paper, we consider the general quasi-differential expressions \"\" each of order n with complex coefficients and their formal adjoints on the interval (a,b). It is shown in direct sum spaces \"\" of functions defined on each of the separate intervals with the cases of one and two singular end-points and when all solutions of the equation \"\" and its adjoint \"\" are in \"\" (the limit circle case) that all well-posed extensions of the minimal operator \"\" have resolvents which are HilbertSchmidt integral operators and consequently have a wholly discrete spectrum. This implies that all the regularly solvable operators have all the standard essential spectra to be empty. These results extend those of formally symmetric expression \"\" studied in [1-10] and those of general quasi-differential expressions

Serum Level of Thyroid Hormones in Patients with Chronic Hepatitis C Virus Infection  [PDF]
Mohamed Abdel-Fattah El-Feki, Nilly Helmy Abdalla, Mohamed Ibrahim Atta, Ahmed Amin Ibrahim
Open Journal of Endocrine and Metabolic Diseases (OJEMD) , 2016, DOI: 10.4236/ojemd.2016.63017
Abstract: Objective: There are clinical and laboratory associations between thyroid and liver diseases. Hepatitis C virus (HCV) is known to be responsible for both hepatic and extrahepatic diseases. The most frequent and clinically important endocrine extrahepatic diseases are thyroid disorders and type 2 diabetes mellitus. We aim to study the relationship between the serum level of thyroid hormones (THs) and the severity of liver disease in patients with chronic hepatitis C virus (CHC) infection. Methods: 60 patients with CHC infection were selected for the study. They were divided into two groups: with or without liver cirrhosis. Those with liver cirrhosis were further subdivided according to the Child-Turcotte-Pugh scoring system. Serum levels of free T3 (FT3), free T4 (FT4) and TSH were measured to all patients. Results: There was decrease in the FT3 and FT4 levels and increase in the TSH levels in patients with CHC with cirrhosis when compared to patients with CHC without cirrhosis. Conclusion: Thyroid profile abnormalities were seen in cirrhotic HCV patients when compared to non-cirrhotic patients. The abnormalities in the serum level of THs (decreased FT3, FT4, and increased TSH) are strongly associated with the severity of liver damage and advancing of the child score.
The Effects of Rosemary (Rosmarinus officinalis) Leaves Powder on Glucose Level, Lipid Profile and Lipid Perodoxation  [PDF]
Louay Labban, Usama El-Sayed Mustafa, Yasser Mahmoud Ibrahim
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.56044

Introduction: Various herbs have been used as treatment and prevention for several chronic diseases such as diabetes, hypercholesterolemia and triglyceridemia; one of those herbs is Rosemary, which has biological antioxidant mechanisms. Rosemary is a thorny Rhamnaceous plant which is widely distributed in Europe and South-Eastern Asia. It’s used in traditional medicine for its therapeutic properties. The objective of this study was to investigate the effects of Rosemary (Rosmarinus officinalis) leaves powder on glucose level and lipid profile in human. Material and Methods: Forty eight adults’ men and women participated in this study which has been carried out in the UOK University. The participants were randomly selected and divided into 3 groups. The first group was given 2 g/day of Rosemary leaves powder, the second group was given 5 g/day of Rosemary leaves powder while the third group was given 10 g/day of Rosemary leaves powder for a period of 4 weeks. Blood samples were analyzed for glucose, lipid profile and antioxidant at the beginning and the end of the study and the results were statistically analyzed. Results: The results indicated that a significant decrease in blood glucose level in the groups given 5

Potent Anticonvulsant 1H-Imidazol-5(4H)-One Derivatives with Low Neurotoxicity  [PDF]
Mosaad Sayed Mohamed, Rehab Kamel Mahmoud, Amira Ibrahim Sayed, Moustafa E. El-Araby
Open Journal of Medicinal Chemistry (OJMC) , 2012, DOI: 10.4236/ojmc.2012.22004
Abstract: We report here the synthesis and in vivo anticonvulsant/neurotoxicity activities of a series of compounds belonging to 2-aryl-4-arylidene-1-phenyl-1H-imidazol-5(4H)-one. The scaffold is based on the commonality of 5-membered lactam ring structures as successful anticonvulsant agents. The present compounds exhibited a range of anticonvulsant activity in pentylenetetrazole (PTZ)-induced seizure test. In particular, the protection was excellent by compounds bearing furylmethylidene on C4, possibly due to good pharmacokinetic properties. It was found that high lipophilicity and/or electron deficient aryl ring substitution at C4 compromised the anticonvulsant activities. For example, chloro analogues were found much less active than unsubstituted phenyl or furyl derivatives. Regarding side effects, active compounds exerted no observable neurotoxic effect at their therapeutic doses in Chimney test.
On the spectra of non-selfadjoint differential operators and their adjoints in direct sum spaces
Sobhy El-Sayed Ibrahim
International Journal of Mathematics and Mathematical Sciences , 2003, DOI: 10.1155/s0161171203007841
Abstract: The general ordinary quasidifferential expression Mp of nthorder, with complex coefficients and its formal adjoint Mp
On the domain of selfadjoint extension of the product of Sturm-Liouville differential operators
Sobhy El-Sayed Ibrahim
International Journal of Mathematics and Mathematical Sciences , 2003, DOI: 10.1155/s0161171203008020
Abstract: The second-order symmetric Sturm-Liouville differential expressions τ1,τ2,…,τn with real coefficients are considered on the interval I=(a,b), −∞≤a
On the -boundedness of solutions for products of quasi-integro differential equations
Sobhy El-Sayed Ibrahim
International Journal of Mathematics and Mathematical Sciences , 2003, DOI: 10.1155/s0161171203008007
Abstract: Given a general quasi-differential expressions τ1,τ2,…,τn each of order n with complex coefficients and their formal adjoints are τ1
Myocardial tagging by Cardiovascular Magnetic Resonance: evolution of techniques--pulse sequences, analysis algorithms, and applications
El-Sayed H Ibrahim
Journal of Cardiovascular Magnetic Resonance , 2011, DOI: 10.1186/1532-429x-13-36
Abstract: Heart disease is the main killer in the western world as it causes considerable morbidity and mortality [1]. More understanding of intrinsic myocardial kinematics could result in improving the interpretation and prediction of changes in different heart conditions. Conventional imaging techniques are limited to assessing the motion of the inner and outer surfaces of the heart wall. Although cardiac function can be evaluated using echocardiography by techniques like speckle tracking, cardiovascular magnetic resonance (CMR) is excelling in terms of tissue contrast, spatial resolution, and signal-to-noise ratio (SNR). Furthermore, echocardiographic imaging makes simplifying geometric assumptions, which are not applicable in distorted heart anatomy. Computerized tomography (CT) is limited by relatively high radiation dose that restricts repeated studies or studies on healthy volunteers. In the past couple of decades, CMR proved to be a valuable and safe tool for cardiovascular imaging [2,3]. Cardiac anatomical, functional, vascular, and metabolic information can be obtained with CMR/MR spectroscopy sequences.Regular anatomical images show the inner (endocardium) and outer (epicardium) borders of the heart chambers, which upon segmentation provide valuable measures about the heart global function, e.g. ejection fraction (EF), stroke volume, and myocardial thickness. Although these global measures represent the current standard for evaluating the heart condition, extensive research has shown that regional myocardial functions, e.g. as strain, strain rate, and torsion, allow for early identification of dysfunction, and therefore are becoming extremely important for clinical risk assessment, patient treatment, and therapeutic efficiency. More importantly, many cardiac disorders do not affect the heart wall uniformly, e.g. most ischemic heart diseases affect localized regions of the myocardium. This makes global measures insensitive to alterations in regional performance, and
On the boundary conditions for products of Sturm-Liouville differential operators
Sobhy El-Sayed Ibrahim
Tamkang Journal of Mathematics , 2001, DOI: 10.5556/j.tkjm.32.2001.187-199
Abstract: In this paper, the second-order symmetric Sturm-Liouville differential expressions $ au_1, au_2, ldots, au_n $ with real coefficients are considered on the interval $ I = (a,b) $, $ - infty le a < b le infty $. It is shown that the characterization of singular self-adjoint boundary conditions involves the sesquilinear form associated with the product of Sturm-Liouville differential expressions and elements of the maximan domain of the product operators, and is an exact parallel of the regular case. This characterization is an extension of those obtained in [6], [8], [11-12], [14] and [15].
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