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Search Results: 1 - 10 of 4713 matches for " Hyoung Shin "
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Chemotherapeutic Effect of Withaferin A in Human Oral Cancer Cells  [PDF]
In-Hyoung Yang, Lee-Han Kim, Ji-Ae Shin, Sung-Dae Cho
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.68080
Abstract: Withaferin A (WA) is a bioactive compound derived from a medicinal plant Withania somnifera and has potential therapeutic effects against various types of cancers. The purpose of this study is to investigate an apoptotic effect of WA and identify its molecular target in HSC-3 and HSC-4 human oral cancer cell lines using Trypan blue exclusion assay, DAPI staining and western blotting. WA inhibited cell viability and induced apoptosis in a concentration- or time-dependent manner, as evidenced by induction of nuclear condensation and fragmentation, activation of caspase 3 and poly (ADP-ribose) polymerase (PARP) cleavage. WA-induced apoptosis was partly diminished by Z-VAD, a pancaspase inhibitor. WA also increased Bim and Bax protein in HSC-3 and HSC-4 cells, respectively. These results suggest that WA may be a potential chemotherapeutic drug candidate against human oral cancer.
Density functional study of orbital-selective magnetism in FeAs-based superconductors
Hyungju Oh,Donghan Shin,Hyoung Joon Choi
Physics , 2010,
Abstract: We performed spin-polarized density functional calculations of lanthanide-series (Ln) iron oxypnictides LnFeAsO (Ln=La, Ce, Pr, Nd, Sm, and Gd) with constrained Fe magnetic moments, finding that in-plane dxy and out-of-plane dyz orbital characters are preferred for small Fe magnetic moments. Comparison of LnFeAsO compounds shows that the antiferromagnetism (AFM) from the Fe dxy orbital is itinerantly driven by orbital-dependent Fermi-surface nesting while AFM from the Fe dyz orbital is driven by superexchange mechanism. The Fe magnetic moments of the two orbital characters show different coupling strengths to Fermi-surface electrons orbital-selectively, suggesting that they may play different roles in superconductivity and in AFM, and making d orbital characters of the magnetic moment resolvable by measuring the electronic structures.
Systematic Approach for Scheduling of Tasks and Messages under Noise Environment
Hyoung Yuk Kim,Hye Min Shin,Hong Seong Park
Journal of Systemics, Cybernetics and Informatics , 2003,
Abstract: High degree of EMI (Electro-Magnetic Interference) or noise is generated in the plant environment, where control systems consist of smart sensors, smart actuators, and controllers connected via a fieldbus. The noise generated by some devices such as high-power motors may cause communication errors and delay the successful transmission of data. Therefore, the noise condition is one of the important parameters considered in the design of a reliable network-based control system. This paper presents the scheduling method of task and message to guarantee the given end-to-end constraints under noise environments. The presented scheduling method is applied to an example of a control system that uses CAN (Controller Area Network), considering two kinds of noise models. The comparison results for each noise condition shows the importance of considering the noise condition in system design. System designers are able to design the control system, guaranteeing its requirements under a noise environment by using the proposed scheduling method.
Acupuncture for Spinal Cord Injury and Its Complications: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
In Heo,Byung-Cheul Shin,Young-Dae Kim,Eui-Hyoung Hwang
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/364216
Brief review on iron-based superconductors: are there clues for unconventional superconductivity?
Hyungju Oh,Jisoo Moon,Donghan Shin,Chang-Youn Moon,Hyoung Joon Choi
Physics , 2011,
Abstract: Study of superconductivity in layered iron-based materials was initiated in 2006 by Hosono's group, and boosted in 2008 by the superconducting transition temperature, Tc, of 26 K in LaFeAsO1-xFx. Since then, enormous researches have been done on the materials, with Tc reaching as high as 55 K. Here, we review briefly experimental and theoretical results on atomic and electronic structures and magnetic and superconducting properties of FeAs-based superconductors and related compounds. We seek for clues for unconventional superconductivity in the materials.
Development of Micro-Heaters with Optimized Temperature Compensation Design for Gas Sensors
Woo-Jin Hwang,Kyu-Sik Shin,Ji-Hyoung Roh,Dae-Sung Lee,Sung-Hoon Choa
Sensors , 2011, DOI: 10.3390/s110302580
Abstract: One of the key components of a chemical gas sensor is a MEMS micro-heater. Micro-heaters are used in both semiconductor gas sensors and NDIR gas sensors; however they each require different heat dissipation characteristics. For the semiconductor gas sensors, a uniform temperature is required over a wide area of the heater. On the other hand, for the NDIR gas sensor, the micro-heater needs high levels of infrared radiation in order to increase sensitivity. In this study, a novel design of a poly-Si micro-heater is proposed to improve the uniformity of heat dissipation on the heating plate. Temperature uniformity of the micro-heater is achieved by compensating for the variation in power consumption around the perimeter of the heater. With the power compensated design, the uniform heating area is increased by 2.5 times and the average temperature goes up by 40?°C. Therefore, this power compensated micro-heater design is suitable for a semiconductor gas sensor. Meanwhile, the poly-Si micro-heater without compensation shows a higher level of infrared radiation under equal power consumption conditions. This indicates that the micro-heater without compensation is more suitable for a NDIR gas sensor. Furthermore, the micro-heater shows a short response time of less than 20ms, indicating a very high efficiency of pulse driving.
Replication of the genetic effects of IFN regulatory factor 5 (IRF5) on systemic lupus erythematosus in a Korean population
Hyoung Shin, Yoon-Kyoung Sung, Chan-Bum Choi, Soo Lee, Hye Lee, Sang-Cheol Bae
Arthritis Research & Therapy , 2007, DOI: 10.1186/ar2152
Abstract: Recently, two studies provided convincing evidence that IFN regulatory factor 5 (IRF5 [MIM 607218]) gene polymorphisms are significantly associated with systemic lupus erythematosus (SLE [MIM 152700]). The studies included – seven independent SLE cohorts from white populations (Sweden-1, Finland, Iceland, USA, Spain, Sweden-2 and Argentina) and involved both family-based and case-control cohorts [1,2]. In both studies, the dbSNP rs2004640 (T > G) of IRF5 showed strong associations with the risk of SLE, for example higher frequencies in SLE cases than controls (combined analysis, 61% in SLE cases versus 51% in controls; P = 4.2 × 10-21). Graham and colleagues, through further experiments in the later study, also identified a common (frequency, 50.0% in white populations) IRF5 haplotype that has both a splice donor site, which allows expression of multiple IRF5 isoforms containing exon 1B, and a separate genetic effect associated with elevated levels of expression of IRF5 [1]. To replicate the association with SLE in an Asian population, we examined the genetic effects in our SLE cohort from a Korean population.A total of 593 Korean SLE patients (mean age, 32.36 (6.99–70.7); male = 35 and female = 558) who fulfilled the 1997 American College of Rheumatology (ACR) criteria for SLE [3] were consecutively enrolled between September 1998 and February 2005 at the Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea. The following clinical and laboratory data were obtained: sex, age, ages at onset of first symptom and clinical diagnosis, ACR diagnosis, and Systemic Lupus International Collaborating Clinics (SLICC)/ACR damage index [4]. As a control group, we included 971 healthy, ethnic-matched subjects (mean age, 37.2 (16.6–78.6); male = 139 and female = 832).Four SNPs (rs729302 (A > C), rs2004640 (G > T), rs752637 (T > C) and rs2280714 (T > C)) were genotyped, using the TaqMan? (Applied Biosystems, Foster City, CA, USA) method [5], in our SLE cases and contro
LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells
Jung-Young Shin, Jeong-Oh Kim, Suk Lee, Hiun-Suk Chae, Jin-Hyoung Kang
BMC Cancer , 2010, DOI: 10.1186/1471-2407-10-425
Abstract: After single treatment and sequential combination of 5-FU and LY, cytotoxic activity was measured by MTS assay. When 5-FU and LY were treated in single and sequential combinations, the expression of p-AKT, p-NFkB, p-p53 and bcl-2 was observed on different concentrations by Western blot analysis. We also investigated the effect on apoptosis and cell cycle distribution using flow cytometry. The LMP2A siRNA inhibition was done to confirm the reversal of decreased 5-FU activity and p-AKT.When 5-FU was sequentially combined with LY, the combination index (CI) value indicated synergistic anti-proliferative effect. The expression of p-AKT and p-NFκB was upregulated by 5-FU alone but sequential treatment of 5-FU and LY decreased the expression of both p-AKT and p-NFκB. When 5-FU was combined with LY, G0/G1 and sub G1 cell population (%) increased. When 5-FU was added to the cells transfected with LMP2A siRNA, its anti-proliferative effect increased and the expression of p-AKT decreased. In sequential combination of 5-FU and LY, the expression of p-p53 was increased and bcl-2 expression was diminished compared to 5-FU alone.These data suggest that sequential combination of 5-FU and LY induce synergistic cytotoxicity and overcome intrinsic and acquired resistance of 5-FU via downregulation of activated p-AKT and mitochondria-dependent apoptosis in EBV gastric cancer cell line, SNU-719.The worldwide incidence of gastric adenocarcinoma is estimated to exceed 75,000 cases/year, and recent studies have shown that Epstein-Barr virus (EBV) is associated with 10%-18% of gastric cancers. In Korea, EBV-positive cells are found in 7%-10% of gastric cancers and the occurrence of EBV-positive gastric cancers is estimated to be around 4,500-6,400 cases/year based on the fact that gastric cancer has the highest incidence of all cancers.EBV not only causes infectious mononucleosis, but is also a herpes virus with oncogenic potential, giving rise to Burkitt's lymphoma, nasopharyngeal carcino
Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations
Seongwon Cha, Imhoi Koo, Sun Choi, Byung Park, Kil Kim, Jae-Ryong Kim, Hyoung Shin, Jong Kim
BMC Medical Genetics , 2009, DOI: 10.1186/1471-2350-10-96
Abstract: The rs7566605 polymorphism was genotyped with 2,364 Koreans, and associations with obesity- and cholesterol-related traits were analyzed statistically via an ANOVA or T-test.Replication of an association with BMI, WHR, fat mass, fat percent, and abdominal fat area failed, and the C allele of rs7566605 was not associated significantly with total cholesterol, HDL cholesterol, or triglyceride. However, it was found in a meta-analysis of a dominant model that the C allele of rs7566605 appeared to affect the level of the total cholesterol, especially in female subjects.We failed to show associations of rs7566605 with cholesterol- and obesity-related phenotypes, although we newly suggest the possible involvement of INSIG2 with the plasma level of the total cholesterol in women.INSIG2 is considered to be a candidate gene with respect to involvement in the development of obesity. A common variant located 10 kb upstream of the gene, rs7566605, was found to be associated with BMI in a recent genome-wide association study [1]. This association has been suitably replicated in several white [1-3], African-American [1], and Asian populations [4-6]. However, the SNP did not have a genetic effect on obesity according to other studies including white [2,7-14], Afro-Caribbean [12], and Asian populations [15-17]. Hence, the INSIG2 polymorphism may have an important effect in overweight populations under certain environmental circumstances, given several positive associations found in studies of overweight subjects [3,4].INSIG2 has attracted the attention of researchers due to its role in cholesterol metabolism [18]. The protein is known to reside in the endoplasmic reticulum, where it binds to SCAP to inhibit it from convoying SREBPs to the Golgi apparatus [18]. Eventually, INSIG2 prevents SREBP from activating cholesterol synthesis because SREBP cannot be processed and activated by the Golgi enzymes. These actions of INSIG2 were also reported in subsequent research involving mice [18
The efficacy and safety study of dietary supplement PURIAM110 on non-insulin taking Korean adults in the stage of pre-diabetes and diabetes mellitus: protocol for a randomized, double-blind, placebo-controlled, and multicenter trial-pilot study
Sunju Park, Jeong-Su Park, Hoyeon Go, Bo-Hyoung Jang, Yongcheol Shin, Seong-Gyu Ko
Trials , 2011, DOI: 10.1186/1745-6215-12-38
Abstract: The efficacy and safety study of PURIAM110 is a double-blinded, placebo-controlled, randomized, and multi-center clinical trial. A total of 45 subjects will participate in this study for 6 weeks.The present protocol will confirm the efficacy and safety of PURIAM110 for pre-diabetes, suggesting more basic knowledge to conduct further randomized controlled trials (RCT). In addition, PURIAM110 can be an alternative dietary supplemental remedy for diabetes patients.ISRCTN: ISRCTN44779824Pre-diabetes is a condition of potential diabetes mellitus with an increased risk of developing type 2 diabetes [1,2]. In other words, it is a state of either impaired fasting glucose (IFG) or impaired glucose tolerance (IGT). Pre-diabetes is asymptomatic in many occasions, but once it develops into type 2 diabetes, it makes patients suffer from polydipsia, polyuria, polyphasia, unusual weight loss, and extreme fatigue [3]. Unmanaged chronic diabetes mellitus affects quality of life and induces life-threatening diabetes-associated complications [4,5]. Its mortality rate cannot be ignored in Korea, becoming the fourth leading cause of death by 2030 [6]. According to the Korean National Health and Nutrition Survey (KNHNS) 2001, prevalence rates of diabetes were 1.4 million (8.1%) in Korean men and 1.3 million (7.5%) in Korean women. Nowadays, it is reported that about 308 million people worldwide are having impaired glucose tolerance (IGT) and among them 25% to 75% will develop diabetes [7,8]. Since the exact figures of Korean pre-diabetes patients and diabetes progressing rates were not reported [4], we can deduce from the above numerical statement that a considerable population must be at the status of potential diabetes. Socioeconomic expenditures are also high, at 193 million won per year for medication [4,9]. Therefore, preventing and treating efforts for the non-insulin taking patients in the stage of pre-diabetes and diabetes are urgently needed to lift the burden from both the nati
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