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Search Results: 1 - 10 of 31409 matches for " Hyun Jin Hwang "
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Immobilization of antibodies on the self-assembled monolayer by antigen-binding site protection and immobilization kinetic control  [PDF]
Myungok Yoon, Hyun Jin Hwang, Jeong Hee Kim
Journal of Biomedical Science and Engineering (JBiSE) , 2011, DOI: 10.4236/jbise.2011.44033
Abstract: The orientation of the biological molecule immobi-lized on a solid surface has been critical in devel-opment of various applications. In this study, ori-entation of antibody was retained by protecting the antigen-binding site of the antibody prior to immo-bilization to -functionalized mixed self-assembled monolayer (SAM) of 12-mercaptododecanoic acid and 1-heptanethiol. More importantly, the number of immobilization bonds formed between each an-tigen-binding site protected antibody molecule and the solid surface was controlled by optimizing the mole fraction of the activated carboxyl group of the linker molecules in the mixed SAM. The amount of antibody used in this study was approximately equivalent to the amount for one monolayer surface coverage. The resulting activity of protected immo-bilized antibody was about 10 fold higher than that of random immobilized antibody
Real hypersurfaces in the complex quadric with commuting Ricci tensor
Young Jin Suh,Doo Hyun Hwang
Mathematics , 2015,
Abstract: We introduce the notion of commuting Ricci tensor for real hypersurfaces in the complex quadric $Q^m = SO_{m+2}/SO_mSO_2$ . It is shown that the commuting Ricci tensor gives that the unit normal vector field $N$ becomes $\frak A$-principal or $\frak A$-isotropic. Then according to each case, we give a complete classification of real hypersurfaces in $Q^m = SO_{m+2}/SO_mSO_2$ with commuting Ricci tensor.
Endovascular coiling versus neurosurgical clipping in patients with unruptured intracranial aneurysm: a systematic review
Hwang Jin,Hyun Min,Lee Hyun,Choi Ji
BMC Neurology , 2012, DOI: 10.1186/1471-2377-12-99
Abstract: Background To compare the effects of endovascular coiling and neurosurgical clipping in patients with unruptured intracranial aneurysm. Methods Sixteen electronic databases were searched for articles published between 1950 and July 2010 to compare clinical outcomes of clipping and coiling. Researchers reviewed all searched articles and extracted data independently. The quality of studies and evidence were evaluated using MINORS and GRADEprofiler, respectively. The odds ratio (OR) was calculated using the inverse variance meta-analysis method for each study outcome. To assess heterogeneity of ORs across cohorts, Cochran’s Q statistic and I2 were used. Results Of 4160 studies, 24 were identified (n = 31865). Clipping resulted in significantly higher disability using the Glasgow Outcome Scale (OR, 2.38; 95% CI, 1.33–4.26) and Modified Rankin Scale (OR, 2.83; 95% CI, 1.42–5.63) when compared with coiling. ORs for complications were also higher with clipping (ORs for neurological and cardiac complications were 1.94 with a 95% confidence interval [CI] of 1.09–3.47 and 2.51 with a 95% CI of 1.15–5.50). Clipping resulted in significantly greater disability in the short term (≤6 m)(OR on the Glasgow Outcome Scale, 2.72; 95% CI, 1.16–6.34), but not in the long term (>6 m)(OR for Glasgow Outcome Scale, 2.12; 95% CI, 0.93–4.84). Conclusions Coiling was a better procedure for treatment of unruptured intracranial aneurysm in terms of disability, complications, especially in the short term. Because of the limitations of the reviewed studies, further studies are required to support the present results.
Real Hypersurfaces in complex two-plane Grassmannians with recurrent Ricci tensor
Young Jin Suh,Doo Hyun Hwang,Changhwa Woo
Mathematics , 2014, DOI: 10.1142/S0219887815500863
Abstract: In this paper, we have introduced a new notion of generalized Tanaka-Webster Reeb recurrent Ricci tensor in complex two-plane Grassmannians $G_2({\mathbb C}^{m+2})$. Next, we give a non-existence property for real hypersurfaces $M$ in $G_2({\mathbb C}^{m+2})$ with such a condition.
In-Cell Protease Assay Systems Based on Trans-Localizing Molecular Beacon Proteins Using HCV Protease as a Model System
Jeong Hee Kim, Min Jun Lee, Inhwan Hwang, Hyun Jin Hwang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0059710
Abstract: This study describes a sensitive in-cell protease detection system that enables direct fluorescence detection of a target protease and its inhibition inside living cells. This live-cell imaging system provides a fluorescent molecular beacon protein comprised of an intracellular translocation signal sequence, a protease-specific cleavage sequence, and a fluorescent tag sequence(s). The molecular beacon protein is designed to change its intracellular localization upon cleavage by a target protease, i.e., from the cytosol to a subcellular organelle or from a subcellular organelle to the cytosol. Protease activity can be monitored at the single cell level, and accordingly the entire cell population expressing the protease can be accurately enumerated. The clear cellular change in fluorescence pattern makes this system an ideal tool for various life science and drug discovery research, including high throughput and high content screening applications.
Content Authoring and Cloud System Implementation for Smart Learning  [PDF]
Hyun-Seo Hwang, Jin-Tae Park, Kyeong-Taek Seo, Jun-Soo Yun, Il-Young Moon, Oh-Young Kwon, Byeong-Jun Kim
Journal of Computer and Communications (JCC) , 2015, DOI: 10.4236/jcc.2015.35017
Abstract:

In this paper, we implement a content authoring and cloud system for cloud-based smart cloud learning. With the advent of the smartphone and mobile devices such as tablets, the educational paradigm is also changing. Was using the computer to aid in the learning e-learning started in ICT education are evolving Over the variety, in recent years, combines smart learning and social learning, cloud-based smart devices in e-learning the concept of Smart Cloud Smart Education Services Learning was gives rise to the term. Smart Cloud and free running is always the knowledge content uploaded by anyone, anywhere, can also be shared with other users. A terminal and location, without limitations on time, are continuously available to the environment of a high- quality knowledge content was coming through a variety of smart media, open educational content platform is built over the level of the possible conditions than e-learning. In this paper, we develop applications and Web sites that can provide authored content for smart cloud learning. In addition, we have built the cloud for content management and the website that can share content with other users. In the future, should wish to study a way that can provide customized services over the learner analysis based on big data technology.

Accuracy and Uncertainty Analysis of PSBT Benchmark Exercises Using a Subchannel Code MATRA
Dae-Hyun Hwang,Seong-Jin Kim,Kyong-Won Seo,Hyuk Kwon
Science and Technology of Nuclear Installations , 2012, DOI: 10.1155/2012/603752
Abstract: In the framework of the OECD/NRC PSBT benchmark, the subchannel grade void distribution data and DNB data were assessed by a subchannel code, MATRA. The prediction accuracy and uncertainty of the zone-averaged void fraction at the central region of the 5 × 5 test bundle were evaluated for the steady-state and transient benchmark data. Optimum values of the turbulent mixing parameter were evaluated for the subchannel exit temperature distribution benchmark. The influence of the mixing vanes on the subchannel flow distribution was investigated through a CFD analysis. In addition, a regionwise turbulent mixing model was examined to account for the nonhomogeneous mixing characteristics caused by the vane effect. The steady-state DNB benchmark data with uniform and nonuniform axial power shapes were evaluated by employing various DNB prediction models: EPRI bundle CHF correlation, AECL-IPPE 1995 CHF lookup table, and representative mechanistic DNB models such as a sublayer dryout model and a bubble crowding model. The DNBR prediction uncertainties for various DNB models were evaluated from a Monte-Carlo simulation for a selected steady-state condition. 1. Introduction The critical heat flux (CHF) is a parameter of great importance, which constrains the thermal power capability of a light water nuclear reactor (LWR). It is usually predicted by a local parameter CHF correlation accompanied with an appropriate thermal-hydraulic field analysis code to obtain the local subchannel grade conditions in the fuel assembly. For this purpose, the subchannel approach has been widely adopted in the design calculation of an LWR core since it provides reasonably accurate results on the flow and enthalpy distributions in rod bundles with a pertinent computing time. The OECD/NRC PWR Subchannel and Bundle Tests (PSBT) benchmark was organized on the basis of the NUPEC database. The purposes of the benchmark are the encouragement to develop a theoretically based microscopic approach as well as a comparison of currently available computational approaches. The benchmark consists of two separate phases: a void distribution benchmark and DNB benchmark. Subchannel-grade void distribution data was employed for validation of a subchannel analysis code under steady-state and transient conditions. The DNB benchmark provided subchannel fluid temperature data, which can be used to determine the turbulent mixing parameter for a subchannel code. The steady-state and transient DNB data can be used to evaluate and improve the currently available DNB prediction models in PWR bundles. The NUPEC
Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family
Hyun Soo Park,Hye Jin Hwang,Gi-Young Kim,Hee-Jae Cha,Wun-Jae Kim,Nam Deuk Kim,Young Hyun Yoo,Yung Hyun Choi
Marine Drugs , 2013, DOI: 10.3390/md11072347
Abstract: The present study investigated possible mechanisms on the apoptosis induction of human leukemic cells by fucoidan, a sulfated polysaccharide found in marine algae. Fucoidan treatment of cells resulted in inhibition of growth and induction of apoptosis, as measured by 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyl-tetrazolium (MTT) assay, fluorescence microscopy, DNA fragmentation, and flow cytometry analysis. The increase in apoptosis was associated with the proteolytic activation of caspases, Bid cleavage, insertion of pro-apoptotic Bax into the mitochondria, release of cytochrome c from mitochondria to cytosol, and loss of mitochondria membrane potential (MMP) in U937 cells. However, apoptosis induced by fucoidan was attenuated by caspase inhibitors, indicating that fucoidan-induced apoptosis was dependent on the activation of caspases. Furthermore, fucoidan treatment effectively activated the p38 mitogen-activated protein kinase (MAPK) and p38 MAPK inhibitor, SB203580, and significantly reduced fucoidan-induced apoptosis through inhibition of Bax translocation and caspases activation, suggesting that the activation of p38 MAPK may play a key role in fucoidan-induced apoptosis. In addition, the authors found fucoidan-induced significantly attenuated in Bcl-2 overexpressing U937 cells, and pretreatment with fucoidan and HA 14-1, a small-molecule Bcl-2 inhibitor, markedly increased fucoidan-mediated apoptosis in Bcl-2 overexpressing U937 cells. Our findings imply that we may attribute some of the biological functions of p38 MAPK and Bcl-2 to their ability to inhibit fucoidan-induced apoptosis.
Genetic Mechanisms in Aspirin-Exacerbated Respiratory Disease
Nami Shrestha Palikhe,Seung-Hyun Kim,Hyun Jung Jin,Eui-Kyung Hwang,Young Hee Nam,Hae-Sim Park
Journal of Allergy , 2012, DOI: 10.1155/2012/794890
Abstract: Aspirin-exacerbated respiratory disease (AERD) refers to the development of bronchoconstriction in asthmatics following the exposure to aspirin or other nonsteroidal anti-inflammatory drugs. The key pathogenic mechanisms associated with AERD are the overproduction of cysteinyl leukotrienes (CysLTs) and increased CysLTR1 expression in the airway mucosa and decreased lipoxin and PGE2 synthesis. Genetic studies have suggested a role for variability of genes in disease susceptibility and the response to medication. Potential genetic biomarkers contributing to the AERD phenotype include HLA-DPB1, LTC4S, ALOX5, CYSLT, PGE2, TBXA2R, TBX21, MS4A2, IL10, ACE, IL13, KIF3A, SLC22A2, CEP68, PTGER, and CRTH2 and a four-locus SNP set composed of B2ADR, CCR3, CysLTR1, and FCER1B. Future areas of investigation need to focus on comprehensive approaches to identifying biomarkers for early diagnosis. 1. Introduction Aspirin-exacerbated respiratory disease (AERD) refers to the development of bronchoconstriction in asthmatics following the ingestion of aspirin or other nonsteroidal anti-inflammatory drugs. It is defined by a clinical syndrome associated with moderate-to-severe asthma and eosinophil inflammation in the upper and lower airways, resulting in chronic rhinosinusitis and asthma [1]. Additionally, the airways of AERD show epithelial disruption, cytokine production, and the upregulation of inflammatory molecules [2]. The prevalence of aspirin hypersensitivity in the general population ranges from 0.6 to 2.5% and is higher in asthmatics [3]. The dysregulation of arachidonic acid metabolism also accounts for the susceptibility to AERD. Metabolites involved are prostaglandins (PGs), leukotrienes (LTs), and thromboxane (TBX). Inhibition of COXs by acetyl salicylic acid (ASA) in the respiratory tract alters arachidonic acid metabolism, leading to a reduction in PGE2. This may increase AERD susceptibility by overproduction of CysLTs [4, 5]. The lipoxygenase (LOX) pathway produces the leukotrienes LTA4, LTB4, and LTC4 as metabolites. 15-lipoxygenase (15-LO) is one of the LOX family members and catalyses the conversion of arachidonic acid to 15-hydroxyperoxyeicosatetranoic acid (15-HPETE). 15-hydroxyeicosatetranoic (15-HETE), a more stable derivative of 15-HPETE, is another important product, which acts as an anti-inflammatory mediator and functional antagonist of LTs [6]. Further products of 15-HPETE include eoxins (EXs) EXA4 and 15-HETE can be conjugated with glutathione, leading to the formation of EXC4, EXD4, and EXE4. AERD has also been correlated with increased CysLT
Hormonal responses upon return of spontaneous circulation after cardiac arrest: a retrospective cohort study
Jin Joo Kim, Sung Youl Hyun, Seong Youn Hwang, Young Bo Jung, Jong Hwan Shin, Yong Su Lim, Jin Seong Cho, Hyuk Jun Yang, Gun Lee
Critical Care , 2011, DOI: 10.1186/cc10019
Abstract: This is a retrospective review of the chart and laboratory findings in a single medical facility. The patients admitted to the intensive care unit after successful resuscitation after out-of-hospital cardiac arrest were retrospectively identified and evaluated. Patients with hormonal diseases, patients who received cortisol treatment, those experiencing trauma, and pregnant women were excluded. Serum cortisol, adrenocorticotropic hormone (ACTH), and anti-diuretic hormone (ADH (vasopressin)) were analyzed and a corticotropin-stimulation test was performed. Mortality at one week and one month after admission, and neurologic outcome (cerebral performance category (CPC)) one month after admission were evaluated.A total of 117 patients, including 84 males (71.8%), were evaluated in this study. One week and one month after admission, 87 (74.4%) and 65 patients (55.6%) survived, respectively. Relative adrenal insufficiency, and higher plasma ACTH and ADH levels were associated with shock-related mortality (P = 0.046, 0.005, and 0.037, respectively), and ACTH and ADH levels were also associated with late mortality (P = 0.002 and 0.004, respectively). Patients with relative adrenal insufficiency, ACTH ≧5 pg/mL, and ADH ≧30 pg/mL, had a two-fold increased risk of a poor outcome (shock-related mortality): (odds ratio (OR), 2.601 and 95% confidence interval (CI), 1.015 to 6.664; OR, 2.759 and 95% CI, 1.060 to 7.185; OR, 2.576 and 95% CI, 1.051 to 6.313, respectively). Thirty-five patients (29.9%) had a good CPC (1 to 2), and 82 patients (70.1%) had a bad CPC (3 to 5). Age ≧50 years and an ADH ≧30 pg/mL were associated with a bad CPC (OR, 4.564 and 95% CI, 1.794 to 11.612; OR, 6.568 and 95% CI, 1.918 to 22.483, respectively).The patients with relative adrenal insufficiency and higher blood levels of ACTH and ADH upon ROSC after cardiac arrest had a poor outcome. The effectiveness of administration of cortisol and ADH to patients upon ROSC after cardiac arrest is uncertain and ad
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