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Search Results: 1 - 10 of 8119 matches for " Hyuk-Sang Jung "
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Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation
Min Jung Lee, Minhee Jang, Hyuk-Sang Jung, Sung-Hoon Kim, Ik-Hyun Cho
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-40
Abstract: EP significantly decreased formalin-induced nociceptive behavior during phase II, the magnitude of paw edema, and the activation of c-Fos in L4-L5 spinal dorsal horn. EP also attenuated the phosphorylation of extracellular signal-regulated kinase (ERK) in the neurons of L4-L5 spinal dorsal horn after formalin injection. Interestingly, the i.t. administration of PD98059, an ERK upstream kinase (MEK) inhibitor, completely blocked the formalin-induced inflammatory nociceptive responses.These results demonstrate that EP may effectively inhibit formalin-induced inflammatory nociception via the inhibition of neuronal ERK phosphorylation in the spinal dorsal horn, indicating its therapeutic potential in suppressing acute inflammatory pain.
Minocycline markedly reduces acute visceral nociception via inhibiting neuronal ERK phosphorylation
Ik-Hyun Cho, Min Jung Lee, Minhee Jang, Nam Gil Gwak, Ka Yeon Lee, Hyuk-Sang Jung
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-13
Abstract: Minocycline (4, 10, or 40 mg/kg) significantly decreased acetic acid-induced nociception (0-60 minutes post-injection) and the enhancement in the number of c-Fos positive cells in the T5-L2 spinal cord induced by acetic acid injection. Also, the expression of spinal phosphorylated extracellular signal-regulated kinase (p-ERK) induced by acetic acid was reduced by minocycline pre-administration. Interestingly, intrathecal introduction of PD98059, an ERK upstream kinase inhibitor, markedly blocked the acetic acid-stimulated pain responses.These results demonstrate that minocycline effectively inhibits acetic acid-induced acute abdominal nociception via the inhibition of neuronal p-ERK expression in the spinal cord, and that minocycline may have therapeutic potential in suppressing acute abdominal pain.Minocycline is a second-generation tetracycline antibiotic derivative that effectively crosses the blood-brain barrier [1], and which has a proven safety record in humans [2]. Minocycline has anti-inflammatory and neuroprotective effects in animal models of cerebral ischaemia [3,4], traumatic injury [5], glutamate-induced neurotoxicity [6], experimental autoimmune encephalonmyelitis [7], Huntington's disease [8] and Parkinson's disease [2,9,10]. Minocycline's efficacy has been bolstered by studies showing decreased secondary neuronal damage via the inhibition of microglial activation. Recently, it has been demonstrated that this minocycline-mediated microglial inhibition attenuates the development of pain hypersensitivity by inhibiting proinflammatory cytokine expression in rat models of both neuropathic pain and spinal immune activation by intrathecal human immunodeficiency virus-1 (HIV-1) gp120 [11,12]. Also, minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) in the spinal cord [13]. In addition, we confirmed that minocycline attenuates tactile hy
Association between Urinary Albumin Excretion and Intraocular Pressure in Type 2 Diabetic Patients without Renal Impairment
Jin A. Choi, Kyungdo Han, Hyuk-Sang Kwon
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096335
Abstract: Background To assess the relationship between urinary albumin excretion and intraocular pressure (IOP) in type 2 diabetes patients without renal impairment. Methods We explored the effects of albuminuria on high IOP in 402 non-glaucomatous type 2 diabetes without renal impairment who participated in the 2011 Korean National Health and Nutrition Examination Survey (KNHANES). Multiple logistic regression analysis was used to assess the relationship between log-transformed albumin/creatinine ratio (ACR) tertiles and an IOP of ≥18 mmHg after adjusting for age, gender, hypertension, body mass index, triglycerides, area of residence, and education level. Results Subjects with a high IOP ≥18 mmHg were more likely to be current smokers (P = 0.038), heavy drinkers (P = 0.006), and to have high systolic blood pressure (P = 0.016), triglycerides (P = 0.008), and a higher log-transformed ACR (P = 0.022).In multivariate regression analysis, ACR tertile was associated with the prevalence of high IOP significantly (P = 0.022). The associations between ACR tertiles and high IOP were significant in overweight patients and those with abdominal obesity (P = 0.003 and 0.003, respectively). In contrast, there were no associations in the subgroup of patients who were not overweight and those without abdominal obesity (P = 0.291 and 0.561, respectively). Conclusions Urinary albumin excretion is associated with high IOP in the type 2 diabetes population without renal insufficiency. The effect of the albuminuria on IOP was evident in a subgroup of patients with components of metabolic syndrome.
Sarcopenia as a Determinant of Blood Pressure in Older Koreans: Findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008–2010
Kyungdo Han, Yu-Mi Park, Hyuk-Sang Kwon, Seung-Hyun Ko, Seung-Hwan Lee, Hyeon Woo Yim, Won-Chul Lee, Yong Gyu Park, Mee Kyoung Kim, Yong-Moon Park
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0086902
Abstract: Background Blood pressure (BP) is directly and causally associated with body size in the general population. Whether muscle mass is an important factor that determines BP remains unclear. Objective To investigate whether sarcopenia is associated with hypertension in older Koreans. Participants We surveyed 2,099 males and 2,747 females aged 60 years or older. Measurements Sarcopenia was defined as an appendicular skeletal muscle mass divided by body weight (ASM/Wt) that was <1 SD below the gender-specific mean for young adults. Obesity was defined as a body mass index (BMI) ≥25 kg/m2. Subjects were divided into four groups based on presence or absence of obesity or sarcopenia. Hypertension was defined as a systolic BP (SBP) ≥140 mmHg, a diastolic BP (DBP) ≥90 mmHg, or a self-reported current use of antihypertensive medications. Results The overall prevalence of hypertension in the four groups was as follows 49.7% for non-obese non-sarcopenia, 60.9% for non-obese sarcopenia, 66.2% for obese non-sarcopenia and 74.7% for obese sarcopenia. After adjustment for age, gender, regular activity, current smoking and alcohol use, the odds ratio (OR) for having hypertension was 1.5 (95% confidence interval (CI) = 1.23–1.84) in subjects in the non-obese sarcopenia group, 2.08 (95% CI = 1.68–2.57) in the obese non-sarcopenia group and 3.0 (95% CI = 2.48–3.63) in the obese sarcopenia group, compared with the non-obese non-sarcopenia group (p for trend <0.001). Controlling further for body weight and waist circumference did not change the association between hypertension and sarcopenia. The association between sarcopenia and hypertension was more robust in the subjects with diabetes mellitus. Conclusion Body composition beyond BMI has a considerable impact on hypertension in elderly Koreans. Subjects with sarcopenic obesity appear to have a greater risk of hypertension than simply obese or sarcopenia subjects.
Changes in Serum Levels of Bone Morphogenic Protein 4 and Inflammatory Cytokines after Bariatric Surgery in Severely Obese Korean Patients with Type 2 Diabetes
Mee Kyoung Kim,Eun-Hee Jang,Oak-Kee Hong,Hyun-Ji Chun,Soon-Jib Yoo,Ki-Hyun Baek,Wook Kim,Eung Kook Kim,Ki-Ho Song,Hyuk-Sang Kwon
International Journal of Endocrinology , 2013, DOI: 10.1155/2013/681205
Abstract: Serum bone morphogenic protein- (BMP-) 4 levels are associated with human adiposity. The aim of this study was to investigate changes in serum levels of BMP-4 and inflammatory cytokines after Roux-en-Y gastric bypass (RYGB). Fifty-seven patients with type 2 diabetes underwent RYGB. Serum levels of BMP-4 and various inflammatory markers, including high-sensitivity C-reactive protein (hsCRP), free fatty acids (FFAs), and plasminogen activator inhibitor- (PAI-) 1, were measured before and 12 months after RYGB. Remission was defined as glycated hemoglobin <6.5% for at least 1 year in the absence of medications. Levels of PAI-1, hsCRP, and FFAs were significantly decreased at 1 year after RYGB. BMP-4 levels were also significantly lower at 1 year after RYGB than at baseline ( ). Of the 57 patients, 40 (70%) had diabetes remission at 1 year after surgery (remission group). Compared with patients in the nonremission group, patients in the remission group had lower PAI-1 levels and smaller visceral fat areas at baseline. There was a difference in the change in the BMP-4 level according to remission status. Our data demonstrate a significant beneficial effect of bariatric surgery on established cardiovascular risk factors and a reduction in chronic nonspecific inflammation after surgery. 1. Introduction Bone morphogenic proteins (BMPs) are members of the transforming growth factor-β superfamily. Although they were originally identified as bone-inducing proteins, the activities of BMPs are not restricted to bone formation [1]. Recent data indicate that BMP-4 induces the differentiation of white fat, the predominant type of adipose tissue [2]. Exposing pluripotent 10T1/2 cells to exogenous BMP-4 induces adipocyte lineage commitment [3]. Adipocyte precursor cells (APCs) derived from subcutaneous fat differentiate well in the presence of classical induction cocktail, whereas those from visceral fat differentiate poorly but can be induced to differentiate by addition of BMP-4 [4]. Activation of BMP-4 signaling may be associated with increased adiposity in humans [3]. It is still unclear whether BMP-4 acts via an endocrine mechanism or an autocrine pathway and whether cellular expression of BMP-4 reflects circulating blood levels of BMP-4 [5]. Recently, we showed that serum BMP-4 levels are associated with human adiposity, insulin resistance, and metabolic syndrome in nondiabetic subjects [6]. However, no studies have investigated the changes in BMP-4 levels in severely obese patients with type 2 diabetes after bariatric surgery. Adipose tissue is suggested to
Predicting the Development of Diabetes Using the Product of Triglycerides and Glucose: The Chungju Metabolic Disease Cohort (CMC) Study
Seung-Hwan Lee, Hyuk-Sang Kwon, Yong-Moon Park, Hee-Sung Ha, Seung Hee Jeong, Hae Kyung Yang, Jin-Hee Lee, Hyeon-Woo Yim, Moo-Il Kang, Won-Chul Lee, Ho-Young Son, Kun-Ho Yoon
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0090430
Abstract: Background To determine whether the TyG index, a product of the levels of triglycerides and fasting plasma glucose (FPG) might be a valuable marker for predicting future diabetes. Methods A total of 5,354 nondiabetic subjects who had completed their follow-up visit for evaluating diabetes status were selected from a large cohort of middle-aged Koreans in the Chungju Metabolic Disease Cohort study. The risk of diabetes was assessed according to the baseline TyG index, calculated as ln[fasting triglycerides (mg/dL) × FPG (mg/dL)/2]. The median follow-up period was 4.6 years. Results During the follow-up period, 420 subjects (7.8%) developed diabetes. The baseline values of the TyG index were significantly higher in these subjects compared with nondiabetic subjects (8.9±0.6 vs. 8.6±0.6; P<0.0001) and the incidence of diabetes increased in proportion to TyG index quartiles. After adjusting for age, gender, body mass index, waist circumference, systolic blood pressure, high-density lipoprotein (HDL)-cholesterol level, a family history of diabetes, smoking, alcohol drinking, education level and serum insulin level, the risk of diabetes onset was more than fourfold higher in the highest vs. the lowest quartile of the TyG index (relative risk, 4.095; 95% CI, 2.701–6.207). The predictive power of the TyG index was better than the triglyceride/HDL-cholesterol ratio or the homeostasis model assessment of insulin resistance. Conclusions The TyG index, a simple measure reflecting insulin resistance, might be useful in identifying individuals at high risk of developing diabetes.
Large cavernous hemangioma in the cecum treated by laparoscopic ileocecal resection
Jung Wook Huh, Sang Hyuk Cho, Jae Hyuk Lee, Hyeong Rok Kim
World Journal of Gastroenterology , 2009,
Abstract: A cavernous hemangioma of the cecum is a rare vascular malformation but is clinically important because of the possibility of massive bleeding. We report a case of a large cavernous hemangioma with pericolic infiltration in the cecum which was removed successfully using minimally invasive surgery.
The Effects of Propionate and Valerate on Insulin Responsiveness for Glucose Uptake in 3T3-L1 Adipocytes and C2C12 Myotubes via G Protein-Coupled Receptor 41
Joo-Hui Han, In-Su Kim, Sang-Hyuk Jung, Sang-Gil Lee, Hwa-Young Son, Chang-Seon Myung
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095268
Abstract: Since insulin resistance can lead to hyperglycemia, improving glucose uptake into target tissues is critical for regulating blood glucose levels. Among the free fatty acid receptor (FFAR) family of G protein-coupled receptors, GPR41 is known to be the Gαi/o-coupled receptor for short-chain fatty acids (SCFAs) such as propionic acid (C3) and valeric acid (C5). This study aimed to investigate the role of GPR41 in modulating basal and insulin-stimulated glucose uptake in insulin-sensitive cells including adipocytes and skeletal muscle cells. Expression of GPR41 mRNA and protein was increased with maximal expression at differentiation day 8 for 3T3-L1 adipocytes and day 6 for C2C12 myotubes. GPR41 protein was also expressed in adipose tissues and skeletal muscle. After analyzing dose-response relationship, 300 μM propionic acid or 500 μM valeric acid for 30 min incubation was used for the measurement of glucose uptake. Both propionic acid and valeric acid increased insulin-stimulated glucose uptake in 3T3-L1 adipocyte, which did not occur in cells transfected with siRNA for GPR41 (siGPR41). In C2C12 myotubes, these SCFAs increased basal glucose uptake, but did not potentiate insulin-stimulated glucose uptake, and siGPR41 treatment reduced valerate-stimulated basal glucose uptake. Therefore, these findings indicate that GPR41 plays a role in insulin responsiveness enhanced by both propionic and valeric acids on glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes, and in valerate-induced increase in basal glucose uptake in C2C12 myotubes.
A Nanopore Structured High Performance Toluene Gas Sensor Made by Nanoimprinting Method
Kwang-Su Kim,Woon-Hyuk Baek,Jung-Min Kim,Tae-Sik Yoon,Hyun Ho Lee,Chi Jung Kang,Yong-Sang Kim
Sensors , 2010, DOI: 10.3390/s100100765
Abstract: Toluene gas was successfully measured at room temperature using a device microfabricated by a nanoimprinting method. A highly uniform nanoporous thin film was produced with a dense array of titania (TiO2) pores with a diameter of 70~80 nm using this method. This thin film had a Pd/TiO2 nanoporous/SiO2/Si MIS layered structure with Pd-TiO2 as the catalytic sensing layer. The nanoimprinting method was useful in expanding the TiO2 surface area by about 30%, as confirmed using AFM and SEM imaging. The measured toluene concentrations ranged from 50 ppm to 200 ppm. The toluene was easily detected by changing the Pd/TiO2 interface work function, resulting in a change in the I-V characteristics.
Analysis of Skin Humidity Variation Between Sasang Types
Soon-Oh Jung,Soo-Jin Park,Han Chae,Soo Hyun Park,Minwoo Hwang,Sang-Hyuk Kim,Young-Kyu Kwon
Evidence-Based Complementary and Alternative Medicine , 2009, DOI: 10.1093/ecam/nep087
Abstract: The purpose of this study was to examine the relationship between variations in skin humidity (SH) induced by perspiration across Sasang types and to identify novel and effective Sasang classification factors. We also analyzed the responses of each Sasang type to sweating-related QSCC II items. The results revealed a significant difference in SH across gender and significant differences in SH before and after perspiration between Tae-Eum and So-Eum men. In addition, Tae-Eum women showed significant differences in SH compared with women classified as another Sasang type. Furthermore, evaluation of the items related to sweating in the QSCC II and their relationship to each constitution revealed a significant difference between Tae-Eum and other Sasang types. Overall, the results of this study indicate that there is a distinct SH difference following perspiration between Tae-Eum and other Sasang types. Such findings may aid in Sasang typology diagnostic testing with the support of further sophisticated clinical studies.
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