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Search Results: 1 - 10 of 9572 matches for " Hyo-Jung Choi "
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General Guide for Korean Acupuncture & Moxibustion  [PDF]
Hyo-Jung Kwon, Yong-Suk Kim
Open Journal of Immunology (OJI) , 2015, DOI: 10.4236/oji.2015.53010
Abstract: As ancient Korean and Chinese dynasties held close relationships in politics and culture throughout history, the medicine of the two nations were developed in mutual influence. For instance, the current version of Lingshu, the second half of the Huangdineijing, was transcribed from The Bible of Acupuncture, which was brought to the Chinese Song dynasty from the Korean Koryo dynasty in 1092. While maintained a close relationship with traditional Chinese medicine, Korean medicine had continued to develop unique systems on its own over the history and established typical types of acupuncture methods, which are different from those of traditional Chinese medicine [1]. In the 17th century, a royal physician by the name of Dr. Heo Jun wrote Donguibogam, the first encyclopedia of Korean medicine in Korea. It remained to be a book of instruction for Korean Medicine Doctors. Another book called Donguisusebowon was published in 1901 on the basis of the theory of four constitutions by Dr. Lee Je-Ma at the end of the Chosun dynasty [2]. There were two other representative Korean acupuncture methods: Saam acupuncture and Constitutional acupuncture (Taeguek acupuncture). Theories of Korean acupuncture applied a summarized framework for each individual to diagnose a physical condition, explaining the biologic phenomena within the concept of constitutional medicine [1]. The diagnosis systems of several Korean acupuncture styles were focused on simplifying the understanding of the body’s core imbalances, and the resulting diagnosis enabled practitioners to devise therapeutic strategies that were based on constitutional energy traits. Saam acupuncture used 12 energy (or Qi) traits, mainly controlled by the 12 corresponding Meridians, that underlie diverse superficial biologic phenomena [2] [3]. It was suggested that these 12 energies determined the inclinations of the whole body, and they were targeted to recover the balance of the body’s constancy. Taegeuk acupuncture was identified by Sasang constitutional medicine according to the patient’s innate constitution. Sasang constitutional medicine identified four constitutions according to the individual’s inherent disparities among major Organ energies, expressed as the size of the Organs, all of which determined the physiologic characteristics of the individual patient and served as a major imbalance succeeding diverse pathologic processes. These constitutional traits were suggested to be the source of individual differences in apparently similar physiologic or pathologic reactions [2].
1H NMR-Based Metabolite Profiling of Plasma in a Rat Model of Chronic Kidney Disease
Ju-Ae Kim, Hyo-Jung Choi, Yong-Kook Kwon, Do Hyun Ryu, Tae-Hwan Kwon, Geum-Sook Hwang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0085445
Abstract: Chronic kidney disease (CKD) is characterized by the gradual loss of the kidney function to excrete wastes and fluids from the blood. 1H NMR-based metabolomics was exploited to investigate the altered metabolic pattern in rats with CKD induced by surgical reduction of the renal mass (i.e., 5/6 nephrectomy (5/6 Nx)), particularly for identifying specific metabolic biomarkers associated with early of CKD. Plasma metabolite profiling was performed in CKD rats (at 4- or 8-weeks after 5/6 Nx) compared to sham-operated rats. Principle components analysis (PCA), partial least squares-discriminant analysis (PLS-DA) and orthogonal partial least squares-discriminant analysis (OPLS-DA) score plots showed a significant separation between the groups. The resulting metabolic profiles demonstrated significantly increased plasma levels of organic anions, including citrate, β-hydroxybutyrate, lactate, acetate, acetoacetate, and formate in CKD. Moreover, levels of alanine, glutamine, and glutamate were significantly higher. These changes were likely to be associated with complicated metabolic acidosis in CKD for counteracting systemic metabolic acidosis or increased protein catabolism from muscle. In contrast, levels of VLDL/LDL (CH2)n and N-acetylglycoproteins were decreased. Taken together, the observed changes of plasma metabolite profiles in CKD rats provide insights into the disturbed metabolism in early phase of CKD, in particular for the altered metabolism of acid-base and/or amino acids.
Vasopressin V2R-Targeting Peptide Carrier Mediates siRNA Delivery into Collecting Duct Cells
Hyun Jun Jung, Jung-Suk Lim, Hyo-Jung Choi, Mi Suk Lee, Jong-Ho Kim, Sang-Yeob Kim, Soyoun Kim, Eunjung Kim, Tae-Hwan Kwon
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0040010
Abstract: Internalization of receptor proteins after interacting with specific ligands has been proposed to facilitate siRNA delivery into the target cells via receptor-mediated siRNA transduction. In this study, we demonstrated a novel method of vasopressin V2 receptor (V2R)-mediated siRNA delivery against AQP2 in primary cultured inner medullary collecting duct (IMCD) cells of rat kidney. We synthesized the dDAVP conjugated with nine D-arginines (dDAVP-9r) as a peptide carrier for siRNA delivery. The structure of synthetic peptide carrier showed two regions (i.e., ligand domain to V2R (dDAVP) and siRNA carrying domain (nine D-arginine)) bisected with a spacer of four glycines. The results revealed that 1) synthesized dDAVP-9r peptides formed a stable polyplex with siRNA; 2) siRNA/dDAVP-9r polyplex could bind to the V2R of IMCD cells and induced AQP2 phosphorylation (Ser 256); 3) siRNA/dDAVP-9r polyplex was stable in response to the wide range of different osmolalities, pH levels, or to the RNases; 4) fluorescein-labeled siRNA was delivered into V2R-expressing MDCK and LLC-PK1 cells by siRNA/dDAVP-9r polyplex, but not into the V2R-negative Cos-7 cells; and 5) AQP2-siRNA/dDAVP-9r polyplex effectively delivered siRNA into the IMCD cells, resulting in the significant decrease of protein abundance of AQP2, but not AQP4. Therefore, for the first time to our knowledge, we demonstrated that V2R-mediated siRNA delivery could be exploited to deliver specific siRNA to regulate abnormal expression of target proteins in V2R-expressing kidney cells. The methods could be potentially used in vivo to regulate abnormal expression of proteins associated with disease conditions in the V2R-expressing kidney cells.
Which is the best?: Re-ranking Answers Merged from Multiple Web Sources
Hyo-Jung Oh,Pum-Mo Ryu,Hyunki Kim
Journal of Emerging Technologies in Web Intelligence , 2012, DOI: 10.4304/jetwi.4.1.35-42
Abstract: The main motivation of this paper is to devise a way to select the best answers collected from multiple web sources. Depending on questions, we need to combine multiple QA modules. To this end, we analyze real-life questions for their characteristics and classify them into different domains and genres. In the proposed distributed QA framework, local optimal answers are selected by several specialized sub-QAs. For fining global optimal answers, merged candidates are re-ranked by adjusting confidence weights based on the question analysis. We adopt the idea of the margin separation of SVM classification algorithm to adjust confidence weights calculated by own ranking methods in sub-QAs. We also prove the effects of the proposed re-ranking algorithm based on a series of experiments.
YANG Bong-keun as a Health Reformer and a Pioneer of Social Medicine
SHIN Young-Jeon,YOON Hyo-Jung
Korean Journal of Medical History , 2005,
Abstract: YANG Bong-keun (1897-1982) had lived as a medical doctor and a social and public health reformer during the turbulent period of the opening of the port to the western society occupation by and liberation from Japan and the partition of the Korean Peninsular He actively participated in the March First Movement Shinganhoe and other activities for Korea’s liberation from Japan He also founded Bogunwoondongsa an organization for public health movement for Korean people and published Bogeunwoondong a magazine for introducing and educating new ideas and knowledge of health for Korean people After the defeat of Japan in the World War II he worked for the protection and repatriation of Korean residents in the Manjoo area as a head of policy division of the Northeastern office of the Korean Provisional Government He also participated in the foundation of Yanbian Hospital and medical school for Korean-Chinese in China His holistic approach of health and public health movement accentuation of preventive medicine and a body under his/her own will public health movement as a part of everyday life movement and minjoong oriented humanism were closely linked with the idea of social medicine that originated from the European society in the 19th century Those are also valuable ideas to be considered and implemented in this time Moreover his effort of health for Korean people on the way of modernization and liberation of Korea provides an example of being a respectable health reformer and pioneer of social medicine
Suppression of STAT3 and HIF-1 Alpha Mediates Anti-Angiogenic Activity of Betulinic Acid in Hypoxic PC-3 Prostate Cancer Cells
Jimin Shin, Hyo-Jeong Lee, Deok-Beom Jung, Ji Hoon Jung, Hyo-Jung Lee, Eun-Ok Lee, Seok Geun Lee, Beom Sang Shim, Seung Hoon Choi, Seong Gyu Ko, Kwang Seok Ahn, Soo-Jin Jeong, Sung-Hoon Kim
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0021492
Abstract: Background Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates various cellular processes such as cell survival, angiogenesis and proliferation. In the present study, we examined that betulinic acid (BA), a triterpene from the bark of white birch, had the inhibitory effects on hypoxia-mediated activation of STAT3 in androgen independent human prostate cancer PC-3 cells. Methodology/Principal Findings BA inhibited the protein expression and the transcriptional activities of hypoxia-inducible factor-1α (HIF-1α) under hypoxic condition. Consistently, BA blocked hypoxia-induced phosphorylation, DNA binding activity and nuclear accumulation of STAT3. In addition, BA significantly reduced cellular and secreted levels of vascular endothelial growth factor (VEGF), a critical angiogenic factor and a target gene of STAT3 induced under hypoxia. Furthermore, BA prevented in vitro capillary tube formation in human umbilical vein endothelial cells (HUVECs) maintained in conditioned medium of hypoxic PC-3 cells, implying anti-angiogenic activity of BA under hypoxic condition. Of note, chromatin immunoprecipitation (ChiP) assay revealed that BA inhibited binding of HIF-1α and STAT3 to VEGF promoter. Furthermore, silencing STAT3 using siRNA transfection effectively enhanced the reduced VEGF production induced by BA treatment under hypoxia. Conclusions/Significance Taken together, our results suggest that BA has anti-angiogenic activity by disturbing the binding of HIF-1α and STAT3 to the VEGF promoter in hypoxic PC-3 cells.
Acupuncture for sequelae of Bell's palsy: a randomized controlled trial protocol
Hyo-Jung Kwon, Jong-In Kim, Myeong Lee, Jun-Yong Choi, Sungkeel Kang, Jie-Yoon Chung, Young-Jin Kim, Seung-Hoon Lee, Sanghoon Lee, Dongwoo Nam, Yong-Suk Kim, Jae-Dong Lee, Do-Young Choi
Trials , 2011, DOI: 10.1186/1745-6215-12-71
Abstract: This study consists of a randomized controlled trial with two parallel arms: an acupuncture group and a waitlist group. The acupuncture group will receive acupuncture treatment three times per week for a total of 24 sessions over 8 weeks. Participants in the waitlist group will not receive any acupuncture treatments during this 8 week period, but they will participate in the evaluations of symptoms at the start of the study, at 5 weeks and at 8 weeks after randomization, at which point the same treatment as the acupuncture group will be provided. The primary outcome will be analyzed by the change in the Facial Disability Index (FDI) from baseline to week eight. The secondary outcome measures will include FDI from baseline to week five, House-Brackmann Grade, lip mobility, and stiffness scales.Current Controlled-Trials ISRCTN43104115; registration date: 06 July 2010; the date of the first patient's randomization: 04 August 2010Bell's palsy is an acute, idiopathic, unilateral paralysis of the face. Its cause is unknown, but mounting evidence suggests that reactivated herpes viruses from cranial nerve ganglia play a key role in the development of this condition; its pattern is consistent with that of peripheral neural dysfunction [1,2]. Inflammation of the facial nerve initially results in reversible neuropraxia and Wallerian degeneration ultimately ensues [1].The incidence of Bell's palsy is approximately 30/100,000 people per year [3]. The prognosis is good, and approximately 70% of patients recover completely within 6 months without treatment. However, 30% of Bell's palsy patients have sequelae, such as residual paresis (29%), contracture (17%), and facial spasm or synkinesis (16%) [3]. The incomplete recovery of facial symmetry can have a long-term impact on the quality of life, such as difficulty with drinking, eating and speaking, as well as psychosocial problems [4]. The symmetry of the face is a determinant of facial charm and influences interpersonal attractio
Activation of AMP-Activated Protein Kinase and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells
Sung-Yun Cho,Hyo-Jeong Lee,Hyo-Jung Lee,Deok-Beom Jung
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/974313
Abstract:
Thermal Stability of the R Phase of a Rapidly Solidified Ti-47.3Ni (at%) Alloy
Tae-hyun Nam,Hyo-jung Moon,Su-jin Chun,Yinong Liu
Transactions on Electrical and Electronic Materials , 2012,
Abstract: Transformation behavior of rapidly solidified Ti-47.3Ni (at%) alloy ribbons and thermal stability of the R phase in theribbons were investigated by means of differential scanning calorimetry (DSC), X-ray diffraction, and transmissionelectron microscopy. Rapidly solidified Ti-47.3Ni alloy ribbons showed the two-stage B2-R-B19' martensitictransformation behavior. The B2-R transformation in the ribbons was observed even after annealing at 1,223 K,which was attributed to the fact that a specific orientation relationship between Ti2Ni and matrix in the ribbons ismaintained after annealing at 1,223 K. The DSC peak temperature of the B2-R transformation (TR*) decreased withraising annealing temperature, which was attributed to the increased volume fraction of Ti2Ni, thus causing anincreased Ni content in the matrix.
Inhibition of Connexin 26/43 and Extracellular-Regulated Kinase Protein Plays a Critical Role in Melatonin Facilitated Gap Junctional Intercellular Communication in Hydrogen Peroxide-Treated HaCaT Keratinocyte Cells
Hyo-Jung Lee,Hyo-Jeong Lee,Eun Jung Sohn,Eun-Ok Lee,Jin-Hyoung Kim,Min-Ho Lee,Sung-Hoon Kim
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/589365
Abstract: Though melatonin was known to regulate gap junctional intercellular communication (GJIC) in chick astrocytes and mouse hepatocytes, the underlying mechanism by melatonin was not elucidated in hydrogen peroxide- (H2O2-) treated HaCaT keratinocyte cells until now. In the current study, though melatonin at 2 mM and hydrogen peroxide (H2O2) at 300 μM showed weak cytotoxicity in HaCaT keratinocyte cells, melatonin significantly suppressed the formation of reactive oxygen species (ROS) in H2O2-treated HaCaT cells compared to untreated controls. Also, the scrape-loading dye-transfer assay revealed that melatonin enhances the intercellular communication by introducing Lucifer Yellow into H2O2-treated cells. Furthermore, melatonin significantly enhanced the expression of connexin 26 (Cx26) and connexin 43 (Cx43) at mRNA and protein levels, but not that of connexin 30 (Cx30) in H2O2-treated HaCaT cells. Of note, melatonin attenuated the phosphorylation of extracellular signal-regulated protein kinases (ERKs) more than p38 MAPK or JNK in H2O2-treated HaCaT cells. Conversely, ERK inhibitor PD98059 promoted the intercellular communication in H2O2-treated HaCaT cells. Furthermore, combined treatment of melatonin (200 μM) and vitamin C (10 μg/mL) significantly reduced ROS production in H2O2-treated HaCaT cells. Overall, these findings support the scientific evidences that melatonin facilitates gap junctional intercellular communication in H2O2-treated HaCaT keratinocyte cells via inhibition of connexin 26/43 and ERK as a potent chemopreventive agent.
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