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Search Results: 1 - 10 of 21120 matches for " Hun Sik Kim "
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Thermodynamic Assessment of UO2 Pellet Oxidation in Mixture Atmospheres under Spent Fuel Pool Accident  [PDF]
Dong-Joo Kim, Jong Hun Kim, Keon Sik Kim, Jae Ho Yang, Sun Ki Kim, Yang-Hyun Koo
World Journal of Nuclear Science and Technology (WJNST) , 2015, DOI: 10.4236/wjnst.2015.52009
Abstract: For an analysis of the oxidation behavior of UO2 nuclear fuel pellet under a loss of water coolant accident in a spent nuclear fuel pool of an LWR, thermodynamic assessments of UO2 oxidation were carried out under various atmospheric conditions. In a steam atmosphere, it was assessed that UO2 would not be fully oxidized into U3O8 due to the relatively lower oxygen partial pressure, while UO2 will be fully oxidized into U3O8 in an air atmosphere. In an air and steam mixture atmosphere, the UO2 oxidation was dominantly affected by the air volumetric fraction, because of the relatively higher oxygen partial pressure of air. In addition, the effect of H2 volumetric fraction on the oxygen partial pressure under a mixture atmosphere was calculated, and it was revealed that UO2 pellet oxidation could be reduced above the critical value of H2 volumetric fraction.
Thermal Conductivity Measurement of Zr-ZrO2 Simulated Inert Matrix Nuclear Fuel Pellet  [PDF]
Dong-Joo Kim, Young Woo Rhee, Jong Hun Kim, Jang Soo Oh, Keon Sik Kim, Jae Ho Yang
World Journal of Nuclear Science and Technology (WJNST) , 2013, DOI: 10.4236/wjnst.2013.32008
Abstract:

For an evaluation of a thermal conductivity of Zr + 30 vol% ZrO2 simulated inert matrix nuclear fuel pellet, a simulated fuel pellet was fabricated using a hot-pressing method at 800°C in a vacuum and at a 20 MPa load. And several thermophysical properties of the simulated inert matrix fuel pellet were measured and calculated. The thermal diffusivity and linear thermal expansion as a function of temperature of the simulated fuel pellet were measured using a laser flash method and a dilatometry, respectively. Finally, based on the experimental data, the thermal conductivity of the simulated inert matrix fuel pellet was calculated and evaluated.

Design of Human Sensibility Model via Color and Gray Information and Its Application to Content-based Image Retrieval
Hun-Woo Yoo,Dong-Sik Jang,Dae-Ki Kim,Dong-Won Park
Asian Journal of Information Technology , 2012,
Abstract: We propose a new emotion-based image retrieval method in this study. Our method was motivated by Soen’s evaluation of human sensibility on color patterns. Thirteen adjective words expressing emotions such as “like”, “beautiful”, “natural”, “dynamic”, “warm”, “gay”, “cheerful”, “unstable”, “light”, “strong”, “gaudy”, “hard”, and “heavy” are modeled by 19-dimensional color array and 4 x 3 gray matrix. Once the query is presented in text format, emotion model-based query formulation produces the associated color array and gray matrix. Then, images related to the query are retrieved from the database based on the multiplication of color array and gray matrix, each of which is extracted from a database image. For experiments over 440 images, we obtained an average retrieval rate of 0.61 for the use of color array and an average retrieval rate of 0.47 for the use of gray matrix.
First Record of Paranebalia longipes (Crustacea: Phyllocarida: Leptostraca) from South Korea
Ji-Hun Song,Min-Seop Kim,Gi-Sik Min
Animal Systematics, Evolution and Diversity , 2012, DOI: http://dx.doi.org/10.5635/ased.2012.28.4.221
Abstract: Paranebalia longipes (Willemoes-Suhm, 1875) is cosmopolitan and has been usually found in the algal and sponge debris on the sandy mud substrates. This species can be clearly distinguished from other species of Paranebalia by the presence of serration on posterior margin of pleopods, the number of articles on antennule and antenna, and number of teeth on flange of antennule fourth article. The genus Paranebalia is new to Korea. In this paper, we provide detail descriptions of the diagnostic characteristics and illustrations of the P. longipes. Additionally, type locality and world distribution of the genus Paranebalia are provided.
Inhibitory Activity of Bevacizumab to Differentiation of Retinoblastoma Cells
Jang Won Heo, Jin Hyoung Kim, Chang Sik Cho, Hyoung Oh Jun, Dong Hun Kim, Young Suk Yu, Jeong Hun Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033456
Abstract: Vascular endothelial growth factor (VEGF) is a major regulator in retinal and choroidal angiogenesis, which are common causes of blindness in all age groups. Recently anti-VEGF treatment using anti-VEGF antibody has revolutionarily improved the visual outcome in patients with vaso-proliferative retinopathies. Herein, we demonstrated that bevacizumab as an anti-VEGF antibody could inhibit differentiation of retinoblastoma cells without affection to cellular viability, which would be mediated via blockade of extracellular signal-regulated kinase (ERK) 1/2 activation. The retinoblastoma cells expressed VEGFR-2 as well as TrkA which is a neurotrophin receptor associated with differentiation of retinoblastoma cells. TrkA in retinoblastoma cells was activated with VEGF treatment. Interestingly even in the concentration of no cellular death, bevascizumab significantly attenuated the neurite formation of differentiated retinoblastoma cells, which was accompanied by inhibition of neurofilament and shank2 expression. Furthermore, bevacizumab inhibited differentiation of retinoblastoma cells by blockade of ERK 1/2 activation. Therefore, based on that the differentiated retinoblastoma cells are mostly photoreceptors, our results suggest that anti-VEGF therapies would affect to the maintenance or function of photoreceptors in mature retina.
Antimicrobial Peptides for Therapeutic Applications: A Review
Min-Duk Seo,Hyung-Sik Won,Ji-Hun Kim,Tsogbadrakh Mishig-Ochir,Bong-Jin Lee
Molecules , 2012, DOI: 10.3390/molecules171012276
Abstract: Antimicrobial peptides (AMPs) have been considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and different mechanisms of action compared to conventional antibiotics. Although AMPs possess considerable benefits as new generation antibiotics, their clinical and commercial development still have some limitations, such as potential toxicity, susceptibility to proteases, and high cost of peptide production. In order to overcome those obstacles, extensive efforts have been carried out. For instance, unusual amino acids or peptido-mimetics are introduced to avoid the proteolytic degradation and the design of short peptides retaining antimicrobial activities is proposed as a solution for the cost issue. In this review, we focus on small peptides, especially those with less than twelve amino acids, and provide an overview of the relationships between their three-dimensional structures and antimicrobial activities. The efforts to develop highly active AMPs with shorter sequences are also described.
Unified Platform for AI and Big Data Analytics  [PDF]
Sik Kim, Yongjin Kwon
Journal of Computer and Communications (JCC) , 2017, DOI: 10.4236/jcc.2017.58001
Abstract: This paper describes an integrated platform for machine learning and big data analysis. The integrated platform is configured in a way that builds a large distributed data processing environment in the computing environment that makes up the NVIDIA AI platform. In addition, this paper describes the background of this idea selection and the use of the software to build the unified platform. The technical details are shown in terms of how to create the proposed platform. In the anlaysis section, the methodology is provided and also the steps are explained as to how to use this integration platform. Finally, the expected effects are elaborated in the conclusion section.
Behavior of a Scale Factor for Wiener Integrals and a Fourier Stieltjes Transform on the Wiener Space  [PDF]
Young Sik Kim
Applied Mathematics (AM) , 2018, DOI: 10.4236/am.2018.95035
Abstract: The purpose of this paper is to investigate the behavior of a Wiener integral along the curve C of the scale factor ρ > 0 for the Wiener integral ∫C0[0,T]F(ρx)dm(x) about the function \"\" defined on the Wiener space C0[0,T], where θ(t,u) is a Fourier-Stieltjes transform of a complex Borel measure.
Natural Killer Cells from Patients with Chronic Rhinosinusitis Have Impaired Effector Functions
Ji Heui Kim, Gye Eun Kim, Gye Song Cho, Hyung-Joon Kwon, Chul Hyun Joo, Hun Sik Kim, Yong Ju Jang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0077177
Abstract: Natural killer (NK) cells are multicompetent lymphocytes of the innate immune system that play a central role in host defense and immune regulation. Although increasing evidence suggests that innate immunity plays a key role in the pathogenesis of chronic rhinosinusitis (CRS), the role of NK cells in CRS has been poorly studied. This study aimed to characterize the peripheral blood NK cells from patients with CRS, and to compare the functions of these cells with those from non-CRS controls. The correlation between NK cell functional activity and prognosis was also assessed. Eighteen CRS patients and 19 healthy non-CRS controls were included. The patients with CRS were classified into two subgroups, namely a treatment-responsive group and recalcitrant group. NK cell degranulation was determined by measuring the cell surface expression of CD107a against 721.221 and K562 cells. Intracytoplasmic cytokine production was determined by flow cytometry. Compared to the controls, the NK cells of CRS group had an impaired ability to degranulate and to produce cytokines such as IFN-γ and TNF-α. The recalcitrant subgroup showed the most severe defects in NK cell effector functions. Moreover, the decreased NK cell functions in patients with CRS were associated with poor prognostic factors such as concomitant asthma and peripheral blood eosinophilia. NK cells, which were originally named for their ability to mediate spontaneous cytotoxicity towards diseased cells including infected cells, may play an important role in regulating the inflammatory process in CRS pathogenesis.
AFM-Detected Apoptotic Changes in Morphology and Biophysical Property Caused by Paclitaxel in Ishikawa and HeLa Cells
Kyung Sook Kim, Chang Hoon Cho, Eun Kuk Park, Min-Hyung Jung, Kyung-Sik Yoon, Hun-Kuk Park
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030066
Abstract: The apoptosis of cancer cells is associated with changes in the important cell properties including morphology, surface roughness and stiffness. Therefore, the changes in morphology and biophysical properties can be a good way of evaluating the anticancer activity of a drug. This study examined the effect of paclitaxel on the properties of Ishikawa and HeLa cells using atomic force microscopy (AFM), and the relationship between the changes in morphology and the biophysical properties and apoptosis was discussed. The viability and proliferation of the cells were analyzed using the methylthiazol tetrazolium (MTT) method and a TUNEL assay to confirm cellular apoptosis due to a paclitaxel treatment. AFM observations clearly showed the apoptotic morphological and biophysical changes in Ishikawa and HeLa cells. After the paclitaxel treatment, the cell membrane was torn and holed, the surface roughness was increased, and the stiffness was decreased. These changes were observed more apparently after a 24 h treatment and in Ishikawa cells compared to HeLa cells. The MTT and TUNEL assays results revealed the Ishikawa cells to be more sensitive to paclitaxel than HeLa cells and definite apoptosis occurred after a 24 h treatment. These results showed good agreement with the AFM results. Therefore, research on the morphological and biophysical changes by AFM in cancer cells will help to evaluate the anticancer activities of the drugs.
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