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Search Results: 1 - 10 of 45430 matches for " Hong Cai "
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Modulation of presynaptic nAChRs on postsynaptic GABA receptor in optic tectum of juvenileXenopus
Hong Wang,Haoran Cai
Chinese Science Bulletin , 2003, DOI: 10.1007/BF03183241
Abstract: Using the blind patch-clamp technique with the whole-cell mode, we have studied the modulation of presynaptic receptor on postsynaptic γ-aminobutyric acid (GABA) receptor measuring miniature inhibitory postsynaptic currents (mIPSCs) in optic tectum ofXenopus during critical peroid. It was demonstrated that compared with mature neurons, mIPSCs recorded from immature neurons had smaller amplitude and longer decay time. mIPSCs are mediated by GABAa receptor. The nicotinic acetylcholine receptor agonists (carbachol, cytisine, nicotine, DMPP and so on) could increase the frequency of mIPSCs. The enhancement of mIPSCs frequency induced by nAChR agonists was calcium-dependent. However, the choline, a product of hydrolyzed acetylcholine, could not increase the frequency of mIPSCs. DH-β-E, a competitive antagonist of nAChR, blocked the increase of mIPSCs frequency induced by carbachol. Mecamyllamine, an α3β4 subtype of nAChR antagonist, also blocked the carbachol-induced enhancement of mIPSCs. On the other hand, MLA, α7 subtype of nAChR antagonist, had no effect on it. Thus, it seems that nAChR could presynaptically modulate the mIPSCs and α3β4 subtype of nAChR might be involved. But α7 nAChR subtype of nAChR would not be involved. The modulation is calciumdependent. Meanwhile, we found that Ca2+-free solution could elicit giant PSCs. The frequency of mIPSCs also is related with the level of HP.
Pyritization in the Gaojiashan Biota
YaoPing Cai,Hong Hua
Chinese Science Bulletin , 2007, DOI: 10.1007/s11434-007-0080-9
Abstract: The Late Sinian (Ediacaran) Gaojiashan Biota was a soft-bodied fossil-Lagerst tte dominated by substantial pyritized, three-dimensionally preserved tubular and conotubular fossils. Soft-tissue pyritization is extremely scarce in the fossil records, especially in the Precambrian, therefore it has very important and unique significance for the study of pyritization in the Gaojiashan Biota. Early pyritization played a pivotal role in the fossil preservation and two main factors ensured the successful pyritization of the fossils, namely rapid burial and permineralization. The former was controlled by secular storm deposition, and the latter was achieved by sufficient supply of available iron from sediments. SEM data of Conotubus demonstrate two types of preservation of the tubes (defined as type A and type B, respectively). In type A, pyritization took place relatively earlier and completely preserved both tube wall and coelom, but no detailed structure. While in type B, pyritization took place somewhat later and preserved the integrated tube wall, but partially the coelom. The size frequency distribution of the pyrite framboids suggests that pyritization took place in two different environments with entire different oxygen content.
[(2-Morpholinoethyl)(2-pyridylmethylene)amine]dithiocyanatozinc(II)
Bang-Hong Cai
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536808044061
Abstract: The title compound, [Zn(NCS)2(C12H17N3O)], was prepared by the reaction of zinc acetate with pyridine-2-carbaldehyde, 2-morpholinoethylamine and ammonium thiocyanate in an ethanol solution. The ZnII atom is five coordinate with a distorted trigonal–bipyramidal geometry, coordinating with three N atoms of the Schiff base (2-morpholinoethyl)(2-pyridylmethylidene)amine and two N atoms from two thiocyanate ligands. The morpholine ring adopts a chair configuration.
Poly[(μ2-azido-κ2N1:N1)[μ2-5-(8-quinolyloxymethyl)tetrazolato-κ4N1,O,N5:N4]zinc(II)]
Hong-ling Cai
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809016924
Abstract: In the title compound, [Zn(C11H8N5O)(N3)]n, the Zn atom is hexacoordinated by five N atoms and one O atom in a distorted octahedral geometry. The chelating 5-(8-quinolyloxymethyl)tetrazolate ligands are approximately planar, with a dihedral angle of 3.6 (2)° between the quinoline and tetrazole planes. Adjacent Zn atoms are linked by two bridging azide ligands across a centre of inversion, and further coordination by one N atom of an adjacent tetrazole unit forms two-dimensional frameworks in (100). C—H...N interactions exist between ligands in neighbouring layers.
Bis[4-bromo-2-(cyclopentyliminomethyl)phenolato]copper(II)
Bang-Hong Cai
Acta Crystallographica Section E , 2009, DOI: 10.1107/s1600536809006606
Abstract: The title compound, [Cu(C12H13BrNO)2], was prepared by the reaction of 5-bromosalicylaldehyde, cyclopentylamine and copper(II) acetate in an ethanol solution. The CuII atom lies on an inversion center and is four-coordinated in a square-planar geometry by two N and two O atoms from two 4-bromo-2-(cyclopentyliminomethyl)phenolate Schiff base ligands.
Administration and quality control of large-scale clinical trials of traditional Chinese medicine
Hong-cai SHANG
Zhong Xi Yi Jie He Xue Bao , 2007,
Abstract: ABSTRACT: Large-scale clinical trial is an important measure of clinical evaluation on drugs. This paperintroduces the concept and features of large-scale clinical trial, the possibility and necessity of large-scale clinical trial of traditional Chinese medicine, as well as its administration and quality control, with Myocardial Infarction Secondary Prevention Study in Traditional Chinese Medicine (MISPS-TCM), a National Program Subject, as an example.
Applications and approved projects on traditional Chinese medicine in National Natural Science Foundation of China in 2010
Hong-cai Shang
Zhong Xi Yi Jie He Xue Bao , 2011,
Abstract: In this article, the authors firstly summarized the number of applications submitted to and projects supported by the National Natural Science Foundation of China (NSFC) in the field of traditional Chinese medicine research in 2010. Then they described the district distribution, research direction layout and allotment of the approved projects in the three primary disciplines (traditional Chinese medicine, Chinese materia medica and integrated traditional Chinese and Western medicine) and their 43 subdisciplines. The targeting suggestions for improvement were given respectively by concluding the reason of disapproved projects from the point of view of applicants and supporting institution, and by stating the common problems existing in the review process from the perspectives of fund managers and evaluation experts. Lastly, the major funding fields in the near future were predicted in the hope of providing guidance for applicants.
Chinese herbal medicine Lingqi Huangban Granule protects retinal pigment epithelial cells against oxidative stress-induced injury in vitro
Cai-hong Li
Zhong Xi Yi Jie He Xue Bao , 2012,
Abstract: OBJECTIVE: To observe the protective effects of drug-contained serum of Lingqi Huangban Granule (LQHBG), a compound traditional Chinese herbal medicine, on oxidative stress-induced injury in rabbit retinal pigment epithelial (RPE) cells in vitro. METHODS: The oxidative stress of rabbit RPE cells in vitro was induced with hydrogen peroxide (500 μmol/L) and different concentrations of LQHBG were administered to rats to prepare medicated serum. RPE cells were randomized into normal control group (no hydrogen peroxide), model group (hydrogen peroxide), model plus serum group (hydrogen peroxide and 10% control serum), model plus low-dose LQHBG group (hydrogen peroxide and low-dose LQHBG-medicated serum) and model plus high-dose LQHBG group (hydrogen peroxide and high-dose LQHBG-medicated serum). Teminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay and flow cytometry (FCM) were used to measure apoptosis of cultured rabbit RPE cells. Protein expressions of caspase-3 and Bcl-XL were observed by Western blot method.RESULTS: FCM results showed that the apoptotic rates of the normal control group, model group, control serum group and serum containing low- and high-dose LQHBG groups were (4.85±0.26) %, (20.02±1.37) %, (21.84±0.94) %, (13.56±0.55) %, and (8.58±0.39) %, respectively; compared with the model group, the apoptotic rates of RPE cells in the low- and high-dose LQHBG groups were obviously reduced in a dose-related manner (P<0.05). TUNEL results showed that nuclei of apoptotic cells were stained brown; the number of apoptotic cells in the low- and high-dose LQHBG groups was obviously less than that in the model group. The protein expression of caspase-3 was up-regulated in the model and control serum groups, which was higher than that in the high-dose LQHBG group (P<0.05). The protein expression of Bcl-XL was down-regulated in the model and control serum groups, which was lower than that in the low- and high-dose LQHBG groups (P<0.01). CONCLUSION: Drug-contained serum of LQHBG obviously reduces apoptosis and partly protects rabbit RPE cells from oxidative stress-induced injury. The protective function is due to an improvement in antioxidant abilities, down-regulation of the expression of caspase-3 and up-regulation of the expression of Bcl-XL.
Clinical orientation of post-marketing Chinese patent drugs: an evidence-based practice
Hong-cai SHANG
Zhong Xi Yi Jie He Xue Bao , 2008,
Abstract: : Unclear clinical orientation in practice has become one of the common problems with the effective application of famous and superior Chinese herbal drugs, thus restricting their development. The authors suggest that there are three aspects of this problem. Clinical evaluation and orientation of the famous and superior Chinese herbal drugs is an important task, and it is also a requirement for the internationalization of traditional Chinese medicine. Literature evaluation-pharmacology research-clinical expertise analysis method will establish a theoretical basis and method for post-marketing development of famous and superior Chinese patent drugs.
A Data-Driven Simulation Model for China Haze Monitor and Governance  [PDF]
Xiaoyan Lu, Hong Chen, Miao Wang, Zhengying Cai
World Journal of Engineering and Technology (WJET) , 2016, DOI: 10.4236/wjet.2016.42036
Abstract: Recently, the China haze becomes more and more serious, but it is very difficult to model and control it. Here, a data-driven model is introduced for the simulation and monitoring of China haze. First, a multi-dimensional evaluation system is built to evaluate the government performance of China haze. Second, a data-driven model is employed to reveal the operation mechanism of China’s haze and is described as a multi input and multi output system. Third, a prototype system is set up to verify the proposed scheme, and the result provides us with a graphical tool to monitor different haze control strategies.
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