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Search Results: 1 - 10 of 87736 matches for " I-Shyan Sheen "
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MELD score can predict early mortality in patients with rebleeding after band ligation for variceal bleeding
Wei-Ting Chen,Chun-Yen Lin,I-shyan Sheen,Chang-Wen Huang
World Journal of Gastroenterology , 2011, DOI: 10.3748/wjg.v17.i16.2120
Abstract: AIM: To investigate the outcomes, as well as risk factors for 6-wk mortality, in patients with early rebleeding after endoscopic variceal band ligation (EVL) for esophageal variceal hemorrhage (EVH). METHODS: Among 817 EVL procedures performed for EVH between January 2007 and December 2008, 128 patients with early rebleeding, defined as rebleeding within 6 wk after EVL, were enrolled for analysis. RESULT: The rate of early rebleeding after EVL for acute EVH was 15.6% (128/817). The 5-d, 6-wk, 3-mo, and 6-mo mortality rates were 7.8%, 38.3%, 55.5%, and 58.6%, respectively, in these early rebleeding patients. The use of beta-blockers, occurrence of hypovolemic shock, and higher model for end-stage liver disease (MELD) score at the time of rebleeding were independent predictors for 6-wk mortality. A cut-off value of 21.5 for the MELD score was found with an area under ROC curve of 0.862 (P < 0.001). The sensitivity, specificity, positive predictive value, and negative predictive value were 77.6%, 81%, 71.7%, and 85.3%, respectively. As for the 6-mo survival rate, patients with a MELD score ≥ 21.5 had a significantly lower survival rate than patients with a MELD score < 21.5 (P < 0.001). CONCLUSION: This study demonstrated that the MELD score is an easy and powerful predictor for 6-wk mortality and outcomes of patients with early rebleeding after EVL for EVH.
None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis
Wen-Juei Jeng, Chun-Yen Lin, Ji-Yih Chen, Chang-Wen Huang, Chien-Hao Huang, I-Shyan Sheen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0048217
Abstract: Background & Aims A combination of pegylated interferon-alpha and ribavirin (PR) is the standard therapy for patients with chronic hepatitis C. The impact of polymorphism of interleukin-28B (IL28B) on sustained virological response (SVR) to PR has been well documented in patients with CHC genotype-1 (GT1), but it is controversial in genotype-2 (GT2) CHC patients. This study investigated the predictability of six single nucleotide polymorphisms (SNP) of IL28B on the treatment responses of PR in patients with CHC GT2. Method 197 CHC GT2 consecutive patients who received PR treatment in our prospective cohort were enrolled. Hepatitis C virus (HCV) genotyping, quantification of HCV-RNA and genotyping of the ten SNPs of IL28B were performed. Six SNPs of IL28B were chosen for analysis. The propensity score matching (PSM) analysis was applied using patients with CHC GT1 in another prospective cohort as a positive comparison to avoid covariate bias. Results The distribution of the six SNPs was similar in GT1 and GT2 patients. Five of these SNPs had strong association with treatment responses in GT1 but not in GT2 patients. After PSM analysis, these five SNPs still showed strong association with rapid virological response (RVR), cEVR and SVR in GT1 and had no influence in GT2 patients. Furthermore, rs12979860 and baseline viral load were the predictors for both RVR and SVR in GT1 patients. However, only baseline viral load could predict RVR and SVR in GT2 patients. In addition, in patients without RVR, rs12979860 was the only predictor for SVR in GT1 but no predictor for SVR was found in GT2. Conclusions The genetic polymorphisms of IL28B had no impact on treatment responses in GT2 patients.
Collaborative Localization Algorithms for Wireless Sensor Networks with Reduced Localization Error
Prasan Kumar Sahoo,I-Shyan Hwang
Sensors , 2011, DOI: 10.3390/s111009989
Abstract: Localization is an important research issue in Wireless Sensor Networks (WSNs). Though Global Positioning System (GPS) can be used to locate the position of the sensors, unfortunately it is limited to outdoor applications and is costly and power consuming. In order to find location of sensor nodes without help of GPS, collaboration among nodes is highly essential so that localization can be accomplished efficiently. In this paper, novel localization algorithms are proposed to find out possible location information of the normal nodes in a collaborative manner for an outdoor environment with help of few beacons and anchor nodes. In our localization scheme, at most three beacon nodes should be collaborated to find out the accurate location information of any normal node. Besides, analytical methods are designed to calculate and reduce the localization error using probability distribution function. Performance evaluation of our algorithm shows that there is a trade off betweendeployed number of beacon nodes and localization error, and average localization time of the network can be increased with increase in the number of normal nodes deployed over a region.
IL28B SNP rs12979860 Is a Critical Predictor for On-Treatment and Sustained Virologic Response in Patients with Hepatitis C Virus Genotype-1 Infection
Chun-Yen Lin,Ji-Yih Chen,Tsung-Nan Lin,Wen-Juei Jeng,Chien-Hao Huang,Chang-Wen Huang,Su-Wei Chang,I-Shyan Sheen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018322
Abstract: Single nucleotide polymorphisms (SNPs) of interleukin-28B (IL28B) have received considerable interest for their association with sustained virological response (SVR) when treating patients of genotype-1 hepatitis C virus (GT1-HCV) chronic infection with pegylated interferon and ribavirin (PegIFN/RBV). This study was to investigate the predictive power of IL28B SNPs for on-treatment responses and SVR in treatment-na?ve patients with GT1-HCV chronic infection.
Performance Study of Homogeneous Uplink Scheduling in Hybrid ONU-BS Architecture
I-Shyan Hwang,Jhong-Yue Lee
Lecture Notes in Engineering and Computer Science , 2011,
Abstract:
Altered expression patterns of lipid metabolism genes in an animal model of HCV core-related, nonobese, modest hepatic steatosis
Ming-Ling Chang, Chau-Ting Yeh, Jeng-Chang Chen, Chau-Chun Huang, Shi-Ming Lin, I-Shyan Sheen, Dar-In Tai, Chia-Ming Chu, Wei-Pin Lin, Ming-Yu Chang, Chun-Kai Liang, Cheng-Tang Chiu, Deng-Yn Lin
BMC Genomics , 2008, DOI: 10.1186/1471-2164-9-109
Abstract: We developed mice that conditionally express the hepatitis C virus (HCV) core protein regulated by the tetracycline transactivator (tTA). Microarray analyses and reverse-transcription polymerase chain reaction were performed using liver samples of both the double transgenic mice (DTM), which express both the HCV core and tTA, and single transgenic mice (STM), which express tTA alone, at 2 months of age. Functional categories of genes with altered expression were classified using gene ontology programs. Serum glucose, lipid levels, and systemic blood pressure were also measured.Approximately 20–30% of hepatocytes from the DTM were steatotic. No significant differences were observed in the serum glucose, lipid content, or blood pressure levels between the DTM and STM. Gene expression analyses revealed Sterol-regulatory element-binding protein (SREBP) pathway activation and dysregulation of the following genes involved in lipid metabolism: 3-hydroxy-3-methylglutaryl-coenzyme A synthase 1, Apolipoprotein AII, Apolipoprotein CI, acyl-CoA thioesterase I, and fatty acid binding protein 1; in mitochondrial function: solute carrier family 25 member 25 and cytochrome c oxidase subunit II; in immune reaction: complement component 3, lymphocyte antigen 6 complex, locus A, lymphocyte antigen 6 complex, locus C, lymphocyte antigen 6 complex, locus D, and lymphocyte antigen 6 complex, locus E.Some genes of lipid metabolism, mitochondrial function, and immune reaction and the SREBP pathway are involved in HCV core-related, nonobese, modest hepatic steatosis.Nonalcoholic fatty liver disease (NAFLD) can be a severe, progressive liver disease leading to the development of cirrhosis [1]. Obesity and type 2 diabetes are well-known risk factors for the development of NAFLD. However, NAFLD is not rare in nonobese adults. The result of examining over 700 nonobese individuals older than 30 years with NAFLD who participated in medical examinations shows that NAFLD can be considered an early
Dynamic Fuzzy Controlled RWA Algorithm for IP/GMPLS over WDM Networks
I-Shyan Hwang,I-Feng Huang,Shin-Cheng Yu,
I-Shyan Hwang
,I-Feng Huang,andShin-Cheng Yu

计算机科学技术学报 , 2005,
Abstract: This paper proposes a dynamic RWA scheme using fuzzy logic control on IP/GMPLS over WDM networks to achieve the best quality of network transmission. The proposed algorithm dynamically allocates network resources and reserves partial bandwidth based on the current network status, which includes the request bandwidth, average utilization for each wavelength and its coefficient of variance (C.V.) of data traffic, to determine whether the connection can be set up. Five fuzzy sets for request bandwidth, average rate and C.V. of data traffic are used to divide the variable space: very large (LP), large (SP), normal (ZE), small (SN), and very small (LN). Setting the fuzzy limit is a key part in the proposed algorithm. The simulation of scenarios in this paper has two steps. In the first step, the adaptive fuzzy limits are evaluated based on average transmission cost pertaining to ten network statuses. The second step is to compare the proposed algorithm with periodic measurement of traffic (PMT) in ATM networks in six network situations to show that the proposed FC-RWA algorithm can provide better network transmission.
QoS-Aware Active Queue Management for Multimedia Services over the Internet
I-Shyan Hwang,Bor-Jiunn Hwang,Pen-Ming Chang,Cheng-Yu Wang
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
A Scalable Interleaved DBA Mechanism within Polling Cycle for the Ethernet Passive Optical Networks
I-Shyan Hwang,Jhong-Yue Lee,Zen-Der Shyu
Lecture Notes in Engineering and Computer Science , 2010,
Abstract:
Fault-Tolerant Architecture with Dynamic Wavelength and Bandwidth Allocation Scheme in WDM-EPON
I-Shyan Hwang,Zen-Der Shyu,Chun-Che Chang
Lecture Notes in Engineering and Computer Science , 2008,
Abstract:
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