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Search Results: 1 - 10 of 1748 matches for " Hitoshi Sugiyama "
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Rupture of the Anterolateral Papillary Muscle Caused by a High Lateral Branch Occlusion  [PDF]
Kayo Sugiyama, Masaki Kano, Satoshi Takahashi, Nobusato Koizumi, Hitoshi Ogino
Open Journal of Thoracic Surgery (OJTS) , 2018, DOI: 10.4236/ojts.2018.81002
Abstract: Although necrosis of the left ventricular papillary muscles during acute myocardial infarction is common, rupture of the anterolateral papillary muscle due to occlusion of high lateral branch is rare. We present a rare case of anterolateral papillary muscle rupture caused by occlusion of a high lateral branch of the left coronary artery. Although the patient was in cardiogenic shock on admission, she was successfully treated by emergency mitral valve replacement after percutaneous catheter intervention and intra-aortic balloon pumping support. This case implies that the anterolateral papillary muscle can have a single blood supply and that it can be ruptured by an occlusion of a high lateral branch. Prompt diagnosis, immediate mechanical stabilization and aggressive surgical treatment are essential to save this group of patients.
Cesarean Scar Pregnancy: A Report of 11 Cases and Review of the Literature Regarding Subsequent Pregnancy  [PDF]
Chiaki Heshiki, Keiko Mekaru, Maho Miyagi, Sugiko Oishi, Kozue Akamine, Hitoshi Sugiyama, Tadatsugu Kinjo, Hitoshi Masamoto, Yoichi Aoki
Open Journal of Obstetrics and Gynecology (OJOG) , 2016, DOI: 10.4236/ojog.2016.61002
Abstract: Background: There is no consensus regarding the optimal treatment for cesarean scar pregnancy (CSP) because treatment efficacy, safety, and the influence on subsequent pregnancy must be taken into consideration. Here we report our experience with 11 cases of CSP and review the literature regarding subsequent pregnancy. Methods: Records of 11 CSP cases that were treated at our hospital were retrospectively reviewed. CSP was treated by local methotrexate (MTX) injection or laparotomic or laparoscopic removal of the gestational mass and myometrial repair. Outcome of subsequent pregnancy after treatment was followed-up until delivery. Results: Local MTX injection was performed for six cases, laparotomic removal of the gestational mass and myometrial repair was performed for two, and laparoscopic removal of the gestational mass and myometrial repair was performed for three. The uterus was preserved in all cases. After CSP treatment, eight pregnancies occurred in five cases, resulting in six live births and two miscarriages. Conclusion: Advantages and disadvantages of various treatment methods for CSP continue to be elucidated. Serum hCG level, location of the gestational mass, thickness of the lower uterine segment at the time of diagnosis, and whether the patient wishes for fertility preservation should be considered when choosing a treatment plan.
Insulin Release from the Beta Cells in Acatalasemic Mice Is Highly Susceptible to Alloxan-Induced Oxidative Stress  [PDF]
Kazunori Takemoto, Wakana Doi, Ken Kataoka, Kohji Ishihara, Da-Hong Wang, Hitoshi Sugiyama, Noriyoshi Masuoka
Journal of Diabetes Mellitus (JDM) , 2015, DOI: 10.4236/jdm.2015.52010
Abstract: Background: Catalase deficiency (acatalasemia) is sensitive to alloxan, and the administration to acatalasemic mice develops hyperglycemia under mild conditions. However, the mechanism is still poorly understood. Methods: Alloxan was used to induce the oxidative stress and intraperitoneally administered to acatalasemic and normal mice. The blood samples of these mice after 1, 3, 5 and 7 days were examined. The pancreatic islets 7 days after alloxan administration were isolated, and the insulin released under 3 mM and 20 mM glucose was examined. Results: After alloxan administration, increase of oxidative markers in blood and pancreatic apoptosis in acatalasemic mice were observed immediately. Insulin in blood was lowered after 3 days, and the insulin in acatalasemic mice was lower than that in normal mice. Hyperglycemia in the acatalasemic mice was observed after 3 days. The pancreatic islets after 7 days were isolated. A reduction of the insulin released from the islets under glucose stimulation was observed. The stimulation indexes of the normal and acatalasemic mice were 1.4 ± 0.6 and 0.7 ± 0.3, respectively. Conclusions: Alloxan induced a deterioration of glucose-dependent insulin secretion ability from the islets, and the deterioration mostly contributed to hyperglycemia, rather than apoptosis.
Designing various component analysis at will
Akisato Kimura,Masashi Sugiyama,Sakano Hitoshi,Hirokazu Kameoka
Computer Science , 2012,
Abstract: This paper provides a generic framework of component analysis (CA) methods introducing a new expression for scatter matrices and Gram matrices, called Generalized Pairwise Expression (GPE). This expression is quite compact but highly powerful: The framework includes not only (1) the standard CA methods but also (2) several regularization techniques, (3) weighted extensions, (4) some clustering methods, and (5) their semi-supervised extensions. This paper also presents quite a simple methodology for designing a desired CA method from the proposed framework: Adopting the known GPEs as templates, and generating a new method by combining these templates appropriately.
The Use of Cavitation Peening to Increase the Fatigue Strength of Duralumin Plates Containing Fastener Holes  [PDF]
Hitoshi Soyama
Materials Sciences and Applications (MSA) , 2014, DOI: 10.4236/msa.2014.56047
Abstract:

An effective method for improving the fatigue life of Duralumin plates with fastener holes, such as those used in the construction of aircraft, is to introduce a compressive residual stress around the fastener holes. Cavitation peening is a novel peening method that uses the cavitation impact produced when a high-speed water jet is injected into a water-filled chamber. In this paper, Duralumin plate specimens with holes were treated by cavitation peening under various conditions, and the fatigue strength of the specimens was determined using a plate bending fatigue test. It was revealed that a compressive residual stress was introduced not only on surfaces perpendicular to the axis of the cavitating jet but also on the walls of holes which were parallel to this. It was found that a 51% improvement in fatigue strength could be achieved by cavitation peening. Note that this is first report demonstrating an improvement in the fatigue life of Duralumin plates with fastener holes by cavitation peening.

Is Independent Choice Possible?  [PDF]
Hitoshi Inamori
Journal of Quantum Information Science (JQIS) , 2016, DOI: 10.4236/jqis.2016.61005
Abstract: This paper questions the generally accepted assumption that one can make a random choice that is independent of the rest of the universe. We give a general description of any setup that could be conceived to generate random numbers. Based on the fact that the initial state of such setup together with its environment cannot be known, we show that the independence of its generated output cannot be guaranteed. Some consequences of this theoretical limitation are discussed.
No Quantum Process Can Explain the Existence of the Preferred Basis: Decoherence Is Not Universal  [PDF]
Hitoshi Inamori
Journal of Quantum Information Science (JQIS) , 2016, DOI: 10.4236/jqis.2016.63014
Abstract: Environment induced decoherence, and other quantum processes, have been proposed in the literature to explain the apparent spontaneous selection—out of the many mathematically eligible bases—of a privileged measurement basis that corresponds to what we actually observe. This paper describes such processes, and demonstrates that—contrary to common belief—no such process can actually lead to a preferred basis in general. The key observation is that environment induced decoherence implicitly assumes a prior independence of the observed system, the observer and the environment. However, such independence cannot be guaranteed, and we show that environment induced decoherence does not succeed in establishing a preferred measurement basis in general. We conclude that the existence of the preferred basis must be postulated in quantum mechanics, and that changing the basis for a measurement is, and must be, described as an actual physical process.
Combination Treatment of Rosuvastatin or Atorvastatin, with Regular Exercise Improves Arterial Wall Stiffness in Patients with Coronary Artery Disease
Kensuke Toyama, Seigo Sugiyama, Hideki Oka, Yuri Iwasaki, Hitoshi Sumida, Tomoko Tanaka, Shinji Tayama, Hideaki Jinnouchi, Hisao Ogawa
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041369
Abstract: Objective Statin- and exercise-therapy are both clinically beneficial by preventing cardiovascular events in patients with coronary artery disease (CAD). However, there is no information on the vascular effects of the combination of statins and exercise on arterial wall stiffness in CAD patients. Methods The present study is a sub-analysis of PRESET study that determined the effects of 20-week treatment with statins (rosuvastatin, n = 14, atorvastatin, n = 14) combined with regular exercise on arterial wall stiffness assessed by measurement of brachial and ankle pulse wave velocity (baPWV) in CAD patients. Results The combination of statins and regular exercise significantly improved exercise capacity, lipid profile, including low- and high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein (hs-CRP), baPWV (baseline: 1747±355, at 20 weeks of treatment: 1627±271 cm/s, p = 0.008), and basophil count (baseline: 42±32, 20 weeks: 26±15 cells/μL, p = 0.007), but had no effect on blood pressure (baseline: 125±22, 20 weeks: 121±16 mmHg). Changes in baPWV correlated significantly with changes in basophil count (r = 0.488, p = 0.008), but not with age, lipids profile, exercise capacity, or hs-CRP. Conclusion In CAD patients, the combination treatment with statins and exercise resulted in significant amelioration of arterial wall stiffness, at least in part, through reduction of circulating basophils.
Suppression of Adiponectin by Aberrantly Glycosylated IgA1 in Glomerular Mesangial Cells In Vitro and In Vivo
Tatsuyuki Inoue, Hitoshi Sugiyama, Masashi Kitagawa, Keiichi Takiue, Hiroshi Morinaga, Ayu Ogawa, Yoko Kikumoto, Shinji Kitamura, Yohei Maeshima, Hirofumi Makino
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033965
Abstract: The pathogenesis of IgA nephropathy (IgAN) may be associated with the mesangial deposition of aberrantly glycosylated IgA1. To identify mediators affected by aberrantly glycosylated IgA1 in cultured human mesangial cells (HMCs), we generated enzymatically modified desialylated and degalactosylated (deSial/deGal) IgA1. The state of deglycosylated IgA1 was confirmed by lectin binding to Helix aspersa (HAA) and Sambucus nigra (SNA). In the cytokine array analysis, 52 proteins were upregulated and 34 were downregulated in HMCs after stimulation with deSial/deGal IgA1. Among them, the secretion of adiponectin was suppressed in HMCs after stimulation with deSial/deGal IgA1. HMCs expressed mRNAs for adiponectin and its type 1 receptor, but not the type 2 receptor. Moreover, we revealed a downregulation of adiponectin expression in the glomeruli of renal biopsy specimens from patients with IgAN compared to those with lupus nephritis. We also demonstrated that aberrantly glycosylated IgA1 was deposited in the mesangium of patients with IgAN by dual staining of HAA and IgA. Moreover, the urinary HAA/SNA ratio of lectin binding was significantly higher in IgAN compared to other kidney diseases. Since adiponectin has anti-inflammatory effects, including the inhibition of adhesion molecules and cytokines, these data suggest that the local suppression of this adipokine by aberrantly glycosylated IgA1 could be involved in the regulation of glomerular inflammation and sclerosis in IgAN.
Alternative splicing produces structural and functional changes in CUGBP2
Hitoshi Suzuki, Makoto Takeuchi, Ayumu Sugiyama, AHM Alam, Luyen Vu, Yoshiharu Sekiyama, Hieu Dam, Shin-ya Ohki, Toshifumi Tsukahara
BMC Biochemistry , 2012, DOI: 10.1186/1471-2091-13-6
Abstract: The present study investigated the expression of exon 14, which is an alternatively spliced exon and encodes the first half of the third RRM of CUGBP2. The ratio of exon 14 skipping product (R3δ) to its inclusion was reduced in neuronal cells induced from P19 cells and in the brain. Although full length CUGBP2 and the CUGBP2 R3δ isoforms showed a similar effect on the inclusion of the smooth muscle (SM) exon of the ACTN1 gene, these isoforms showed an opposite effect on the skipping of exon 11 in the insulin receptor gene. In addition, examination of structural changes in these isoforms by molecular dynamics simulation and NMR spectrometry suggested that the third RRM of R3δ isoform was flexible and did not form an RRM structure.Our results suggest that CUGBP2 regulates the splicing of ACTN1 and insulin receptor by different mechanisms. Alternative splicing of CUGBP2 exon 14 contributes to the regulation of the splicing of the insulin receptor. The present findings specifically show how alternative splicing events that result in three-dimensional structural changes in CUGBP2 can lead to changes in its biological activity.The CELF (CUGBP and ETR-3 Like Factor)/Bruno-like protein family plays important roles in the regulation of alternative splicing and translation [1-5]. In mammals, the CELF/Bruno-like family includes six members and is classified into two subgroups based on overall sequence similarity. One group is composed of CUGBP1 and CUGBP2, which share 76% amino acid sequence identity [6]. The other group contains BRUNOL1 (CELF3), BRUNOL5 (CELF5), BRUNOL6 (CELF6), and CELF4, which share 62-66% a.a. sequence identity with each other and 44% sequence identity with CUGBP1 [6]. CELF proteins have two consecutive RNA recognition motifs (RRMs) (RRM1-2) in the N-terminal region and another RRM (RRM3) in the C-terminal region. RRM2 and RRM3 are separated by a linker region that consists of 160-230 amino acids. CELF family members are expressed in multiple tissues with
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