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Search Results: 1 - 10 of 14920 matches for " Huai-Na Qiu "
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Activation of Eosinophils Interacting with Dermal Fibroblasts by Pruritogenic Cytokine IL-31 and Alarmin IL-33: Implications in Atopic Dermatitis
Chun-Kwok Wong, Karen Ming-Lam Leung, Huai-Na Qiu, Joyce Yin-Sau Chow, Angela On Kei Choi, Christopher Wai-Kei Lam
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0029815
Abstract: Background IL-31 is a pruritogenic cytokine, and IL-33 is an alarmin for damaging inflammation. They together relate to the pathogenesis of atopic dermatitis (AD). Eosinophil infiltration into the inner dermal compartment is a predominant pathological feature of AD. We herein investigated the in vitro inflammatory effects of IL-31 and IL-33 on the activation of human eosinophils and dermal fibroblasts. Methodology/Principal Findings Receptors, adhesion molecules and signaling molecules were assessed by Western blot or flow cytometry. Chemokines and cytokine were quantitated by multiplex assay. Functional IL-31 receptor component IL-31RA, OSMR-β and IL-33 receptor component ST2 were constitutively expressed on the surface of eosinophils. Co-culture of eosinophils and fibroblasts significantly induced pro-inflammatory cytokine IL-6 and AD-related chemokines CXCL1, CXCL10, CCL2 and CCL5. Such inductions were further enhanced with IL-31 and IL-33 stimulation. IL-31 and IL-33 could significantly provoke the release of CXCL8 from eosinophils and fibroblasts, respectively, which was further enhanced upon co-culture. In co-culture, eosinophils and fibroblasts were the main source for the release of CCL5, and IL-6, CXCL1, CXCL8, CXCL10 and CCL2, respectively. Direct interaction between eosinophils and fibroblasts was required for CXCL1, CXCL10, CXCL8 and CCL5 release. Cell surface expression of intercellular adhesion molecule-1 on eosinophils and fibroblasts was up-regulated in co-culture upon IL-31 and IL-33 stimulation. The interaction between eosinophils and fibroblasts under IL-31 and IL-33 stimulation differentially activated extracellular signal-regulated kinase, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase, nuclear factor-κB and phosphatidylinositol 3-kinase–Akt pathways. Using specific signaling molecule inhibitors, the differential induction of IL-31 and IL-33-mediated release of cytokines and chemokines such as IL-6 and CXCL8 from co-culture should be related to their distinct activation profile of intracellular signaling pathways. Conclusions/Significance The above findings suggest a crucial immunopathological role of IL-31 and IL-33 in AD through the activation of eosinophils-fibroblasts interaction via differential intracellular signaling mechanisms.
Peroxisome proliferator-activated receptor-γ is essential in the pathogenesis of gastric carcinoma
Xiu-Mei Ma, Hong Yu, Na Huai
World Journal of Gastroenterology , 2009,
Abstract: AIM: To investigate whether peroxisome proliferator-activated receptor γ (PPAR-γ) is expressed in human gastric carcinoma and whether PPAR-γ is a potential target for gastric carcinoma therapy.METHODS: PPAR-γ protein in gastric carcinoma was examined by immunohistochemistry. In the gastric carcinoma cell line MGC803, PPAR-γ, survivin, Skp2 and p27 protein and mRNA were examined by Western blotting and real-time reverse transcription-polymerase chain reaction, respectively; proliferation was examined by MTT; apoptosis was examined by chromatin staining with Hoechst 33342 and fluorescence activated cell sorting (FACS). and cell cycle was examined by FACS; the knockdown of PPAR-γ was done by RNA interference.RESULTS: A high level of expression of PPAR-γ was observed in human gastric carcinoma and in a human gastric carcinoma cell line MGC803. The PPAR-γ agonist 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) inhibited growth, and induced apoptosis and G1/G0 cell cycle arrest in MGC803 cells in a concentration-dependent and time-dependent manner. The effect of 15d-PGJ2 on MGC803 cells was not reversed by the selective and irreversible antagonist GW9662 for PPAR-γ. Furthermore, survivin and Skp2 expression were decreased, whereas p27 expression was enhanced following 15d-PGJ2 treatment in a dose-dependent manner in MGC803 cells. Interestingly, we also found that small interfering RNA for PPAR-γ inhibited growth and induced apoptosis in MGC803 cells. The inhibition of PPAR-γ function may be a potentially important and novel modality for treatment and prevention of gastric carcinoma.CONCLUSION: A PPAR-γ agonist inhibited growth of human gastric carcinoma MGC803 cells by inducing apoptosis and G1/G0 cell cycle arrest with the involvement of survivin, Skp2 and p27 and not via PPAR-γ.
UV Irradiation Chlorine Dioxide Photocatalytic Oxidation of Simulated Fuchsine Wastewater by UV-Vis and Online FTIR Spectrophotometric Method
Laishun Shi,Xiaomei Wang,Na Li,Chunlei Huai
ISRN Analytical Chemistry , 2012, DOI: 10.5402/2012/951465
Abstract:
UV Irradiation Chlorine Dioxide Photocatalytic Oxidation of Simulated Fuchsine Wastewater by UV-Vis and Online FTIR Spectrophotometric Method
Laishun Shi,Xiaomei Wang,Na Li,Chunlei Huai,Jie Liu
ISRN Analytical Chemistry , 2012, DOI: 10.5402/2012/951465
Abstract: The photocatalyst TiO2/SiO2 was prepared and used for chlorine dioxide photocatalytic oxidation of simulated fuchsine wastewater under UV irradiation. The removal efficiency of fuchsine treated by photocatalytic oxidation process is higher than that of chemical oxidation process. By using UV-Vis and online FTIR analysis technique, the intermediates during the degradation process were obtained. The benzene ring in fuchsine was degraded into quinone and carboxylic acid and finally changed into carbon dioxide and water during the photocatalytic oxidation. The degradation reaction mechanism of fuchsine by UV irradiation chlorine dioxide photocatalytic oxidation was proposed based upon the experiment evidence. 1. Introduction The effluents produced by some of our industries are harmful to the health and general well-being of man. When undesirable substances are present in liquid effluents, it can be disastrous as their presence pose severe threat to the immediate recipients. Wastewaters from various industries, factories, laboratories, and so forth are serious problems to the environment. Addressing these problems calls out for a tremendous amount of research to be conducted to identify robust new methods of purifying water at lower cost and with less energy, while at the same time minimizing the use of chemicals and impact on the environment [1]. In recent years, a variety of wastewater treatment techniques have been applied to degrade and remove refractory materials from wastewaters, including chemical oxidation [2], biodegradation [3], electrochemical oxidation degradation [4], catalytic oxidation degradation [5, 6], and so on. Also, to obtain a high removal efficiency of hazardous materials, a combination of physical and chemical techniques should also be employed [7]. These wastewater treatment processes generate very toxic wastewater, whose treatment is often difficult due to the presence of some non-biodegradable species with complex structure. Hence there is considerable current interest in developing alternative and more cost-effective methods to treat those refractory materials. Advanced oxidation processes (AOPs) have been developed to meet the increasing need of an effective wastewater treatment. AOP generates powerful oxidizing-agent hydroxyl radicals which completely destroy major classes of organic pollutants at ambient conditions. The combination of UV irradiation with photocatalysts is one of such methods which have attracted considerable attention in recent years, due to its effectiveness in mineralization (i.e., conversion to inorganic
Aqua(propanedioato-κ2O1,O3)[2-(1H-pyrazol-1-yl-κN2)-1,10-phenanthroline-κ2N,N′]nickel(II) trihydrate
Huai Yi Yan,Tai Qiu Hu,Jing Min Shi
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809017188
Abstract: In the title mononuclear complex, [Ni(C3H2O4)(C15H10N4)(H2O)]·3H2O, the metal center is coordinated in a distorted NiN3O3 geometry. In the crystal structure, intermolecular O—H...O hydrogen bonds link the components into a two-dimensional network. In addition, there are weak π–π stacking interactions between symmetry-related phenanthroline rings, with a centroid–centroid distance of 3.6253 (17) .
Analysis of the causes of ocular injuries in various armed services in China
Huai-yu QIU,Mao-nian ZHANG,Ying ZHANG
Medical Journal of Chinese People's Liberation Army , 2011,
Abstract: Objective To study the causes of ocular injuries in various armed forces for more effective prevention of the occurrence of ocular injuries.Methods Twenty-one military hospitals were selected as the objects of study,and the questionnaires were distributed to the hospitals before Jan.1,2009.The data of soldiers with ocular trauma who had visited the hospitals from Jan.1,2009 to Dec.31,2009 were collected and statistically analyzed with WPSS 13.0 software.Results Five hundred and two cases(549 eyes) of ocular injury were investigated.Sport-related injury was on the top rank of causes(181/502,36.1%),and it was more often seen in navy and air-force.Of sport-related injuries,69.1% of them were caused by playing basket-ball and 18.8% by playing football.Work-related injury was the second cause(140/502,27.9%).The highest ratio of work-related injury was in marine force(31/67,46.3%).The ratios of military training-related injury in army and armed police were 21.4% and 21.3%,respectively,but the incidence was only 4.4% in navy.The analysis of training subjects showed that about 49.2% was skill related training,such as parachuting,manipulation of firearms;and 29.5% was physical exercise or confrontational exercises.It was also found that the ratio of sport-related injury increased and military training-related injury decreased with a raise of education level of soldiers.Conclusions It is important to pay attention to ocular injury in military personnel during physical exercise and sport.Also,it will be more effective to prevent ocular injury according to different causes in various armed forces.
An investigation of medical care of ocular injuries of servicemen in grassroots hospitals
Huai-yu QIU,Mao-nian ZHANG,Ying ZHANG
Medical Journal of Chinese People's Liberation Army , 2011,
Abstract: Objective To investigate the status of treatment of ocular injuries in servicemen in grassroots hospitals,and the rate of misdiagnosis.Methods The data of 953 cases of ocular injury attended in 21 regimental hospitals from 2002-01-01 to 2008-12-31,were retrospectively analyzed.The course of diagnasis and trcatment of ocular injuries was investigated,including the interval between injury and the first surgery,the reason leading to delay of surgery,variety misdiagnosis,and the causes leading to misdiagnosis,etc.The collected data were then statistically analyzed by SPSS13.0 software.Results Among 109 cases of open ocular injury,98(89.9%) of them were closed with suture,and 68(62.4%) were sutured primarily within 24 hours.The common cause of delayed operation was a delay of transfer.The longest interval for the operation of closed injury of eyeball was in region Ⅲ.The frequent misdiagnoses were retinal detachment,optic nerve injury,foreign objects in eyeball and false blindness.Conclusion It is important to emphasize the limitation term of treatment of ocular injuries,particularly in the treatment of retinal detachment,optic nerve injury,foreign objects in eyeball and false blindness.
The mean residence time of river water in the Canada Basin
Min Chen,Na Xing,YiPu Huang,YuSheng Qiu
Chinese Science Bulletin , 2008, DOI: 10.1007/s11434-008-0077-z
Abstract: Seawater was collected from the western Arctic Ocean for measurements of 18O, 226Ra and 228Ra. The fractions of river runoff and sea ice melt-water in water samples were estimated by using δ 18O-S-PO* tracer system. The mean residence time of river water in the Canada Basin was calculated based on the relationship between 228Ra/226Ra)A.R. and the fractions of river runoff in the shelf and deep ocean. Our results showed that the river runoff fractions in the Canada Basin were significantly higher than those in the shelf regions, suggesting that the Canada Basin is a major storage region for Arctic river water. 228Ra activity concentrations in the Chukchi shelf and the Beaufort shelf ranged from 0.16 to 1.22 Bq/m3, lower than those reported for shelves in the low and middle latitudes, indicating the effect of sea ice melt-water. A good positive linear relationship was observed between 228Ra/226Ra)A.R. and the fraction of river runoff for shelf waters, while the 228Ra/226Ra)A.R. in the Canada Basin was located below this regressive line. The low 228Ra/226Ra)A.R. in the Canada Basin was ascribed to 228Ra decay during shelf waters transporting to the deep ocean. The residence time of 5.0–11.0 a was estimated for the river water in the Canada Basin, which determined the time response of surface freshening in the North Atlantic to the river runoff into the Arctic Ocean.
Effects of simulated acid rain on cation releasing in soils of South China
Wu Qing,Qiu Rong liang,Lu Yue na
环境科学学报(英文版) , 1998,
Abstract: EfectsofsimulatedacidrainoncationreleasinginsoilsofSouthChinaWuQing,QiuRongliang,LuYuenaDepartmentofEnvironmentalScience,Z...
The mean residence time of river water in the Canada Basin
CHEN Min,XING Na,HUANG YiPu,QIU YuSheng,

科学通报(英文版) , 2008,
Abstract: Seawater was collected from the western Arctic Ocean for measurements of 18O, 226Ra and 228Ra. The fractions of river runoff and sea ice melt-water in water samples were estimated by using δ 18O-S-PO* tracer system. The mean residence time of river water in the Canada Basin was calculated based on the relationship between 228Ra/226Ra)A.R. and the fractions of river runoff in the shelf and deep ocean. Our results showed that the river runoff fractions in the Canada Basin were significantly higher than those in the shelf regions, suggesting that the Canada Basin is a major storage region for Arctic river water. 228Ra activity concentrations in the Chukchi shelf and the Beaufort shelf ranged from 0.16 to 1.22 Bq/m3, lower than those reported for shelves in the low and middle latitudes, indicating the effect of sea ice melt-water. A good positive linear relationship was observed between 228Ra/226Ra)A.R. and the fraction of river runoff for shelf waters, while the 228Ra/226Ra)A.R. in the Canada Basin was located below this regressive line. The low 228Ra/226Ra)A.R. in the Canada Basin was ascribed to 228Ra decay during shelf waters transporting to the deep ocean. The residence time of 5.0–11.0 a was estimated for the river water in the Canada Basin, which determined the time response of surface freshening in the North Atlantic to the river runoff into the Arctic Ocean. Supported by the Program for New Century Excellent Talents in University of China (Grant No. NCET-04-0593) and the Chinese First Arctic Expedition Foundation
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