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Search Results: 1 - 10 of 3777 matches for " Hyun-Whee Bae "
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Gender-Specific Metabolomic Profiling of Obesity in Leptin-Deficient ob/ob Mice by 1H NMR Spectroscopy
Eun-Young Won, Mi-Kyung Yoon, Sang-Woo Kim, Youngae Jung, Hyun-Whee Bae, Daeyoup Lee, Sung Goo Park, Chul-Ho Lee, Geum-Sook Hwang, Seung-Wook Chi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075998
Abstract: Despite the numerous metabolic studies on obesity, gender bias in obesity has rarely been investigated. Here, we report the metabolomic analysis of obesity by using leptin-deficient ob/ob mice based on the gender. Metabolomic analyses of urine and serum from ob/ob mice compared with those from C57BL/6J lean mice, based on the 1H NMR spectroscopy in combination with multivariate statistical analysis, revealed clear metabolic differences between obese and lean mice. We also identified 48 urine and 22 serum metabolites that were statistically significantly altered in obese mice compared to lean controls. These metabolites are involved in amino acid metabolism (leucine, alanine, ariginine, lysine, and methionine), tricarbocylic acid cycle and glucose metabolism (pyruvate, citrate, glycolate, acetoacetate, and acetone), lipid metabolism (cholesterol and carnitine), creatine metabolism (creatine and creatinine), and gut-microbiome-derived metabolism (choline, TMAO, hippurate, p-cresol, isobutyrate, 2-hydroxyisobutyrate, methylamine, and trigonelline). Notably, our metabolomic studies showed distinct gender variations. The obese male mice metabolism was specifically associated with insulin signaling, whereas the obese female mice metabolism was associated with lipid metabolism. Taken together, our study identifies the biomarker signature for obesity in ob/ob mice and provides biochemical insights into the metabolic alteration in obesity based on gender.
Chronic Resveratrol Treatment Protects Pancreatic Islets against Oxidative Stress in db/db Mice
Young-Eun Lee, Ji-Won Kim, Eun-Mi Lee, Yu-Bae Ahn, Ki-Ho Song, Kun-Ho Yoon, Hyung-Wook Kim, Cheol-Whee Park, Guolian Li, Zhenqi Liu, Seung-Hyun Ko
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0050412
Abstract: Resveratrol (RSV) has anti-inflammatory and anti-oxidant actions which may contribute to its cardiovascular protective effects. We examined whether RSV has any beneficial effects on pancreatic islets in db/db mice, an animal model of type 2 diabetes. The db/db and db/dm mice (non-diabetic control) were treated with (db-RSV) or without RSV (db-control) (20 mg/kg daily) for 12 weeks. After performing an intraperitoneal glucose tolerance test and insulin tolerance test, mice were sacrificed, the pancreas was weighed, pancreatic β-cell mass was quantified by point count method, and the amount of islet fibrosis was determined. 8-Hydroxydeoxyguanosine (8-OHdG), an oxidative stress marker, was determined in 24 h urine and pancreatic islets. RSV treatment significantly improved glucose tolerance at 2 hrs in db/db mice (P = 0.036), but not in db/dm mice (P = 0.623). This was associated with a significant increase in both pancreas weight (P = 0.011) and β-cell mass (P = 0.016). Islet fibrosis was much less in RSV-treated mice (P = 0.048). RSV treatment also decreased urinary 8-OHdG levels (P = 0.03) and the percentage of islet nuclei that were positive for 8-OHdG immunostaining (P = 0.019). We conclude that RSV treatment improves glucose tolerance, attenuates β-cell loss, and reduces oxidative stress in type 2 diabetes. These findings suggest that RSV may have a therapeutic implication in the prevention and management of diabetes.
Genetically confirmed Wilson disease in a 9-month old boy with elevations of aminotransferases
Joo Whee Kim,Jong Hyun Kim,Jeong Kee Seo,Jae Sung Ko
World Journal of Hepatology , 2013, DOI: 10.4254/wjh.v5.i3.156
Abstract: Wilson disease (WD) is an autosomal recessive disorder of copper transport caused by alteration of the adenosine triphosphatase 7B gene. It is rare to diagnose WD below the age of three years. Molecular genetic testing is one of the most important diagnostic methods and may confirm the diagnosis in equivocal cases. We report a case of a 9-mo old boy with WD who presented as chronic hepatitis. Genetic analysis showed compound heterozygotes of p.G1186S and c.4006delA.
NS-398 induces caspase-dependent, mitochondria-mediated intrinsic apoptosis of hepatoma cells  [PDF]
Il Han Song, Suk Bae Kim, Hyun Duk Shin, Ha Yan Kang, Eun Young Kim
Advances in Bioscience and Biotechnology (ABB) , 2012, DOI: 10.4236/abb.2012.326084
Abstract: The present study was conducted to investigate whether mitochondrial pathway of apoptosis is involved in cyclooxygenase-2 (COX-2) inhibitor-induced growth inhibition of hepatoma cells. The growth rate and pattern of NS-398 (selective COX-2 inhibitor)-treated Hep3B hepatoma cells were analyzed by microscopic examination, DNA fragmentation gel analysis and flow cytometry followed by the cleavage of down-stream caspase 3 and the release of cytosolic fraction of cytochrome c assessed by Western blot analysis. NS-398 induced the growth inhibition of hepatoma cells depending on the concentration of this COX-2 inhibitor and time sequence. Ladder patterned-DNA fragmentation and cytometric redistribution to sub-G1 phase in cell cycle were revealed in NS-398-induced growth inhibition of hepatoma cells. Cytochrome c was translocated from mitochondria to cytosol in time-dependent manner following NS-398 treatment to hepatoma cells. COX-2 inhibitor induces the growth inhibition of hepatoma cells via caspase-dependent, mitochondria-mediated intrinsic apoptosis pathway. These results strongly suggest the possibility of therapeutic implication of COX-2 inhibitor in HCC.
Some eigenvalue results for perturbations of maximal monotone operators
In-Sook Kim and Jung-Hyun Bae
Journal of Inequalities and Applications , 2013, DOI: 10.1186/1029-242X-2013-72
Abstract: We study the solvability of nonlinear eigenvalue problem for maximal monotone operators under a normalization observation. The investigation is based on degree theories for appropriate classes of operators and a regularization method by the duality operator is used. Let $X$ be a real reflexive Banach space with its dual $X^*$ and $\Omega$ a bounded open set in $X$. Suppose that $T:D(T)\subset X\to X^*$ is a maximal monotone operator and $C:(0,\infty)\times\overline{\Omega}\to X^*$ is a bounded demicontinuous operator satisfying condition $(S_+)$. Applying the Browder degree theory, we solve nonlinear eigenvalue problem of the form $Tx+C(\lambda,x)=0.$ In the case where $Tx+\lambda Cx=0$, an eigenvalue result for generalized pseudomonotone densely defined perturbations is obtained by the Kartsatos-Skrypnik degree theory.
The GDOF of 3-user MIMO Gaussian interference channel
Jung Hyun Bae,Jungwon Lee,Inyup Kang
Mathematics , 2012,
Abstract: The paper establishes the optimal generalized degrees of freedom (GDOF) of 3-user $M \times N$ multiple-input multiple-output (MIMO) Gaussian interference channel (GIC) in which each transmitter has $M$ antennas and each receiver has $N$ antennas. A constraint of $2M \leq N$ is imposed so that random coding with message-splitting achieves the optimal GDOF. Unlike symmetric case, two cross channels to unintended receivers from each transmitter can have different strengths, and hence, well known Han-Kobayashi common-private message splitting would not achieve the optimal GDOF. Instead, splitting each user's message into three parts is shown to achieve the optimal GDOF. The capacity of the corresponding deterministic model is first established which provides systematic way of determining side information for converse. Although this deterministic model is philosophically similar to the one considered by Gou and Jafar, additional constraints are imposed so that capacity description of the deterministic model only contains the essential terms for establishing the GDOF of Gaussian case. Based on this, the optimal GDOF of Gaussian case is established with $\mathcal{O}(1)$ capacity approximation. The behavior of the GDOF is interestingly different from that of the corresponding symmetric case. Regarding the converse, several multiuser outer bounds which are suitable for asymmetric case are derived by non-trivial generalization of the symmetric case.
Outage-based ergodic link adaptation for fading channels with delayed CSIT
Jung Hyun Bae,Jungwon Lee,Inyup Kang
Mathematics , 2012,
Abstract: Link adaptation in which the transmission data rate is dynamically adjusted according to channel variation is often used to deal with time-varying nature of wireless channel. When channel state information at the transmitter (CSIT) is delayed by more than channel coherence time due to feedback delay, however, the effect of link adaptation can possibly be taken away if this delay is not taken into account. One way to deal with such delay is to predict current channel quality given available observation, but this would inevitably result in prediction error. In this paper, an algorithm with different view point is proposed. By using conditional cdf of current channel given observation, outage probability can be computed for each value of transmission rate $R$. By assuming that the transmission block error rate (BLER) is dominated by outage probability, the expected throughput can also be computed, and $R$ can be determined to maximize it. The proposed scheme is designed to be optimal if channel has ergodicity, and it is shown to considerably outperform conventional schemes in certain Rayleigh fading channel model.
On the achievable region for interference networks with point-to-point codes
Jung Hyun Bae,Jungwon Lee,Inyup Kang
Mathematics , 2013,
Abstract: This paper studies evaluation of the capacity region for interference networks with point-to-point (p2p) capacity-achieving codes. Such capacity region has recently been characterized as union of several sub-regions each of which has distinctive operational characteristics. Detailed evaluation of this region, therefore, can be accomplished in a very simple manner by acknowledging such characteristics, which, in turn, provides an insight for a simple implementation scenario. Completely generalized message assignment which is also practically relevant is considered in this paper, and it is shown to provide strictly larger achievable rates than what traditional message assignment does when a receiver with joint decoding capability is used.
Simple transmission strategies for interference channel
Jung Hyun Bae,Jungwon Lee,Inyup Kang
Mathematics , 2012,
Abstract: In this paper, we investigate performances of simple transmission strategies. We first consider two user SISO Gaussian symmetric interference channel (IC) for which Etkin, Tse and Wang proposed a scheme (ETW scheme) which achieves one bit gap to the capacity. We compare performance of point-to-point (p2p) codes with that of the ETW scheme in practical range of transmitter power. It turns out that p2p coding scheme performs better or as nearly good as the ETW scheme. Next, we consider K user SISO Gaussian symmetric IC. We define interference regimes for K user SISO Gaussian symmetric IC and provide closed-form characterization of the symmetric rate achieved by the p2p scheme and the ETW scheme. Using this characterization, we evaluate performances of simple strategies with K=3, and show the similar trend to two user case.
Effects of Carbon Dioxide Treatment and Modified Atmosphere Packaging on the Quality of Long Distance Transporting “Maehyang” Strawberry  [PDF]
Hyun Jin Choi, Yeong Seuk Bae, Jung Soo Lee, Me Hea Park, Ji Gang Kim
Agricultural Sciences (AS) , 2016, DOI: 10.4236/as.2016.712074
Abstract: This study was conducted to investigate the effects of carbon dioxide (CO2) and modified atmosphere (MA) packaging on the quality of strawberry during long distance transportation. “Maehyang” strawberries (Fragaria x ananassa Duch.) with red color on 70% of the fruit surface were harvested in Gyeongnam province, Korea. The samples were placed in gas-tight chamber with 30% CO2 concentration for 3 hours at 3°C. Strawberry samples were then packaged with modified atmosphere-modified humidity (MA/MH) packaging film. Samples treated with CO2 alone and combined CO2 with MA packaging were stored for one day at 1°C, transported for 10 days at 1°C, and distributed for 3 days at 4°C. Carbon dioxide alone or combination with MA packaging was effective in maintaining quality of “Maehyang” strawberries. Carbon dioxide treatment significantly increased firmness and reduced softening index and decay rate during 14 day transportation and distribution. Samples treated with CO2 + MA had higher overall score with low softening index and weight loss after 14 days of transportation and low temperature distribution compared to CO2 treatment only. The results indicated that a short term application of CO2 or combination treatment of CO2 and MA could be good postharvest handling for maintaining freshness of “Maehyang” strawberries during long distance vessel export.
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