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Search Results: 1 - 10 of 4568 matches for " Hiroshi Morinaga "
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Guiding of Waves between Absorbing Walls  [PDF]
Dmitrii Kouznetsov, Makoto Morinaga
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.37076
Abstract: Guiding of waves between parallel absorbing walls is considered. The principal mode is constructed; its absorption is estimated. The agreement with previous results about reflection of waves from absorbing walls is discussed. Roughly, the effective absorption of the principal mode is proportional the minus third power of the distance between walls, minus 1.5 d power of the wavenumber and minus 0.5 power of the local absorption of the wave in the wall. This estimate is suggested as hint for the design of the atomic waveguides, and also as tool for optimization of attenuation of the amplified spontaneous emission (and suppression of parasitic oscillations) in high power lasers.
Primary submucosal nodular plasmacytoma of thestomach: a poorly recognized variant of gastriclymphoma
Maki Kanzawa, Chihoko Hirai, Yukiko Morinaga, Fumi Kawakami, Shigeo Hara, Hiroshi Matsuoka, Tomoo Itoh
Diagnostic Pathology , 2013, DOI: 10.1186/1746-1596-8-30
Abstract:
Recent Advances in Japanese Fisheries Science in the Kuroshio-Oyashio Region through Development of the FRA-ROMS Ocean Forecast System: Overview of the Reproducibility of Reanalysis Products  [PDF]
Hiroshi Kuroda, Takashi Setou, Shigeho Kakehi, Shin-ichi Ito, Takeshi Taneda, Tomonori Azumaya, Denzo Inagake, Yutaka Hiroe, Kenji Morinaga, Makoto Okazaki, Takashi Yokota, Takeshi Okunishi, Kazuhiro Aoki, Yugo Shimizu, Daisuke Hasegawa, Tomowo Watanabe
Open Journal of Marine Science (OJMS) , 2017, DOI: 10.4236/ojms.2017.71006
Abstract: To address various fisheries science problems around Japan, the Japan Fisheries Research and Education Agency (FRA) has developed an ocean forecast system by combining an ocean circulation model based on the Regional Ocean Modeling System (ROMS) with three-dimensional variational analysis schemes. This system, which is called FRA-ROMS, is a basic and essential tool for the systematic conduct of fisheries science. The main aim of FRA-ROMS is to realistically simulate mesoscale variations over the Kuroshio-Oyashio region. Here, in situ oceanographic and satellite data were assimilated into FRA-ROMS using a weekly time window. We first examined the reproducibility through comparison with several oceanographic datasets with an Eulerian reference frame. FRA-ROMS was able to reproduce representative features of mesoscale variations such as the position of the Kuroshio path, variability of the Kuroshio Extension, and southward intrusions of the Oyashio. Second, using a Lagrangian reference frame, we estimated position errors between ocean drifters and particles passively transported by simulated currents, because particle tracking is an essential technique used in applications of reanalysis products to fisheries science. Finally, we summarize recent and ongoing fisheries studies that use FRA-ROMS and mention several new developments and enhancements that will be implemented in the near future.
Circular magneto-optical trap for neutral atoms
Makoto Morinaga
Physics , 2005,
Abstract: We propose and experimentally demonstrate a novel scheme to magneto-optically trap neutral atoms in a ring shaped trap that can be used to transfer atoms into a circular magnetic trap with high density. This inturn enables to evaporatively cool atoms and study the behaviour of ultra cold gases in a periodic 2-dimensional potential. The circular magneto-optical trap itself is also of interest to investigate the properties of magneto-optical trap of deformed shape, such as reduction of photon-reabsorption.
Deriving the static interaction between electric dipoles via the quantum gauge transformation
Makoto Morinaga
Physics , 2013,
Abstract: Gauge transformation leaves the electric and the magnetic fields unchanged as long as the gauge function is treated classically. In this paper we consider the gauge transformation commonly used to obtain the electric dipole interaction Hamiltonian in a system of dipoles and the electromagnetic field (Goeppert-Mayer transformation) and treat the vector potential that appear in the gauge function as an operator. While it modifies the electric field, the static interaction between the dipoles is derived.
Guiding of Light with Pinholes
Makoto Morinaga
Physics , 2014,
Abstract: A new type of light waveguide using linearly aligned pinholes is presented. Results of basic experiments are compared with theoretical estimates calculated using continuous model. Since this waveguide utilizes no transparent material, it can be used to guide electromagnetic waves of wide wavelength ranges as well as other waves such as matter waves.
Wave Propagation through an Array of Slits
Makoto Morinaga
Physics , 2014, DOI: 10.1007/s10043-015-0045-1
Abstract: Propagation of a wave through an array of slits is theoretically investigated. The asymptotic expansion of the matrix elements of the propagation operator is derived and compared with numerical calculations. And then the eigenmodes and eigenvalues of the propagation operator are estimated. Our analysis should provide an insight into the properties of waveguides composed of opaque masks that have been proposed recently.
Suppression of Adiponectin by Aberrantly Glycosylated IgA1 in Glomerular Mesangial Cells In Vitro and In Vivo
Tatsuyuki Inoue, Hitoshi Sugiyama, Masashi Kitagawa, Keiichi Takiue, Hiroshi Morinaga, Ayu Ogawa, Yoko Kikumoto, Shinji Kitamura, Yohei Maeshima, Hirofumi Makino
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033965
Abstract: The pathogenesis of IgA nephropathy (IgAN) may be associated with the mesangial deposition of aberrantly glycosylated IgA1. To identify mediators affected by aberrantly glycosylated IgA1 in cultured human mesangial cells (HMCs), we generated enzymatically modified desialylated and degalactosylated (deSial/deGal) IgA1. The state of deglycosylated IgA1 was confirmed by lectin binding to Helix aspersa (HAA) and Sambucus nigra (SNA). In the cytokine array analysis, 52 proteins were upregulated and 34 were downregulated in HMCs after stimulation with deSial/deGal IgA1. Among them, the secretion of adiponectin was suppressed in HMCs after stimulation with deSial/deGal IgA1. HMCs expressed mRNAs for adiponectin and its type 1 receptor, but not the type 2 receptor. Moreover, we revealed a downregulation of adiponectin expression in the glomeruli of renal biopsy specimens from patients with IgAN compared to those with lupus nephritis. We also demonstrated that aberrantly glycosylated IgA1 was deposited in the mesangium of patients with IgAN by dual staining of HAA and IgA. Moreover, the urinary HAA/SNA ratio of lectin binding was significantly higher in IgAN compared to other kidney diseases. Since adiponectin has anti-inflammatory effects, including the inhibition of adhesion molecules and cytokines, these data suggest that the local suppression of this adipokine by aberrantly glycosylated IgA1 could be involved in the regulation of glomerular inflammation and sclerosis in IgAN.
Acatalasemic mice are mildly susceptible to adriamycin nephropathy and exhibit increased albuminuria and glomerulosclerosis
Keiichi Takiue, Hitoshi Sugiyama, Tatsuyuki Inoue, Hiroshi Morinaga, Yoko Kikumoto, Masashi Kitagawa, Shinji Kitamura, Yohei Maeshima, Da-Hong Wang, Noriyoshi Masuoka, Keiki Ogino, Hirofumi Makino
BMC Nephrology , 2012, DOI: 10.1186/1471-2369-13-14
Abstract: ADR was intravenously administered to both homozygous acatalasemic mutant mice (C3H/AnLCsbCsb) and control wild-type mice (C3H/AnLCsaCsa). The functional and morphological alterations of the kidneys, including albuminuria, renal function, podocytic, glomerular and tubulointerstitial injuries, and the activities of catalase were then compared between the two groups up to 8 weeks after disease induction. Moreover, the presence of a mutation of the toll-like receptor 4 (tlr4) gene, which was previously reported in the C3H/HeJ strain, was investigated in both groups.The ADR-treated mice developed significant albuminuria and glomerulosclerosis, and the degree of these conditions in the ADR-treated acatalasemic mice was higher than that in the wild-type mice. ADR induced progressive renal fibrosis, renal atrophy and lipid peroxide accumulation only in the acatalasemic mice. In addition, the level of catalase activity was significantly lower in the kidneys of the acatalasemic mice than in the wild-type mice during the experimental period. The catalase activity increased after ADR injection in wild-type mice, but the acatalasemic mice did not have the ability to increase their catalase activity under oxidative stress. The C3H/AnL strain was found to be negative for the tlr4 gene mutation.These data indicate that catalase deficiency plays an important role in the progression of renal injury in the ADR nephropathy model.The degree of oxidative stress and the severity of subsequent tissue injury may depend on an imbalance between the excessive production of reactive oxygen species and the antioxidant defense. The antioxidants include the enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPX), which detoxify reactive oxygen species. Catalase (E.C.1.11.1.6) is a major enzyme that catalyzes the decomposition of hydrogen peroxide (H2O2) and plays a role in cellular antioxidant defense mechanisms [1]. The main reaction of catalase is the catalytic reaction (
Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages
Yoshitomo Morinaga, Katsunori Yanagihara, Shigeki Nakamura, Hiroo Hasegawa, Masafumi Seki, Koichi Izumikawa, Hiroshi Kakeya, Yoshihiro Yamamoto, Yasuaki Yamada, Shigeru Kohno, Shimeru Kamihira
Respiratory Research , 2010, DOI: 10.1186/1465-9921-11-158
Abstract: The human monocytic cell line THP-1 was infected with LPN, NUL1 strain. MG132-treated cells were used as apoptotic control cells. After infection, the type of cell death was analyzed by using microscopy, LDH release and flow cytometry. As a proinflammatory mediator, high-mobility group box 1 (HMGB-1), was measured. Cathepsin B activity was also measured and the inhibitory effects of cathepsin B on LPN-induced cell death were analyzed.THP-1 cells after treatment with high dose of LPN showed necrotic features with releasing HMGB-1. This necrosis and the HMGB-1 release were inhibited by a specific lysosomal cathepsin B inhibitor and were characterized by a rapid and high activation of cathepsin B that was not observed in apoptotic control cells. The necrosis was also accompanied by cathepsin B-dependent poly(ADP-ribose) polymerase (PARP) cleavage.We demonstrate here that L. pneumophila rapidly induces cathepsin B-dependent necrosis in a dose-dependent manner and releases a proinflammatory mediator, HMGB-1, from macrophages. This report describes a novel aspect of the pathogenesis of Legionnaires' disease and provides a possible therapeutic target for the regulation of inflammation.Legionella pneumophila is an intracellular pathogen that causes rapidly advancing pneumonia and is sometimes life-threatening. After inhalation into the lung, the organism initially infects alveolar macrophages and replicates in these cells. The infected macrophages produce cytokines such as IL-β and TNF-α that activate both themselves and other immune cells [1]. However, although the functions of macrophages in response to this pathogen are crucial for innate immunity, the mechanism by which this pathogen induces such a severe immune response is not well understood.In infectious diseases, cell death that occurs as a result of interactions between the infectious organism and the host cell can have important implications for host defense or bacterial survival. Apoptosis is a typical programmed
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