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Search Results: 1 - 10 of 596 matches for " Hypertrophy "
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Morton’s Neuroma; Surgical Exploration Is an Option in Symptomatic Patients with Normal Investigation  [PDF]
Syed Mohsin Ali, Mujtaba Ahmed Siddiqi
Open Journal of Orthopedics (OJO) , 2018, DOI: 10.4236/ojo.2018.811042
Abstract: Morton neuroma is well described problem to metatarsophalangeal Joint (MTPJ) Etiology of Morton’s Neuroma which has wide range of problems from trauma, and nerve hypertrophy etc. Clinical evaluation is very important for diagnosis and sometimes investigations like ultrasound or MRI scan are helpful for conformation of diagnosis. Management varies from orthotics, shoe modification, injections or surgical excision. We are reporting a case which showed importance of surgical exploration when investigation is normal and difficulty in making diagnosis clinically.
Interplay of histone acetylation and transcription factors in cardiac hypertrophy
Ramachandran GR,Qureshi SF,Anantapur V, Nallari P
International Journal of Biological and Medical Research , 2011,
Abstract: Adult cardiac disease is the most frequent cause of mortality in the western world where death, as a result of heart failure, is more prevalent than all disorders combined. Heart failure can be defined as a deficiency in the ability of the heart to pump an adequate supply of blood around the body which can be exemplified by cardiomyopathies. Hypertrophic Cardiomyopathy results due to pathological thickening of the heart muscles(sarcomeres replicate) /cardiac hypertrophy. Several(around 600) mutations have been identified in sarcomeric as well as other modifier genes that precipitate Hypertrophic cardiomyopathy. Our lab has also identified several novel mutations in the sarcomeric genes in the Indian population which could correlate to the epigenetics of the genes.Epigenetic changes like histone acetylation and DNA methylation are transient and involves no base changes. Recently , multiple transcriptional pathways have been identified involved in cardiac hypertrophy along with epigenetic modifications . Here we have tried to concentrate upon the role of histone acetylation and associated transcription factors in cardiac hypertrophy with respect to Hypertrophic Cardiomyopathy for the identification of therapeutic targets in molecular pathways . We hypothesise that apart from the pathways reviewed below, several others are yet to be unearthed for a greater understanding. Of special interest is the fact that reactivation of fetal genes leads to cardiac hypertrophy which is possible due to the interplay of transcription factors and histone acetyl transferase/histone deacetylases . Also, the pathways are highly complex since some classes of HDAC promote hypertrophy while others repress . Several therapeutic targets have been identified and many drugs against HCM are in variable stages of clinical trials with respect to histone deacetylases and transcription factors.
An analysis of electrocardiographic criteria for determining left ventricular hypertrophy
Gasperin, Carlos Alberto;Germiniani, Helio;Facin, Carlos Roberto;Souza, Admar Moraes de;Cunha, Cláudio Leinig Pereira da;
Arquivos Brasileiros de Cardiologia , 2002, DOI: 10.1590/S0066-782X2002000100006
Abstract: objective: to determine the most sensitive criterion for the detection of left ventricular hypertrophy according to echocardiographically defined left ventricular mass. methods: the sokolow-lyon voltage, sokolow-lyon-rappaport, cornell voltage duration product, white-bock, and romhilt-estes point scoring criteria were compared with left ventricular mass index, corrected for body surface, obtained from the echocardiograms of 306 outpatients (176 females, 130 males), of all age groups. results: the cornell voltage duration product criteria index had the greatest sensitivity in women (54.90%), and the sokolow-lyon-rappaport index was most sensitive in men (73.53%). when applied to men at the same voltage amplitude (20mm) as that in women, the cornell index showed increased sensitivity relative to the conventional index (28mm) of 67.65% (p£0.01) and a sensitivity similar to that of the sokolow-lyon-rappaport index, with higher specificity (p£0.01). the white-bock and romhilt-estes criteria were the least sensitive in men and women, despite their high specificity. the electrocardiographic criteria were more efficient when dilatation predominated over left ventricular hypertrophy. conclusion: the cornell index had greater sensitivity in women, and the sokolow-lyon-rappaport index was more sensitive in men. when applied to men at the same voltage amplitude as that of women, the cornell index had an increase in sensitivity similar to that of the sokolow-lyon-rappaport index.
An analysis of electrocardiographic criteria for determining left ventricular hypertrophy
Gasperin Carlos Alberto,Germiniani Helio,Facin Carlos Roberto,Souza Admar Moraes de
Arquivos Brasileiros de Cardiologia , 2002,
Abstract: OBJECTIVE: To determine the most sensitive criterion for the detection of left ventricular hypertrophy according to echocardiographically defined left ventricular mass. METHODS: The Sokolow-Lyon voltage, Sokolow-Lyon-Rappaport, Cornell voltage duration product, White-Bock, and Romhilt-Estes point scoring criteria were compared with left ventricular mass index, corrected for body surface, obtained from the echocardiograms of 306 outpatients (176 females, 130 males), of all age groups. RESULTS: The Cornell voltage duration product criteria index had the greatest sensitivity in women (54.90%), and the Sokolow-Lyon-Rappaport index was most sensitive in men (73.53%). When applied to men at the same voltage amplitude (20mm) as that in women, the Cornell index showed increased sensitivity relative to the conventional index (28mm) of 67.65% (P<=0.01) and a sensitivity similar to that of the Sokolow-Lyon-Rappaport index, with higher specificity (P<=0.01). The White-Bock and Romhilt-Estes criteria were the least sensitive in men and women, despite their high specificity. The electrocardiographic criteria were more efficient when dilatation predominated over left ventricular hypertrophy. CONCLUSION: The Cornell index had greater sensitivity in women, and the Sokolow-Lyon-Rappaport index was more sensitive in men. When applied to men at the same voltage amplitude as that of women, the Cornell index had an increase in sensitivity similar to that of the Sokolow-Lyon-Rappaport index.
Apical Right Ventricular Hypertrophic Cardiomyopathy—A Case Report  [PDF]
Ramachandran Muthiah
Case Reports in Clinical Medicine (CRCM) , 2016, DOI: 10.4236/crcm.2016.52010
Abstract: A relatively infrequent form of hypertrophic cardiomyopathy is the isolated apical variant and it is more common in oriental people, especially in the Japanese. It contributes 25% of cases of hypertrophic cardiomyopathy in Japan but only 1% to 2% in the non-Japanese population. It may occasionally present in the elderly and classically involve the apex of the left ventricle. An isolated apical right ventricular involvement had been detected in an elderly female by transthoracic two-dimensional echocardiographic imaging.
Distribution of cardiac geometric patterns on echocardiography in essential hypertension. Impact of two criteria of stratification
Rosa, Eduardo Cantoni;Moisés, Valdir Ambrósio;Sesso, Ricardo Cintra;Kohlmann, Nárcia E. B.;Plavnik, Frida Liane;Zanella, Maria Teresa;Ribeiro, Artur Beltrame;Kohlmann Júnior, Osvaldo;
Arquivos Brasileiros de Cardiologia , 2001, DOI: 10.1590/S0066-782X2001000500002
Abstract: purpose: to evaluate 2 left ventricular mass index (lvmi) normality criteria for the prevalence of left ventricular geometric patterns in a hypertensive population ( ht ) . methods: 544 essential hypertensive patients, were evaluated by echocardiography, and different left ventricular hypertrophy criteria were applied: 1 - classic : men - 134 g/m2 and women - 110 g/m2 ; 2- obtained from the 95th percentil of lvmi from a normotensive population (nt). results: the prevalence of 4 left ventricular geometric patterns, respectively for criteria 1 and 2, were: normal geometry - 47.7% and 39.3%; concentric remodelying - 25.4% and 14.3%; concentric hypertrophy - 18.4% and 27.7% and excentric hypertrophy - 8.8% and 16.7%, which confered abnormal geometry to 52.6% and 60.7% of hypertensive. the comparative analysis between nt and normal geometry hypertensive group according to criteria 1, detected significative stuctural differences,"( *p < 0.05):lvmi- 78.4 ± 1.50 vs 85.9 ±0.95 g/m2 *; posterior wall thickness -8.5 ± 0.1 vs 8.9 ± 0.05 mm*; left atrium - 33.3 ± 0.41 vs 34.7 ± 0.30 mm *. with criteria 2, significative structural differences between the 2 groups were not observed. conclusion: the use of a reference population based criteria, increased the abnormal left ventricular geometry prevalence in hypertensive patients and seemed more appropriate for left ventricular hypertrophy detection and risk stratification.
Distribution of cardiac geometric patterns on echocardiography in essential hypertension. Impact of two criteria of stratification
Rosa Eduardo Cantoni,Moisés Valdir Ambrósio,Sesso Ricardo Cintra,Kohlmann Nárcia E. B.
Arquivos Brasileiros de Cardiologia , 2001,
Abstract: PURPOSE: To evaluate 2 left ventricular mass index (LVMI) normality criteria for the prevalence of left ventricular geometric patterns in a hypertensive population ( HT ) . METHODS: 544 essential hypertensive patients, were evaluated by echocardiography, and different left ventricular hypertrophy criteria were applied: 1 - classic : men - 134 g/m2 and women - 110 g/m2 ; 2- obtained from the 95th percentil of LVMI from a normotensive population (NT). RESULTS: The prevalence of 4 left ventricular geometric patterns, respectively for criteria 1 and 2, were: normal geometry - 47.7% and 39.3%; concentric remodelying - 25.4% and 14.3%; concentric hypertrophy - 18.4% and 27.7% and excentric hypertrophy - 8.8% and 16.7%, which confered abnormal geometry to 52.6% and 60.7% of hypertensive. The comparative analysis between NT and normal geometry hypertensive group according to criteria 1, detected significative stuctural differences,"( *p < 0.05):LVMI- 78.4 ± 1.50 vs 85.9 ±0.95 g/m2 *; posterior wall thickness -8.5 ± 0.1 vs 8.9 ± 0.05 mm*; left atrium - 33.3 ± 0.41 vs 34.7 ± 0.30 mm *. With criteria 2, significative structural differences between the 2 groups were not observed. CONCLUSION: The use of a reference population based criteria, increased the abnormal left ventricular geometry prevalence in hypertensive patients and seemed more appropriate for left ventricular hypertrophy detection and risk stratification.
Aortic Stenosis and Stressed Heart Morphology  [PDF]
Celalettin Karatepe, Fatih Yal?in
World Journal of Cardiovascular Surgery (WJCS) , 2014, DOI: 10.4236/wjcs.2014.49022
Abstract: Myocardial geometric remodeling is a response to increased stress which includes increased afterload situations during clinical conditions. In this review, we have focused on early and late geometric features in aortic stenosis, importance of recognition of these findings and consequences due to progression of valve disease. We have also pointed out the similarities in early focal and global myocardial geometric remodeling in acute and chronic conditions as hypertension and acute stress cardiomypathy which are associated with myocardial functional and geometric response to acute or chronic stress exposure and relevant increased afterload. In aortic stenosis, target organ involvement in disease progression has been evaluated and discussed in the report. In addition to quantitative evaluation of valve disease, importance of myocardial involvement and global assessment of patients with aortic stenosis also have been mentioned in the report. Finally, we have discussed the importance of global myocardial geometric changes and timing for surgery before development of heart failure in this specific group of patients.
Enalaprilato na preven??o da hipertrofia ventricular esquerda induzida pelo isoproterenol
Costa, Eduardo A. S.;Luna Fo, Bráulio;Póvoa, Rui;Ferreira Fo, Celso;Murad, Neif;Ferreira, Marcelo;Ferreira, Celso;
Arquivos Brasileiros de Cardiologia , 1997, DOI: 10.1590/S0066-782X1997000700006
Abstract: purpose: to evaluate whether the enalaprilat, angiotensin i enzyme conversion inhibitor, could prevent the left ventricular hypertrophy (lvh) induced by isoproterenol. methods: seventy two adult wistar-epm rats were divided into four groups: con, control; ena, treated with enalaprilat (1mg/kg via subcutaneous (sc) for 8 days); iso, treated with isoproterenol (0.3mg via sc for 8 days) e ena+iso, treated with both drugs simultaneously. each group had the arterial blood pressure, cardiac rate and the left ventricle (lv) weight determined in 10 animals. in 8 animals from each group a small sample was taken from the lv and stained with hematoxyline-eosine and picrosirius for morphometric and ultra-structural studies with optic and transmission electronic microscopy. results: the iso group showed that the lv weight increased 47% in comparison with control. on the other hand the ena+iso group showed only 22.1% increase (p<0.05). the morphometric and ultra-structural analyses revealed that isoproterenol induced cardiomyocite hypertrophy and augmented the content of the type i collagen in the cardiac interstitium. conclusion: enalaprilat inhibited the isoproterenol action on the cardiomyocite, avoiding partially the lvh and decreasing the content of collagen fibers.
A administra??o de nandrolona n?o promove hipertrofia do músculo sóleo em ratos
Cunha, Tatiana S.;Tanno, Ana Paula;Marcondes, Fernanda K.;Perez, Sérgio E.A.;Selistre-Araújo, Heloisa S.;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2006, DOI: 10.1590/S0004-27302006000300017
Abstract: anabolic androgenic steroids (aas) are compounds formed from testosterone or one of its derivatives, which are largely used by amateur e professional athletes to improve the athletic performance. however, the scientific information about the relation between the use of aas and muscle hypertrophy is controversial. the aim of this study was to evaluate the effects of testosterone and physical training on muscle hypertrophy. male wistar rats received i.m. injections of deca-durabolin? or vehicle during 6 weeks. trained rats were submitted to a resistance physical training, by jumping up and down in water carrying an overload. sedentary and trained animals were anesthetized and sacrificed. soleus muscle was removed for the quantification of total protein and dna concentration. in the end of the treatment, body weight of trained animals treated with vehicle or aas was lower than the body weight of respective sedentary. total protein concentration and the ratio muscle weight/body weight of all experimental groups were not altered. trained group treated with aas presented lower dna concentration than trained group treated with vehicle. the administration of nandrolone decanoate did not promote hypertrophy on soleus muscle, not even when the use of aas was associated to resistance physical training.
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