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Search Results: 1 - 10 of 590 matches for " Holly Hedrick "
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The Effects of Fetal Surgery on Retinopathy of Prematurity Development
Sudha Nallasamy,Stefanie L. Davidson,Lori J. Howell,Holly Hedrick
Ophthalmology and Eye Diseases , 2009,
Abstract: Background: Fetal surgery is selectively offered for severe or life-threatening fetal malformations. These infants are often born prematurely and are thus at risk for retinopathy of prematurity (ROP). It is not known whether fetal surgery confers an increased risk of developing severe ROP relative to published rates in standard premature populations ≤37 weeks of age grouped by birth weight (
The Effects of Fetal Surgery on Retinopathy of Prematurity Development
Sudha Nallasamy, Stefanie L. Davidson, Lori J. Howell, Holly Hedrick, Alan W. Flake, Timothy M. Crombleholme, N. Scott Adzick and Terri L. Young
Ophthalmology and Eye Diseases , 2012,
Abstract: Background: Fetal surgery is selectively offered for severe or life-threatening fetal malformations. These infants are often born prematurely and are thus at risk for retinopathy of prematurity (ROP). It is not known whether fetal surgery confers an increased risk of developing severe ROP relative to published rates in standard premature populations ≤37 weeks of age grouped by birth weight (<1500 grams or ≥1500 grams). Design: This is a retrospective chart review. Methods: We reviewed the charts of 137 patients who underwent open fetal/fetoscopic surgery from 1996–2004. Surgical indications included twin-twin transfusion syndrome (TTTS), myelomeningocele (MMC), congenital diaphragmatic hernia (CDH), sacrococcygeal teratoma (SCT), cystic adenomatoid malformation of the lung (CCAM), and twin reversed arterial perfusion sequence (TRAP). Of these, 17 patients had local ROP examination data. Binomial tests were performed to assess whether rates of ROP in our fetal/fetoscopic surgery cohort were significantly different from published rates. Results: There were 5 patients each with an underlying diagnosis of TTTS and MMC, 2 patients each with CDH and TRAP, and 1 patient each with SCT, CCAM, and mediastinal teratoma. The mean gestational age at surgery was 234/7 ± 23/7 weeks, mean gestational age at birth was 30 ± 25/7 weeks, and mean birth weight was 1449 ± 510 grams (610–2485). Compared to published rates of ROP and threshold ROP, our fetal surgery patients had significantly higher rates of ROP and threshold ROP in both the <1500 grams and the ≥1500 grams group (all p-values < 0.05). Conclusions: Fetal/fetoscopic surgery appears to significantly increase the rate of ROP and threshold ROP development. Greater numbers are needed to confirm these observations.
Physiological Properties of Cholinergic and Non-Cholinergic Magnocellular Neurons in Acute Slices from Adult Mouse Nucleus Basalis
Tristan Hedrick,Jack Waters
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0011046
Abstract: The basal forebrain is a series of nuclei that provides cholinergic input to much of the forebrain. The most posterior of these nuclei, nucleus basalis, provides cholinergic drive to neocortex and is involved in arousal and attention. The physiological properties of neurons in anterior basal forebrain nuclei, including medial septum, the diagonal band of Broca and substantia innominata, have been described previously. In contrast the physiological properties of neurons in nucleus basalis, the most posterior nucleus of the basal forebrain, are unknown.
Resistance to malaria in humans: the impact of strong, recent selection
Hedrick Philip W
Malaria Journal , 2012, DOI: 10.1186/1475-2875-11-349
Abstract: Malaria is one of the leading causes of death worldwide and has been suggested as the most potent type of selection in humans in recent millennia. As a result, genes involved in malaria resistance are excellent examples of recent, strong selection. In 1949, Haldane initially suggested that infectious disease could be a strong selective force in human populations. Evidence for the strong selective effect of malaria resistance includes the high frequency of a number of detrimental genetic diseases caused by the pleiotropic effects of these malaria resistance variants, many of which are “loss of function” mutants. Evidence that this selection is recent comes from the genetic dating of the age of a number of these malaria resistant alleles to less than 5,000 years before the present, generally much more recent than other human genetic variants. An approach to estimate selection coefficients from contemporary case–control data is presented. In the situations described here, selection is much greater than 1%, significantly higher than generally observed for other human genetic variation. With these selection coefficients, predictions are generated about the joint change of alleles S and C at the β-globin locus, and for α-thalassaemia haplotypes and S, variants that are unlinked but exhibit epistasis. Population genetics can be used to determine the amount and pattern of selection in the past and predict selection in the future for other malaria resistance variants as they are discovered.
Effect of temperature on spiking patterns of neocortical layer 2/3 and layer 6 pyramidal neurons
Tristan Hedrick,Jack Waters
Frontiers in Neural Circuits , 2012, DOI: 10.3389/fncir.2012.00028
Abstract: The spiking patterns of neocortical pyramidal neurons are shaped by the conductances in their apical dendrites. We have previously shown that the spiking patterns of layer 5 pyramidal neurons change with temperature, probably because temperature modulates the electrical coupling between somatic and dendritic compartments. Here we determine whether temperature has similar effects on the spiking patterns of layer 2/3 and layer 6 pyramidal neurons in acute slices of mouse primary motor cortex. In both cell types, decreasing temperature led to more irregular spiking patterns. Our results indicate that a decrease in spiking regularity with decreasing temperature, probably mediated by increased electrical coupling between soma and dendrites, is common to all pyramidal neurons in motor cortex.
Spiking Patterns of Neocortical L5 Pyramidal Neurons in Vitro Change with Temperature
Tristan Hedrick,Jack Waters
Frontiers in Cellular Neuroscience , 2011, DOI: 10.3389/fncel.2011.00001
Abstract: A subset of pyramidal neurons in layer 5 of the mammalian neocortex can fire action potentials in brief, high-frequency bursts while others fire spikes at regularly spaced intervals. Here we show that individual layer 5 pyramidal neurons in acute slices from mouse primary motor cortex can adopt both regular and burst spiking patterns. During constant current injection at the soma, neurons displayed a regular firing pattern at 36–37°C, but switched to burst spiking patterns upon cooling the slice to 24–26°C. This change in firing pattern was reversible and repeatable and was independent of the somatic resting membrane potential. Hence these spiking patterns are not inherent to discrete populations of pyramidal neurons and are more interchangeable than previously thought. Burst spiking in these neurons is the result of electrical interactions between the soma and distal apical dendritic tree. Presumably the interactions between soma and distal dendrite are temperature-sensitive, suggesting that the manner in which layer 5 pyramidal neurons translate synaptic input into an output spiking pattern is fundamentally altered at sub-physiological temperatures.
Partition Learning for Multiagent Planning
Jared Wood,J. Karl Hedrick
Journal of Robotics , 2012, DOI: 10.1155/2012/590479
Abstract: Automated surveillance of large geographic areas and target tracking by a team of autonomous agents is a topic that has received significant research and development effort. The standard approach is to decompose this problem into two steps. The first step is target track estimation and the second step is path planning by optimizing directly over target track estimation. This standard approach works well in many scenarios. However, an improved approach is needed for the scenario when general, nonparametric estimation is required, and the number of targets is unknown. The focus of this paper is to present a new approach that inherently handles the task to search for and track an unknown number of targets within a large geographic area. This approach is designed for the case when the search is performed by a team of autonomous agents and target estimation requires general, nonparametric methods. There are consequently very few assumptions made. The only assumption made is that a time-changing target track estimation is available and shared between the agents. This estimation is allowed to be general and nonparametric. Results are provided that compare the performance of this new approach with the standard approach. From these results it is concluded that this new approach improves search and tracking when the number of targets is unknown and target track estimation is general and nonparametric. 1. Introduction The advancement of computing technology has enabled the practical development of intelligent autonomous systems. Intelligent autonomous systems can be used to perform difficult sensing tasks. One such sensing task is to search for and track targets over large geographic areas. Much research has gone into this task resulting in a standard approach. This standard approach decomposes the problem into two steps. (1)Target track estimation. (2)Agent path optimization based on target track estimation. Significant research has been accomplished for each of these steps. Target track estimation has largely been solved [1–5] and this paper proposes no new methods for target track estimation. Agent path optimization based on target track estimation has been solved for many scenarios. However, the general scenario of when the number of targets is unknown still requires more development. The standard approach in general works particularly well when it can be assumed that there is a single target [6–14]. And in many scenarios the standard approach works well even when there are multiple targets [15, 16]. However, when there are multiple targets, methods following
Lujiatun Psittacosaurids: Understanding Individual and Taphonomic Variation Using 3D Geometric Morphometrics
Brandon P. Hedrick, Peter Dodson
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069265
Abstract: Psittacosaurus is one of the most abundant and speciose genera in the Dinosauria, with fifteen named species. The genus is geographically and temporally widespread with large sample sizes of several of the nominal species allowing detailed analysis of intra- and interspecific variation. We present a reanalysis of three separate, coeval species within the Psittacosauridae; P. lujiatunensis, P. major, and Hongshanosaurus houi from the Lujiatun beds of the Yixian Formation, northeastern China, using three-dimensional geometric morphometrics on a sample set of thirty skulls in combination with a reevaluation of the proposed character states for each species. Using these complementary methods, we show that individual and taphonomic variation are the joint causes of a large range of variation among the skulls when they are plotted in a morphospace. Our results demonstrate that there is only one species of Psittacosaurus within the Lujiatun beds and that the three nominal species represent different taphomorphotypes of P. lujiatunensis. The wide range of geometric morphometric variation in a single species of Psittacosaurus implies that the range of variation found in other dinosaurian groups may also be related to taphonomic distortion rather than interspecific variation. As the morphospace is driven primarily by variation resulting from taphonomic distortion, this study demonstrates that the geometric morphometric approach can only be used with great caution to delineate interspecific variation in Psittacosaurus and likely other dinosaur groups without a complementary evaluation of character states. This study presents the first application of 3D geometric morphometrics to the dinosaurian morphospace and the first attempt to quantify taphonomic variation in dinosaur skulls.
Sedimentation in Mountain Streams: A Review of Methods of Measurement  [PDF]
Lara B. Hedrick, James T. Anderson, Stuart A. Welsh, Lian-Shin Lin
Natural Resources (NR) , 2013, DOI: 10.4236/nr.2013.41011

The goal of this review paper is to provide a list of methods and devices used to measure sediment accumulation in wadeable streams dominated by cobble and gravel substrate. Quantitative measures of stream sedimentation are useful to monitor and study anthropogenic impacts on stream biota, and stream sedimentation is measurable with multiple sampling methods. Evaluation of sedimentation can be made by measuring the concentration of suspended sediment, or turbidity, and by determining the amount of deposited sediment, or sedimentation on the streambed. Measurements of deposited sediments are more time consuming and labor intensive than measurements of suspended sediments. Traditional techniques for characterizing sediment composition in streams include core sampling, the shovel method, visual estimation along transects, and sediment traps. This paper provides a comprehensive review of methodology, devices that can be used, and techniques for processing and analyzing samples collected to aid researchers in choosing study design and equipment.


Time-Varying Wing-Twist Improves Aerodynamic Efficiency of Forward Flight in Butterflies
Lingxiao Zheng, Tyson L. Hedrick, Rajat Mittal
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0053060
Abstract: Insect wings can undergo significant chordwise (camber) as well as spanwise (twist) deformation during flapping flight but the effect of these deformations is not well understood. The shape and size of butterfly wings leads to particularly large wing deformations, making them an ideal test case for investigation of these effects. Here we use computational models derived from experiments on free-flying butterflies to understand the effect of time-varying twist and camber on the aerodynamic performance of these insects. High-speed videogrammetry is used to capture the wing kinematics, including deformation, of a Painted Lady butterfly (Vanessa cardui) in untethered, forward flight. These experimental results are then analyzed computationally using a high-fidelity, three-dimensional, unsteady Navier-Stokes flow solver. For comparison to this case, a set of non-deforming, flat-plate wing (FPW) models of wing motion are synthesized and subjected to the same analysis along with a wing model that matches the time-varying wing-twist observed for the butterfly, but has no deformation in camber. The simulations show that the observed butterfly wing (OBW) outperforms all the flat-plate wings in terms of usable force production as well as the ratio of lift to power by at least 29% and 46%, respectively. This increase in efficiency of lift production is at least three-fold greater than reported for other insects. Interestingly, we also find that the twist-only-wing (TOW) model recovers much of the performance of the OBW, demonstrating that wing-twist, and not camber is key to forward flight in these insects. The implications of this on the design of flapping wing micro-aerial vehicles are discussed.
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