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Search Results: 1 - 10 of 325376 matches for " Hulda S Hreggvidsdottir "
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High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts
Heidi W?h?maa, Hanna Schierbeck, Hulda S Hreggvidsdottir, Karin Palmblad, Anne-Charlotte Aveberger, Ulf Andersson, Helena Harris
Arthritis Research & Therapy , 2011, DOI: 10.1186/ar3450
Abstract: Synovial fibroblasts obtained from rheumatoid arthritis (RA) and osteoarthritis (OA) patients were stimulated with HMGB1 alone or in complex with LPS, IL-1α or IL-1β. Tumour necrosis factor (TNF) production was determined by enzyme-linked immunospot assay (ELISPOT) assessment. Levels of IL-10, IL-1-β, IL-6 and IL-8 were measured using Cytokine Bead Array and matrix metalloproteinase (MMP) 3 production was determined by ELISA.Stimulation with HMGB1 in complex with LPS, IL-1α or IL-1β enhanced production of TNF, IL-6 and IL-8. HMGB1 in complex with IL-1β increased MMP production from both RASF and OASF. The cytokine production was inhibited by specific receptor blockade using detoxified LPS or IL-1 receptor antagonist, indicating that the synergistic effects were mediated through the partner ligand-reciprocal receptors TLR4 and IL-1RI, respectively.HMGB1 in complex with LPS, IL-1α or IL-1β boosted proinflammatory cytokine- and MMP production in synovial fibroblasts from RA and OA patients. A mechanism for the pathogenic role of HMGB1 in arthritis could thus be through enhancement of inflammatory and destructive mechanisms induced by other proinflammatory mediators present in the arthritic joint.The highly conserved protein high mobility group box protein 1 (HMGB1) exerts vital functions in the nucleus of all eukaryotic cells. When tissue injury is inflicted and inflammation is induced, HMGB1 can be released extracellularly and can then convey inflammatory functions. Extracellular HMGB1 may induce cytokine production, up-regulation of adhesion molecules on endothelial cells and activation of dendritic cells and T cells [1-11]. The reported presence of extracellular HMGB1 in multiple inflammatory conditions and the beneficial effects of HMGB1 blockade in preclinical models of inflammatory diseases have thus led to the acknowledgement of HMGB1 as an inflammatory mediator with pathogenic functions in several inflammatory diseases (reviewed in [12]).HMGB1 interacts with th
Convers o ao pentecostalismo e altera es cognitivas e de identidade
Hulda Stadtler
REVER : Revista de Estudos da Religi?o , 2002,
Consistent Estimation of Gibbs Energy Using Component Contributions
Elad Noor ,Hulda S. Haraldsdóttir ,Ron Milo ,Ronan M. T. Fleming
PLOS Computational Biology , 2013, DOI: 10.1371/journal.pcbi.1003098
Abstract: Standard Gibbs energies of reactions are increasingly being used in metabolic modeling for applying thermodynamic constraints on reaction rates, metabolite concentrations and kinetic parameters. The increasing scope and diversity of metabolic models has led scientists to look for genome-scale solutions that can estimate the standard Gibbs energy of all the reactions in metabolism. Group contribution methods greatly increase coverage, albeit at the price of decreased precision. We present here a way to combine the estimations of group contribution with the more accurate reactant contributions by decomposing each reaction into two parts and applying one of the methods on each of them. This method gives priority to the reactant contributions over group contributions while guaranteeing that all estimations will be consistent, i.e. will not violate the first law of thermodynamics. We show that there is a significant increase in the accuracy of our estimations compared to standard group contribution. Specifically, our cross-validation results show an 80% reduction in the median absolute residual for reactions that can be derived by reactant contributions only. We provide the full framework and source code for deriving estimates of standard reaction Gibbs energy, as well as confidence intervals, and believe this will facilitate the wide use of thermodynamic data for a better understanding of metabolism.
Steady-State Metabolite Concentrations Reflect a Balance between Maximizing Enzyme Efficiency and Minimizing Total Metabolite Load
Naama Tepper, Elad Noor, Daniel Amador-Noguez, Hulda S. Haraldsdóttir, Ron Milo, Josh Rabinowitz, Wolfram Liebermeister, Tomer Shlomi
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0075370
Abstract: Steady-state metabolite concentrations in a microorganism typically span several orders of magnitude. The underlying principles governing these concentrations remain poorly understood. Here, we hypothesize that observed variation can be explained in terms of a compromise between factors that favor minimizing metabolite pool sizes (e.g. limited solvent capacity) and the need to effectively utilize existing enzymes. The latter requires adequate thermodynamic driving force in metabolic reactions so that forward flux substantially exceeds reverse flux. To test this hypothesis, we developed a method, metabolic tug-of-war (mTOW), which computes steady-state metabolite concentrations in microorganisms on a genome-scale. mTOW is shown to explain up to 55% of the observed variation in measured metabolite concentrations in E. coli and C. acetobutylicum across various growth media. Our approach, based strictly on first thermodynamic principles, is the first method that successfully predicts high-throughput metabolite concentration data in bacteria across conditions.
Identidade étnica e poder: os quilombos nas políticas públicas brasileiras
Calheiros, Felipe Peres;Stadtler, Hulda Helena Coraciara;
Revista Katálysis , 2010, DOI: 10.1590/S1414-49802010000100016
Abstract: by specifically analyzing how residents of quilombos are affected by the new national policy for technical and rural extension assistance (pnater), this article examines the relation of power between public policies and ethnic identities. it discusses how the reformulated concept of development influences government activity in rural contexts and the adoption of compensatory actions for excluded portions of the population. it briefly presents the social, legal and conceptual trajectory of the quilombos, localizing the dynamics of power in the construction of quilombola identity, a project in constant re-elaboration by brazilian society.
Mechanical and water vapor permeability properties of biodegradables films based on methylcellulose, glucomannan, pectin and gelatin
Chambi, Hulda Noemi Mamani;Grosso, Carlos Raimundo Ferreira;
Ciência e Tecnologia de Alimentos , 2011, DOI: 10.1590/S0101-20612011000300029
Abstract: mimic biological structures such as the cell wall of plant tissues may be an alternative to obtain biodegradable films with improved mechanical and water vapor barrier properties. this study aims to evaluate the mechanical properties and water vapor permeability (wvp) of films produced by using the solvent-casting technique from blended methylcellulose, glucomannan, pectin and gelatin. first, films from polysaccharides at ph 4 were produced. the film with the best mechanical performance (tensile strength = 72.63 mpa; elongation = 9.85%) was obtained from methylcellulose-glucomannan-pectin at ratio 1:4:1, respectively. then, gelatin was added to this polysaccharide blend and the ph was adjusted to 4, 5 and 6. results showed significant improvement in wvp when films were made at ph 5 and at polysaccharides/gelatin ratio of 90/10 and 10/90, reaching 0.094 and 0.118 g.mm/h.m2.kpa as values, respectively. films with the best mechanical properties were obtained from the blend of polysaccharides, whereas wvp was improved from the blend of polysaccharides and gelatin at ph 5.
Mercedes Delgado Fernández,Marconi Edson Esmeraldo,Hulda Oliveira Giesbrecht
Ingeniería Industrial , 2002,
Abstract: El trabajo aborda un análisis comparativo de diferentes encuestas e indicadores utilizados para la evaluación de la innovación tecnológica, para lo cual se establecen las semejanzas y diferencias, con los objetivos y exigencias de cada instrumento de evaluación, mostrándose un conjunto de recomendaciones para las condiciones de América Latina en términos de innovación.
Prevalence and characteristics of epilepsy in the Belgian shepherd variants Groenendael and Tervueren born in Denmark 1995–2004
Mette Berendt, Christina Gull?v, Stine Christensen, Hulda Gudmundsdottir, Hanne Gredal, Merete Fredholm, Lis Alban
Acta Veterinaria Scandinavica , 2008, DOI: 10.1186/1751-0147-50-51
Abstract: All owners of Groenendael and Tervueren dogs born between January 1995 and December 2004 and registered in the Danish Kennel Club (1,248 dogs) were contacted and asked to answer a mailed questionnaire concerning epilepsy. Positive responders were subsequently validated in a follow-up interview conducted by telephone using a standardized questionnaire. Owners were questioned about age at first seizure, seizure frequency, seizure duration, a detailed description of seizure phenomenology, post-ictal signs and if a veterinarian had diagnosed the dog with epilepsy.Prevalence of epilepsy was estimated at 9.5%. Mean age of epilepsy debut was 3.3 years (range 0.5–8.0 years). There was an almost equal number of Groenendael (25) and Tervueren (24). The distribution of females and males was 31 and 18 respectively. Twenty-five per cent experienced focal seizures, 53% experienced focal seizures with secondary generalization and 18% experienced primary generalized seizures. In four percent seizures were unclassifiable. The most commonly reported focal seizure phenomenology included ataxia, crawling, swaying, fearful behavior, salivation, excessive attention seeking and disorientation. In 16% of the cases, epilepsy led to euthanasia. Intact dogs with epilepsy had a significantly increased risk of being euthanized because of epilepsy compared to neutered dogs with epilepsy. In 22% of the cases the owners reported that anxiety/hyperactivity/stress could act as a seizure provoking factor.A high prevalence of epilepsy appears to be present in the Danish Groenendael and Tervueren population. The relatively late debut age of epilepsy in this breed contributes greatly to the increased prevalence of epileptic individuals, because dogs developing epilepsy late in life are used for breeding unintended.Epilepsy is a neurological condition characterized by episodic cerebral neuronal dysfunction leading to seizures with convulsion or more focal signs as, i.e. localized motor signs, autonomic s
Evaluation of the Implementation of Undergraduate General Studies Entrepreneurship Curriculum in Federal Universities in North-Central Geo-Political Zone, Nigeria  [PDF]
Hulda Maxwell Davwet, Dorah Nanman Damar, Meshach Gomam Goyit, Yakubu Gorah Kajang
Creative Education (CE) , 2019, DOI: 10.4236/ce.2019.106088
Abstract: The study evaluated the Implementation of Undergraduate Entrepreneurship Curriculum in Federal Universities in North Central Geo-Political Zone, Nigeria. The study was aimed at finding out the level of the implementation of the GST entrepreneurship education in federal universities in Nigeria and how it has equipped the undergraduate students with the necessary entrepreneurship skills that would enable them?topractice after graduation. Four research questions and two hypotheses were raised for the study. A cross-sectional survey research design was used for the study. The population of the study constituted of seven federal universities in the study area 14 directors, 49 GST lecturers and 25,087 final year (400 levels) undergraduate students. The sample size of the study consisted of five federal universities, 10 Directors (including five GST Directors & five Entrepreneurship Directors), 29 GST lecturers and 1826?final year (400 levels)?undergraduate students using multi-stage sampling technique. The instruments for data collection were structured Undergraduate General Studies Entrepreneurship Curriculum Implementation Questionnaires (UGSECIQ) which were sub-divided into three sections for:?directors, lecturers and students. Content validity was established on the questionnaire by three experts, each from Curriculum Studies, Business Management and Measurement and Evaluation from the University of Jos. A reliability coefficient of 0.890, 0.901 and 0.957 for the directors, lecturers and students’ responses respectively were obtained through Cronbach Alpha. The data obtained for the research questions were analysed using mean, standard deviation and simple percentage while chi-square for independent samples and ANOVA were used for testing the hypotheses using SPSS version 21.0. The results of the findings revealed that the implementation process of the undergraduate GST entrepreneurship education was constrained by inadequate funding to
Production and characterization of lipid microparticles produced by spray cooling encapsulating a low molar mass hydrophilic compound
Leonel, Alda Jusceline;Chambi, Hulda Noemi Mamani;Barrera-Arellano, Daniel;Pastore, Heloise Oliveira;Grosso, Carlos Raimundo Ferreira;
Ciência e Tecnologia de Alimentos , 2010, DOI: 10.1590/S0101-20612010005000014
Abstract: the objective of this research was to produce and characterize lipid particles (mpls) that may be used as carriers of high amounts of hydrophilic core and evaluate the influence of the core amount on the performance of lipid microparticles. the mpls were produced by spray cooling from solid and liquid lipid mixtures (stearic and oleic fatty acids and partly hydrogenated vegetable fat) containing glucose solution as core and soy lecithin as surfactant. the performance of mpls was evaluated by means of the effective amount of encapsulated core, the core amount present on the surface of mpls (superficial glucose) and the core release profile in aqueous solution. morphological observations showed that mpls presented spherical shape and a rugged and continuous surface, and an average diameter between 25 and 32 μm. the effective amount of encapsulated core was greater than 78% for all formulations evaluated. larger amounts of superficial glucose were found in formulations in which more concentrated glucose solutions were used, regardless of the glucose lipid-solution ratio. the release results showed that core retention was significantly influenced by the glucose solution concentration, whereas release modulation was influenced by the glucose lipid-solution ratio.
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