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Search Results: 1 - 10 of 5273 matches for " Hoyoung Chung "
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Phylogenetic analysis and characterization of mitochondrial DNA for Korean native cattle  [PDF]
Hoyoung Chung
Open Journal of Genetics (OJGen) , 2013, DOI: 10.4236/ojgen.2013.31003
This study was aimed to preserve mitochondria from liver tissues of Korean native cattle (KNC) as genetic resources and to analyze phylogenetic relationships among cattle breeds using the whole sequences of mtDNA. Mitochondria of KNC has been isolated with the alkaline lysis procedure using1 gof liver tissues, and measurements showed numbers of cells (2.64 × 1010), concentration (114.6 ug/ml), proteins (0.278 ug/ml), and absorbance (0.029) in 260 nm. Mitochondrial DNAs (mtDNA) were extracted from the isolated mitochondria to determine whole sequences that can be used to estimate genetic distances among cattle breeds. Designing of primers based on the bovine mtDNA sequence was resulted in 16 primer sets covering the whole mtDNA regions. The analysis of 40 KNC mtDNA sequences revealed 69 polymorphic sites that were less than the average number of SNP (single nucleotide polymorphism) for other populations (82 sites) in this study. As expected, the highest observation of SNPs was found in the D-loop region, and a total of 29 SNPs were shared between cattle populations. The haplotype analysis, which used 13 SNPs located in D-loop, COX2, ND5, CYTB, and non coding regions, revealed that KNC showed clearly different haplotypes that may be used to distinguish KNC from other breeds as well as to characterize individual identifications. The phylogenetic analysis revealed that KNC showed a relatively close genetic distance with Japanese black cattle (JBC) comparing with other breeds. Estimations of the average nucleotide diversity (0.0008) and the ratio of transition/ transversion (0.1050) of KNC were placed somewhere in the middle of genetic diversity among cattle breeds. The identified genetic variants and results of phylogenetic analysis will help understanding the phylogenetic relationships of KNC and provide useful genetic information for further studies regarding SNPs in mtDNA regions.
Associations of Single Nucleotide Polymorphisms in the Bovine FADS6 Gene with Fatty Acid Composition in Hanwoo (Korean Cattle)  [PDF]
Krishnamoorthy Srikanth, Anam Kwan, Eunjin Lee, Seonkwan Kim, Youngjo Lim, Hoyoung Chung
Open Journal of Genetics (OJGen) , 2015, DOI: 10.4236/ojgen.2015.54010
Abstract: The bovine fatty acid desaturase (FADS) gene cluster consists of FADS1, FADS2, FADS3, and FADS6, which acts as key enzymes in fatty acid metabolism. Of these, the genetics effects of variants in FADS1, FADS2 and FADS3 have been previously studied. However, the genetic effects of variants of FADS6 gene have not been studied. The aim of this study was to identify genetic variants in the bovine fatty acid desaturase 6 (FADS6) gene and study their association with fatty acid composition in Hanwoo cattle. Six genetic variants were observed, three each in intron 2 and exon 6 by DNA sequencing analyses. The association of genetic variants with fatty acid composition was evaluated in 90 Hanwoo steers. The variants were confirmed and the animals were genotyped by RFLP (Restriction Fragment Length Polymorphism) and AS-PCR (Allele Specific PCR) analyses. The analysis revealed that palmitoleic acid (C16:1n7) was associated with g.3391G > A, g.3660A > C and g.15657C > T, and stearic acid (C18:0) showed highly significant association with g.3660A > C segments. Both g.3391G > A, g.3660A > C also had strong additive and dominance effect for Palmitoleic acid, while g.3660A > C also had a strong dominance effect for stearic acid. These results could be useful for modulating fatty acid composition in beef and produce meat with higher monounsaturated fatty acid to saturated fatty acid ratio (MUFA/SFA), which had been shown to have positive health effect in humans.
Inhibitory Effects of Chung Hun Wha Dam Tang (CHWDT) on High-Fat Diet-Induced Obesity via AMP-Activated Protein Kinase Activation
Md. Jamal Uddin,Yeonsoo Joe,Min Zheng,Sena Kim,Hoyoung Lee,Tae-Oh Kwon,Hun Taeg Chung
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/652473
Abstract: The Chung Hun Wha Dam Tang (CHWDT) herbal combination was reported to cease dizziness and phlegm. However, the effect of CHWDT in obesity has not yet been known mechanically. Therefore, we investigated whether this CHWDT could protect the cells from lipogenesis, gluconeogenesis, and inflammation in both in vivo and in vitro. CHWDT significantly decreased body weight, epididymal and perirenal fat content without affecting feed intake in high-fat diet-induced obese mice model. Additionally, CHWDT inhibited obesity-induced SREBP1, FAS, PGC1α, G6Pase, PEPCK and increased CPT1, ACO, and LCAD genes expression in vivo and in vitro. Proinflammatory cytokines like TNF-α and iNOS expression were reduced by CHWDT in both Raw264.7 macrophages and HepG2 cells. In addition, NO production was also significantly decreased by CHWDT in LPS-stimulated macrophages. Furthermore, AMPKα activation by CHWDT was involved in inhibition of obesity by reducing triglycerides production and increasing CPT1 expression. Based on all of the results, we suggest that CHWDT has inhibitory effects on obesity-induced lipogenesis, gluconeogenesis, and inflammation via AMPKα activation.
Gene Flow between the Korean Peninsula and Its Neighboring Countries
Jongsun Jung,Hoyoung Kang,Yoon Shin Cho,Ji Hee Oh,Min Hyung Ryu,Hye Won Chung,Jeong-Sun Seo,Jong-Eun Lee,Bermseok Oh,Jong Bhak,Hyung-Lae Kim
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011855
Abstract: SNP markers provide the primary data for population structure analysis. In this study, we employed whole-genome autosomal SNPs as a marker set (54,836 SNP markers) and tested their possible effects on genetic ancestry using 320 subjects covering 24 regional groups including Northern ( = 16) and Southern ( = 3) Asians, Amerindians ( = 1), and four HapMap populations (YRI, CEU, JPT, and CHB). Additionally, we evaluated the effectiveness and robustness of 50K autosomal SNPs with various clustering methods, along with their dependencies on recombination hotspots (RH), linkage disequilibrium (LD), missing calls and regional specific markers. The RH- and LD-free multi-dimensional scaling (MDS) method showed a broad picture of human migration from Africa to North-East Asia on our genome map, supporting results from previous haploid DNA studies. Of the Asian groups, the East Asian group showed greater differentiation than the Northern and Southern Asian groups with respect to Fst statistics. By extension, the analysis of monomorphic markers implied that nine out of ten historical regions in South Korea, and Tokyo in Japan, showed signs of genetic drift caused by the later settlement of East Asia (South Korea, Japan and China), while Gyeongju in South East Korea showed signs of the earliest settlement in East Asia. In the genome map, the gene flow to the Korean Peninsula from its neighboring countries indicated that some genetic signals from Northern populations such as the Siberians and Mongolians still remain in the South East and West regions, while few signals remain from the early Southern lineages.
Design of a Bovine Low-Density SNP Array Optimized for Imputation
Didier Boichard, Hoyoung Chung, Romain Dassonneville, Xavier David, André Eggen, Sébastien Fritz, Kimberly J. Gietzen, Ben J. Hayes, Cynthia T. Lawley, Tad S. Sonstegard, Curtis P. Van Tassell, Paul M. VanRaden, Karine A. Viaud-Martinez, George R. Wiggans, for the Bovine LD Consortium
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0034130
Abstract: The Illumina BovineLD BeadChip was designed to support imputation to higher density genotypes in dairy and beef breeds by including single-nucleotide polymorphisms (SNPs) that had a high minor allele frequency as well as uniform spacing across the genome except at the ends of the chromosome where densities were increased. The chip also includes SNPs on the Y chromosome and mitochondrial DNA loci that are useful for determining subspecies classification and certain paternal and maternal breed lineages. The total number of SNPs was 6,909. Accuracy of imputation to Illumina BovineSNP50 genotypes using the BovineLD chip was over 97% for most dairy and beef populations. The BovineLD imputations were about 3 percentage points more accurate than those from the Illumina GoldenGate Bovine3K BeadChip across multiple populations. The improvement was greatest when neither parent was genotyped. The minor allele frequencies were similar across taurine beef and dairy breeds as was the proportion of SNPs that were polymorphic. The new BovineLD chip should facilitate low-cost genomic selection in taurine beef and dairy cattle.
A Fast and Reliable Hybrid Data Delivery Protocol for Large-Scale Heterogeneous Sensor Networks
Sanggil Kang,Yujin Lim,Wilmarc Lopez,Hoyoung Hwang
International Journal of Distributed Sensor Networks , 2012, DOI: 10.1155/2012/890238
Abstract: We propose a hybrid data delivery method for the large-scale heterogeneous sensor networks, which is a fast and reliable delivery protocol for the aggregated data from the sinks to the GW. We develop a new multicriteria-ranking algorithm which determines multiple forwarders for each hop by ranking neighbor nodes. To rank the nodes, we compute the fitness value using features for each node such as the received signal strength, nodal delay, and hop distance. We determine the time of sending among forwarders using the waiting time assignment algorithm. In the experimental section, we show that our method outperforms conventional data delivery protocols in terms of data delivery ratio and end-to-end delay.
Detecting Specific Health-Related Events Using an Integrated Sensor System for Vital Sign Monitoring
Mourad Adnane,Zhongwei Jiang,Samjin Choi,Hoyoung Jang
Sensors , 2009, DOI: 10.3390/s90906897
Abstract: In this paper, a new method for the detection of apnea/hypopnea periods in physiological data is presented. The method is based on the intelligent combination of an integrated sensor system for long-time cardiorespiratory signal monitoring and dedicated signal-processing packages. Integrated sensors are a PVDF film and conductive fabric sheets. The signal processing package includes dedicated respiratory cycle (RC) and QRS complex detection algorithms and a new method using the respiratory cycle variability (RCV) for detecting apnea/hypopnea periods in physiological data. Results show that our method is suitable for online analysis of long time series data.
Cartesian Grid Method with Cut Cell in the Mold Filling Simulation

Youngsim Choi,Junho Hong,Hoyoung Hwang,Jeongkil Choi,

材料科学技术学报 , 2008,
Abstract: In this paper, a Cartesian grid method with cut cell has been developed to simulate mold filling of casting process. Cut cells at the cast-mold interface are generated on the Cartesian grid. With the boundary cut cells, a special treatment is necessary. That is Cartesian grid method with cut cell. A simple shape was tested and the cut cell method was compared with the traditional one on Cartesian grids. And, a developed method was applied to the real casting product simulation. Cartesian grid system causes momentum loss and unsound fluid flow patterns because of inaccurate generation of meshes. These problems have been improved by using cut cell method.
Solid Boundary as Energy Source and Sink in a Dry Granular Dense Flow: A Comparison between Two Turbulent Closure Models  [PDF]
Chung Fang
Engineering (ENG) , 2014, DOI: 10.4236/eng.2014.613087
Abstract: Solid boundary as energy source and sink of the turbulent kinetic energy of the grains, and its influence on the mean and turbulent features of a dry granular dense flow, are investigated by using the proposed zero- and first-order turbulent closure models. The first and second laws of thermodynamics are used to derive the equilibrium closure relations, with the dynamic responses postulated by a quasi-static theory for weak turbulent intensity. Two closure models are applied to analyses of a gravity-driven flow down an inclined moving plane. While the calculated mean porosity and velocity correspond to the experimental outcomes, the influence of the turbulent eddy evolution can be taken into account in the first-order model. Increasing velocity slip on the inclined plane tends to enhance the turbulent dissipation nearby, and the turbulent kinetic energy near the free surface. The turbulent dissipation demonstrates a similarity with that of Newtonian fluids in turbulent boundary layer flows. While two-fold roles of the solid boundary are apparent in the first-order model, its role as an energy sink is more obvious in the zero-order model.
Human Cultural Evolution: Postmodernity as Rational Global Diversity  [PDF]
Dingyu Chung
Open Journal of Social Sciences (JSS) , 2017, DOI: 10.4236/jss.2017.55022
Abstract: This paper proposes that human culture has evolved from authoritative local premodernity through rational local modernity to the coming rational global postmodernity with diverse cultural types. Premodernity, modernity, and postmodernity are the cultural adaptations to the drastic social changes from the Agricultural, Industrial, and Information Revolutions. The cultural types analogous to biological species are the nine cultural types derived from the instinctive cultural type model based on the instinctive sociality trichotomy (individualistic, collectivistic, and interdependent) and the instinctive worldview trichotomy (territorial, connective, and competitive). Western culture originated from the Middle East and Greece has competitive worldview, while Eastern culture originated from India and China has connective worldview. Different cultural types have different perceptions, moralities, religions, politics, and economies. Currently, the world is the chaotic diverse global society where the cultural types clash. The coming postmodernity as rational global diversity is produced by the three rational global diverse systems. The rational global diverse system for the coming postmodern international politics is the three-tier international politics consisting of nations with geopolitical boundaries, the 12 regional communities with cultural-geographic boundaries, and the global international organizations without boundary. The rational global diverse system for the coming postmodern international trade is the trichotomic international trade containing free competitive, free connective, and fair protectionist international trades. The rational global diverse system for the coming postmodern common ground between religion and science is the cultural theology of trinity consisting of the transcendental, immanent, and imaginary cultural origins. The coming postmodernity as rational global diversity will bring rational order and peace among global diverse cultural types.
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