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Search Results: 1 - 10 of 214820 matches for " I??k ?zgüney "
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Development and Characterisation of Natamycin Mini-Matrices Prepared by Hot-Melt Extrusion for Vaginal Delivery  [PDF]
Betül Rumeysa Temel, I??kzgüney
Journal of Materials Science and Chemical Engineering (MSCE) , 2018, DOI: 10.4236/msce.2018.63004
Abstract: In this study, bioadhesive mini-matrices of natamycin were prepared for vaginal application by hot-melt extrusion. In addition, melt viscosity measurements, thermogravimetric analysis, in vitro drug release studies and in vitro mucoadhesion test were performed. High molecular weight grades of KlucelTM hydroxypropylcellulose were used as a thermoplastic polymer. TEC and PEG 400 were chosen as plasticizer. According to the obtained results of melt viscosity measurements, the maximum torque of extrudates prepared using PEG 400 increased with increasing drug loading. The thermo-gravimetric analyses showed that natamycin is stable up to 198℃ and this result gives the opportunity to hot melt extrussion process at 90℃. In vitro drug release results showed that the release was extended up to 72 hours and drug release rate increased with increasing drug loading. In respect to the in vitro mucoadhesion test results, the values of work of mucoadhesion were found high as 771,977 mN.mm, 753,199 mN.mm, 686,356 mN.mm for the prepared hot melt extruded mini-matrices. Our results showed that the developed formulations were found worthy of further studies.
Value of IGF-I levels in the evaluation of response to treatment with levosimendan in patients with severe heart failure
Serhat I??k,Mustafa ?etin,Hülya ?i?ek?io?lu,zgül U?ar
Anadolu Kardiyoloji Dergisi , 2011,
Abstract: Objective: Levosimendan treatment has inotropic, anti-stunning, and cardioprotective effects in the setting of acute decompensated heart failure (HF). Among studies conducted on the treatment of heart failure, those based on the growth hormone axis are of particular interest. The aim of this study was to determine the value of baseline insulin-like growth factor 1 (IGF-I) measurements in predicting response to levosimendan treatment. Methods: The study population included patients on standard heart failure treatment who presented with functional capacity NYHA class 3-4 and left ventricular (LV) ejection fraction less than 35% were enrolled in this prospective, cohort study. Pre- and post-treatment symptoms of patients (72 hours after the completion of levosimendan infusion) and echocardiographic parameters were evaluated and blood samples were collected. Mann-Whitney U, Pearson Chi-square and Wilcoxon Sign Rank tests were used for statistical analysis. Correlations were determined using Spearman correlation analysis.Results: Thirty patients were enrolled in this study, 83.3% of whom were male and 16.7% were female, with a mean age of 62.6 ±10.1 years. Mean baseline IGF-I level was 106.9±47.0 μg/L. Statistically significant improvements were observed in NYHA class, mean brain natriuretic peptide (BNP) levels, LV ejection fraction and LV end-systolic volume values following treatment with levosimendan (respective pre-treatment and post-treatment values: 3.5±0.5 vs. 2.5±0.7, p<0.001; 1209.8±398.6 pg/ml vs. 704.1±344.6 pg/ml, p<0.001, and 25.7±6.6% vs. 29.0±6.8%, p=0.021, and 164.1±45.7 ml vs. 152.8±50.6 ml, p=0.012). Fourteen patients (46.7%) had low IGF-I levels, taking into consideration variations due to age and gender. Patients with normal baseline IGF-I values showed more significant decreases in BNP levels in response to treatment compared to those with low baseline IGF-I levels (650.5±367.2 pg/ml vs. 340.1±269.0 pg/ml, p=0.014). Conclusion: Baseline IGF-I levels may be used to predict response to levosimendan treatment in patients hospitalized for decompensated HF.
Antimicrobial activity of some endemic plant species from Turkey
M Benli, Kney, ü Bing l, F Geven, N Yii
African Journal of Biotechnology , 2007,
Abstract: Six plant extracts obtained from different parts such as the leaves, flowers and seeds of four species of the endemic plants in Turkey were tested on a total of 14 microorganisms, 10 of which were bacterial strains and 4 yeast strains. Verbascum eriocarpum (flower) extract was found to be effective against Staphylococcus aureus; Stachys cretica subsp. anatolica (leaf and flower) and Heracleum paphlagonicum (seed) extracts were found to be effective against Bacillus subtilis; and Alcea apterocarpa (seed and sepal) extract was found to be effective against Pseudomonas aeruginosa. No antimicrobial activity was observed in Heracleum paphlagonicum (leaf) and Alcea apterocarpa (leaf) plant extracts. The minimum inhibitory concentration (MIC) values of the plant extracts were calculated to be between 0.859 mg/ml and 110.5 mg/ml and the minimum bacteriocidal concentration (MBC) values were calculated to be between 3.44 mg/ml and 132 mg/ml.
Giant germ cell tumor with mediastinal localization: A report of two cases
Fatih Metero?lu,Maruf ?anl?,A. Feridun I??k,Bülent Tun??zgür
Dicle Medical Journal , 2010,
Abstract: Germ celled tumors frequently localize in anterior mediastinum.In this study we presented two germ cell tumors with different localization and huge size. We discussed two cases with germ cell tumors operated in our clinic togetherwith literature findings. Chest x-ray, computerized tomography (CT) and transthorasic tru-cut biopsy were used for diagnosis. The huge intratorasic teratomas are rarely seen and surgical full resection is the most importantfactor in survival.
Phytochemical Investigation of Leontice leontopetalum L. subsp. ewersmannii with Antioxidant and Anticholinesterase Activities
Ufuk Kolak,I??l Hac?bekiro?lu,Mehmet Bo?a,Fevzi ?zgk?e
Records of Natural Products , 2011,
Abstract: Two known quinolizidine alkaloids, lupanine and leontiformidine, were isolated from the tubers of L. leontopetalum subsp. ewersmannii. Lupanine having the highest inhibition of lipid peroxidation at 100 m g/mL among the tested samples indicated almost the same ABTS cation radical scavenging activity with BHT, a -tocopherol and (+)-catechin at the same concentration . Lupanine and the alkaloidal extract showed almost the same butyrylcholinesterase inhibitory activity with galantamine at 200 m g/mL.
Relationship among Gensini score and levels of glucose and adiponectin in patients with stable angina pectoris
Ferhat ?zyurtlu,zgül Y?ld?z,Erkan Ayhan,Turgay I??k
Journal of Clinical and Experimental Investigations , 2012,
Abstract: Objectives: Adiponectin is an adipocyte-secreted proteinthat modulates insulin sensitivity and whose low circulatingconcentration is associated with insulin resistance.We evaluated the association between serum adiponectinand blood glucose levels with coronary artery diseaseseverity on the angiogram in patients with stable anginapectoris.Materials and methods: The study included 160 patients(82 males) with stable angina pectoris. The patients weredivided into three groups according to the blood glucoselevels on admission; thus, 24 had normal glucose group,53 had impaired glucose tolerance group, and 53 haddiabetes mellitus (DM) group. The severity of coronarylesions was assessed using the Gensini score. Serumadiponectin levels were measured in the all group.Results: The hypertension, hyperlipidemia, obesity, andinsulin resistance were significantly higher in the DMgroup. Patients with DM significantly lower serum levelsof adiponectin (13.55±7.16, p=0.002). The mean Gensiniscore was 40.84± 37.25 in the DM group (p=0.006).Conclusion: Serum adiponectin levels may be a clue forseverity coronary artery disease in patients with stableangina pectoris. J Clin Exp Invest 2012; 3(2): 229-234
PQStream: A Data Stream Architecture for Electrical Power Quality
Dilek Kü?ük,Tolga ?nan,Burak Boyrazo?lu,Serkan Buhan,zgül Salor,I??k ?ad?rc?,Muammer Ermi?
Computer Science , 2015,
Abstract: In this paper, a data stream architecture is presented for electrical power quality (PQ) which is called PQStream. PQStream is developed to process and manage time-evolving data coming from the country-wide mobile measurements of electrical PQ parameters of the Turkish Electricity Transmission System. It is a full-fledged system with a data measurement module which carries out processing of continuous PQ data, a stream database which stores the output of the measurement module, and finally a Graphical User Interface for retrospective analysis of the PQ data stored in the stream database. The presented model is deployed and is available to PQ experts, academicians and researchers of the area. As further studies, data mining methods such as classification and clustering algorithms will be applied in order to deduce useful PQ information from this database of PQ data.
Belge Y netiminin De i en Yüzü: Standartla ma al malar ve Uluslararas Uygulamalar / Changing Face of Records Management: Standardization Studies and International Practices
zgür Külcü
Bilgi Dünyas? , 2007,
Abstract: z Geleneksel belge y netimi kurumsal er evede belgelerin y netimine d nük uygulama programlar ndan olu maktad r. zellikle 90’l y llarla birlikte belge y netimi, de i en ko ullar n da etkisiyle ok daha geni er evede tan mlanmaya ba lanm t r. Toplumsal ya amda, y netim anlay ndaki de i im ve küreselle me, belge i lemlerinin elektronik ortama ta nmas ve elektronik belge y netimi ile ileti im teknolojileri, belge y netimi al malar n uluslararas boyuta ta m t r. Bu er evede makalede, belge y netimi alan nda geli tirilen ulusal ve uluslararas düzenlemelerin, standartlar n ve uygulama modellerinin de erlendirilmesi ama lanm t r.AbstractTraditionally records management applications consisted of the practice oriented programs comprising usually the records management in (mostly governmental) institutions. However, especially after 90s, records management concept has been comprehended and described broader than ever, because of the effects of changing conditions. Developments and globalization in social life and management approaches, fulfillment of the records processes in electronic media, and through electronic records management and communication technology, records management studies became more and more a concern of the international platform. In that scope, this study aims at evaluating the international and national regulations, standards and practical models in the area of records management.
Kurumsal Bilgi Kayna Olarak E-posta Y netim Sistemleri = E-mail Management Systems as an Enterprise Information Resource
Külcü,zgür
Bilgi Dünyas? , 2012,
Abstract: al mada, e-posta kullan m ve y netimine ili kin uluslararas ko ullar incelenmekte, bu er evede Türkiye’de 28 kurum rne inde ger ekle tirilen anket verileri de erlendirilmektedir. Betimleme y nteminin kullan ld al mada literatür incelemesi ve anket tekniklerine dayanarak gerekli veriler elde edilmi tir. Ara t rmada e-posta kullan m na ili kin elde edilen verilerin, ilgili alanda sistemler geli tirmeye al an ara t rmac lara yard mc olmas beklenmektedir. Kurumsal e-posta y netimine ili kin temel sorunlar aras nda mesajlar n üretimi, düzenlenmesi, ay klanmas ve uzun süre korunmas n i eren e-posta y netim sistemlerinin geli tirilmesi yer almaktad r. Ayr ca insan kaynaklar , mali ve idari konular n y netimi ile belge ve ar iv y netimi al malar n kapsam na alan, i erisine e-posta y netiminin de dahil oldu u sistemlerin bütünle tirilmesi güncel ara t rma konular aras ndad r. / This study examines the universal usage and management of e-mail communication and compares with the data, gathered from 28 Turkish institutions. This is a descriptive research in nature and the quantitative data were collected through surveys. It is expected that the results one-mail communication and its usage styles will shed a ligth into researcher who are working on system development. One of the basic problems of organizational e-mail management systems are lack of e-mail systems including message creation, maintenance, disposition, and long term preservation. Furthermore, the results indicate that integration of human resources management, financial and administrative management systems and archival management systems with e-mail managment system is another major problem.
Küreselle me Sürecince Avrupa Birli i’nde Belge Y netimi Uygulamalar ve Türkiye / Records Management Practices in the Course of Globalization in European Union and Turkey
zgür Külcü
Bilgi Dünyas? , 2006,
Abstract: The practices being realised in records and archive management in European Union during the accelerated globalisation after 1990’s was examined. In thatrespect entrepreneurial initiatives, projects, regulations, practice oriented models and standards, which appeared in the course of EU integration of Turkey were overviewed. Moreover, the approaches of the EU in the realm of the European integration process, which may have chances to effect the development of records and archival practices in Turkey, were discussed and evaluated.
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