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Search Results: 1 - 10 of 21188 matches for " Hyung Soo Han "
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Discussion: One Stage Reconstruction of Skull Exposed by Burn Injury Using Tissue Expansion Technique
Sung-No Jung,Soo-Hyung Han
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.2.124
A Study on the Genetic Inheritance of Ankyloglossia Based on Pedigree Analysis
Soo-Hyung Han,Min-Cheol Kim1,Yun-Seok Choi,Jin-Soo Lim
Archives of Plastic Surgery , 2012, DOI: http://dx.doi.org/10.5999/aps.2012.39.4.329
Abstract: Background Ankyloglossia or tongue-tie is a congenital anomaly characterized by an abnormallyshort lingual frenum. Its prevalence in the newborn population is approximately 4%. Its modeof inheritance has been studied in some articles, but no conclusion has been established. Also,no relevant report has been published in Korea. This study was conducted to elucidate thegenetic inheritance of ankyloglossia via pedigree analysis.Methods In this study, 149 patients with no other congenital anomaly who underwentfrenuloplasty between March 2001 and March 2010 were studied. Pedigrees were made viapre- or post-operative history taking, and patients with uncertain histories were excluded.In the patient group that showed a hereditary nature, the male-to-female ratio, inheritancerate, and pattern of inheritance were investigated.Results One hundred (67.11%) of the patients were male and 49 (32.89%) were female(male-female ratio=2.04:1). Ninety-one (61.07%) patients reported no other relative withankyloglossia, and 58 (38.93%) patients had a relative with this disease. The inheritance ratewas 20.69% in the 58 cases with a hereditary nature. In the group with no family history ofankyloglossia, the male-female ratio was 3.79:1, which significantly differed from that ofthe group with a family history of ankyloglossia. X-chromosome mediated inheritance andvariation in the gene expression was revealed in the pedigree drawn for the groups withhereditary ankyloglossia.Conclusions Ankyloglossia has a significant hereditary nature. Our data suggest X-linkedinheritance. This study with 149 patients, the first in Korea, showed X-linked inheritance inpatients with a sole anomaly.
Mild Hypothermia Attenuates Intercellular Adhesion Molecule-1 Induction via Activation of Extracellular Signal-Regulated Kinase-1/2 in a Focal Cerebral Ischemia Model
Jung Sook Choi,Jaechan Park,Kyoungho Suk,Cheil Moon,Yong-Ki Park,Hyung Soo Han
Stroke Research and Treatment , 2011, DOI: 10.4061/2011/846716
Abstract: Intercellular adhesion molecule-1 (ICAM-1) in cerebral vascular endothelium induced by ischemic insult triggers leukocyte infiltration and inflammatory reaction. We investigated the mechanism of hypothermic suppression of ICAM-1 in a model of focal cerebral ischemia. Rats underwent 2 hours of middle cerebral artery occlusion and were kept at 37°C or 33°C during occlusion and rewarmed to normal temperature immediately after reperfusion. Under hypothermic condition, robust activation of extracellular signal-regulated kinase-1/2 (ERK1/2) was observed in vascular endothelium of ischemic brain. Hypothermic suppression of ICAM-1 was reversed by ERK1/2 inhibition. Phosphorylation of signal transducer and activator of transcription 3 (STAT3) in ischemic vessel was attenuated by hypothermia. STAT3 inhibitor suppressed ICAM-1 production induced by stroke. ERK1/2 inhibition enhanced phosphorylation and DNA binding activity of STAT3 in hypothermic condition. In this study, we demonstrated that hypothermic suppression of ICAM-1 induction is mediated by enhanced ERK1/2 activation and subsequent attenuation of STAT3 action. 1. Introduction Intercellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin superfamily and the principal ligand for leukocyte function-associated antigen-1 (LFA-1), a member of the integrin superfamily. ICAM-1/LFA-1 adhesion system assists leukocyte movement into the tissue. LFA-1-positive leukocytes are induced to adhere to ICAM-1-positive endothelial surface [1, 2], and then to pass through the basement membrane into the tissue [3, 4]. Many animal and human studies indicate that ICAM-1 is implicated in the pathogenesis of ischemic cardiovascular and cerebrovascular disorders [5–8]. Especially during reperfusion period of stroke, infiltrated leukocytes contribute to the secondary injury by producing toxic substances that damage the brain cells and disrupt the blood-brain barrier [9, 10]. Since ICAM-1 is an important factor of leukocyte infiltration and reperfusion injury in stroke, intervention of ICAM-1 induction has been a promising therapeutic strategy against stroke. The remarkable benefit of mild hypothermia in brain ischemia has long been recognized and remains one of the most powerful neuroprotective strategies in cerebral ischemia both experimentally and clinically [11]. Many studies indicate that inflammatory response contributes significantly to the secondary injury after ischemia [12, 13], and protection by mild hypothermia is associated with anti-inflammatory processes [14–16]. Even though there is considerable
First Contact to Odors: Our Current Knowledge about Odorant Receptor
Hyoung-Gon Song,Jae Young Kwon,Hyung Soo Han,Yong-Chul Bae,Cheil Moon
Sensors , 2008, DOI: 10.3390/s8106303
Abstract: Chemical senses – especially smell – are known to be important for the fundamental life events such as sensing predators, selecting mates, as well as finding food. The chemical senses are decoded in the olfactory system which is able to detect and differentiate thousands of odorous substances comprised of chemically divergent structures (i.e. odorants). The high selectivity of the olfactory system is heavily dependent on the receptors for each odorants (i.e. odorant receptors). Thus, studying odorant receptors may not only facilitate our understanding the initial events of olfaction but provide crucial knowledge for developing a novel, odorant receptor-based biosensor for chemical screening. Here we provide a review of recent advances in our understanding of odorant receptors.
Therapeutic Hypothermia in Stroke
Midori A. Yenari,Fred Colbourne,Thomas M. Hemmen,Hyung Soo Han
Stroke Research and Treatment , 2011, DOI: 10.4061/2011/157969
Therapeutic Hypothermia in Stroke
Midori A. Yenari,Fred Colbourne,Thomas M. Hemmen,Hyung Soo Han,Derk Krieger
Stroke Research and Treatment , 2011, DOI: 10.4061/2011/157969
The limited immunomodulatory effects of escharectomy on the kinetics of endotoxin, cytokines, and adhesion molecules in major burns
Tae-Hyung Han,Soo-Yeon Lee,Jung-Eun Kwon,In-Suk Kwak,Kwang-Min Kim
Mediators of Inflammation , 2004, DOI: 10.1080/09629350400003191
Abstract: ESCHARECTOMY has been shown to improve the survival rates and the outcomes in burns. This observational study was conducted to assess the role of escharectomy on the inflammatory mediators in major burns. Seventeen ASA physical status II or status III adult surviving major burn patients were recruited. When the escharectomy was scheduled, a series of blood samples was obtained at −3 and −1 days preoperation, and
Life History Traits and the Rate of Molecular Evolution in Galliformes (Aves)
Eo, Soo Hyung
Journal of Ecology and Field Biology , 2008,
Abstract: Rates of molecular evolution are known to vary widely among taxonomic groups. A number ofstudies, examining various taxonomic groups, have indicated that body size is negatively and clutch size ispositively correlated with the rates of nucleotide substitutions among vertebrate species. Generally, either smallerbody mass or larger clutch size is associated with shorter generation times and higher metabolic rates. However,this generality is subject to ongoing debate, and large-scale comparative studies of species below the Order levelare lacking. In this study, phylogenetically independent methods were used to test for relationships between ratesof the mitochondrial cytochrome b evolution and a range of life history traits, such as body mass and clutchsize in the Order Galliformes. This analysis included data from 67 species of Galliformes birds and 2 outgroupspecies in Anseriformes. In contrast to previous studies, taxa were limited to within-Order level, not to Classor higher. I found no evidence to support an effect of life history traits on the rate of molecular evolution withinthe Galliformes. These results suggest that such relationship may be too weak to be observed in comparisonsof closely related species or may not be a general pattern that is applicable to all nucleotide sequences or alltaxonomic groups.
Characterization of Salvia Miltiorrhiza ethanol extract as an anti-osteoporotic agent
Yan Cui, Bidur Bhandary, Anu Marahatta, Geum-Hwa Lee, Bo Li, Do-Sung Kim, Soo-Wan Chae, Hyung-Ryong Kim, Han-Jung Chae
BMC Complementary and Alternative Medicine , 2011, DOI: 10.1186/1472-6882-11-120
Abstract: We studied Sprague-Dawley female rats aged 12 weeks, divided into six groups: sham-operated control (SHAM), OVX rats supplemented with SM (1, 3, 10 and 30 mg/kg) orally for 8 weeks. At the end of the experiment, blood samples were collected and biochemistry analysis was performed. Specimens from both tibia and liver were processed for light microscopic examination. DEXA and μ-CT analyses of the tibia were also performed.SM treatment significantly ameliorated the decrease in BMD and trabecular bone mass according to DEXA and trabecular bone architecture analysis of trabecular bone structural parameters by μ-CT scanning. In serum biochemical analysis, SM decreased the released TRAP-5b, an osteoclast activation marker and oxidative stress parameters including MDA and NO induced by OVX.The preventive effect of SM was presumably due to its anti-oxidative stress partly via modulation of osteoclast maturation and number. In current study, SM appears to be a promising osteoporosis therapeutic natural product.Osteoporosis is a multifactorial skeletal disease that is characterized by compromised bone strength predisposing a person to an increased risk of fracture [1]. Long-term administration of currently prevalent medications may lead to an increased risk of severe side effects like cancer [2]. Salvia miltiorrhiza (SM) has long been used as a traditional oriental medicine for cardiovascular disease. Accumulating evidence also indicates that SM has anti-osteoporotic effects. The dried root of Salvia miltiorrhiza Bunge (Labiatae) is also named Danshen or Tanshen. The herb is mainly produced in Anhui, Shanxi, Hebei, Shuan, and Jiangsu provinces in China [3]. Among the chemical constituents of Danshen, there are tanshinone I, tanshinone IIA, tanshinone IIB, cryptotanshinone, tanshindiol C, 15,16-dihydrotanshinone I, isotanshinone I, isotanshinone II and other tanshinones [4]. Several biological activities have been detected for the major tanshinones through in vivo and/or in vit
Time-dependent effects of hypothermia on microglial activation and migration
Jung-Wan Seo, Jong-Heon Kim, Jae-Hong Kim, Minchul Seo, Hyung Soo Han, Jaechan Park, Kyoungho Suk
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-164
Abstract: Microglial cells in culture were subjected to mild (33?°C) or moderate (29?°C) hypothermic conditions before, during, or after lipopolysaccharide (LPS) or hypoxic stimulation, and the production of nitric oxide (NO), proinflammatory cytokines, reactive oxygen species, and neurotoxicity was evaluated. Effects of hypothermia on microglial migration were also determined in in vitro as well as in vivo settings.Early-, co-, and delayed-hypothermic treatments inhibited microglial production of inflammatory mediators to varying degrees: early treatment was the most efficient, and delayed treatment showed time-dependent effects. Delayed hypothermia also suppressed the mRNA levels of proinflammatory cytokines and iNOS, and attenuated microglial neurotoxicity in microglia-neuron co-cultures. Furthermore, delayed hypothermia reduced microglial migration in the Boyden chamber assay and wound healing assay. In a stab injury model, delayed local hypothermia reduced migration of microglia toward the injury site in the rat brain.Taken together, our results indicate that delayed hypothermia is sufficient to attenuate microglial activation and migration, and provide the basis of determining the optimal time window for therapeutic hypothermia. Delayed hypothermia may be neuroprotective by inhibiting microglia-mediated neuroinflammation, indicating the therapeutic potential of post-injury hypothermia for patients with brain damages exhibiting some of the inflammatory components.
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