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Search Results: 1 - 10 of 11644 matches for " Hyun Ju Cho "
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Posturographic Evaluation of Dizziness Complaining Patients under Suspicion to Develop Parkinson's Disease  [PDF]
Hyun Cho
Neuroscience & Medicine (NM) , 2011, DOI: 10.4236/nm.2011.21004
Abstract: Although the typical clinical signs of Parkinson disease (PD) are tremor, rigidity, bradykinesia, and postural instability, PD is preceded by a preclinical phase during which neuronal degeneration develops without typical symptoms. More general nonspecific symptoms including dizziness have also been described to predate the typical PD signs for several years. All subjects were selected among patients in the Willis Hospital (Pusan, South of Korea), with complaints of diz-ziness from September 2009 to September 2010 and the baseline neurological screening and clinical ENT examination, to which the results were within the normal range. At baseline, 113 participants underwent neurological screening and provided information on dizziness. Of those participants, 103 were enrolled including 63 subjects in the control group. We used posturography. It allows quantitative assessment of vestibular-spinal component of body balance. The parame-ter of average speed of pressure center displacement to the lateral plan (VMX) and antero-posterior plan (VMY), which presented statistically significant differences between the groups except VMX with closed eyes. (p = 0.008 and p = 0.012, with closed eyes). With open eyes, only VMY showed significant difference between the groups (p = 0.010). In this study, the patients with dizziness and subjective complaints related to typical clinical signs of PD complaints presented higher instability in the orthostatic position than the control group of patients with dizziness and without such complaint. It could suggest that dizziness may be one symptom of preclinical PD and progress to overt postural instability. It is believed that a stepwise approach with a simple and inexpensive initial screening test of preclinical PD is required.
Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens  [PDF]
Dong Gu Lee, So-Youn Mok, Changsun Choi, Eun Ju Cho, Hyun Young Kim, Sanghyun Lee
Journal of Agricultural Chemistry and Environment (JACEN) , 2012, DOI: 10.4236/jacen.2012.11005
Abstract: To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of Blumea balsamifera were tested for their ability to inhibit aldose reductase (AR) activity in rat lenses. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC50 value, 0.11 μg/mL). Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibitory activity (IC50 value, 4.03 μM). The content of apigenin was measured in B. balsamifera (0.47 mg/g) by HPLC/UV analysis. Our result suggests that B. balsamifera could be a useful natural source for the development of a novel AR inhibitory agent against diabetic complications.


Effect of Farnesyl Caffeate-Induced Apoptosis of Lung Carcinoma Cell Line from Damage to DNA  [PDF]
Kyu Sik Kim, Akemi Umeyama, Toshihiro Hashimoto, Hyun-Ju Cho, Je-Jung Lee, Masao Takei
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.49096
Abstract:

Farnesyl caffeate, synthesis of propolis and polar bud excretion, has been reported to exhibit anti-allergic effects in mice. However, little is known about anti-tumor effects. In this study, we investigated the effect of Farnesyl caffeate in cell proliferation of lung carcinoma cell line (H157). Antiproliferative effect and apoptosis on H157 cell were evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay (MTT) and DNA fragmentation assay, respectively. Farnesyl caffeate inhibited the growth of H157 cell in dose-dependent manner. Morphological changes of nuclei by staining Hoechst 33258 and DNA fragmentation suggested that Farnesyl caffeate induced death involved in a mechanism of apoptosis. Moreover, caspase-3, caspase-7 and caspase-9 were activated by Farnesyl caffeate on H157 cell. The protein expressions of Bax and Bcl-2 were down-regulated by Farnesyl caffeate, resulting in cytochrome c release from the mitochondria. Farnesyl caffeate significantly increased the expression of p53 proteins which indicates that p53 plays a pivotal role in the initiation phase of Farnesyl caffeate-induced HepG2 cell apoptosis. These results demonstrated Farnesyl caffeate-induced apoptosis in human lung carcinoma cell line. More detailed mechanism of  Farnesyl caffeate-induced H157 apoptosis remains to be elucidated.

 

The Apoptotic Effect of the Methanol Extract of Polygonum cuspidatum through Up-Regulation Death Receptor 5 and CHOP in HSC-2 Human Oral Cancer Cells  [PDF]
Hyun-Ju Yu, Ji-Ae Shin, Eun-Sun Choi, Jae-Gyu Jeon, Nam-Pyo Cho, Sung-Dae Cho
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.31001
Abstract: Polygonum cuspidatum is used as a traditional medicinal herb for the therapy of various diseases including several types of cancers. In the present study, we focused on addressing the anti-cancer activity and molecular mechanism of methanol extract of Polygonum cuspidatum (MEPC) in HSC-2 human oral cancer cells. The effect of MEPC on oral cancer cells was estimated by 3-(4,5-dimethylthiazol-20yl)-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium (MTS) assay, 4’-6-diamidino-2-phenylindole (DAPI) staining and Western blot analysis. MEPC inhibited the cell viability and induced apoptosis through the induction of death receptor (DR) 5. MEPC also increased the expression of C/EBP homologous protein/growth arrest and the DNA damage-inducible gene 153 (CHOP), a transcription factor induced by ER stress. Thus, we concluded that the induction of CHOP leading to DR5 up-regulation is required for the anti-cancer activity of MEPC in HSC-2 cells and MEPC may be a promising drug candidate for oral cancer.
Multiple stress fractures of the lower extremity in healthy young men
Hyun-Ju Choi,Hong-Man Cho
Journal of Orthopaedics and Traumatology , 2012, DOI: 10.1007/s10195-011-0156-9
Abstract: Stress fractures result from abnormal stresses imposed on normal bones by the continued and repeated actions of muscles or from normal stresses imposed on abnormal bones. The risk factors that can cause such stress fractures include excessive use, such as, in soldiers or athletes, nutritional deficiencies, and endocrine disorders. In addition, disease may arise from long-standing rheumatoid arthritis, osteoporosis, corticosteroid therapy, joint stiffness or contracture, or the correction of angular deformity. In these cases, stress fractures may occur in one area or multiple areas. However, no case of multiple stress fractures in a young man who was not a professional athlete and who had no stress fracture risk factor, such as, an endocrine disease, has been previously reported.
Effect of pH and EC of Hydroponic Solution on the Growth of Greenhouse Rose
Hyun Ju Kim,Young-Son Cho,Oh-Keun Kwon,Myung-Whan Cho
Asian Journal of Plant Sciences , 2005,
Abstract: High temperature and high light intensity in summer season tend to induce unbalance water uptake and mineral elements in hydroponic cultured roses. In addition, differential uptake of various elements causes unstable pH in root zone. To solve this problem the best managing range of nutrient, EC and pH, nutrient solutions were made of three levels of EC at 0.2, 0.7 and 1.2 dS m 1 and three pH levels, 4.0, 6.0 and 8.0, were adjusted. Stem length of rose was the greatest when a nutrient solution of pH 8.0 and EC 0.2 or 0.7 dS m 1 was supplied. The yield of cut-flowers was also the greatest when plants were fed with a solution of pH 8.0 regardless of EC. Maintaining of pH was possible in EC 0.7 dS m 1 at pinching time. The rhyzosphere pH was positively correlated with the EC in culture media even it was not changed in neutral pH range 6.0-7.0 in EC 0.2 dS m 1. Dry weight was mostly positively related with pH and dry weight of cut-flower and it was greatest at pH 8.0 in EC 1.2 dS m 1, however DWR, node numbers and leaf area were greater at pH 4.0 in EC 0.2. Stem Osmotic Potential (OP) was positively related with the culture media pH in EC 0.2 and 0.7 dS m 1. Leaf greenness was also positively related with the pH and EC. Cut-flower length and commercial cut-flower ratio, weight and leaf length were not significantly affected by EC but pH was more effective in low EC. Higher pH induced greater root growth. T-N was mostly greater at neutral cultural media in low or mid EC level but reversed effect was shown in high EC level (EC 1.2 dS m 1). The uptake pattern of Mg and Ca was same as higher at pH 6.0 in mid or low EC level and not affected by pH in low EC level. In conclusion, the best culture media of pH range is neutral with mid or low EC level which is economically valuable and practically viable.
Effect of Hydroponic Solution pH on the Growth of Greenhouse Rose
Hyun-Ju Kim,Young-Son Cho,Oh-Keun Kwon,Myung-Whan Cho
Asian Journal of Plant Sciences , 2005,
Abstract: High temperature and high light intensity during the summer season tend to induce an unbalance absorption of water and mineral elements of hydroponic cultured roses. In addition, differential uptake of various elements causes pH of the root zone to change constantly. To solve this problem, the experiment was carried out to examine the effect of pH of nutrient solution on the growth of rose plants in rockwool slabs. Nutrient solutions adjusted to pH 4.0, 6.0 and 8.0 were supplied at 5 days or 20 days after pinching. The pinching time and solution pH had little effect on pH of root zone. The pH 8.0 were supplied at 5 days after pinching maintained root zone pH slightly higher and at a more desirable level. Stem length was not significantly affected by either solution pH or pinching stage, except it was slightly smaller in pH 4.0 solution supplied at 20 days after pinching. The yield of cut flowers was the greatest when pH 8.0 solution was supplied from 5 days after pinching. A desirable pH of root zone was maintained by supplying a nutrient solution of pH 8.0 from 10 days to 25 days after pinching. When comparing the study of the higher concentration of pH 8.0 to conventional one must concentration of pH 8.0 to conventional one must considered being unable to supply to it to most of cultivar due to the different absorbing characteristics of water and nutrient according to the difference of cultivar.
Display of Multimeric Antimicrobial Peptides on the Escherichia coli Cell Surface and Its Application as Whole-Cell Antibiotics
Ju Ri Shin, Ki Jung Lim, Da Jung Kim, Ju Hyun Cho, Sun Chang Kim
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0058997
Abstract: Concerns over the increasing emergence of antibiotic-resistant pathogenic microorganisms due to the overuse of antibiotics and the lack of effective antibiotics for livestock have prompted efforts to develop alternatives to conventional antibiotics. Antimicrobial peptides (AMPs) with a broad-spectrum activity and rapid killing, along with little opportunity for the development of resistance, represent one of the promising novel alternatives. Their high production cost and cytotoxicity, however, limit the use of AMPs as effective antibiotic agents to livestock. To overcome these problems, we developed potent antimicrobial Escherichia coli displaying multimeric AMPs on the cell surface so that the AMP multimers can be converted into active AMP monomers by the pepsin in the stomach of livestock. Buf IIIb, a strong AMP without cytotoxicity, was expressed on the surface of E. coli as Lpp-OmpA-fused tandem multimers with a pepsin substrate residue, leucine, at the C-terminus of each monomer. The AMP multimers were successfully converted into active AMPs upon pepsin cleavage, and the liberated Buf IIIb-L monomers inhibited the growth of two major oral infectious pathogens of livestock, Salmonella enteritidis and Listeria monocytogenes. Live antimicrobial microorganisms developed in this study may represent the most effective means of providing potent AMPs to livestock, and have a great impact on controlling over pathogenic microorganisms in the livestock production.
Protective Effect of Proanthocyanidin against Diabetic Oxidative Stress
Takako Yokozawa,Eun Ju Cho,Chan Hum Park,Ji Hyun Kim
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/623879
Abstract: We investigated the antidiabetic potential of proanthocyanidin and its oligomeric form in STZ-induced diabetic model rats and db/db type 2 diabetic mice. Proanthocyanidin ameliorated the diabetic condition by significant decreases of serum glucose, glycosylated protein, and serum urea nitrogen as well as decreases of urinary protein and renal-AGE in STZ-induced diabetic rats and decrease of serum glucose as well as significant decrease of glycosylated protein in db/db type 2 diabetic mice. The suppression of ROS generation and elevation of the GSH/GSSG ratio were also observed in the groups administered proanthocyanidin. Moreover, proanthocyanidin, especially its oligomeric form, affected the inflammatory process with the regulation of related protein expression, iNOS, COX-2 and upstream regulators, NF-κB, and the IκB-α. In addition, it had a marked effect on hyperlipidemia through lowering significant levels of triglycerides, total cholesterol, and NEFA. Moreover, expressions in the liver of SREBP-1 and SREBP-2 were downregulated by the administration of proanthocyanidins. The protective effect against hyperglycemia and hyperlipidemia in type 1 and 2 diabetic models was significantly strong in the groups administered the oligomeric rather than polymeric form. This suggests that oligomers act as a regulator in inflammatory reactions caused by oxidative stress in diabetes.
Fulminant myocarditis managed with pulsatile extracorporeal life support; use of Twin Pulse Life support (T-PLS?)
Eun Cho, Joonhwa Hong, Hyun Kang, Ju Choe, Sang-Wook Kim
Journal of Cardiothoracic Surgery , 2011, DOI: 10.1186/1749-8090-6-159
Abstract: We report on two cases of fulminant myocarditis. They developed profound hypoxemia, acidosis, pulmonary edema, and oliguria. T-PLS?(Twin Pulse Life support, New heart bio.BHK, Seoul, Korea) was used in order to prevent further deterioration. Both patients recovered well from fulminant myocarditis with T-PLS support. Echocardiograms showed normal ejection fraction after recovery. Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.A 32-year-old woman without previous medical history was referred to the emergency department with dizziness for one day. On admission, the vital signs were unstable, with a blood pressure of 70/40 mmHg, heart rate of 91 beats/min, and body temperature of 35.4°C. White blood cell count was 16,470 109/L and troponin I was 2.563 ng/mL. Arterial blood gas analysis showed metabolic acidosis. EKG demonstrated sinus tachycardia. Hemodynamic status showed rapid deterioration during the subsequent hours. Systolic blood pressure was below 90 mmHg, with a heart rate faster than 100 beats/min. Urine output decreased, too. Hypoxemia did not resolve with supplementary oxygen. Echocardiogram showed a left ventricular ejection fraction of 21% with global hypokinesia. She was admitted to the intensive care unit (ICU) with a diagnosis of probable viral myocarditis. Ventilator therapy was initiated. She developed atrial fibrillation with rapid ventricular response. Hemodynamic status showed further worsening. Urine output further decreased and she developed hypoxemia with pulmonary edema, lactic acidosis. On the second day of admission, we decided to place the patient on a T-PLS. A 17 French femoral venous and a 14 French arterial cannula were inserted percutaneously. The pump was started with a flow of 2.13 L/min/m2, a pump rate of 47/min, and 100% oxygen at 4 L/min. The membrane oxygenator was replaced
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