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Search Results: 1 - 10 of 4859 matches for " Hye Won Jeong "
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Nanosilver Colloids-Filled Photonic Crystal Arrays for Photoluminescence Enhancement
Park Seong-Je,Lee Soon-Won,Jeong Sohee,Lee Ji-Hye
Nanoscale Research Letters , 2010,
Abstract: For the improved surface plasmon-coupled photoluminescence emission, a more accessible fabrication method of a controlled nanosilver pattern array was developed by effectively filling the predefined hole array with nanosilver colloid in a UV-curable resin via direct nanoimprinting. When applied to a glass substrate for light emittance with an oxide spacer layer on top of the nanosilver pattern, hybrid emission enhancements were produced from both the localized surface plasmon resonance-coupled emission enhancement and the guided light extraction from the photonic crystal array. When CdSe/ZnS nanocrystal quantum dots were deposited as an active emitter, a total photoluminescence intensity improvement of 84% was observed. This was attributed to contributions from both the silver nanoparticle filling and the nanoimprinted photonic crystal array.
Antiresorptive Activity of Bacillus-Fermented Antler Extracts: Inhibition of Osteoclast Differentiation
Sik-Won Choi,Seong-Hee Moon,Hye Jeong Yang,Dae Young Kwon
Evidence-Based Complementary and Alternative Medicine , 2013, DOI: 10.1155/2013/748687
Immunogenicity and safety of virus-like particle of the porcine encephalomyocarditis virus in pig
Hye-Young Jeoung, Won-Ha Lee, WooSeog Jeong, Bo-Hye Shin, Hwan-Won Choi, Hee Lee, Dong-Jun An
Virology Journal , 2011, DOI: 10.1186/1743-422x-8-170
Abstract: VLPs were successfully generated from Sf9 cells infected with recombinant baculovirus and were confirmed to be approximately 30-40 nm by transmission electron microscopy (TEM). Immunization of mice with 0.5 μg crude protein containing the VLPs resulted in significant protection from EMCV infection (90%). In swine, increased neutralizing antibody titers were observed following twice immunization with 2.0 μg crude protein containing VLPs. In addition, high levels of neutralizing antibodies (from 64 to 512 fold) were maintained during a test period following the second immunization. No severe injection site reactions were observed after immunization and all swine were healthy during the immunization periodRecombinant EMCV VLPs could represent a new vaccine candidate to protect against EMCV infection in pig farms.The porcine encephalomyocarditis virus (EMCV) is a member of the genus Cardiovirus of the family Picornaviridae, the genome is a single-stranded positive sense RNA of approximately 7.8 kb with a unique large open reading frame (ORF) [1]. Porcine EMCV infection, which is characterized by acute myocarditis and sudden death in preweaned piglets and severe reproductive failure in sows, results in severe economic losses for swine production [2-4].An inactivated EMCV vaccine is considered as one of the effective strategies for preventing EMCV infection in domestic and wild animals [5,6]. Recently, vaccination with porcine EMCV virus-like particles (VLPs) has also been examined as a novel candidate for protection against porcine EMCV [7]. However, VLP-based vaccines against porcine EMCV produced using a baculovirus system have not yet been developed.One of the most important technological developments to emerge from the baculovirus expression system was the observation that the expression of viral capsid proteins could lead to the assembly of VLPs that mimic the overall structure of authentic viral particles but are devoid of viral nucleic acids [8]. VLPs represent a
Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo
Won-Kyung Cho,Hyunil Kim,Yu Jeong Choi,Nam-Hui Yim,Hye Jin Yang,Jin Yeul Ma
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/985151
Abstract: Porcine epidemic diarrhea virus (PEDV) causes diarrhea of pigs age-independently and death of young piglets, resulting in economic loss of porcine industry. We have screened 333 natural oriental herbal medicines to search for new antiviral candidates against PEDV. We found that two herbal extracts, KIOM 198 and KIOM 124, contain significant anti-PED viral effect. KIOM 198 and KIOM 124 were identified as Epimedium koreanum Nakai and Lonicera japonica Thunberg, respectively. The further plaque and CPE inhibition assay in vitro showed that KIOM 198 has much stronger antiviral activity than KIOM 124. Additionally, KIOM 198 exhibited a similar extent of antiviral effect against other subtypes of Corona virus such as sm98 and TGE viruses. Cytotoxicity results showed that KIOM 198 is nontoxic on the cells and suggest that it can be delivered safely for therapy. Furthermore, when we orally administered KIOM 198 to piglets and then infected them with PEDV, the piglets did not show any disease symptoms like diarrhea and biopsy results showed clean intestine, whereas control pigs without KIOM 198 treatment exhibited PED-related severe symptoms. These results imply that KIOM 198 contains strong antiviral activity and has a potential to be developed as an antiviral phytomedicine to treat PEDV-related diseases in pigs.
Efficacy of Ketamine in Improving Pain after Tonsillectomy in Children: Meta-Analysis
Hye Kyung Cho, Kyu Won Kim, Yeon Min Jeong, Ho Seok Lee, Yeon Ji Lee, Se Hwan Hwang
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0101259
Abstract: Background and objectives The goal of this meta-analysis study was to perform a systematic review of the literature on the effects of ketamine on postoperative pain following tonsillectomy and adverse effects in children. Subjects and Methods Two authors independently searched three databases (MEDLINE, SCOPUS, Cochrane) from their inception of article collection to February 2014. Studies that compared preoperative ketamine administration (ketamine groups) with no treatment (control group) or opioid administration (opioid group) where the outcomes of interest were postoperative pain intensity, rescue analgesic consumption, or adverse effects (sedation, nausea and vomiting, bad dream, worsening sleep pattern, and hallucination) 0–24 hours after leaving the operation room were included in the analysis. Results The pain score reported by the physician during first 4 hours and need for analgesics during 24 hours postoperatively was significantly decreased in the ketamine group versus control group and was similar with the opioid group. In addition, there was no significant difference between ketamine and control groups for adverse effects during 24 hours postoperatively. In the subgroup analyses (systemic and local administration) regarding pain related measurements, peritonsillar infiltration of ketamine was more effective in reducing the postoperative pain severity and need for analgesics. Conclusion Preoperative administration of ketamine systemically or locally could provide pain relief without side-effects in children undergoing tonsillectomy. However, considering the insufficient evaluation of efficacy of ketamine according to the administration methods and high heterogeneity in some parameters, further clinical trials with robust research methodology should be conducted to confirm the results of this study.
Lymphopenia is an important prognostic factor in peripheral T-cell lymphoma (NOS) treated with anthracycline-containing chemotherapy
Yu Ri Kim, Jin Seok Kim, Soo Jeong Kim, Hyun Ae Jung, Seok Jin Kim, Won Seog Kim, Hye Won Lee, Hyeon Seok Eom, Seong Hyun Jeong, Joon Seong Park, June-Won Cheong, Yoo Hong Min
Journal of Hematology & Oncology , 2011, DOI: 10.1186/1756-8722-4-34
Abstract: A total of 118 patients with PTCL-NOS treated with anthracycline-containing chemotherapy from 4 Korean institutions were included.Thirty-six patients (30.5%) had a low absolute lymphocyte count (ALC, < 1.0 × 109/L) at diagnosis. Patients with lymphopenia had shorter overall survival (OS) and progression-free survival (PFS) rates compared with patients with high ALCs (P = 0.003, P = 0.012, respectively). In multivariate analysis, high-intermediate/high-risk International Prognostic Index (IPI) scores and lymphopenia were both associated with shorter OS and PFS. Treatment-related mortality was 25.0% in the low ALC group and 4.8% in the high ALC group (P = 0.003). In patients considered high-intermediate/high-risk based on IPI scores, lymphopenia was also associated with shorter OS and PFS (P = 0.002, P = 0.001, respectively).This study suggests that lymphopenia could be an independent prognostic marker to predict unfavorable OS and PFS in patients with PTCL-NOS treated with anthracycline-containing chemotherapy and can be used to further stratify high-risk patients using IPI scores.Peripheral T-cell lymphomas (PTCL) account for approximately 12% to 15% of all non-Hodgkin's lymphomas in Western countries and 15% to 20% in Asian countries [1,2]. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), is the most common heterogeneous subgroup of PTCL because it includes lymphomas with no definitive clinical or biologic profile and it cannot be classified into a specific subtype [3]. PTCL-NOS is a highly aggressive lymphoma with a poor response to conventional chemotherapy and a 5-year overall survival (OS) of about 25% to 45% [4]. Anthracycline-containing chemotherapy, such as CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) or CHOP-like regimens, are considered to be standard therapy for PTCL-NOS, although remission rates are less than satisfactory [1]. More intensive regimens, such as hyper-CVAD (hyperfractionated cyclophosphamide, vincristine,
Classification of rice (Oryza sativa l. japonica nipponbare) immunophilins (FKBPs, CYPs) and expression patterns under water stress
Jun Ahn, Dae-Won Kim, Young You, Min Seok, Jeong Park, Hyunsik Hwang, Beom-Gi Kim, Sheng Luan, Hong-Seog Park, Hye Cho
BMC Plant Biology , 2010, DOI: 10.1186/1471-2229-10-253
Abstract: FKBP and CYP proteins in rice (Oryza sativa cv. Japonica) were identified and classified, and given the appropriate name for each IMM, considering the ortholog-relation with Arabidopsis and Chlamydomonas or molecular weight of the proteins. 29 FKBP and 27 CYP genes can putatively be identified in rice; among them, a number of genes can be putatively classified as orthologs of Arabidopsis IMMs. However, some genes were novel, did not match with those of Arabidopsis and Chlamydomonas, and several genes were paralogs by genetic duplication. Among 56 IMMs in rice, a significant number are regulated by salt and/or desiccation stress. In addition, their expression levels responding to the water-stress have been analyzed in different tissues, and some subcellular IMMs located by means of tagging with GFP protein.Like other green photosynthetic organisms such as Arabidopsis (23 FKBPs and 29 CYPs) and Chlamydomonas (23 FKBs and 26 CYNs), rice has the highest number of IMM genes among organisms reported so far, suggesting that the numbers relate closely to photosynthesis. Classification of the putative FKBPs and CYPs in rice provides the information about their evolutional/functional significance when comparisons are drawn with the relatively well studied genera, Arabidopsis and Chlamydomonas. In addition, many of the genes upregulated by water stress offer the possibility of manipulating the stress responses in rice.Proteins that bind to immunosuppressive drugs, such as FK506, rapamycin and cyclophilin A (CsA), have been called FKBPs (FK506/rapamycin-binding proteins) and CYPs or cyclophilins (cyclosporin A-binding proteins), respectively, being collectively referred to immunophilins [1]. Despite their lack of structural similarity, these two families share a common peptidyl-prolyl isomerase (PPIase), catalyzing the cis/trans isomerization of proline imidic peptide bonds [2]. The Cis/trans isomerization of the Xaa-Pro bond results in slow phases in protein folding, which is
Obesity-Related Metabolomic Analysis of Human Subjects in Black Soybean Peptide Intervention Study by Ultraperformance Liquid Chromatography and Quadrupole-Time-of-Flight Mass Spectrometry
Min Jung Kim,Hye Jeong Yang,Jin Hee Kim,Chang-Won Ahn,Jong Ho Lee,Kang Sung Kim,Dae Young Kwon
Journal of Obesity , 2013, DOI: 10.1155/2013/874981
Abstract: The present study aimed to identify key metabolites related to weight reduction in humans by studying the metabolic profiles of sera obtained from 34 participants who underwent dietary intervention with black soybean peptides (BSP) for 12 weeks. This research is a sequel to our previous work in which the effects of BSP on BMI and blood composition of lipid were investigated. Sera of the study were subjected to ultra performance liquid chromatography and quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS), and the data were analyzed using partial least-squares discriminate analysis (PLS-DA) score plots. Body mass index and percent body fat of the test group were reduced. Levels of betaine, benzoic acid, pyroglutamic acid, pipecolic acid, N-phenylacetamide, uric acid, L-aspartyl-L-phenylalanine, and lysophosphatidyl cholines (lysoPCs) (C18:1, C18:2, C20:1, and C20:4) showed significant increases. Levels of L-proline, valine, L-leucine/isoleucine, hypoxanthine, glutamine, L-methionine, phenylpyruvic acid, several carnitine derivatives, and lysoPCs (C14:0, PC16:0, C15:0, C16:0, C17:1, C18:0, and C22:0) were significantly decreased. In particular, lysoPC 16:0 with a VIP value of 12.02 is esteemed to be the most important metabolite for evaluating the differences between the 2 serum samples. Our result confirmed weight-lowering effects of BSP, accompanied by favorable changes in metabolites in the subjects’ blood. Therefore, this research enables us to better understand obesity and increases the predictability of the obesity-related risk by studying metabolites present in the blood. 1. Introduction Obesity is considered a perilous disease because, besides being widespread, it is the primary risk factor for the development of various physical, mental, and social disorders such as cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancers, mental depression, and social stigmatization [1, 2]. Causes of obesity are numerous, including imbalance between calorie intake and expenditure, genetic susceptibility, emotional reasons, and environmental factors such as life style [3]. Thus appropriate diet and good eating habits are the foundation for physical fitness. Certain Korean traditional fermented soybean foods; fermented soybean and fermented soybean pastes, notably Chungkukjang and Doenjang, may help to alleviate or fight obesity [4–6]. Research results by Yang et al. indicated that feeding chungkukjang decreased blood pressure and serum levels of lipids in rats [7]. Soh et al. tried to identify the weight-reducing effects
Biphasic Electrical Currents Stimulation Promotes both Proliferation and Differentiation of Fetal Neural Stem Cells
Keun-A Chang,Jin Won Kim,Jeong a. Kim,Sungeun Lee,Saeromi Kim,Won Hyuk Suh,Hye-Sun Kim,Sunghoon Kwon,Sung June Kim,Yoo-Hun Suh
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0018738
Abstract: The use of non-chemical methods to differentiate stem cells has attracted researchers from multiple disciplines, including the engineering and the biomedical fields. No doubt, growth factor based methods are still the most dominant of achieving some level of proliferation and differentiation control - however, chemical based methods are still limited by the quality, source, and amount of the utilized reagents. Well-defined non-chemical methods to differentiate stem cells allow stem cell scientists to control stem cell biology by precisely administering the pre-defined parameters, whether they are structural cues, substrate stiffness, or in the form of current flow. We have developed a culture system that allows normal stem cell growth and the option of applying continuous and defined levels of electric current to alter the cell biology of growing cells. This biphasic current stimulator chip employing ITO electrodes generates both positive and negative currents in the same culture chamber without affecting surface chemistry. We found that biphasic electrical currents (BECs) significantly increased the proliferation of fetal neural stem cells (NSCs). Furthermore, BECs also promoted the differentiation of fetal NSCs into neuronal cells, as assessed using immunocytochemistry. Our results clearly show that BECs promote both the proliferation and neuronal differentiation of fetal NSCs. It may apply to the development of strategies that employ NSCs in the treatment of various neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases.
Age- and Influenza Activity-Stratified Case Definitions of Influenza-Like Illness: Experience from Hospital-Based Influenza Surveillance in South Korea
Tae Un Yang, Hee Jin Cheong, Joon Young Song, Jin Soo Lee, Seong-Heon Wie, Young Keun Kim, Won Suk Choi, Jacob Lee, Hye Won Jeong, Woo Joo Kim
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0084873
Abstract: Objectives This study aims to identify clinical case definitions of influenza with higher accuracy in patients stratified by age group and influenza activity using hospital-based surveillance system. Methods In seven tertiary hospitals across South Korea during 2011–2012 influenza season, respiratory specimens were obtained from patients presenting an influenza-like illness (ILI), defined as having fever plus at least one of following symptoms: cough, sore throat or rhinorrhea. Influenza was confirmed by reverse transcriptase-polymerase chain reaction. We performed multivariate logistic regression analyses to identify clinical variables with better relation with laboratory-confirmed influenza, and compared the accuracy of combinations. Results Over the study period, we enrolled 1417 patients, of which 647 had laboratory-confirmed influenza. Patients with cough, rhinorrhea, sore throat or headache were more likely to have influenza (p<0.05). The most accurate criterion across the study population was the combination of cough, rhinorrhea, sore throat and headache (sensitivity 71.3%, specificity 60.1% and AUROC 0.66). The combination of rhinorrhea, sore throat and sputum during the peak influenza activity period in the young age group showed higher accuracy than that using the whole population (sensitivity 89.3%, specificity 72.1%, and AUROC 0.81). Conclusions The accuracy of clinical case definitions of influenza differed across age groups and influenza activity periods. Categorizing the entire population into subgroups would improve the detection of influenza patients in the hospital-based surveillance system.
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