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Search Results: 1 - 10 of 6229 matches for " Hiroshi Inoue "
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How different is early-onset childhood disintegrative disorder from autistic disorder with speech loss?  [PDF]
Hiroshi Kurita, Kanna Inoue
Open Journal of Psychiatry (OJPsych) , 2013, DOI: 10.4236/ojpsych.2013.32A007

To examine the difference between early-onset (< age 3) childhood disintegrative disorder (CDD) and autistic disorder with speech loss (ADSL), 8 children with early-onset CDD (mean age = 7.6 years, SD = 3.8; 6 males) were compared with 92 age and gender-ratio comparable children with ADSL (mean age = 6.8 years, SD = 4.1; 70 males) on 24 variables not directly related to the key features of CDD (regression after normal development for at least the first 2 years after birth). Compared with the ADSL group, the early-onset CDD group had a tendency to have a higher rate of a psychosocial event before speech loss (SL) (early-onset CDD, 75.0% vs ADSL, 37.0%, p = 0.057; effect size (phi) = 0.211, p < 0.05); a significantly higher rate of fearfulness during SL (62.5% vs 4.3%, p = 0.000; phi = 0.551, p < 0.05); and a tendency to have a higher rate of epilepsy (25.0% vs 3.3%, p = 0.050; phi = 0.271, p < 0.05), a tendency to have a lower rate of the Childhood Autism Rating Scale-Tokyo Version (CARS-TV) total score ≥ 30 (75.0% vs 95.7%, p = 0.072; phi = 0.236, p < 0.05), and a significantly lower rate of CARS-TV item 2 (imitation) score ≥ 2 (50.0% vs 82.6%, p = 0.049; phi = 0.221, p < 0.05) on the first visit. The two groups did not exhibit any significant difference in the other 19 variables. The findings of no significant difference in the great majority and a significant difference in the small minority of the 24 variables between the two groups support integrating CDD into regressive autism spectrum disorder and studying CDD as its prototypical form.

Rhodium Nanoparticle-Loaded Carbon Black Electrocatalyst for the Glycerol Oxidation Reaction in Alkaline Medium  [PDF]
Binh Thi Xuan Lam, Masanobu Chiku, Eiji Higuchi, Hiroshi Inoue
Advances in Nanoparticles (ANP) , 2016, DOI: 10.4236/anp.2016.51007
Abstract: Rhodium nanoparticle-loaded carbon black (Rh/CB) was prepared by a wet method, and its activity and durability for glycerol oxidation reaction (GOR) in alkaline medium were compared with Pt, Pd and Au nanoparticle-loaded CB (Pt/CB, Pd/CB and Au/CB). In the cyclic voltammogram of the Rh/CB electrode, the redox waves due to hydrogen adsorption/desorption and the surface OH monolayer formation/reduction were observed at more negative potentials than the Pt/CB and Pd/CB electrodes. The onset and peak potentials of the GOR current densities for the Rh/CB electrode were ca. 0.55 and 0.30 V vs. Hg/HgO, respectively, which were 0.10 and 0.20 V more negative than the Pt/CB electrode whose GOR activity was the best, indicating that Rh was a fascinating metal for reducing the overpotential for GOR. In the electrostatic electrolysis with the Rh/CB and Pt/CB electrodes, the decrease in the GOR current density in the former with time was suppressed compared to that in the latter, suggesting that the tolerance to poisoning for the Rh/CB electrode was superior to that for the Pt/CB electrode.
PtAg Nanoparticle Electrocatalysts for the Glycerol Oxidation Reaction in Alkaline Medium  [PDF]
Binh Thi Xuan Lam, Masanobu Chiku, Eiji Higuchi, Hiroshi Inoue
Advances in Nanoparticles (ANP) , 2016, DOI: 10.4236/anp.2016.53018
Abstract: To improve the activity for glycerol oxidation reaction (GOR) of Pt, PtAg (mole ratio of Pt/Ag = 3 and 1) alloy nanoparticle-loaded carbon black (Pt/CB, PtAg(3:1)/CB, PtAg(1:1)/CB) catalysts were prepared by a wet method. The resultant catalysts, moreover, were heat-treated in a N2 atmosphere at 200°C. The alloying of Pt with Ag for each PtAg/CB was confirmed by X-ray diffractometry and electron dispersive X-ray spectrometry. The heat-treatment did not change the crystal structure of the PtAg alloys and increased their particle size. X-ray photoelectron spectroscopy exhibited that stabilizers were completely removed from the PtAg alloy surface, and the Pt4f and Ag3d doublets due to metallic Pt and Ag, respectively, shifted to lower binding energies, supporting the alloying of Pt with Ag. Both PtAg/CB electrodes had two oxidation waves of glycerol irrespective of heat-treatment, which was different from the Pt/CB electrode. The onset potential of the first oxidation wave was -0.60 V, which was 0.20 V less positive than that for the Pt/CB electrode, indicating the alloying of Pt with Ag greatly improved the GOR activity of Pt. The heat-treated PtAg(3:1)/ CB electrode improved the GOR current density of the second oxidation peak. In the potentiostatic electrolysis at -0.1 and 0 V for both PtAg/CB electrodes, the ratio of oxidation current density at 60 min to that at 5 min (j60/j5), an indicator of the catalyst deterioration, at 0 V was higher than that at -0.1 V, because the adsorbed oxidation intermediates were greatly consumed at the larger overpotential. The heat-treatment of the PtAg(3:1)/CB electrode increased the j60/j5 value at -0.1 V but decreased that at 0 V. This could be attributed to the formation of high-order oxidation intermediates which might have stronger poisoning
Evaluation of genetic diversity and conservation priorities for Egyptian chickens  [PDF]
Sherif Ramadan, Boniface B. Kayang, Eiji Inoue, Keijiro Nirasawa, Hiroshi Hayakawa, Shin’ichi Ito, Miho Inoue-Murayama
Open Journal of Animal Sciences (OJAS) , 2012, DOI: 10.4236/ojas.2012.23025
Abstract: In this study, 21 microsatellite markers were used to genotype 196 Egyptian local chickens obtained from Fayoumi (n = 35), Dandarawy (n = 30), Baladi (n = 29), Sinai (n = 30), El-Salam (n = 36), and Golden Montazah (n = 36) strains. The results were compared to two pure commercial chicken populations reared in Japan-White Leghorn (n = 42) and Rhode Island Red (n = 43). A total of 162 alleles were observed, with an average of 7.7 alleles per locus. The average expected heterozygosity for the Egyptian chickens was 0.595. The closest pairwise Nei’s genetic distance was recorded between Sinai and Golden Montazah (0.038) and the smallest pairwise FST value (0.006) was observed between Baladi and Sinai. The most probable structure clustering of the eight studied populations was at K = 6. Baladi, Sinai and Golden Montazah strains were clustered together forming admixed mosaic cluster. Dandarawy ranked firstly and contributed the most to aggregate genetic diversity based on two prioritization methods. The information resulting from this study may be used as an initial guide to design further investigations for development of sustainable genetic improvement and conservation programs for the Egyptian chicken genetic resources.
The Reliability of Assessment of Ki-67 Expression on Core Needle Biopsy and the Surgical Specimens of Invasive Breast Cancer: Comparison of Local Pathologists’ Assessment and Central Review  [PDF]
Yoshio Mizuno, Tsuneo Natori, Naoko Takeda, Junichi Yamada, Hiroaki Abe, Yuko Inoue, Hiroshi Seto, Kazuhiko Sato
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.325107
Abstract: Purpose: The aim of this study was to assess the reliability of Ki-67 expression on core needle biopsy (CNB) and the surgical specimens of invasive breast cancer. We examined the concordance rate of Ki-67 expressions, hormone receptors, and human epidermal growth factor receptor 2 (HER2) status from a CNB with from a surgery in invasive breast cancer. Methods: A retrospective study was conducted on a clinical database of patients who underwent surgery for early breast cancer. Of these, 193 patients who underwent CNB before the surgery were enrolled. A cut-off value of 20% was used for Ki-67-positive criteria. Expression of estrogen receptor (ER), progesterone receptor (PgR), and HER2 were examined and compared with that of Ki-67. To evaluate discordance between the pathologists’ earlier assessments, we re-examined Ki-67 expression among the Ki-67 discordant group in a central laboratory. Results: The concordance rate for Ki-67 expression between the two specimen types was 77.7%, which was significantly lower than that for ER, PgR, and HER2 expression (95.9%, 88.1%, and 91.6%, respectively). The concordance rate for re-examined Ki-67 expression among the Ki-67 discordant group improved to 93.8% and was not significantly different from that for the other receptors. Conclusion: The concordance rate for Ki-67 expression between biopsy and surgical specimens was significantly lower than that for ER, PgR, and HER2 expressions, but re-examination of Ki-67 expression in a central laboratory revealed no significant difference among the receptors, suggesting the need for standard pathological assessment of Ki-67 expression for clinical use as a predictive marker of breast cancer.
A Case of Acute Cauda Equina Syndrome for Combined Lumbar Ossification of the Posterior Longitudinal and Yellow Ligament  [PDF]
Kazumasa Nakamura, Yuichirou Yokoyama, Akihito Wada, Yasuhiro Inoue, Keiji Hasegawa, Shintaro Tsuge, Hiroshi Takahashi, Yasuaki Iida
Open Journal of Orthopedics (OJO) , 2014, DOI: 10.4236/ojo.2014.46024
Abstract: Acute cauda equina syndrome is known as a symptom of lumbar disc herniation, but to date, there have been no reports of cases caused by lumbar vertebral ligament ossification. We encountered a 61-year-old female patient with acute cauda equina syndrome associated with lumbar vertebral OPLL and OLF. The symptoms were improved by emergency laminectomy. One year after the surgery, the disturbances of gait and urination have been resolved.

Seasonal/Interannual Variations of Carbon Sequestration and Carbon Emission in a Warm-Season Perennial Grassland
Deepa Dhital,Tomoharu Inoue,Hiroshi Koizumi
Journal of Ecosystems , 2014, DOI: 10.1155/2014/729294
Abstract: Carbon sequestration and carbon emission are processes of ecosystem carbon cycling that can be affected while land area converted to grassland resulting in increased soil carbon storage and below-ground respiration. Discerning the importance of carbon cycle in grassland, we aimed to estimate carbon sequestration in photosynthesis and carbon emission in respiration from soil, root, and microbes, for four consecutive years (2007–2010) in a warm-season perennial grassland, Japan. Soil carbon emission increased with increasing growing season temperature which ranged from 438 to 1642?mg?CO2?m?2?h?1. Four years’ average soil carbon emission for growing season, nongrowing season, and annual emission was 1123, 364, and 1488?g?C?m?2, respectively. Nongrowing and snow covered season soil carbon emission contributed 23–25% and 14–17% to the annual emission. Above-ground biomass varied seasonally and variation in green biomass affected soil carbon emission with increasing temperature and precipitation. Temperature effect on root carbon emission contributed about 1/4th of the total soil carbon emission. Variation in soil and root carbon emission is affected by below-ground biomass. Long-term estimation concluded that seasonal and interannual variations in carbon sequestration and emission are very common in grassland ecosystem. 1. Introduction Carbon sequestration and emission can be affected while the ecosystem land area converted to the grassland [1–3], resulting in increased soil carbon storage [4, 5], below-ground respiration, and carbon cycling [6]. Land area converted to grassland has been reported to affect ecosystem carbon balance in short term through increased variations in ecosystem carbon cycling [7–9]. Moreover, one of the major long-term effects of such land conversion is the reduced carbon sink strength of grassland ecosystems [10]. Grasslands are able to store 10–30% of global soil organic carbon due to its large coverage (40%) of the earth’s terrestrial surface and are considered to sequester large amounts of carbon from the atmosphere and hence acquire significant sink/source capacity of the ecosystem and play a major role in the global carbon balance [11–13]. Soil as a whole is a large pool of atmospheric carbon. Globally, it accumulates 1500–2000 petagrams (Pg carbon, 1?Pg = 1015?g) in the form of soil organic carbon in the upper 1?m of soil [14, 15] or even greater [16], which is at least three times larger than atmospheric carbon. Small variation in carbon storage in grassland soil will greatly affect the concentration of atmospheric carbon and
A Case of Relapsing Polychondritis Successfully Treated with Combination of a Glucocorticoid and Cyclosporine  [PDF]
Koichiro Takahashi, Hiroshi Inoue, Hironori Sadamatsu, Hitomi Umeguchi, Naoko Sueoka-Aragane, Shinya Kimura
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.67057
Relapsing polychondritis is a rare cartilaginous inflammatory disease affecting the external ear, nose, peripheral joints and tracheobronchial tree. It is characterized by recurrent inflammation and degeneration of cartilage and connective tissue. A 72-year-old man complained of dyspnea, cough and wheezing for 2 months. Diffuse wall thickening and narrowing from the trachea to segmental bronchus were seen on chest CT. Tracheostomy was performed in order to avoid as-phyxia, and he was diagnosed as relapsing polychondritis on the basis of pathology evaluation of a tracheal biopsy specimen. He was treated with high doses of a glucocorticoid, with which his symptoms improved. However, the cough and wheezing recurred after tapering of the glucocorticoid. His symptoms thereafter were improved by combination of the glucocorticoid with cyclosporine. The immunosuppressive agent provided effective treatment for glucocorticoid-resistant relapsing polychondritis.
Impurity-Induced Electronic Nematic State in Iron-Pnictide Superconductors
Yoshio Inoue,Youichi Yamakawa,Hiroshi Kontani
Physics , 2011, DOI: 10.1103/PhysRevB.85.224506
Abstract: We propose that impurity-induced electronic nematic state is realized above the orthorhombic structure transition temperature $T_S$ in iron-pnictide superconductors. In the presence of strong orbital fluctuations near $T_S$, it is theoretically revealed that a single impurity induces non-local orbital order with $C_2$-symmetry, consistently with recent STM/STS measurements. Each impurity-induced $C_2$ orbital order aligns along a-axis by applying tiny uniaxial pressure along b-axis. In this impurity-induced nematic phase, the resistivity shows sizable in-plane anisotropy ($\rho_b/\rho_a \sim 2$) even above $T_S$, actually observed in various "detwinned" samples. The present study indicates the existence of strong orbital fluctuations in iron-pnictide superconductors.
Comparing Oncotype DX Recurrence Score Categories with Immunohistochemically Defined Luminal Subtypes  [PDF]
Yoshio Mizuno, Hiromi Fuchikami, Naoko Takeda, Junichi Yamada, Yuko Inoue, Hiroshi Seto, Kazuhiko Sato
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.73023
Abstract: Background: At the 13th St Gallen International Breast Cancer Conference in 2013, a new definition of luminal A-like and luminal B-like breast cancer was proposed, involving the expression of estrogen receptor (ER), progesterone receptor (PgR), and Ki-67. We examined the rate of concordance between the risk groups using the Oncotype DX recurrence score (RS) and the previous and newly proposed luminal subtypes with the standardized Ki-67 assessment. Method: The relationship between a previously and newly proposed, immunohistochemically defined luminal A and B subtype with the Oncotype DX RS of 41 cases of T1-2 N0-1 M0 (ER positive, HER2 negative) breast cancer was assessed. We first classified the patients into the previously defined luminal A and B subtypes, according to the level of Ki-67 as either “low” (<14%) or “high” (≥14%), as assessed by local pathologists. Next, to consider the necessity for standardizing Ki-67 measurement methods, we re-examined Ki-67 with a central review. By introducing PgR positivity (≥20%), we classified these patients to newly proposed luminal subtypes and compared them with the risk groups stratified by Oncotype DX RS. Results: In the previously proposed luminal subtypes, the concordance rate between luminal A and the low RS category was 76.5% according to local pathologists and 90.1% by central review, whereas the rate between luminal B and the intermediate to high RS category was 46.7% and 45.8%, respectively. In newly proposed luminal subtypes, the concordance rate between luminal A and low RS category was 100% and between the luminal B and intermediate to high RS category was 53.6%. Conclusions: Although this study was based on a retrospective chart review of a small sample size, the newly proposed luminal subtypes including addition of PgR positivity with the standardized Ki-67 assessment appeared to improve the concordance rate especially between luminal A and low RS category.
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