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Search Results: 1 - 10 of 38350 matches for " Hugo van Oostrom "
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Predictability of Painful Stimulation Modulates the Somatosensory-Evoked Potential in the Rat
Manon W. H. Schaap, Hugo van Oostrom, Arie Doornenbal, Annemarie M. Baars, Saskia S. Arndt, Ludo J. Hellebrekers
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061487
Abstract: Somatosensory-evoked potentials (SEPs) are used in humans and animals to increase knowledge about nociception and pain. Since the SEP in humans increases when noxious stimuli are administered unpredictably, predictability potentially influences the SEP in animals as well. To assess the effect of predictability on the SEP in animals, classical fear conditioning was applied to compare SEPs between rats receiving SEP-evoking electrical stimuli either predictably or unpredictably. As in humans, the rat’s SEP increased when SEP-evoking stimuli were administered unpredictably. These data support the hypothesis that the predictability of noxious stimuli plays a distinctive role in the processing of these stimuli in animals. The influence of predictability should be considered when studying nociception and pain in animals. Additionally, this finding suggests that animals confronted with (un)predictable noxious stimuli can be used to investigate the mechanisms underlying the influence of predictability on central processing of noxious stimuli.
Nociception and Conditioned Fear in Rats: Strains Matter
Manon W. H. Schaap, Hugo van Oostrom, Arie Doornenbal, José van 't Klooster, Annemarie M. Baars, Saskia S. Arndt, Ludo J. Hellebrekers
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083339
Abstract: When using rats in pain research, strain-related differences in outcomes of tests for pain and nociception are acknowledged. However, very little is known about the specific characteristics of these strain differences. In this study four phylogenetically distant inbred rat strains, i.e. Wistar Kyoto (WKY), Fawn Hooded (FH), Brown Norway (BN) and Lewis (LE), were investigated in different tests related to pain and nociception. During Pavlovian fear conditioning, the LE and WKY showed a significantly longer duration of freezing behaviour than the FH and BN. Additionally, differences in c-Fos expression in subregions of the prefrontal cortex and amygdala between rat strains during retrieval and expression of conditioned fear were found. For example, the BN did not show recruitment of the basolateral amygdala, whereas the WKY, FH and LE did. During the hot plate test, the WKY and LE showed a lower thermal threshold compared to the BN and FH. In a follow-up experiment, the two most contrasting strains regarding behaviour during the hot plate test and Pavlovian fear conditioning (i.e. FH and WKY) were selected and the hot plate test, Von Frey test and somatosensory-evoked potential (SEP) were investigated. During the Von Frey test, the WKY showed a lower mechanical threshold compared to the FH. When measuring the SEP, the FH appeared to be less reactive to increasing stimulus intensities when considering both peak amplitudes and latencies. Altogether, the combined results indicate various differences between rat strains in Pavlovian fear conditioning, nociception related behaviours and nociceptive processing. These findings demonstrate the necessity of using multiple rat strains when using tests including noxious stimuli and suggest that the choice of rat strains should be considered. When selecting a strain for a particular study it should be considered how this strain behaves during the tests used in that study.
A Counselling Model for BRCA1/2 Genetic Susceptibility Testing
Iris van Oostrom, Aad Tibben
Hereditary Cancer in Clinical Practice , 2004, DOI: 10.1186/1897-4287-2-1-19
Abstract: When genetic susceptibility testing for hereditary breast and/or ovarian cancer was introduced in the nineties, professionals were concerned about the psychological consequences of learning one's genetic status. Women carrying a BRCA1/2 mutation have to deal with considerable health risks [1-3] and are confronted with difficult choices concerning risk management. Mutation carriers can opt for regular surveillance, for prophylactic mastectomy and/or prophylactic bilateral salpingo oophorectomy, and/or for chemoprevention trials. Besides important health risks and the far-reaching impact of risk management options, these women may be psychologically vulnerable due to unresolved loss experiences [4,5]. Many have witnessed the disease in relatives and have lost a mother or sister, possibly leaving young children behind. Furthermore mutation carriers risk to pass or to have passed the mutation onto their children with all the above-mentioned consequences for them.Because of the potentially far-reaching implications of BRCA1/2 susceptibility testing, the "Huntington protocol" was adopted for the counselling of unaffected individuals who wanted to know whether they had inherited a familial BRCA1/2 mutation. This "Huntington protocol" has a long history. As the availability of DNA analysis for the HD gene was set to become a reality, the Committee of International Huntington Association and the Working Group on Huntington's disease of the World Federation of Neurology gave consideration to the manner in which these tests should be carried out (IHA/WFN 1994). In general, the guidelines recommend that individuals at risk who participate in predictive testing programmes are seen for two to four counseling sessions, spread over a 3-month period, before disclosure of the test results. Predictive testing requires informed consent by the individual at risk, and the provision of psychological support. If the test is abnormal, counselling must be available for the family and others
Weer-woord van eer?
F.P. van Oostrom
BMGN : Low Countries Historical Review , 1990,
Nested Term Graphs (Work In Progress)
Clemens Grabmayer,Vincent van Oostrom
Computer Science , 2014, DOI: 10.4204/EPTCS.183.4
Abstract: We report on work in progress on 'nested term graphs' for formalizing higher-order terms (e.g. finite or infinite lambda-terms), including those expressing recursion (e.g. terms in the lambda-calculus with letrec). The idea is to represent the nested scope structure of a higher-order term by a nested structure of term graphs. Based on a signature that is partitioned into atomic and nested function symbols, we define nested term graphs both in a functional representation, as tree-like recursive graph specifications that associate nested symbols with usual term graphs, and in a structural representation, as enriched term graph structures. These definitions induce corresponding notions of bisimulation between nested term graphs. Our main result states that nested term graphs can be implemented faithfully by first-order term graphs. keywords: higher-order term graphs, context-free grammars, cyclic lambda-terms, higher-order rewrite systems
Getting personal with marketing research: A first year teaching innovation. A Practice Report
Mary FitzPatrick,Janet Davey,Monica van Oostrom
International Journal of the First Year in Higher Education , 2010, DOI: 10.5204/intjfyhe.v1i1.24
Abstract: ‘Research’ can be a challenging topic for lecturers to teach, and a dry subject for students to learn. This paper presents a teaching innovation that involves first year students personally in the topic of marketing research - both as participant/producers of the research data and as clients/end-users of the marketing research. The teaching/learning innovation is based on pedagogical principles to make research theory accessible by bringing marketing research to life. It begins with personal data produced by the students, which is collated and then presented in the lectures, overlaid on a collage of the students’ ID photos to make the innovation visually engaging and to illustrate a real-life application of the marketing research process. For the students, this application that describes their own behaviours and opinions is immediately relevant. For us as teachers it is an exciting teaching activity that simultaneously demonstrates the practice, benefits, and processes of marketing research.
Layer Systems for Proving Confluence
Bertram Felgenhauer,Aart Middeldorp,Harald Zankl,Vincent van Oostrom
Computer Science , 2014, DOI: 10.1145/2710017
Abstract: We introduce layer systems for proving generalizations of the modularity of confluence for first-order rewrite systems. Layer systems specify how terms can be divided into layers. We establish structural conditions on those systems that imply confluence. Our abstract framework covers known results like modularity, many-sorted persistence, layer-preservation and currying. We present a counterexample to an extension of persistence to order-sorted rewriting and derive new sufficient conditions for the extension to hold. All our proofs are constructive.
Innovación, cultura y tama o: la microempresa en una región ultraperiférica
González de la Fe, Teresa,Hernández Hernández, Nuria,van Oostrom, Madelon
Arbor : Ciencia, Pensamiento y Cultura , 2012, DOI: 10.3989/arbor.2012.753n1008
Abstract: The analysis of innovation activities, attitudes, beliefs and behaviours of micro companies has few precedents in innovation studies, although this group represents over 95% of all businesses in Spain and the European Union. This paper presents the empirical results of a study on innovation in micro firms, which aims to identify and explain the factors that most affect their ability to innovate, based on the approach of the Triple Helix. Among these factors, next stand out: human, social and relational capital, the ability to absorb foreign knowledge and the existence of an innovative culture that facilitates the attitudes, beliefs and opportunities necessary to innovate in collaborative environments with multiple relationships and interactions. The analysis is completed with a characterization of micro companies, attending to the weight of these factors and some of the innovation barriers that were identified. El análisis de las actividades, actitudes, creencias y comportamientos innovadores en las microempresas tiene pocos antecedentes en los estudios sobre la innovación, a pesar de que este colectivo representa a más del 95% del tejido empresarial en Espa a y en el entorno europeo. En este trabajo se presentan los resultados empíricos de un estudio sobre la innovación en microempresas, que trata de identificar y explicar los factores que más inciden en su capacidad innovadora, basándose en el enfoque de la Triple Hélice. Entre los factores destacan el capital humano, social y relacional, la capacidad de absorción de conocimientos ajenos, así como la existencia de una cultura innovadora que facilita las actitudes, creencias y oportunidades necesarias para innovar en entornos colaborativos con múltiples relaciones e interacciones. El análisis se ha completado con una caracterización de las microempresas en función del peso de estos factores y las barreras a la innovación identificadas.
Infinitary Term Rewriting for Weakly Orthogonal Systems: Properties and Counterexamples
Joerg Endrullis,Clemens Grabmayer,Dimitri Hendriks,Jan Willem Klop,Vincent van Oostrom
Computer Science , 2014, DOI: 10.2168/LMCS-10(2:7)2014
Abstract: We present some contributions to the theory of infinitary rewriting for weakly orthogonal term rewrite systems, in which critical pairs may occur provided they are trivial. We show that the infinitary unique normal form property fails by an example of a weakly orthogonal TRS with two collapsing rules. By translating this example, we show that this property also fails for the infinitary lambda-beta-eta-calculus. As positive results we obtain the following: Infinitary confluence, and hence the infinitary unique normal forms property, holds for weakly orthogonal TRSs that do not contain collapsing rules. To this end we refine the compression lemma. Furthermore, we establish the triangle and diamond properties for infinitary multi-steps (complete developments) in weakly orthogonal TRSs, by refining an earlier cluster-analysis for the finite case.
Cost-effectiveness of a workplace intervention for sick-listed employees with common mental disorders: design of a randomized controlled trial
Sandra H van Oostrom, Johannes R Anema, Berend Terluin, Henrica CW de Vet, Dirk L Knol, Willem van Mechelen
BMC Public Health , 2008, DOI: 10.1186/1471-2458-8-12
Abstract: The study is designed as a randomized controlled trial with a follow-up of one year. Employees eligible for this study are on sick leave for 2 to 8 weeks with common mental disorders. The workplace intervention will be compared with usual care. The workplace intervention is a stepwise approach that aims to reach consensus about a return-to-work plan by active participation and strong commitment of both the sick-listed employee and the supervisor. Outcomes will be assessed at baseline, 3, 6, 9 and 12 months. The primary outcome of this study is lasting return-to-work, which will be acquired from continuous registration systems of the companies after the follow-up. Secondary outcomes are total number of days of sick leave during the follow-up, severity of common mental disorders, coping style, job content, and attitude, social influence, and self-efficacy determinants. Cost-effectiveness will be evaluated from the societal perspective. A process evaluation will also be conducted.Return-to-work is difficult to discuss in the workplace for sick-listed employees with mental disorders and their supervisors. Therefore, this intervention offers a unique opportunity for the sick-listed employee and the supervisor to discuss barriers for return-to-work. Results of this study will possibly contribute to improvement of disability management for sick-listed employees with common mental disorders. Results will become available in 2009.ISRCTN92307123Common mental disorders (CMDs) are common in the community and often affect functioning to such an extent that they are associated with work absenteeism. In many developed countries, 35% to 45% of absenteeism from work is due to mental health problems [1]. Prolonged absence from work often results in a lack of social structure and meaningful activity[2,3] and is associated with a reduced probability of eventual return-to-work (RTW) and an increased probability of subsequent economic and social deprivation [4,5]. In the beginning of the
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