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Search Results: 1 - 10 of 135 matches for " Hubertus Jarry "
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Pre-infection physical exercise decreases mortality and stimulates neurogenesis in bacterial meningitis
David Liebetanz, Joachim Gerber, Christina Schiffner, Sandra Schütze, Florian Klinker, Hubertus Jarry, Roland Nau, Simone C Tauber
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-168
Abstract:
In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol
Robert Hermann, Hendrik Wolff, Hubertus Jarry, Paul Thelen, Carsten Gruendker, Margret Rave-Fraenk, Heinz Schmidberger, Hans Christiansen
Radiation Oncology , 2008, DOI: 10.1186/1748-717x-3-19
Abstract: PC cells LNCaP (androgen-sensitive) and PC-3 (androgen-independent) were evaluated. Estrogen receptor (ER) expression was analyzed by means of immunostaining. Cells were incubated in FCS-free media with genistein 10 μM and estradiol 10 μM 24 h before irradiation and up to 24 h after irradiation. Clonogenic survival, cell cycle changes, and expression of p21 were assessed.LNCaP expressed both ER-α and ER-β, PC-3 did not. Incubation of LNCaP and PC-3 with genistein resulted in a significant reduction of clonogenic survival. Incubation with estradiol exhibited in low concentrations (0.01 μM) stimulatory effects, while higher concentrations did not influence survival. Both genistein 10 μM and estradiol 10 μM increased low-dose hyper-radiosensitivity [HRS] in LNCaP, while hormonal incubation abolished HRS in PC-3. In LNCaP cells hormonal stimulation inhibited p21 induction after irradiation with 4 Gy. In PC-3 cells, the proportion of cells in G2/M was increased after irradiation with 4 Gy.We found an increased HRS to low irradiation doses after incubation with estradiol or genistein in ER-α and ER-β positive LNCaP cells. This is of high clinical interest, as this tumor model reflects a locally advanced, androgen dependent PC. In contrast, in ER-α and ER-β negative PC-3 cells we observed an abolishing of the HRS to low irradiation doses by hormonal stimulation. The effects of both tested compounds on survival were ER and p53 independent. Since genistein and estradiol effects in both cell lines were comparable, neither ER- nor p53-expression seemed to play a role in the linked signalling. Nevertheless both compounds targeted the same molecular switch. To identify the underlying molecular mechanisms, further studies are needed.Curative therapy of prostate carcinoma (PC) is of major concern, as PC is the leading cancer diagnosis in the male population [1]. In locally advanced tumor stages the recommended treatment is radiotherapy combined with simultaneous application of LHR
The Four Principles of Geographic Routing
Aubin Jarry
Computer Science , 2014,
Abstract: Geographic routing consists in using the position information of nodes to assist in the routing process, and has been a widely studied subject in sensor networks. One of the outstanding challenges facing geographic routing has been its applicability. Authors either make some broad assumptions on an idealized version of wireless networks which are often unverifiable, or they use costly methods to planarize the communication graph. The overarching questions that drive us are the following. When, and how should we use geographic routing? Is there a criterion to tell whether a communication network is fit for geographic routing? When exactly does geographic routing make sense? In this paper we formulate the four principles that define geographic routing and explore their topological consequences. Given a localized communication network, we then define and compute its geographic eccentricity, which measures its fitness for geographic routing. Finally we propose a distributed algorithm that either enables geographic routing on the network or proves that its geographic eccentricity is too high.
VRAC: Simulation Results #1
Florian Huc,Aubin Jarry
Computer Science , 2009,
Abstract: In order to make full use of geographic routing techniques developed for large scale networks, nodes must be localized. However, localization and virtual localization techniques in sensor networks are dependent either on expensive and sometimes unavailable hardware (e.g. GPS) or on sophisticated localization calculus (e.g. triangulation) which are both error-prone and with a costly overhead. Instead of localizing nodes in a traditional 2-dimensional space, we use directly the raw distance to a set of anchors to route messages in a multi-dimensional space. This should enable us to use any geographic routing protocol in a robust and efficient manner in a very large range of scenarios. We test this technique for two different geographic routing algorithms, namely GRIC and ROAM. The simulation results show that using the raw coordinates does not decrease their efficiency.
VRAC: Virtual Raw Anchor Coordinates Routing in Sensor Networks -- Concepts and Experimental Protocol
Florian Huc,Aubin Jarry
Computer Science , 2009,
Abstract: In order to make full use of geographic routing techniques developed for large scale networks, nodes must be localized. However, localization and virtual localization techniques in sensor networks are dependent either on expensive and sometimes unavailable hardware (e.g. GPS) or on sophisticated localization calculus (e.g. triangulation) which are both error-prone and with a costly overhead. Instead of localizing nodes in a traditional 2-dimensional space, we intend to use directly the raw distance to a set of anchors to route messages in the multi-dimensional space. This should enable us to use any geographic routing protocol in a robust and efficient manner in a very large range of scenarios.
Risk Zones of Human Leishmaniases in the Western Mediterranean Basin: Correlations between Vector Sand Flies, Bioclimatology and Phytosociology
Rispail, Philippe;Dereure, Jacques;Jarry, Daniel;
Memórias do Instituto Oswaldo Cruz , 2002, DOI: 10.1590/S0074-02762002000400004
Abstract: correspondence analysis was applied to sand fly sampling in 865 stations from the western mediterranean basin. the position of each of 24 species was determined with respect to the bioclimatic belts. thus, the multidimensional analyses manifest clear correlations between bioclimatic belts and their expression in the area, the phytosociological groupings, and vector species of visceral and cutaneous leishmaniases. the transfer of these data to usual maps allows to delimit the geographical distribution of these diseases in the western mediterranean basin and contributes to the determination, in a rational manner, of the high risk zones.
Risk Zones of Human Leishmaniases in the Western Mediterranean Basin: Correlations between Vector Sand Flies, Bioclimatology and Phytosociology
Rispail Philippe,Dereure Jacques,Jarry Daniel
Memórias do Instituto Oswaldo Cruz , 2002,
Abstract: Correspondence analysis was applied to sand fly sampling in 865 stations from the Western Mediterranean basin. The position of each of 24 species was determined with respect to the bioclimatic belts. Thus, the multidimensional analyses manifest clear correlations between bioclimatic belts and their expression in the area, the phytosociological groupings, and vector species of visceral and cutaneous leishmaniases. The transfer of these data to usual maps allows to delimit the geographical distribution of these diseases in the Western Mediterranean basin and contributes to the determination, in a rational manner, of the high risk zones.
Survival advantage of siblings and spouses of centenarians in 20th-century Quebec
Valérie Jarry,Alain Gagnon,Robert Bourbeau
Canadian Studies in Population , 2012,
Abstract: Longevity runs in families, either through genetic or environmental influences. Using Quebec civil registration and historical Canadiancensuses, we compared the longevity of siblings and spouses of 806 centenarians to a group of controls, all born in Quebec at the turnof the 20th century. Our results show that siblings of centenarians, who share half of their genes and a common childhood environment,lived 3–4 years longer than their birth cohort. However, husbands and wives of centenarians lived 4 and 2.5 years longer than theircounterparts of the same sex, respectively, suggesting that longevity is also modulated by shared environment in adulthood.
VRAC: Theory #1
Aubin Jarry,Pierre Leone,Jose Rolim
Computer Science , 2010,
Abstract: In order to make full use of geographic routing techniques developed for sensor networks, nodes must be localized. However, traditional localization and virtual localization techniques are dependent either on expensive and sometimes unavailable hardware (e.g. GPS) or on sophisticated localization calculus (e.g. triangulation) which are both error-prone and with a costly overhead. Instead of actually localizing nodes in the physical two-dimensional Euclidean space, we use directly the raw distance to a set of anchors to produce multi-dimensional coordinates. We prove that the image of the physical two-dimensional Euclidean space is a two-dimensional surface, and we show that it is possible to adapt geographic routing strategies on this surface, simply, efficiently and successfully.
Die Salomonische S ulenordnung. Eine unkonventionelle Erfindung und ihre historischen Umst nde
Günther, Hubertus
RIHA Journal , 2011,
Abstract: As early as 1549, i.e. 50 years before Villalpando's famous Ezechiel commentary was published, Jacques Androuet Ducerceau introduced the Salomonic Order in his Exempla arcuum, a series of engravings in which the Salomonic Order is even presented as a part of a canon of orders. For the first time, the article draws attention to this hitherto neglected early example. The author analyses Ducerceau's canon within the broader context of renaissance theories of architecture, treatises on the columnar order, and conceptions of the origins of good or artful architecture, some of which can be traced back to medieval positions. Furthermore, it is argued that the dismissal of the italic orders in favor of the Salomonic order by Ducerceau and others is inextricably linked to the increasing nationalist tendencies of the renaissance.
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