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Search Results: 1 - 10 of 79000 matches for " Hsiu-Tzu Chen "
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A study of nurses’ job satisfaction: The relationship to professional commitment and friendship networks  [PDF]
Li-Se Yang, Hsieh-Hua Yang, Hsiu-Tzu Chen, Mei-Fang Chang, Yu-Fen Chiu, Ya-Wen Chou, Yen-Chi Cheng
Health (Health) , 2012, DOI: 10.4236/health.2012.411167
Abstract: We suggest that employees’ job satisfaction has relationship to friendship network other than professional commitment, and argue that friendship network in the same ward and across wards will have different effects on employees’ job satisfaction. A cross-sectional survey design utilizing questionnaires was selected to fulfill the research objectives. All of the 405 nurses in the En Chou Kong Hospital were surveyed. Three hundred and three nurses completed the questionnaire representing a response rate of 74.8%. The instruments included friendship network nomination, professional commitment scale, and nurses’ job satisfaction scale (NJSS). The regression model of job satisfaction was constructed, using friendship network variables in the ward and across wards and professional commitment as independent variables. R square for each model is 0.22-0.36 for the four dimensions of job satisfaction. Professional commitment is the robust predictor. The efficiency of friendship network in the ward is a good predictor, while it is negative related to satisfaction of work load. Further, the indegree in the ward is negative related to work load. Implication was discussed.
Multifocal Demyelinating Leukoencephalopathy Induced by Levamisole Therapy
Hsiu-Ping Chang,Hung-Chou Kuo,Tzu-Chen Yen,Chin-Chang Huang
Chang Gung Medical Journal , 2006,
Abstract: The neurotoxic effects of levamisole therapy have been rarely reported. In this article,we report two patients who developed multifocal demyelinating leukoencephalopathy(MDL) after levamisole treatment. Clinically, they had dizziness, nausea, vomiting, confusion,mental dullness, speechlessness, and memory impairment after the treatment. The totaldosage of levamisole was 300 mg and 1800 mg, respectively. The onset of symptoms wasacute or subacute, from a few hours to several weeks. Initial brain magnetic resonance imaging(MRI) demonstrated diffuse multifocal enhancing lesions in the subcortical white matter.After the withdrawal of levamisole, and during the follow-up period, the neurological andneuropsychological manifestations and serial brain MRI improved gradually. We concludethat levamisole treatment may induce MDL, and that the brain MRI changes may correlatewell with the recovery of clinical features and neuropsychological findings. In addition,early steroid treatment is crucial, and the neurotoxic effect of levamisole is not dose-dependentand may be idiosyncratic or immune-mediated.
Relationships between serum HER2 ECD, TIMP-1 and clinical outcomes in Taiwanese breast cancer
Hsiu-Pei Tsai, Shin-Cheh Chen, Huei-Tzu Chien, Yi-Yin Jan, Tzu-Chieh Chao, Miin-Fu Chen, Ling-Ling Hsieh
World Journal of Surgical Oncology , 2012, DOI: 10.1186/1477-7819-10-42
Abstract: One hundred and eighty-five female breast cancer patients, who received curative mastectomy without neo-adjuvant chemotherapy at Chang-Gung Memorial Hospital, were recruited with informed consent for this study. Pre-operative serum levels of HER2 ECD and TIMP-1 were measured using an enzyme-linked immunosorbent assay.Twenty-three cases (12.4%) were classified HER2 ECD positive. HER2 ECD positivity was significantly associated with age, lymph node involvement, histological grade, estrogen receptor status, progesterone receptor status, tissue HER2/neu overexpression, and disease-free survival (DFS). In an age, stage, ER and HER2/neu status matched subgroup (N = 41), the serum level of TIMP-1 was significantly associated with HER2 ECD positivity and DFS.A high serum TIMP-1 was significantly associated with HER2 ECD positivity and a poorer DFS among Taiwanese primary breast cancer patients with HER2 overexpression.Amplification or overexpression of HER2/neu, a 185 kDa transmembrane tyrosine kinase receptor, has been reported in 20-30% of invasive breast cancers (IBCs) [1]. It predicts a more aggressive clinical course such as a transition from in situ growth to invasion [2], aggressive disease progression and poor treatment response [3-5]. In addition, it has been shown that there is a high concordant HER2/neu status in paired primary tumor and distant metastatic lesions on analysis by both immunohistochemistry (IHC) and by fluorescence in situ hybridization (FISH) [6-9]. Therefore, HER2/neu status is an important diagnostic and prognostic biomarker and is also one of the most dependable criteria for the use of trastuzumab-based chemotherapy to treat breast cancer.In addition to HER2/neu status of the tumor tissue, the extracellular domain (ECD) of HER2 (HER2 ECD), which is shed from the HER2/neu receptor after a proteolysis process, has been shown to show a better correlation with tumor burden, treatment response, disease-free status and overall survival than the full-
Following the Transfer of Technology: The Embedded Social Connections in Taiwan’s Tobacco Settlements  [PDF]
Han-Hsiu Chen
Advances in Historical Studies (AHS) , 2016, DOI: 10.4236/ahs.2016.52010
Abstract: This paper examines the way in which the transfer of technology of the tobacco curing method shaped the local social relationships in Taiwan’s tobacco settlement. Ever since the tobacco industry had been initiated by Japan’s colonial policy, the tobacco leaves had been cured in tobacco buildings, which had a distinctive Japanese design. The farmers perceived the curing process to be the hardest part of their work. Using tobacco buildings to cure leaves was a complicated process, since it involved a combination of labour power exchange, time management and personal knowledge of temperature and humidity control. In this situation, a particular ‘labour power exchange’ emerged, which helped farmers to manage their time and labour power on the one hand, and on the other hand, an intimate social relationship was formed and tobacco buildings became a social centre in the local area. However, following the development of technology, curing machines were introduced to replace the traditional tobacco buildings in the 1970s. This transformation not only changed the curing method, but it also had an impact on local social relationships. By drawing on documentary research and interviews conducted with farmers and residents in tobacco settlements in Taiwan, this paper attempts to explore the story of how people, place and the tobacco industry are connected by this transfer of technology in the contemporary society.
Investigation of a Potential Scintigraphic Tracer for Imaging Apoptosis: Radioiodinated Annexin V-Kunitz Protease Inhibitor Fusion Protein
Mei-Hsiu Liao,Tong-Rong Jan,Chao-Chih Chiang,Kuo-Chen Yen,Tse-Zung Liao,Ming-Wei Chen,Chin-Wen Chi,Tze-Chein Wun,Tzu-Chen Yen,Shiaw-Pyng Wey
Journal of Biomedicine and Biotechnology , 2011, DOI: 10.1155/2011/675701
Abstract: Radiolabeled annexin V (ANV) has been widely used for imaging cell apoptosis. Recently, a novel ANV-Kunitz-type protease inhibitor fusion protein, ANV-6L15, was found to be a promising probe for improved apoptosis detection based on its higher affinity to phosphatidylserine (PS) compared to native ANV. The present paper investigates the feasibility of apoptosis detection using radioiodinated ANV-6L15. Native ANV and ANV-6L15 were labeled with iodine-123 and iodine-125 using Iodogen method. The binding between the radioiodinated proteins and erythrocyte ghosts or chemical-induced apoptotic cells was examined. ANV-6L15 can be radioiodinated with high yield (40%−60%) and excellent radiochemical purity (>95%). 123I-ANV-6L15 exhibited a higher binding ratio to erythrocyte ghosts and apoptotic cells compared to 123I-ANV. The biodistribution of 123I-ANV-6L15 in mice was also characterized. 123I-ANV-6L15 was rapidly cleared from the blood. High uptake in the liver and the kidneys may limit the evaluation of apoptosis in abdominal regions. Our data suggest that radiolabled ANV-6L15 may be a better scintigraphic tracer than native ANV for apoptosis detection.
Oncogenic Transformation by Inhibitor-Sensitive and -Resistant EGFR Mutants
Heidi Greulich ,Tzu-Hsiu Chen,Whei Feng,Pasi A J?nne,James V Alvarez,Mauro Zappaterra,Sara E Bulmer,David A Frank,William C Hahn,William R Sellers ,Matthew Meyerson
PLOS Medicine , 2005, DOI: 10.1371/journal.pmed.0020313
Abstract: Background Somatic mutations in the kinase domain of the epidermal growth factor receptor tyrosine kinase gene EGFR are common in lung adenocarcinoma. The presence of mutations correlates with tumor sensitivity to the EGFR inhibitors erlotinib and gefitinib, but the transforming potential of specific mutations and their relationship to drug sensitivity have not been described. Methods and Findings Here, we demonstrate that EGFR active site mutants are oncogenic. Mutant EGFR can transform both fibroblasts and lung epithelial cells in the absence of exogenous epidermal growth factor, as evidenced by anchorage-independent growth, focus formation, and tumor formation in immunocompromised mice. Transformation is associated with constitutive autophosphorylation of EGFR, Shc phosphorylation, and STAT pathway activation. Whereas transformation by most EGFR mutants confers on cells sensitivity to erlotinib and gefitinib, transformation by an exon 20 insertion makes cells resistant to these inhibitors but more sensitive to the irreversible inhibitor CL-387,785. Conclusion Oncogenic transformation of cells by different EGFR mutants causes differential sensitivity to gefitinib and erlotinib. Treatment of lung cancers harboring EGFR exon 20 insertions may therefore require the development of alternative kinase inhibition strategies.
Numerical analysis of airflow alteration in central airways following tracheobronchial stent placement
Chien-Yi Ho, Hsiu-Mei Liao, Chih-Yen Tu, Chih-Yang Huang, Chuen-Ming Shih, Min-Ying Su, Jeon-Hor Chen, Tzu-Ching Shih
Experimental Hematology & Oncology , 2012, DOI: 10.1186/2162-3619-1-23
Abstract: Airway tumors related to central airway compression produces dyspnea, stridor, hemorrhage, obstructive pneumonia, or combinative syndromes. These patients branded with a poor prognosis may not benefit from surgery with a curative intent; however, they will require procedures for palliation with the hopes of being provided with an improved quality of life. In 1915, Brunings and Albrecht [1] raised the model of endoscopic tracheal stent placement for the therapy of airway strictures. As the development of material technology, the commercial silicon stent which could use rigid bronchoscopy to place the implants was proposed by Duman [2]. From that time, metallic airway stent insertion can achieve symptomatic relief in the majority of patients with airway obstruction, and mounting researches aimed at evaluating the effectiveness of metallic airway stents implants based on the change in lung function [3-8], clinical symptoms [9-12], comorbidity incidence [13,14], and survival rate [15-22], have been reported. However, it was difficult to examine or evaluate the efficacy in some patients with severe airway obstruction [23,24].Computer tomography (CT) with two-dimensional (2D) or three-dimensional (3D) reconstruction image study can help to evaluate the improvement of the anatomic structure. However, the real alteration of airflow and the spread of gas particles in central airway before and after airway stents placement could not be accurately accessed before the Computational Fluid Dynamics (CFD) software was applied to mimic the internal luminal 3D airflow alteration [16], and to imitate normal human airway internal alterations [25,26]. Xu and Liu [18,21] reported the change in airway flow and pressure during airway obstruction. Kabilan [22] also used the CFD software to record and analyze the sheep airway flow. In 2005, Chen [23] combined 3D computer tomography and CFD software to investigate the coronary artery disease after stent placement. However, there was no repor
Comparison of the Effects of Air Pollution on Outpatient and Inpatient Visits for Asthma: A Population-Based Study in Taiwan
Hui-Hsien Pan, Chun-Tzu Chen, Hai-Lun Sun, Min-Sho Ku, Pei-Fen Liao, Ko-Hsiu Lu, Ji-Nan Sheu, Jing-Yang Huang, Jar-Yuan Pai, Ko-Huang Lue
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096190
Abstract: Background A nationwide asthma survey on the effects of air pollution is lacking in Taiwan. The purpose of this study was to evaluate the time trend and the relationship between air pollution and health care services for asthma in Taiwan. Methods Health care services for asthma and ambient air pollution data were obtained from the National Health Insurance Research database and Environmental Protection Administration from 2000 through 2009, respectively. Health care services, including those related to the outpatient and inpatient visits were compared according to the concentration of air pollutants. Results The number of asthma-patient visits to health-care facilities continue to increase in Taiwan. Relative to the respective lowest quartile of air pollutants, the adjusted relative risks (RRs) of the outpatient visits in the highest quartile were 1.10 (P-trend = 0.013) for carbon monoxide (CO), 1.10 (P-trend = 0.015) for nitrogen dioxide (NO2), and 1.20 (P-trend <0.0001) for particulate matter with an aerodynamic diameter ≦10μm (PM10) in the child group (aged 0–18). For adults aged 19–44, the RRs of outpatient visits were 1.13 (P-trend = 0.078) for CO, 1.17 (P-trend = 0.002) for NO2, and 1.13 (P-trend <0.0001) for PM10. For adults aged 45–64, the RRs of outpatient visits were 1.15 (P-trend = 0.003) for CO, 1.19 (P-trend = 0.0002) for NO2, and 1.10 (P-trend = 0.001) for PM10. For the elderly (aged≥ 65), the RRs of outpatient visits in were 1.12 (P-trend = 0.003) for NO2 and 1.10 (P-trend = 0.006) for PM10. For inpatient visits, the RRs across quartiles of CO level were 1.00, 1.70, 1.92, and 1.86 (P-trend = 0.0001) in the child group. There were no significant linear associations between inpatient visits and air pollutants in other groups. Conclusions There were positive associations between CO levels and childhood inpatient visits as well as NO2, CO and PM10 and outpatient visits.
Amyloid-Beta (Aβ) D7H Mutation Increases Oligomeric Aβ42 and Alters Properties of Aβ-Zinc/Copper Assemblies
Wei-Ting Chen, Chen-Jee Hong, Ya-Tzu Lin, Wen-Han Chang, He-Ting Huang, Jhih-Ying Liao, Yu-Jen Chang, Yi-Fang Hsieh, Chih-Ya Cheng, Hsiu-Chih Liu, Yun-Ru Chen, Irene H. Cheng
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0035807
Abstract: Amyloid precursor protein (APP) mutations associated with familial Alzheimer's disease (AD) usually lead to increases in amyloid β-protein (Aβ) levels or aggregation. Here, we identified a novel APP mutation, located within the Aβ sequence (AβD7H), in a Taiwanese family with early onset AD and explored the pathogenicity of this mutation. Cellular and biochemical analysis reveal that this mutation increased Aβ production, Aβ42/40 ratio and prolonged Aβ42 oligomer state with higher neurotoxicity. Because the D7H mutant Aβ has an additional metal ion-coordinating residue, histidine, we speculate that this mutation may promote susceptibility of Aβ to ion. When co-incubated with Zn2+ or Cu2+, AβD7H aggregated into low molecular weight oligomers. Together, the D7H mutation could contribute to AD pathology through a “double punch” effect on elevating both Aβ production and oligomerization. Although the pathogenic nature of this mutation needs further confirmation, our findings suggest that the Aβ N-terminal region potentially modulates APP processing and Aβ aggregation, and further provides a genetic indication of the importance of Zn2+ and Cu2+ in the etiology of AD.
Real-Time Electrocardiogram Transmission from Mount Everest during Continued Ascent
Wei-Fong Kao, Jyh-How Huang, Terry B. J. Kuo, Po-Lun Chang, Wen-Chen Chang, Kuo-Hung Chan, Wen-Hsiung Liu, Shih-Hao Wang, Tzu-Yao Su, Hsiu-chen Chiang, Jin-Jong Chen
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0066579
Abstract: The feasibility of a real-time electrocardiogram (ECG) transmission via satellite phone from Mount Everest to determine a climber’s suitability for continued ascent was examined. Four Taiwanese climbers were enrolled in the 2009 Mount Everest summit program. Physiological measurements were taken at base camp (5300 m), camp 2 (6400 m), camp 3 (7100 m), and camp 4 (7950 m) 1 hour after arrival and following a 10 minute rest period. A total of 3 out of 4 climbers were able to summit Mount Everest successfully. Overall, ECG and global positioning system (GPS) coordinates of climbers were transmitted in real-time via satellite phone successfully from base camp, camp 2, camp 3, and camp 4. At each camp, Resting Heart Rate (RHR) was transmitted and recorded: base camp (54–113 bpm), camp 2 (94–130 bpm), camp 3 (98–115 bpm), and camp 4 (93–111 bpm). Real-time ECG and GPS coordinate transmission via satellite phone is feasible for climbers on Mount Everest. Real-time RHR data can be used to evaluate a climber’s physiological capacity to continue an ascent and to summit.
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