Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 3 )

2018 ( 7 )

2017 ( 11 )

2016 ( 11 )

Custom range...

Search Results: 1 - 10 of 2267 matches for " Hyeok Yil Kwon4 "
All listed articles are free for downloading (OA Articles)
Page 1 /2267
Display every page Item
Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein
Sun Hwa Lee1,#, Dae Won Kim1,#, Seon Ae Eom1, Se-Young Jun1, Meeyoung Park1, Duk-Soo Kim2, Hyung Joo Kwon3, Hyeok Yil Kwon4, Kyu Hyung Han1, Jinseu Park1, Hyun Sook Hwang1, Won Sik Eum1,* & Soo Young Choi1,*
BMB Reports , 2012,
Abstract: We examined that the protective effects of ANX1 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammationin animal models using a Tat-ANX1 protein. Topicalapplication of the Tat-ANX1 protein markedly inhibited TPAinducedear edema and expression levels of cyclooxygenase-2(COX-2) as well as pro-inflammatory cytokines such as interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha(TNF-α). Also, application of Tat-ANX1 protein significantlyinhibited nuclear translocation of nuclear factor-kappa B(NF-κB) and phosphorylation of p38 and extracellular signalregulatedkinase (ERK) mitogen-activated protein kinase(MAPK) in TPA-treated mice ears. The results indicate thatTat-ANX1 protein inhibits the inflammatory response byblocking NF-κB and MAPK activation in TPA-induced miceears. Therefore, the Tat-ANX1 protein may be useful as atherapeutic agent against inflammatory skin diseases.
Characteristics of the aberrant pyramidal tract in comparison with the pyramidal tract in the human brain
Hyeok Kwon, Su Son, Min Chang, Saeyoon Kim, Yong Kwon, Sung Jang
BMC Neuroscience , 2011, DOI: 10.1186/1471-2202-12-108
Abstract: In thirty-four (18.3%, right hemisphere: 20, left hemisphere: 14) of the 186 hemispheres, the APTs separated from the PT at the upper midbrain level, descended through the medial lemniscus from the midbrain to the pons, and then rejoined with the PT at the upper medulla. Nine (26.5%) of the 34 APTs were found to originate from the primary somatosensory cortex without a primary motor cortex origin. Values of fractional anisotropy (FA) and tract volume of the APT were lower than those of the PT (P < 0.05); however, no difference in mean diffusivity (MD) value was observed (P > 0.05).We found that the APT has different characteristics, including less directionality, fewer neural fibers, and less origin from the primary motor cortex than the PT.The pyramidal tract (PT) is a major neuronal pathway for mediation of voluntary movements in the human brain and has been known to have collateral pathways [1,2]. The aberrant pyramidal tract (APT) indicates the collateral pathway of the PT, which separates from the original PT at the level of the midbrain and the pons, and descends through the medial lemniscus [3-6]. Existence of the APT has been demonstrated by various methods, including pathological, electrophysiological, and radiological studies [3,6-10]. In addition, recently, the APT has been suggested as a motor recovery mechanism in stroke [11-14]. However, detailed characteristics of the APT have not been clearly elucidated.Diffusion tensor tractography (DTT), which is derived from diffusion tensor imaging (DTI), allows visualization and estimation of the PT and APT in three dimensions [3,11,12]. Several DTT studies have reported on the presence of the APT in normal subjects or in patients with brain injury [3,11-14]. However, so far, little is known about the characteristics of the APT in the human brain.In the current study, we investigated the characteristics of the APT in comparison with the PT in the normal human brain, using DTT.In the brains of all subjects, PTs w
Rapid re-emergence of YMDD mutation of hepatitis B virus with hepatic decompensation after lamivudine retreatment
So Young Kwon, Won Hyeok Choe, Chang Hong Lee, Jong Eun Yeon, Kwan Soo Byun
World Journal of Gastroenterology , 2008,
Abstract: Lamivudine has a high rate of antiviral resistance. Sequential treatment of anti-hepatitis B virus (HBV) is commonly used for lamivudine resistance. We report 4 cases of patients with rapid redetection of HBV mutants during the lamivudine retreatment. The four patients received lamivudine as an initial treatment of HBV and adefovir and lamivudine as a rescue therapy consecutively. HBV-DNA level, YMDD mutations and adefovir -resistant mutations (RFMP) were tested every 3 mo during the sequential treatment. All the patients showed YMDD mutations during the initial lamivudine therapy. After adefovir therapy for lamivudine resistance, they showed viral breakthrough. Adefovir was switched to lamivudine, however, it did not induce viral suppression at all, rather increased HBV-DNA with rapid reemergence of the YMDD mutations. All the patients had ALT flares, and hepatic decompensation occurred in two patients. After switching to adefovir combined with entecavir or lamivudine for a rescue therapy, the patients had reduction in HBV-DNA and ALT improvement. These cases demonstrated that lamivudine retreatment of patients with preexposed lamivudine resistance leads to rapid reemergence of YMDD mutation with significant viral rebounds and subsequent hepatic decompensation. Sequential administration of lamivudine in patients with a prior history of YMDD mutation should be abandoned.
Injury of the cingulum in patients with putaminal hemorrhage: a diffusion tensor tractography study
Hyeok Gyu Kwon,Young Jin Jung,Han Do Lee,Sung Ho Jang
Frontiers in Human Neuroscience , 2014, DOI: 10.3389/fnhum.2014.00366
Abstract: Objectives: Little is known about the pathophysiological mechanisms of cognitive impairment in patients with putaminal hemorrhage (PH). Using diffusion tensor tractography, we investigated injury of the cingulum in patients with PH.
Transverse Beam Dynamics including Aberration Effects in the Thermal Wave Model using a Functional Method
Ji-ho Jang,Yong-sub Cho,Hyeok-jung Kwon
Physics , 2009, DOI: 10.1016/j.nima.2010.09.077
Abstract: We studied the transverse beam dynamics including aberration effects of sextupole and octupole perturbations in a thermal wave model. A functional integration method was used to calculate the first-order perturbation effects. We found that the model successfully explains a PARMILA simulation results for proton beams without space-charge effects in a FODO lattice.
Investigation of the transverse beam dynamics in the thermal wave model with a functional method
Ji-ho Jang,Yong-sub Cho,Hyeok-jung Kwon
Physics , 2006, DOI: 10.1016/j.physleta.2007.02.017
Abstract: We investigated the transverse beam dynamics in a thermal wave model by using a functional method. It can describe the beam optical elements separately with a kernel for a component. The method can be applied to general quadrupole magnets beyond a thin lens approximation as well as drift spaces. We found that the model can successfully describe the PARMILA simulation result through an FODO lattice structure for the Gaussian input beam without space charge effects.
A lower bound to the action dimension of a group
Sung Yil Yoon
Mathematics , 2004, DOI: 10.2140/agt.2004.4.273
Abstract: The action dimension of a discrete group G, actdim(G), is defined to be the smallest integer m such that G admits a properly discontinuous action on a contractible m-manifold. If no such m exists, we define actdim(G) = infty. Bestvina, Kapovich, and Kleiner used Van Kampen's theory of embedding obstruction to provide a lower bound to the action dimension of a group. In this article, another lower bound to the action dimension of a group is obtained by extending their work, and the action dimensions of the fundamental groups of certain manifolds are found by computing this new lower bound.
Natural Language Understanding Based on Semantic Relations between Sentences
Hyeok Kong
Computer Science , 2012,
Abstract: In this paper, we define event expression over sentences of natural language and semantic relations between events. Based on this definition, we formally consider text understanding process having events as basic unit.
Laboratory characteristics of recent hepatitis A in Korea: Ongoing epidemiological shift
Hee Won Moon, Jin Hee Cho, Mina Hur, Yeo-Min Yun, Won Hyeok Choe, So Young Kwon, Chang Hong Lee
World Journal of Gastroenterology , 2010,
Abstract: AIM: To evaluate seroprevalence of hepatitis A virus (HAV) antibody and investigate demographic, clinical, and laboratory features of recent cases in Korea.METHODS: For the evaluation of hepatitis A seroprevalence, we analyzed the data from 3127 subjects including, healthcare workers and patients who visited Konkuk University Hospital, a secondary referral center, from January to October 2009. The sera with positive IgM were excluded from seroprevalence data for total HAV antibody. We retrospectively reviewed the electronic medical records of 419 patients with HAV, who were diagnosed by the presence of serum IgM antibodies against HAV. All patients presented at Konkuk University Hospital between August 2005 and September 2008.RESULTS: Among 3127 sera tested, 1428 (45.7%) were positive for anti-HAV antibody. The seroprevalence was very low in teenagers or those in their twenties, increased in those in their thirties, and was > 90% in older patients. In children younger than 10 years, seroprevalence was increased again. Most patients with HAV hepatitis were in their twenties and thirties. The γ-glutamyl transpeptidase increased with age and was significantly higher in patients older than 30 years. Indicators of severity, such as decreased albumin and increased bilirubin, were also more prominent in the older age group; however, the leukocyte count was higher and the frequency of leukopenia was lower in younger patients than in older adults.CONCLUSION: There has been an apparent epidemiological shift in HAV seroprevalence and a change in the peak age of HAV hepatitis. This study could provide baseline data of recent hepatitis A in Asia.
Importance of the surrounding colonic mucosa in distinguishing between hyperplastic and adenomatous polyps during acetic acid chromoendoscopy
Jeong Hwan Kim, Sun-Young Lee, Byung Kook Kim, Won Hyeok Choe, So Young Kwon, In-Kyung Sung, Hyung-Seok Park, Choon-Jo Jin
World Journal of Gastroenterology , 2008,
Abstract: AIM: To examine the characteristics of colonic polyps, where it is difficult to distinguish adenomatous polyps from hyperplastic polyps, with the aid of acetic acid chromoendoscopy.METHODS: Acetic acid spray was applied to colonic polyps smaller than 10 mm before complete excision. Endoscopic images were taken before and 15-30 s after the acetic acid spray. Both pre- and post-sprayed images were shown to 16 examiners, who were asked to interpret the lesions as either hyperplastic or adenomatous polyps. Regression analysis was performed to determine which factors were most likely related to diagnostic accuracy.RESULTS: In 50 cases tested by the 16 examiners, the overall accuracy was 62.4% (499/800). Regression analysis demonstrated that surrounding colonic mucosa was the only factor that was significantly related to accuracy in discriminating adenomatous from hyperplastic polyps (P < 0.001). Accuracy was higher for polyps with linear surrounding colonic mucosa than for those with nodular surrounding colonic mucosa (P < 0.001), but was not related to the shape, location, or size of the polyp.CONCLUSION: The accuracy of predicting histology is significantly related to the pattern of colonic mucosa surrounding the polyp. Making a histological diagnosis of colon polyps merely by acetic acid spray is helpful for colon polyps with linear, regularly patterned surrounding colonic mucosa, and less so for those with nodular, irregularly patterned surrounding colonic mucosa.
Page 1 /2267
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.