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Search Results: 1 - 10 of 8001 matches for " HuiLi Dai "
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The changes in telomerase activity and telomere length in HeLa cells undergoing apoptosis induced by sodium butyrate
Jianguo Ren,Huili Xia,Yaoren Dai
Chinese Science Bulletin , 2001, DOI: 10.1007/BF03187012
Abstract: The changes in telomerase activity and telomere length during apoptosis in HeLa cells as induced by sodium butyrate (SB) have been studied. After a 48 h SB treatment, HeLa cells demonstrated characteristic apoptotic hallmarks including chromatin condensation, formation of apoptotic bodies and DNA Laddering which were caused by the cleavage and degradation of DNA between nucleosomes. There were no significant changes in telomerase activity of apoptotic cells, while the telomere length shortened markedly. In the meanwhile, cells became more susceptible to apoptotic stimuli and telomere became more vulnerable to degradation after telomerase activity was inhibited. All the results suggest that the apoptosis induced by SB is closely related to telomere shortening, while telomerase enhances resistance of HeLa cells to apoptotic stimuli by protecting telomere.
The changes in telomerase activity and telomere length in HeLa cells undergoing apop- tosis induced by sodium butyrate

REN Jianguo,XIA Huili,DAI Yaoren,

科学通报(英文版) , 2001,
Abstract: The changes in telomerase activity and telomere length during apoptosis in HeLa cells as induced by sodium butyrate (SB) have been studied. After a 48 h SB treatment, HeLa cells demonstrated characteristic apoptotic hallmarks including chromatin condensation, formation of apoptotic bodies and DNA Laddering which were caused by the cleavage and degradation of DNA between nucleosomes. There were no significant changes in telomerase activity of apoptotic cells, while the telomere length shortened markedly. In the meanwhile, cells became more susceptible to apoptotic stimuli and telomere became more vulnerable to degradation after telomerase activity was inhibited. All the results suggest that the apoptosis induced by SB is closely related to telomere shortening, while telomerase enhances resistance of HeLa cells to apoptotic stimuli by protecting telomere.
An integrated assessment of the impact of precipitation and groundwater on vegetation growth in arid and semiarid areas
Lin Zhu,Huili Gong,Zhenxue Dai,Tingbao Xu,Xiaosi Su
Physics , 2014,
Abstract: Increased demand for water resources together with the influence of climate change has degraded water conditions which support vegetation in many parts of the world, especially in arid and semiarid areas. This study develops an integrated framework to assess the impact of precipitation and groundwater on vegetation growth in the Xiliao River Plain of northern China. The integrated framework systematically combines remote sensing technology with water flow modeling in the vadose zone and field data analysis. The vegetation growth is quantitatively evaluated with the remote sensing data by the Normalized Difference Vegetation Index (NDVI) and the simulated plant water uptake rates. The correlations among precipitation, groundwater depth and NDVI are investigated by using Pearson correlation equations. The results provide insights for understanding interactions between precipitation and groundwater and their contributions to vegetation growth. Strong correlations between groundwater depth, plant water uptake and NDVI are found in parts of the study area during a ten-year drought period. The numerical modeling results indicate that there is an increased correlation between the groundwater depth and vegetation growth and that groundwater significantly contributes to sustaining effective soil moisture for vegetation growth during the long drought period. Therefore, a decreasing groundwater table might pose a great threat to the survival of vegetation during a long drought period.
Statistic inversion of multi-zone transition probability models for aquifer characterization in alluvial fans
Lin Zhu,Zhenxue Dai,Huili Gong,Carl Gable,Pietro Teatini
Physics , 2015,
Abstract: Understanding the heterogeneity arising from the complex architecture of sedimentary sequences in alluvial fans is challenging. This paper develops a statistical inverse framework in a multi-zone transition probability approach for characterizing the heterogeneity in alluvial fans. An analytical solution of the transition probability matrix is used to define the statistical relationships among different hydrofacies and their mean lengths, integral scales, and volumetric proportions. A statistical inversion is conducted to identify the multi-zone transition probability models and estimate the optimal statistical parameters using the modified Gauss-Newton-Levenberg-Marquardt method. The Jacobian matrix is computed by the sensitivity equation method, which results in an accurate inverse solution with quantification of parameter uncertainty. We use the Chaobai River alluvial fan in the Beijing Plain, China, as an example for elucidating the methodology of alluvial fan characterization. The alluvial fan is divided into three sediment zones. In each zone, the explicit mathematical formulations of the transition probability models are constructed with optimized different integral scales and volumetric proportions. The hydrofacies distributions in the three zones are simulated sequentially by the multi-zone transition probability-based indicator simulations. The result of this study provides the heterogeneous structure of the alluvial fan for further study of flow and transport simulations.
Consent for Use of Clinical Leftover Biosample: A Survey among Chinese Patients and the General Public
Yi Ma, HuiLi Dai, LiMin Wang, LiJun Zhu, HanBing Zou, XianMing Kong
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0036050
Abstract: Background Storage of leftover biosamples generates rich biobanks for future studies, saving time and money and limiting physical impact to sample donors. Objective To investigate the attitudes of Chinese patients and the general public on providing consent for storage and use of leftover biosamples. Design, Setting and Participants Cross-sectional surveys were conducted among randomly selected patients admitted to a Shanghai city hospital (n = 648) and members of the general public (n = 492) from May 2010 to July 2010. Main Outcome Measures Face-to-face interviews collected respondents-report of their willingness to donate residual biosample, trust in medical institutions, motivation for donation, concerns of donated sample use, expectations for research results return, and so on. Results The response rate was 83.0%. Of the respondents, 89.1% stated that they completely understood or understood most of questions. Willingness to donate residual sample was stated by 64.7%, of which 16.7% desired the option to withdraw their donations anytime afterwards. Only 42.3% of respondents stated they “trust" or “strongly trust" medical institutions, the attitude of trusting or strongly trusting medical institutions were significantly associated with willingness to donate in the general public group.(p<0.05) The overall assent rate for future research without specific consents was also low (12.1%). Hepatitis B virus carriers were significantly less willing than non-carriers to donate biosamples (32.1% vs. 64.7%, p<0.001). Conclusions Low levels of public trust in medical institutions become serious obstacle for biosample donation and biobanking in China. Efforts to increase public understanding of human medical research and biosample usage and trust in the ethical purposes of biobanking are urgently needed. These efforts will be greatly advanced by the impending legislation on biobanking procedures and intent, and our results may help guide the structure of such law.
Uniqueness for the martingale problem associated with pure jump processes of variable order
Huili Tang
Mathematics , 2007,
Abstract: Let $L$ be the operator defined on $C^2$ functions by $$L f(x)=\int[f(x+h)-f(x)-1_{(|h|\leq 1)}\nabla f(x)\cdot h]\frac{n(x,h)}{|h|^{d+\alpha(x)}}dh.$$ This is an operator of variable order and the corresponding process is of pure jump type. We consider the martingale problem associated with $L$. Sufficient conditions for existence and uniqueness are given. Transition density estimates for $\alpha$-stable processes are also obtained.
Deficiency of Antinociception and Excessive Grooming Induced by Acute Immobilization Stress in Per1 Mutant Mice
Jing Zhang,Zhouqiao Wu,Linglin Zhou,Huili Li,Huajing Teng,Wei Dai,Yongqing Wang,Zhong Sheng Sun
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0016212
Abstract: Acute stressors induce changes in numerous behavioral parameters through activation of the hypothalamic-pituitary-adrenal (HPA) axis. Several important hormones in paraventricular nucleus of the hypothalamus (PVN) play the roles in these stress-induced reactions. Corticotropin-releasing hormone (CRH), arginine-vasopressin (AVP) and corticosterone are considered as molecular markers for stress-induced grooming behavior. Oxytocin in PVN is an essential modulator for stress-induced antinociception. The clock gene, Per1, has been identified as an effecter response to the acute stresses, but its function in neuroendocrine stress systems remains unclear. In the present study we observed the alterations in grooming and nociceptive behaviors induced by acute immobilization stress in Per1 mutant mice and other genotypes (wild types and Per2 mutant). The results displayed that stress elicited a more robust effect on grooming behavior in Per1 mutant mice than in other genotypes. Subsequently, the obvious stress-induced antinociception was observed in the wild-type and Per2 mutant mice, however, in Per1 mutant, this antinociceptive effects were partially-reversed (mechanical sensitivity), or over-reversed to hyperalgesia (thermal sensitivity). The real-time qPCR results showed that in PVN, there were stress-induced up-regulations of Crh, Avp and c-fos in all of genotypes; moreover, the expression change of Crh in Per1 mutant mice was much larger than in others. Another hormonal gene, Oxt, was up-regulated induced by stress in wild-type and Per2 mutant but not in Per1 mutant. In addition, the stress significantly elevated the serum corticosterone levels without genotype-dependent differences, and accordingly the glucocorticoid receptor gene, Nr3c1, expressed with a similar pattern in PVN of all strains. Taken together, the present study indicated that in acute stress treated Per1 mutant mice, there are abnormal hormonal responses in PVN, correlating with the aberrant performance of stress-induced behaviors. Therefore, our findings suggest a novel functional role of Per1 in neuroendocrine stress system, which further participates in analgesic regulation.
The Optimal Control and MLE of Parameters of a Stochastic Single-Species System
Huili Xiang,Zhijun Liu
Discrete Dynamics in Nature and Society , 2012, DOI: 10.1155/2012/676871
Abstract: This paper investigates the optimal control and MLE (maximum likelihood estimation) for a single-species system subject to random perturbation. With the help of the techniques of stochastic analysis and mathematical statistics, sufficient conditions for the optimal control threshold value, the optimal control moment, and the maximum likelihood estimation of parameters are established, respectively. An example is presented to illustrate the feasibility of our theoretical results. 1. Introduction The Malthus model is usually expressed as where , stands for the density of species at moment, and is the intrinsic growth rate. As everyone knows, model (1.1) has epoch-making significance in mathematics and ecology and later, many deterministic mathematical models have been widely studied (see [1–5]). In fact, a population system is inevitably affected by the environmental noise in the real world. As a consequence, it is reasonable to study a corresponding stochastic model. Notice that some recent results, especially on optimal control, for the following stochastic model have been obtained (see [6–9]), where stands for the standard Brownian motion. However, for some pest populations, their generations are nonoverlapping (e.g., poplar and willow weevil, osier weevil and paranthrene tabaniformis) and the discrete models are more appropriate than the continuous ones. Compared with the continuous ones, the study on discrete mathematical models is more challenging. Inspired by [1–12], in this paper we will consider the following discrete model of system (1.2) where , , and any two of them are independent. stands for the noise intensity. We will focus on the optimal control threshold value, the optimal control moment, and the maximum likelihood estimation of parameters. To the best of our knowledge, no work has been done for system (1.3). The rest of this paper is organized as follows. In Section 2, some preliminaries are introduced. In Section 3, we give three results of this paper. As applications of our main results; an example is presented to illustrate the feasibility of our theoretical results in Section 4. 2. Preliminaries In this section, we summarize several definitions, assumptions, and lemmas which are useful for the later sections. Definition 2.1. Only when the quantity of pest population reaches one starts to control the pest population, and the real number is called to be a control threshold value. Definition 2.2. Until the th generation, the total quantity of pest population first reaches the control threshold value, then one says that is the first
Research into the Mental Lexicon Representation of Chinese English Learners Based on Spreading Activation Model
Huili WANG,Yan HOU
Studies in Literature and Language , 2011,
Abstract: Nowadays, the main idea regarding the organization of the lexicon is that words are stored in an organized intertwined semantic network. However, relatively little is known about the actual process that takes place during the course of activation production. Therefore, in order to gain a deeper understanding of the problems in question, this study conducted word association test to 150 sophomores in Dalian University of Technology (DUT) and tried to show the internal relations of mental lexicon in data by calculating the word frequency between certain words through a computer program which is written based on the actual calculating steps. And the innovation of this study is to show the abstract lexicon relation in data and illustrate the mental lexicon representation in three-dimensional figures by Netdraw software. Through the study we find: (1) The responses with higher frequency in the first few positions may not ensure themselves high association strength to the stimuli. And the current research also proves that activation of mental lexicon is not a “one stop” process but a linear forward one. (2) The data of association strength obtained from this study may help us convert the abstract lexicon relation into concrete statistical facts and establish representation of the mental lexicon network model. At last, the mechanism of Spreading Activation Model is illustrated and the implications for future English teaching are provided. Key Words: Mental lexicon; Word association test; Mental lexicon representation; Association strength
Apoptosis of Rheumatoid Arthritis Fibroblast-Like Synoviocytes: Possible Roles of Nitric Oxide and the Thioredoxin 1
Huili Li,Ajun Wan
Mediators of Inflammation , 2013, DOI: 10.1155/2013/953462
Abstract:
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