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Search Results: 1 - 10 of 401435 matches for " Huwaida M. Hassaneen "
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Synthesis of some new Indeno[1,2-e]pyrazolo[5,1-c]-1,2,4-triazin-6-one and Indeno[2,1-c]pyridazine-4-carbonitrile Derivatives  [PDF]
Hamdi M. Hassaneen, Nada M. Abunada, Huwaida M. Hassaneen
Natural Science (NS) , 2010, DOI: 10.4236/ns.2010.212164
Abstract: Diazonium chlorides of 5-amino-3-methypyrazole 1a and 5-amino-4-phenylpyrazole 1b coupled with 1,3-indanedione 2 and led to the formation of acyclic hydrazone 3a and a cyclic product indenopyrazolotriazine 4b respectively. Cyclization of the hydrazone 3a by boiling in acetic acid afforded the corresponding 4a. The hydrazone 3a reacted with malononitrile in boiling ethanol in the presence of piperidine and gave indeno[2,1-c]pyridazine-4-carbonitrile derivatives 5a,b. Also, coupling of 6 with aryl diazonium chlorides gave the corresponding indenopyridazine derivatives 8a-e. Acetylation, benzoylation and hydrolysis of compound 8a afforded the corresponding substitution products 10-12, respectively. The structures of the newly synthesized compounds were established on the basis of chemical and spectral evidences.
Reactivity of 1-methylisoquinoline synthesis of pyrazolyl triazoloisoquinoline and thia-diazolyl isoquinoline derivatives  [PDF]
Hamdi M Hassaneen, Huwaida M. E Hassaneen, Yasmin Sh Mohammed
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.38089
Abstract: The reaction of 1-methylisoquinoline 1 with hy-drazonoyl halides 2 in ethanol in the presence of chitosan under microwave irradiation affords triazoloisoquinoline 4. Product 4 reacts with dimethylformamide-dimethylacetal to give ena- minones 7 which react with hydrazonoyl halides to give pyrazolyl triazoloisoquinoline 13. Also, 1-methylisoquinoline 1 reacts with arylisothio-cyanate to give thioanilide 15 which reacts with hydrazonoyl halides to give the corresponding thiadiazolyl isoquinoline derivatives 20, 24.
Reactivity of 3-Cyanoacetylindole Derivatives: Synthesisof 3-Hydrazonopyrazolyl and 3-Thiadiazolyl Indole Derivatives  [PDF]
Hamdi M. Hassaneen, Huwaida M. E. Hassaneen, Zakaria Ahmed Gomaa
International Journal of Organic Chemistry (IJOC) , 2011, DOI: 10.4236/ijoc.2011.13015
Abstract: The coupling reaction of 3-cyanoacetyl-2-methylindole 1a with the aromatic diazonium salts gave the corresponding arylhydrazones 2a-e. Compounds 2 were used for synthesis of 4-aminopyrazole-5-carbonitrile 4a-e and 5-amino-4-arylazo-3-pyrazoles 5a-e derivatives. Also, treatment of 3-cyanoacetyl-2-phenylindole 1b with phenyl isothiocyanate gave the corresponding thioacetanilide 7. The later compound 7 was utilized as the key intermediate for the synthesis of some new thiadiazole derivatives 9a-r. The structures of all new compounds were elucidated on the basis of elemental analysis and spectral data.
Chemistry of the Enaminone of 1-Acetylnaphthalene under Microwave Irradiation Using Chitosan as a Green Catalyst
Huwaida M. E. Hassaneen
Molecules , 2011, DOI: 10.3390/molecules16010609
Abstract: Enaminone 1 was reacted with hydrazonoyl halides 2a-d to yield 3,4-disubstituted pyrazoles 6a-d. Coupling with arenediazonium chlorides afforded the 2-(arylhydrazono)-3-(1-naphthalenyl)-3-oxopropionaldehydes 13a-c. Compounds 13 could be utilized for the synthesis of a variety of arylpyrazoles, arylazolopyrimidines, and pyridazinones via reaction with hydrazines, aminoazoles, and active methylene derivatives, respectively. A comparative study of aforementioned reactions was carried out with chitosan as a basic ecofriendly catalyst under conventional heating as well as under pressurized microwave irradiation conditions.
Synthesis and Antimicrobial Activity of Some New Pyrazoles, Fused Pyrazolo[3,4-d]-pyrimidine and 1,2-Dihydroimidazo-[2,1-c][1,2,4]triazin-6-one Derivatives
Sobhi Mohamed Gomha,Huwaida M.E. Hassaneen
Molecules , 2011, DOI: 10.3390/molecules16086549
Abstract: A novel series of 7,7-diphenyl-1,2-dihydroimidazo[2,1-c][1,2,4]triazin-6(7H)-one 6a–h, were easily prepared via reactions of novel 2-hydrazinyl-4,4-diphenyl-1H-imidazol-5(4H)-one (2) with hydrazonoyl halides 3a–h. In addition, we also examined the reaction of compound 2 with commercially available active methylene compounds to afford new pyrazoles containing an imidazolone moiety, expected to be biologically active. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H-NMR and mass spectral data. The antifungal and antibacterial activities of the newly synthesized compounds were evaluated.
Synthesis of New Derivatives of Heterocyclic Compounds Containing Pyridine, Pyrimidine and Triazole Ortho-Fused to Isoquinoline Moiety
Hamdi M. Hassaneen,Nada M. Abunada,Huwaida M. E. Hassaneen,Omar A. Miqdad
International Journal of Chemistry , 2012, DOI: 10.5539/ijc.v4n3p86
Abstract: 4-Amino-9,10-dimethoxy-2-phenyl-6,7-dihydro-2(H)-pyrido[2,1-a]isoquinoline-1,3-dicarbonitrile derivatives 4a-c were obtained from the reaction of 6,7-dimethoxy-3,4-dihydroisoqinoline-1-acetonitrile 1 with arylidenemalononitrile 2a-c in boiling acetonitile in the presence of piperidine. The reaction of 4a-c with triethyl orthoformate in acetic anhydride at reflux give the ethoxymethyleneamino derivatives 5a-c. Compounds 5a-c were reacted with hydrazine hydrate and give the corresponding 4-amino-3-imino-2-aryl-3,4,8,9-tetrahydro-2(H)-pyrimido[5?,4?:5,6]pyrido[2,1-a]isoquinoline-1-carbonitrile derivatives 6a-c. Refluxing compound 6a in an excess of triethyl orthoformate give 7a. When compounds 6a-c were refluxed with acetic anhydride or benzoyl chloride in pyridine, they afford the corresponding 4-methyl and 4-phenyl derivatives 8a-c and 9a-c, respectively. Compound 6a was refluxed in diethyloxalate and give product 10. Also, the reaction of 6a with C-acylhydrazonoyl halides 13a,b in refluxing chloroform in the presence of triethylamine afford 14a,b. Correct elemental analyses and spectral data (IR, 1H NMR, 13C NMR and MS) confirm the structure of the synthesized compounds.
Utility of Styrylpyrazoloformimidate in the Synthesis of Fused Heterocyclic Compounds  [PDF]
Hamdi M. Hassaneen, Zakaria Ahmed Gomaa
International Journal of Organic Chemistry (IJOC) , 2015, DOI: 10.4236/ijoc.2015.54021
Abstract: Refluxing of (E)-5-amino-1-phenyl-3-styryl-1H-pyrazole-4-carbonitrile 2 with triethylor-thoformate in acetic anhydride afforded the corresponding formimidate 3. Treatment of 3 with hydrazine hydrate in ethanol afforded amino imino compound 4. Reaction of 4 with diethyl dicarbonate at reflux gave (E)-7-phenyl-9-styryl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine 7. Refluxing of 4 with hydrazine hydrate afforded (E)-4-hydrazinyl-1-phenyl-3-styryl-1H-pyrazolo[3,4-d] pyrimidine 8. Treatment of the latter compound 8 with aldehydes in boiling ethanol in the presence of acetic acid afforded the corresponding hydrazone 10. Oxidative cyclization of the hydrazone 10 led to the formation of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine 11. The latter products re-arranged to pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines 13. The structures of the new products were established on the basis of elemental analysis and spectral data.
Reaction of thiocarboxanilide derivatives of 2-phenylimino-3-phenyl-4-thiazolidinone and 1,3-diphenyl-2-thioxo-4-imidazolone with hydrazonoyl halides and active chloromethylene compounds  [PDF]
Hamdi M. Hassaneen, Omar A. Miqdad, Nada M. Abunada, Ahmad A. Fares
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.33026
Abstract: The potassium salts of thiocarboxanilide of 2- phenylimino-3-phenyl-4-thiazolidinone and 1,3- diphenyl-2-thioxo-4-imidazolone react with hydrazonoyl halides in N,N-dimethylformamide to afford the corresponding 1,3,4-thiadiazoline derivatives. 2-Phenylimino-3-phenyl-4-thiazolidinone reacts with active chloromethylene compounds in N,N-dimethylformamide to give the corresponding thiazolylidenethiazolidin-4-one derivatives. The new compounds were characterized using IR, 1H NMR, 13C NMR and mass spectra.
Correlations and spectral functions in asymmetric nuclear matter
Kh. S. A. Hassaneen,H. Müther
Physics , 2004, DOI: 10.1103/PhysRevC.70.054308
Abstract: The self-energy of nucleons in asymmetric nuclear matter is evaluated employing different realistic models for the nucleon-nucleon interaction. Starting from the Brueckner Hartree Fock approximation without the usual angle-average in the two-nucleon propagator the effects of the hole-hole contributions are investigated within the self-consistent Green's function approach. Special attention is paid to the isospin-dependence of correlations, which can be deduced from the spectral functions of nucleons in asymmetric matter. The strong components of the proton - neutron interaction lead in neutron-rich matter to a larger depletion for the occupation probability of proton states below the Fermi momentum.
Michael Reactions of Arylidenesulfonylacetonitriles. A New Route to Polyfunctional Benzo[a]quinolizines
Tayseer. A. Abdallah,Hyam. A. Abdelhadi,Huwida M. Hassaneen,Hamdi M. Hassaneen
Molecules , 2002, DOI: 10.3390/70700540
Abstract: Arylidenesulfonylacetonitriles react in acetonitrile with 1-methylisoquinoline and isoquinolin-1-yl-acetonitrile in the presence of piperidine to give benzo[a]quinolizines 6,9 and 7,10, respectively. The structures of the products were established on the basis of elemental and spectral analyses and their chemical reactivity.
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