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Search Results: 1 - 10 of 15072 matches for " Huihong Tao "
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Combination Therapy of VEGF-Trap and Gemcitabine Results in Improved Anti-Tumor Efficacy in a Mouse Lung Cancer Model
Shuang Zhou, Yang Yang, Yaoqin Yang, Huihong Tao, Dong Li, Junli Zhang, Gening Jiang, Jianmin Fang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0068589
Abstract: Background Angiogenesis is essential for the growth and metastasis of cancer. Although anti-angiogenic agents, particularly vascular endothelial growth factor (VEGF) inhibitors, have exhibited single-agent activity, there is considerable interest in combining these novel drugs with conventional chemotherapy reagents to achieve an optimal clinical efficacy. The objective of this study was to evaluate the benefits of the combination therapy of vascular endothelial growth factor trap (VEGF-Trap) with gemcitabine in a lung tumor model. Methods A luciferase-expressing Lewis lung carcinoma (LLC) model was established in C57BL/6J mice and tumor-bearing mice were randomized into control, VEGF-Trap, gemcitabine and VEGF-Trap/gemcitabine combination groups. Tumor growth and animal survival were monitored. Tumor microvessel density and cell proliferation were evaluated by CD31 and Ki-67 immunohistochemical analysis. TUNEL assay was performed to detect apoptotic cells. The protein levels of Cyclin D1, Pro-Caspase-3, Bcl-2, MMP2 and MMP9 in tumor extracts were examined by western blot. Results VEGF-Trap in combination with gemcitabine showed significantly enhanced inhibition of tumor growth and prolonged mouse survival compared to the VEGF-Trap or gemcitabine monotherapy. The VEGF-Trap/gemcitabine combination therapy not only potently inhibited tumor angiogenesis and cell proliferation, but also increased cellular apoptosis within tumor tissues. In addition, the combination treatment markedly down-regulated the expression of proliferation, anti-apoptosis and invasion related proteins. Conclusion Combination therapy using VEGF-Trap and gemcitabine resulted in improved anti-tumor efficacy in a lung cancer model and VEGF-Trap/gemcitabine combination might represent a promising strategy in the treatment of human lung cancer.
CCR7 Expression and Intratumoral FOXP3+ Regulatory T Cells are Correlated with Overall Survival and Lymph Node Metastasis in Gastric Cancer
Shuang Zhou, Shuchang Xu, Huihong Tao, Zhiwei Zhen, Guolin Chen, Zhiqiang Zhang, Yaoqin Yang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0074430
Abstract: The aim of this study was to investigate the prognostic value of chemokine receptor CCR7 expression and intratumoral FOXP3+ regulatory T cells (Tregs) in gastric cancer. CCR7+ tumor cells and FOXP3+ Tregs were assessed by immunohistochemistry in tissue microarrays containing gastric cancer from 133 patients. Prognostic effects of low or high CCR7 and FOXP3 expression were evaluated by Cox regression and Kaplan-Meier analysis, as well as the correlation between CCR7 positive score and intratumoral FOXP3+ cell number in a longitudinal assessment. The analysis showed that the high expression levels of CCR7 and FOXP3 were detected in 69.9% and 65.4% of cases, respectively. High CCR7 expression in gastric cancer cells was significantly associated with poor overall survival (OS) (P = 0.010) and lymph node metastasis (P = 0.009), and was an independent factor for worse OS (P = 0.023) by multivariate analysis. High numbers of intratumoral FOXP3+ Tregs significantly correlated with shorter OS (P = 0.021) and lymph node metastasis (P = 0.024), and was also an independent factor for adverse OS (P = 0.035). Furthermore, there was a significantly positive correlation between CCR7 positive score and intratumoral FOXP3+ cell number (r = 0.949, P<0.001). These results revealed that CCR7 expression in gastric cancer cells and intratumoral FOXP3+ Tregs could be considered as a co-indicator of clinical prognosis of gastric cancer.
Depletion of CD4+ CD25+ Regulatory T Cells Promotes CCL21-Mediated Antitumor Immunity
Shuang Zhou, Huihong Tao, Zhiwei Zhen, Haixia Chen, Guolin Chen, Yaoqin Yang
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0073952
Abstract: CCL21 is known to attract dendritic cells (DCs) and T cells that may reverse tumor-mediated immune suppression. The massive infiltration of tumors by regulatory T cells (Tregs) prevents the development of a successful helper immune response. In this study, we investigated whether elimination of CD4+ CD25+ Tregs in the tumor microenvironment using anti-CD25 monoclonal antibodies (mAbs) was capable of enhancing CCL21-mediated antitumor immunity in a mouse hepatocellular carcinoma (HCC) model. We found that CCL21 in combination with anti-CD25 mAbs (PC61) resulted in improved antitumor efficacy and prolonged survival, not only inhibited tumor angiogenesis and cell proliferation, but also led to significant increases in the frequency of CD4+, CD8+ T cells and CD11c+ DCs within the tumor, coincident with marked induction of tumor-specific CD8+ cytotoxic T lymphocytes (CTLs) at the local tumor site. The intratumoral immune responses were accompanied by the enhanced elaboration of IL-12 and IFN-γ, but reduced release of the immunosuppressive mediators IL-10 and TGF-β1. The results indicated that depletion of Tregs in the tumor microenvironment could enhance CCL21-mediated antitumor immunity, and CCL21 combined with anti-CD25 mAbs may be a more effective immunotherapy to promote tumor rejection.
Finite-Time Filtering for Linear Continuous Time-Varying Systems with Uncertain Observations
Huihong Zhao,Chenghui Zhang
Journal of Applied Mathematics , 2012, DOI: 10.1155/2012/710904
Abstract: This paper is concerned with the finite-time ∞ filtering problem for linear continuous time-varying systems with uncertain observations and ℒ2-norm bounded noise. The design of finite-time ∞ filter is equivalent to the problem that a certain indefinite quadratic form has a minimum and the filter is such that the minimum is positive. The quadratic form is related to a Krein state-space model according to the Krein space linear estimation theory. By using the projection theory in Krein space, the finite-time ∞ filtering problem is solved. A numerical example is given to illustrate the performance of the ∞ filter.
The Role of Session Border Controllers in the DMZ of Voice over IP(VoIP) Networks
Huihong Chen,Zhigang Chen
Computer and Information Science , 2009, DOI: 10.5539/cis.v1n3p27
Abstract: SBCs usually sit between two service provider networks in a peering environment, or between an access network and a backbone network to provide service to residential and/or enterprise customers. They provide a variety of functions to enable or enhance session-based multi-media services (e.g., Voice over IP). This thesis analyzes the internet structure of SBC and shows single-box and dual-box SBCs in the DMZ and introduces firewalls and network address translation. And then explain how the SBC cooperates with the firewalls to ensure that VoIP signaling and media traverses the DMZ without compromising the security of the
Metal Stenting with or without Endobiliary Radiofrequency Ablation for Unresectable Extrahepatic Cholangiocarcinoma  [PDF]
Huihong Liang, Zhenwei Peng, Liangqi Cao, Shikun Qian, Zili Shao
Journal of Cancer Therapy (JCT) , 2015, DOI: 10.4236/jct.2015.611106
Abstract: Background: Retrospective comparison of stent patency and survival of patients with unresectable extrahepatic cholangiocarcinoma (CCA) treated by placement of self-expanding metal stents (SEMS) with or without endobiliary radiofrequency ablation (ERFA). Methods: Between January 2010 and September 2014, 76 patients with biliary obstruction caused by unresectable extrahepatic CCA (27 patients with Bismuth type I hilar CCA and 49 patients with distal CCA) were recruited into this study. Patients either received ERFA with SEMS (n = 34) or SEMS only (n = 42). Stent patency and survival of both groups were compared and predictors for overall survival were analyzed. Results: Demographic data were not different between the two groups. Complication rates of both groups were similar. Thirty-day stent patency was obtained in all patients and the median stent patency in the ERFA + SEMS group (9.5 months, 4.5 - 14.0 months) was significantly longer than that in the SEMS group (8.4 months, 4.9 - 11 months) (P = 0.024). The overall survival curve in the ERFA + SEMS group was significantly better than that of the SEMS group (P = 0.036). Multivariate Cox proportional hazards regression analyses showed that ERFA, tumor AJCC stage, extrahepatic CCA type, serum albumin and adjuvant chemotherapy were significant prognostic factors for overall patient survival. Conclusions: ERFA is effective for unresectable extrahepatic CCA and may improve metal stent patency and patient survival for unresectable extrahepatic CCA with biliary obstruction. Prospective randomized trials will be needed to confirm these findings.
Percutaneous Microwave Coagulation for the Treatment of Small Solitary Focal Nodular Hyperplasia of Liver  [PDF]
Huihong Liang, Xiaodong Song, Liangqi Cao, Shikun Qian, Zili Shao
Open Journal of Gastroenterology (OJGas) , 2016, DOI: 10.4236/ojgas.2016.68026
Abstract: Background: Whether percutaneous microwave coagulation (PMC) is safe and effective for the treatment of symptomatic focal nodular hyperplasia (FNH) of the liver remains unknown. Methods: Between January 2006 and September 2015, sixteen patients with solitary symptomatic FNHs in the liver (the largest diameter less than 5 cm) were treated by PMC. The safty and effectiveness were analyzed. Results: There were 4 males and 12 females. All these patients suffered from upper abdominal pain. The FNHs ranged in size from 3.2 cm to 5.0 cm (3.9 cm ± 0.12 cm). All the PMC procedures were performed successfully. All 16 patients had symptomatic improvement after the treatment with no procedure-related morbidity or mortality. Among 16 patients, 15 (93.8%) patients with FNHs were assessed to be ablated completely by CT examination performed within four weeks after PMC treatment. One patient failed to follow up regularly, but showed up 2 years and 7 months later for suffering upper abdominal pain again with original FNH enlargement, and the patient received surgical resection of the FNH and achieved asymptomatic aftermath. Conclusion: PMC is safe and effectiveness for symptomatic liver FNHs. PMC should be considered to be an alternative modality for those solitary FNHs with less than 5 cm in diameter.
Estimation for a Class of Lipschitz Nonlinear Discrete-Time Systems with Time Delay
Huihong Zhao,Chenghui Zhang,Guangchen Wang,Guojing Xing
Abstract and Applied Analysis , 2011, DOI: 10.1155/2011/970978
Abstract: The issue of ∞ estimation for a class of Lipschitz nonlinear discrete-time systems with time delay and disturbance input is addressed. First, through integrating the ∞ filtering performance index with the Lipschitz conditions of the nonlinearity, the design of robust estimator is formulated as a positive minimum problem of indefinite quadratic form. Then, by introducing the Krein space model and applying innovation analysis approach, the minimum of the indefinite quadratic form is obtained in terms of innovation sequence. Finally, through guaranteeing the positivity of the minimum, a sufficient condition for the existence of the ∞ estimator is proposed and the estimator is derived in terms of Riccati-like difference equations. The proposed algorithm is proved to be effective by a numerical example.
Porosity and permeability evolution and evaluation in anisotropic porosity multiscale-multiphase-multicomponent structure
BoJing Zhu,HuiHong Cheng,YanChao Qiao,Chang Liu,YaoLin Shi,Kai Zhang,DongSheng Sun,WeiRen Lin
Chinese Science Bulletin , 2012, DOI: 10.1007/s11434-011-4874-4
Abstract: Based on the hybrid hypersingular integral equation-lattice Boltzmann methods (HHIE-LBM), the porosity and permeability evolution and evaluation process in anisotropic saturated porosity multiscale-multiphase-multicomponent (ASP-MS-MP-MC) structures under ultra high temperature and pressure conditions was analyzed on parallel CPU and GPU platforms. First, virtual physical models at multi-spatial scales (2 μm, 5 μm and 10 μm) were restructured by computerized microtomography technology and data. Second, using HHIE-LBM methods, the anisotropic porosity and permeability tensor at core level and pore level under ultra high temperature and pressure conditions were calculated. Third, the evolution and evaluation process of the porosity and permeability as a function of multi temporal spatial scales was investigated. Finally, the relationship between porosity and permeability and ASP-MS-MP-MC structures (micro-meso-macro-scale) was explored.
The Synergistic Mechanism for the Formation of High-School Students Moral Conduct Tendency in Moral Education

Chen Yuting,Deng Huihong,

系统工程理论与实践 , 1999,
Abstract: Judging from the function of the designing model for the non linear modern educational system, the formation of good moral conduct tendency plays an important role in improving high school moral education effects. On the basis of fuzzy, comprehensive appraisal of high school students' moral behaviour, and by applying relevant synergistic theories and methods, this paper establishes a stochastic model for the formation of collective moral conduct tendency and reveals the nonequilibrium phase transition rules for forming the system's ordered structure. Thus, it offers some new ideas and skills for the scientific management and research in moral education.
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