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There are several reports on the prevalence and importance of milk allergens in the induction of allergic diseases, whereas its role in the induction of autoimmune disease was rarely studied. So, the present work aimed to study the diagnosis and the efficacy of oral antigen specific immunotherapy (OAIT) on two groups of autoimmune disease patients namely, rheumatic arthritis (RA), group II, and systemic lupus erythematosus (SLE), group III, who has allergens for milk as an effective treatment option. From the assessment of the data obtained and the clinical outcome of RA and SLE patients after food elimination strategy and milk immunotherapy, it was evident that there were significant reductions (P < 0.001) in the levels of total IgE, specific IgE, Rheumatic factor (R.F), C-reactive protein (C.R.P), Anti-nuclear antibodies (ANA) and anti-double stranded DNA antibodies (Anti-ds DNA) compared to pretreated levels. Moreover, the immunotherapy induced “blocking antibodies” by remarkable highly significant increasing in IgG, phagocytic inhibition test (PIT %), Complement component 3(C3), and Complement component 4 (C4) levels. More improvement was noticed in the SLE as a result of the immunotherapy. Conclusion: milk desensitization is a gained interest and a safe valuable effective treatment of autoimmune conditions in Egypt.
Current practice parameters
state that extracts rich in proteases, such as fungal and insect extracts, can
be combined during preparation of allergy immunotherapy vaccines. However,
until recently, this guideline has not been the subject of investigation.
Scientists now have data that shed light on high-protease allergenic extract
mixtures used in allergy immunotherapy. A study published in Annals of Allergy, Asthma & Immunology in 2012 reports on the compatibility of combining
fungal and insect extracts and emphasizes the importance of understanding how
protease activities and total glycerin levels in allergy extracts can affect
the stability of allergy immunotherapy vaccine mixtures. This research provides
a critical assessment of the mixing compatibilities of several well-characterized
high-protease extracts and may influence future immunotherapy practice
parameters and immunotherapy extract preparation guidelines.