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Search Results: 1 - 10 of 11048 matches for " Ho-Sung Yoon "
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HSF1-mediated oxidative stress response to menadione in Saccharomyces cerevisiae KNU5377Y3 by using proteomic approach  [PDF]
Il-Sup Kim, Hyun Kim, Young-Saeng Kim, Ingnyol Jin, Ho-Sung Yoon
Advances in Bioscience and Biotechnology (ABB) , 2013, DOI: 10.4236/abb.2013.41007
Abstract: The hat shock transcription factor HSF1 inthe yeast Saccharomyces cerevisiae regulates a wide range of genes and functions in diverse cellular reactions. To investigate the physiological response of HSF1 inthe presence of menadione (MD) in S. cerevisiae KNU 5377Y3, wild-type (k3wt) and isogenic hsf1 mutant (k3h1) cells were introduced. HSF1 was induced when k3wt cells were exposed to the superoxide-generating agent MD and k3h1 cells were hypersensitive to MD. Under MD stress, k3h1 cells down-regulated the expression of metabolic enzymes (Hxk, Fba1, Pgk1, Eno2, and Adh1), antioxidant enzymes (Trx2 and porin), and molecular chaperones and their cofactors (Hsp104, Ssb1, Hsp60, Hsp42, Hsp26, Hsp12, Cpr1, and Sti1). In addition, k3h1 cells increased cellular hydroperoxide levels and protein carbonylation under MD stress as compared to k3wt cells. However, there was a moderate difference in the wild-type (b3wt) and mutant (b3h1) cells derived from S. cerevisiae S288Cunder the same conditions. Thus, these results show that HSF1 is an important component of the stress response system, acting as an activator of cell rescue genes in S. cerevisiae KNU5377Y3, and its expression protects the cells from MD-induced oxidative damage by maintaining redox homeostasis and proteostasis in the presence of MD.
Solvent extraction studies on uranium using amine based extractants and recovery from low grade ore leach liquors
Kim, Chul-Joo;Kumar, Jyothi Rajesh;Kim, Joon-Soo;Lee, Jin-Young;Yoon, Ho-Sung;
Journal of the Brazilian Chemical Society , 2012, DOI: 10.1590/S0103-50532012000700009
Abstract: in this study, amine based extractants (alamine 336, alamine 308, alamine 304 and aliquat 336) diluted in kerosene were used as promising extractants for uranium extraction and separation from other associated elements. alamine 336 was the best extractant for uranium extraction process from sulfate solutions when compared with other amine based extractants, alamine 308, alamine 304 and aliquat 336. synergistic extraction behavior was studied with amines as extractants as well as synergists and organophosphorus reagents used as synergist mixed with amines. synergistic extraction studies with amines were not suitable with each other for better extraction efficiency. however, amines mixed with organophosphorus extractants gave positive synergetic behavior with the highest synergistic coefficient 0.567 calculated from results obtained. the developed methodology was applied to uranium low grade ore processing and 99.83% of uranium was recovered without the interferences of other metals.
A Study on a Solar Simulator for Dye Sensitized Solar Cells
Kyoung-Jun Lee,Jeong-Hoon Kim,Ho-Sung Kim,Dongsul Shin,Dong-Wook Yoo,Hee-Je Kim
International Journal of Photoenergy , 2012, DOI: 10.1155/2012/834347
Abstract: Dye-sensitized solar cells (DSSC) are emerging low-cost, simple alternatives to conventional solar cells. While there has been considerable study on improving the efficiency of DSSCs, there has not been sufficient research on a photovoltaic power conditioning system adaptable to DSSCs or on a solar simulator for DSSCs. When DSSCs are commercialized in the near future, the DSSC modules must be connected to an adaptable power conditioning system in order to manage the energy produced and provide a suitable interface to the load. In the process of developing a power conditioning system, a solar simulator with the characteristics of DSSCs is essential to show the performance of the maximum power point tracking. In this paper, a virtual DSSC is designed and simulated in PSIM. Irradiation factors, temperature and shadow effects are considered in dynamic link library block in PSIM which is linked to the external C routine. A 100 W converter is built to show the performance of a DSSC as the solar simulator controlled by a digital signal processor.
Dependence of GCRs influx on the Solar North-South Asymmetry
Il-Hyun Cho,Young-Sil Kwak,Heon-Young Chang,Kyung-Suk Cho,Young-Deuk Park,Ho-Sung Choi
Physics , 2011, DOI: 10.1016/j.jastp.2011.03.007
Abstract: We investigate the dependence of the amount of the observed galactic cosmic ray (GCR) influx on the solar North-South asymmetry using the neutron count rates obtained from four stations and sunspot data in archives spanning six solar cycles from 1953 to 2008. We find that the observed GCR influxes at Moscow, Kiel, Climax and Huancayo stations are more suppressed when the solar activity in the southern hemisphere is dominant compared with when the solar activity in the northern hemisphere is dominant. Its reduction rates at four stations are all larger than those of the suppression due to other factors including the solar polarity effect on the GCR influx. We perform the student's t-test to see how significant these suppressions are. It is found that suppressions due to the solar North-South asymmetry as well as the solar polarity are significant and yet the suppressions associated with the former are larger and more significant.
Additive Effect between IL-13 Polymorphism and Cesarean Section Delivery/Prenatal Antibiotics Use on Atopic Dermatitis: A Birth Cohort Study (COCOA)
So-Yeon Lee, Jinho Yu, Kang-Mo Ahn, Kyung Won Kim, Youn Ho Shin, Kyung-shin Lee, Seo Ah Hong, Young-ho Jung, Eun Lee, Song-I Yang, Ju-hee Seo, Ji-Won Kwon, Byoung-Ju Kim, Hyo-Bin Kim, Woo-Kyung Kim, Dae Jin Song, Gwang Cheon Jang, Jung Yeon Shim, Soo-Young Lee, Ja-Young Kwon, Suk-Joo Choi, Kyung-Ju Lee, Hee Jin Park, Hye-Sung Won, Ho-Sung Yoo, Mi-Jin Kang, Hyung-Young Kim, Soo-Jong Hong
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0096603
Abstract: Background Although cesarean delivery and prenatal exposure to antibiotics are likely to affect the gut microbiome in infancy, their effect on the development of atopic dermatitis (AD) in infancy is unclear. The influence of individual genotypes on these relationships is also unclear. To evaluate with a prospective birth cohort study whether cesarean section, prenatal exposure to antibiotics, and susceptible genotypes act additively to promote the development of AD in infancy. Methods The Cohort for Childhood of Asthma and Allergic Diseases (COCOA) was selected from the general Korean population. A pediatric allergist assessed 412 infants for the presence of AD at 1 year of age. Their cord blood DNA was subjected to interleukin (IL)-13 (rs20541) and cluster-of-differentiation (CD)14 (rs2569190) genotype analysis. Results The combination of cesarean delivery and prenatal exposure to antibiotics associated significantly and positively with AD (adjusted odds ratio, 5.70; 95% CI, 1.19–27.3). The association between cesarean delivery and AD was significantly modified by parental history of allergic diseases or risk-associated IL-13 (rs20541) and CD14 (rs2569190) genotypes. There was a trend of interaction between IL-13 (rs20541) and delivery mode with respect to the subsequent risk of AD. (P for interaction = 0.039) Infants who were exposed prenatally to antibiotics and were born by cesarean delivery had a lower total microbiota diversity in stool samples at 6 months of age than the control group. As the number of these risk factors increased, the AD risk rose (trend p<0.05). Conclusion Cesarean delivery and prenatal antibiotic exposure may affect the gut microbiota, which may in turn influence the risk of AD in infants. These relationships may be shaped by the genetic predisposition.
A New Case of Turner Syndrome with Early Pubertal Development  [PDF]
Seok Ho Yoon, Dong Jun Lee, Son Moon Shin, So Young Yoon, Sung Won Park
International Journal of Clinical Medicine (IJCM) , 2016, DOI: 10.4236/ijcm.2016.75036
Abstract: Turner syndrome (TS) is a relatively common chromosomal disorder caused by complete or partial X monosomy. The most frequently observed karyotype, 45, X, arises more often by loss of the paternal X or Y chromosome in meiosis or in early embryogenesis than by loss of the maternal X chromosome. The main clinical features of TS are short stature, gonadal dysgenesis, and not to undergo pubertal development (e.g. primary amenorrhea). However, a few rare cases of TS have shown precocious puberty. Our case of a 9-year-old girl did not have any TS-specific clinical hallmarks, with the exception of short stature. She visited our clinic because of her pubertal development and short stature. In this report, we highlight the variability that can occur in patients with TS and emphasizes the need to carefully assess unusual growth patterns in any child, regardless of other underlying conditions.
Technical Report: A New Multi-Device Wireless Power Transfer Scheme Using an Intermediate Energy Storage Circuit
Changseok Yoon,Sung Sik Nam,Sung Ho Cho
Computer Science , 2013,
Abstract: A new multi-device wireless power transfer scheme that reduces the overall charging time is presented. The proposed scheme employs the intermediated energy storage (IES) circuit which consists of a constant power driving circuit and a super-capacitor. By utilizing the characteristic of high power density of the super-capacitor, the receiver can receive and store the energy in short duration and supply to the battery for long time. This enables the overlap of charging duration between all receivers. As a result, the overall charging time can be reduced.
The Removal of Metal Ions (Cu2+ and Zn2+) using Waste-reclaimed Adsorbent for Plating Wastewater Treatment Process
Young-Hoon Jo,Si-Hyun Do,Yoon-Seok Jang,Sung-Ho Kong
Lecture Notes in Engineering and Computer Science , 2010,
A computational approach for identifying pathogenicity islands in prokaryotic genomes
Sung Ho Yoon, Cheol-Goo Hur, Ho-Young Kang, Yeoun Hee Kim, Tae Kwang Oh, Jihyun F Kim
BMC Bioinformatics , 2005, DOI: 10.1186/1471-2105-6-184
Abstract: We present a computational method for detecting potential PAIs in complete prokaryotic genomes by combining sequence similarities and abnormalities in genomic composition. We first collected 207 GenBank accessions containing either part or all of the reported PAI loci. In sequenced genomes, strips of PAI-homologs were defined based on the proximity of the homologs of genes in the same PAI accession. An algorithm reminiscent of sequence-assembly procedure was then devised to merge overlapping or adjacent genomic strips into a large genomic region. Among the defined genomic regions, PAI-like regions were identified by the presence of homolog(s) of virulence genes. Also, GIs were postulated by calculating G+C content anomalies and codon usage bias. Of 148 prokaryotic genomes examined, 23 pathogenic and 6 non-pathogenic bacteria contained 77 candidate PAIs that partly or entirely overlap GIs.Supporting the validity of our method, included in the list of candidate PAIs were thirty four PAIs previously identified from genome sequencing papers. Furthermore, in some instances, our method was able to detect entire PAIs for those only partial sequences are available. Our method was proven to be an efficient method for demarcating the potential PAIs in our study. Also, the function(s) and origin(s) of a candidate PAI can be inferred by investigating the PAI queries comprising it. Identification and analysis of potential PAIs in prokaryotic genomes will broaden our knowledge on the structure and properties of PAIs and the evolution of bacterial pathogenesis.PAIs are distinct genetic elements of pathogens encoding various virulence factors such as protein secretion systems, host invasion factors, iron uptake systems, and toxins [1,2]. PAIs are a subset of genomic islands which have been transferred by horizontal gene transfer (HGT) event and confer virulence upon the recipient. PAIs can be identified by features such as the presence of virulence genes, biased G+C content and cod
Improving Oxygen Binding of Desiccated Human Red Blood Cells  [PDF]
Steingrimur Stefansson, David S. Chung, Jamie Yoon, Won Seok Yoo, Young Wook Park, George Kim, David Hahn, Huyen Le, Sung-Jae Chung, Stephen P. Bruttig, David H. Ho
Advances in Bioscience and Biotechnology (ABB) , 2016, DOI: 10.4236/abb.2016.72006
Abstract: Desiccating human red blood cells (RBCs) to increase their storage life has been the subject of intense research for a number of years. However, drying RBCs invariably compromises their integrity and has detrimental effects on hemoglobin function due to autoxidation. We have previously demonstrated an RBC desiccation and rehydration process that preserves RBC antigenic epitopes better than frozen RBCs. This study expands on those observations by examining what effects this desiccation process has on RBC hemoglobin function with respect to oxygen binding properties. In this paper, we examined RBCs from normal donors which were desiccated to 25% moisture content and stored dry for 2 weeks at room temperature prior to rehydration with plasma followed by structural and functional studies. Our data showed that approximately 98% of the RBCs were intact upon rehydration based on hemolysis assays. Oxygen dissociation curves for the desiccated/rehydrated RBCs showed a left shift compared to fresh RBCs (pO2 = 17 mmHg vs. 26 mmHg, respectively). The desiccated/rehydrated RBCs also showed an increase in methemoglobin compared to fresh RBCs (4.5% vs 0.9%, respectively). 2,3-Diphosphoglycerate concentration of the desiccated/rehydrated RBCs was reduced by 20%. In conclusion, although this RBC dehydration process preserves RBC integrity and hemoglobin oxygen binding properties better than most other dehydration techniques described so far, further optimization and long-term studies are needed to make this procedure acceptable for human transfusion.
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