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Search Results: 1 - 10 of 35604 matches for " Hui Yao "
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Towards Quantum Field Theory in Curved Spacetime for an Arbitrary Observer
Hui Yao
Physics , 2009,
Abstract: We propose a new framework of quantum field theory for an arbitrary observer in curved spacetime, defined in the spacetime region in which each point can both receive a signal from and send a signal to the observer. Multiple motivations for this proposal are discussed. We argue that radar time should be applied to slice the observer's spacetime region into his simultaneity surfaces. In the case where each such surface is a Cauchy surface, we construct a unitary dynamics which evolves a given quantum state at a time for the observer to a quantum state at a later time. We speculate on possible loss of information in the more general cases and point out future directions of our work.
A new approach for HIV-1 protease cleavage site prediction combined with feature selection  [PDF]
Yao Yuan, Hui Liu, Guangtao Qiu
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.612144

Acquired immunodeficiency syndrome (AIDS) is a fatal disease which highly threatens the health of human being. Human immunodeficiency virus (HIV) is the pathogeny for this disease. Investigating HIV-1 protease cleavage sites can help researchers find or develop protease inhibitors which can restrain the replication of HIV-1, thus resisting AIDS. Feature selection is a new approach for solving the HIV-1 protease cleavage site prediction task and it’s a key point in our research. Comparing with the previous work, there are several advantages in our work. First, a filter method is used to eliminate the redundant features. Second, besides traditional orthogonal encoding (OE), two kinds of newly proposed features extracted by conducting principal component analysis (PCA) and non-linear Fisher transformation (NLF) on AAindex database are used. The two new features are proven to perform better than OE. Third, the data set used here is largely expanded to 1922 samples. Also to improve prediction performance, we conduct parameter optimization for SVM, thus the classifier can obtain better prediction capability. We also fuse the three kinds of features to make sure comprehensive feature representation and improve prediction performance. To effectively evaluate the prediction performance of our method, five parameters, which are much more than previous work, are used to conduct complete comparison. The experimental results of our method show that our method gain better performance than the state of art method. This means that the feature selection combined with feature fusion and classifier parameter optimization can effectively improve HIV-1 cleavage site prediction. Moreover, our work can provide useful help for HIV-1 protease inhibitor developing in the future.


A Biographical Look into Arthur Miller’s Understanding of Wives and Mothers
Xiaojuan YAO,Jingrui HUI
Studies in Literature and Language , 2012, DOI: 10.3968/j.sll.1923156320120503.1119
Abstract: The article attempts to examine Arthur Miller’s biographical background especially his mother, his wives and the other women around him and investigate his relationship with them in order to gain a better understanding of the wife and mother figures in Miller’s plays. Seen from the more general background, Miller’s particular outlook on wives and mothers is influenced greatly by his biographical background. His mother’s struggle with his father and her desire for knowledge as well as her courage and strength in the economic crisis, together with his own three marriages, especially his tremulous life with the sex symbol Marilyn Monroe and also all the other women around him all contribute to his shaping of authentic and complex wife and mother images in his plays. Key words: Arthur Miller; Understanding; Mothers; Wives
Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
Hui Yao Lan
International Journal of Biological Sciences , 2011,
Abstract: TGF-β1 has been long considered as a key mediator in renal fibrosis and induces renal scarring largely by activating its downstream Smad signaling pathway. Interestingly, while mice overexpressing active TGF-β1 develop progressive renal injury, latent TGF-β1 plays a protective role in renal fibrosis and inflammation. Under disease conditions, Smad2 and Smad3 are highly activated, while Smad7 is degraded through the ubiquitin proteasome degradation mechanism. In addition to TGF-β1, many pathogenic mediators such as angiotensin II and advanced glycation end products can also activate the Smad pathway via both TGF-β-dependent and independent mechanisms. Smads interact with other signaling pathways, such as the MAPK and NF-κB pathways, to positively or negatively regulate renal inflammation and fibrosis. Studies from gene knockout mice demonstrate that TGF-β1 acts by stimulating its downstream Smads to diversely regulate kidney injury. In the context of renal fibrosis and inflammation, Smad3 is pathogenic, while Smad2 and Smad7 are protective. Smad4 exerts its diverse roles by transcriptionally enhancing Smad3-mediated renal fibrosis while inhibiting NF-κB-driven renal inflammation via a Smad7-dependent mechanism. Furthermore, we also demonstrated that TGF-β1 acts by stimulating Smad3 to positively or negatively regulate microRNAs to exert its fibrotic role in kidney disease. In conclusion, TGF-β/Smad signaling is a major pathway leading to kidney disease. Smad3 is a key mediator in renal fibrosis and inflammation, whereas Smad2 and Smad7 are renoprotective. Smad4 exerts its diverse role in promoting renal fibrosis while inhibiting inflammation. Thus, targeting the downstream TGF-β/Smad3 signaling pathway by gene transfer of either Smad7 or Smad3-dependent microRNAs may represent a specific and effective therapeutic strategy for kidney disease.
Blume-Emery-Griffiths dynamics in social networks
Yao-Hui Yang
Physics , 2008,
Abstract: We introduce the Blume-Emery-Griffiths (BEG) model in a social networks to describe the three-state dynamics of opinion formation. It shows that the probability distribution function of the time series of opinion is a Gaussian-like distribution. We also study the response of BEG model to the external periodic perturbation. One can observe that both the interior thermo-noise and the external field result in phase transition, which is a split phenomena of the opinion distributions. It is opposite between the effect acted on the opinion systems of the amplitude of the external field and of the thermo-noise.
Comparison between the Isotope Tracking Method and Resistivity Tomography of Earth Rock-Fill Dam Seepage Detection  [PDF]
Mingjie Zhao, Hui Wang, Xiao Sun, Yao Zhang
Engineering (ENG) , 2011, DOI: 10.4236/eng.2011.34045
Abstract: This paper compares the different inversion results of three different earth rock-fill dam models with the actual leakage passages by performing isotope tracing tests and resistivity tomographic tests. The accuracy of the experimental results is evaluated, and the characteristics of these two methods are analyzed. As a result, some significant references are offered for earth rock-fill dam’s hidden defects detection. The experimental results show that the leakage and the direction of the seepage can be judged by isotope tracing tests, meanwhile, the degree of the leakage can be confirmed through the determination of the horizontal seepage velocity and the vertical seepage velocity, but it is difficult to properly determine the position of leakage passages and the range of leakage. Relatively speaking, the positions of the leakage passages can be accurately and directly displayed through resistivity tomographic tests. The experiment results show that the resistivity tomographic method is much better than isotope tracing method with regard to earth rock-fill dam’s hidden defects detection, and the resistivity tomographic method expresses much more convenience and much higher precision than isotope tracing method.
In-Vitro Inhibitory Effect of Methanol Extracts of Chinese Herbal Drugs on Supercoiling Activity of Bacterial DNA Gyrase  [PDF]
Hui Xu, Huizhi Chen, Pan Yao, Guodong Lin, Weiwen Chen
Chinese Medicine (CM) , 2013, DOI: 10.4236/cm.2013.41004

A large number of Chinese herbal drugs (CHDs) exhibit antibacterial activities both in vivo and in vitro, but until now little is known regarding their inhibitory mechanisms. Bacterial DNA gyrase is a proven target for antibacterial agents. Aim of this study was to investigate the in-vitro inhibitory effect of methanol extracts of CHDs against supercoiling activity of bacterial DNA gyrase. Fifteen CHDs were selected and extracted with methanol, respectively. Inhibitory effect of the extracts on DNA gyrase was tested using gel-based DNA supercoiling assay. Among fifteen CHDs tested, methanol extracts of Lonicerae Japonicae Flos (S2), Taraxaci Herba (S7), Glycyrrhizae Radix et Rhizoma Praeparata cum Melle (S8) demonstrated an obvious inhibitory effect against supercoiling activity of DNA gyrase, and the others were either less active or could not be determined with the present method. Moreover, it was likely that S7 and S8 inhibit gyrase in a concentration-dependent manner. In conclusion, DNA supercoiling assay is a promising method to study the inhibitory activity of CHDs on bacterial DNA gyrase. Some CHDs do have gyrase-inhibitory activity as proposed. Further investigations are needed to elucidate the inhibition mechanism of these CHDs on supercoiling activity of gyrase.

The Influence of Relationship Characters on Switching Cost: The Moderating Role of Customer Characters  [PDF]
Yong Zhang, Min Hou, Hui Li, Qiong Yao
American Journal of Industrial and Business Management (AJIBM) , 2016, DOI: 10.4236/ajibm.2016.63031
Abstract: With the competitive environment intense, the leader of the market gradually becomes buyers market. For the enterprise, to maintain and retain existing customers, which is to reduce the customer switch to the competition as low as possible, is particularly important. Therefore, how to effectively seize the minds of consumers and understand their behavior trends is the crux for enterprise to win. This study developed a model of the influence of relationship characteristics on switching costs, and we set customer characteristics as a regulated variable which was always set to a leading factor in the previous study. We used smart-phone users as our research object, through the method of questionnaire and established an equation model to analyze data. The results showed that: (1) in general, the relationship characteristics between consumers and businesses (including the length of time and the kind of purchase) respectively played a positive role on the switching costs (including procedural switching costs, relational switching costs and lost benefits costs), (2) the moderating effects of customer characteristics (including involvement and switching tendency) in the relationship between relationship characteristics and switching costs (including the procedural switching costs, relational switching costs and lost benefits costs) are respectively significant. This article verifies the regulated effect of customer characteristics and enriches the antecedent influencing factors of switching costs. So it is of great significance for enterprises to better manage switching costs and effectively retain customers.
Molecular Identification of Chinese Materia Medica and Its Adulterants Using ITS2 and psbA-trnH Barcodes: A Case Study on Rhizoma Menispermi  [PDF]
Pei Yang, Xiwen Li, Hong Zhou, Hao Hu, Hui Zhang, Wei Sun, Yitao Wang, Hui Yao
Chinese Medicine (CM) , 2014, DOI: 10.4236/cm.2014.54023
Abstract: Rhizoma Menispermi, derived from the rhizoma of Menispermum dauricum DC., is one of the most popular Chinese medicines. However Rhizoma Menispermi is often illegally mixed with other species in the herbal market, including Aristolochia mollissimae Hance, which is toxic to the kidneys and potentially carcinogenic. The use of DNA barcoding to authenticate herbs has improved the management and safety of traditional medicines. In this paper, 49 samples belonging to five species, including 34 samples of M. dauricum, from different locations and herb markets in China were collected and identified using DNA barcoding. The sequences of all 34 samples of Rhizoma Menispermi are highly consistent, with only one site variation in internal transcribed spacer 2 (ITS2) of nuclear ribosomal DNA and no variations in the psbA-trnH region. The intra-specific genetic distance is much smaller than inter-specific one. Phylogenetic analysis shows that both sequences allow the successful identification of all species. Nearest distance and BLAST1 methods for the ITS2 and psbA-trnH regions indicate 100% identification efficiency. Our research shows that DNA barcoding can effectively distinguish Rhizoma Menispermi from its adulterants from both commercial and original samples, which provides a new and reliable way to monitor commercial herbs and to manage the modern medicine market.
Downregulation of Telomerase Activity in Breast Cancer Impairs Cells Proliferation, Invasive Ability and Sensitizes Cells to Ultraviolet-Radiation and Adriamycin-Chemotherapy in Vitro  [PDF]
Xiangxia Liu, Chen Yao, Ying Lin, Sanming Wang, Hui Zhang, Shenming Wang
Advances in Breast Cancer Research (ABCR) , 2013, DOI: 10.4236/abcr.2013.23014

Backgroud: Telomerase activity, mainly regulated by the human telomerase reverse transcriptase (hTERT) gene, plays critical roles in tumor growth and progression through the maintenance of telomere length and structure. Telomerase is elevated in most malignant tumors as well as in breast cancer, the ubiquitous expression of telomerase makes it a promising target for cancer therapy. With the goal of down regulating telomerase activity, RNA interference technology has been applied to specifically knockdown the hTERT gene expression in breast cancer cell line MCF-7 and MDA-MB- 231 and determine whether h TERT-specific RNA interference technology serve as an effective method of telomerase-based cancer therapy. Methods: Interfering p Super-retro-puro-hTERT-RNA and the control were transfected into breast cancer cell line MCF-7 and MDA-MB-231. The telomerase activity, cell proliferation, invasive ability and cell response to ultraviolet-radiation or adriamycin-chemotherapy in vitro were recorded in transfected, untransfeced and empty-transfected cells respectively. Results: Telomerase activity was successfully suppressed in transfected cells (P < 0.005). Decreased expression of telomerase activity was associated with reduced cell proliferation (P < 0.001), migration and invasive ability (P < 0.001) and enhanced sensitivity to ultraviolet-radiation or adriamycin-chemotherapy (P <

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