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Search Results: 1 - 10 of 233 matches for " Hirosato Kanda "
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Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury
Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Hirosato Kanda, Yi Dai, Koichi Noguchi
Molecular Pain , 2012, DOI: 10.1186/1744-8069-8-8
Abstract: Using the rat spared nerve injury (SNI) model, we investigated the expression of PAF synthases (LPCAT1 and 2) and PAF receptor (PAFr) mRNAs in the spinal cord. Reverse transcription polymerase chain reaction (RT-PCR) and double-labeling analysis of in situ hybridization histochemistry (ISHH) with immunohistochemistry (IHC) were employed for the analyses. Pain behaviors were also examined with PAFr antagonist (WEB2086).RT-PCR showed that LPCAT2 mRNA was increased in the ipsilateral spinal cord after injury, but not LPCAT1 mRNA. Double-labeling of ISHH with IHC revealed that LPCAT1 and 2 mRNAs were constitutively expressed by a subset of neurons, and LPCAT2 mRNA was increased in spinal microglia after nerve injury. RT-PCR showed that PAFr mRNA was dramatically increased in the ipsilateral spinal cord after nerve injury. Double-labeling analysis of ISHH with IHC revealed that after injury PAFr mRNA was predominantly colocalized with microglia in the spinal cord. Continuous intrathecal administration of the PAFr antagonist suppressed mechanical allodynia following peripheral nerve injury. Delayed administration of a PAFr antagonist did not reverse the mechanical allodynia.Our data show the histological localization of PAF synthases and its receptor in the spinal cord following peripheral nerve injury, and suggest that PAF/PAFr signaling in the spinal cord acts in an autocrine or paracrine manner among the activated microglia and neurons, thus contributing to development of neuropathic pain.Peripheral nerve injury can cause neuropathic pain syndromes characterized by both spontaneous and evoked painful sensations. Although it is thought that plastic alterations in central or peripheral neuronal processing play important roles in the development of neuropathic pain [1-5], the underlying molecular mechanisms are not fully understood. Accumulated evidence shows that glial cells in the spinal cord significantly contribute to neuropathic pain [6,7] and that after peripheral n
Lp Polyharmonic Dirichlet Problems in the Upper Half Plane  [PDF]
Kanda Pan
Advances in Pure Mathematics (APM) , 2015, DOI: 10.4236/apm.2015.514077
Abstract: In this article, a class of Dirichlet problem with Lp boundary data for poly-harmonic function in the upper half plane is mainly investigated. By introducing a sequence of kernel functions called higher order Poisson kernels and a hierarchy of integral operators called higher order Pompeiu operators, we obtain a main result on integral representation solution as well as the uniqueness of the polyharmonic Dirichlet problem under a certain estimate.
No Anomaly and New Renormalization Scheme  [PDF]
Takehisa Fujita, Naohiro Kanda
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.38091
Abstract: We review the physics of chiral anomaly and show that the anomaly equation of δμJμ5 =e216π2εμνρδ FμνFρδis not connected to any physical observables. This is based on the fact that the reaction process of π0→2γ has no diver- gence at all, and the triangle diagrams with the vertex of γμγ5 describing the Z0→2γ decay do not have any di- vergences either. The recent calculated branching ratio of the Z0→2γ decay rate is found to be ГZ0→2γ/Г□2.4×10-8. Further, we discuss the anomaly equation in the Schwinger model which is known as δμJμ5=e2πεμνFμν , and prove that this anomaly equation disagrees with the exact value of the chiral charge δ5=±1 in the Schwinger vacuum. Therefore, the chiral anomaly is a spurious effect induced by the regularization. In connection with the anomaly prob- lem, we clarify the physical meaning why the self-energy of photon should not be included in the renormalization scheme. Also, we present the renormalization scheme in weak interactions without Higgs particles, and this is achieved with a new propagator of massive vector bosons, which does not give rise to any logarithmic divergences in the vertex corrections. Therefore, there is no necessity of the renormalization procedure of the vertex corrections arising from the weak vector boson propagation.
On the effect of secondary protons on baryon and proton number cumulants in event-by-event analysis
Hirosato Ono,Masayuki Asakawa,Masakiyo Kitazawa
Physics , 2013, DOI: 10.1103/PhysRevC.87.041901
Abstract: We investigate the effects of secondary (knockout) protons, which constitute about 20% of the observed protons at STAR, on the higher order cumulants of proton and baryon numbers measured by event-by-event analyses in relativistic heavy ion collisions. We argue that the contribution of this background effect on the cumulants is expressed by a simple formula, and that hence their effects can be removed in the experimental analysis. It is discussed that this background effect has non-negligible contribution to recently observed proton number cumulants at STAR, especially the third-order one, and that the removal of this effect is crucial to investigate the thermodynamical properties of the primordial hot medium appropriately.
Nonequilibrium time evolution of higher order cumulants of conserved charges and event-by-event analysis
Masakiyo Kitazawa,Masayuki Asakawa,Hirosato Ono
Physics , 2013, DOI: 10.1016/j.physletb.2013.12.008
Abstract: We investigate the time evolution of higher order cumulants of conserved charges in a volume with the diffusion master equation. Applying the result to the diffusion of non-Gaussian fluctuations in the hadronic stage of relativistic heavy ion collisions, we show that the fourth-order cumulant of net-electric charge at LHC energy is suppressed compared with the recently observed second-order cumulant at ALICE, if the higher order cumulants at hadronization are suppressed compared with their values in the hadron phase in equilibrium. The significance of the experimental information on the rapidity window dependence of various cumulants in investigating the history of the dynamical evolution of the hot medium created in relativistic heavy ion collisions is emphasized.
Large diamonds grown at high pressure conditions
Kanda, H.;
Brazilian Journal of Physics , 2000, DOI: 10.1590/S0103-97332000000300003
Abstract: a technique has been established to grow large diamonds up to 2 cm. the crystals are bulky polyhedron with yellow, blue, green or brown color as well as colorless, which depend on impurities. the impurities incorporated into the diamond are limited, i.e. nitrogen, boron, nickel, cobalt, silicon and phosphorus.
Continuing 137Cs release to the sea from the Fukushima Dai-ichi Nuclear Power Plant through 2012
J. Kanda
Biogeosciences Discussions , 2013, DOI: 10.5194/bgd-10-3577-2013
Abstract: Rate of cesium-137 (137Cs) release to the sea from the Fukushima Dai-ichi Nuclear Power Plant was estimated until September 2012. Based on publicly released data of 137Cs in seawater near the power plant by Tokyo Electric Power Company, a continuing release of radionuclides to the sea is strongly suggested. The plant has an artificial harbour facility, and the exchange rate of harbour water with surrounding seawater was estimated by decrease of radioactivity immediately after an intense event of radioactive water release. The estimated exchange rate of water in the harbour is 0.44 day 1 during the period from 6 to 19 April 2011. 137Cs radioactivity of the harbour water is substantially higher than seawater outside and remained relatively stable after June 2011. A quasi-steady state was assumed with continuous water exchange, and an average release rate of 137Cs was estimated to be 93 GBq day 1 in summer 2011 and 8.1 GBq day 1 in summer 2012.
The Influence of Job Satisfaction on Mental Health of Factory Workers
Kanda Janyam
The Internet Journal of Mental Health , 2011,
Abstract: Background: The current study aimed to investigate factory workers’ mental health, to examine the level of job satisfaction, and to identify the dimension of job satisfaction that influences mental health. Method: In October 2008, a survey was conducted with 173 factory workers to investigate their mental health with the General Mental Health Questionnaire consisting of 28 items (GHQ-28). The job satisfaction component of the survey, developed for this study, evaluated 5 domains of job satisfaction: (1) pay, (2) work security, (3) co-worker, (4) supervision, and (5) promotion opportunity. Frequency, mean, standard deviation, correlation and multiple linear regression analysis were used for the data analysis. Results: The results revealed that 33.5% of the workers had poor mental health, with anxiety and insomnia at the highest level (29.5%), followed by somatic symptoms (28.9 %), social dysfunction (23.7%), and severe depression (12.1 %). The results from correlation analysis indicated that the overall job satisfaction was negatively related to somatic symptoms, anxiety and insomnia, social dysfunction, and total GHQ scores. Regarding the relationships between psychological symptoms and the 5 dimensions of job satisfaction, severe depression had a negative relation only with work security. On the other hand, work security had the highest negative relation with somatic symptoms, anxiety and insomnia, and social dysfunction. Moreover, the findings from multiple regression analysis indicated a significant negative correlation between independent variables of overall job satisfaction (β = -330) and work security (β = -.303) and the dependent variable of GHQ-28 scores. Thus increased overall job satisfaction and increased work security were related to better mental health. Conversely, lower overall job satisfaction and work security were related to poorer mental health.Conclusions: The findings indicate the relationship between job satisfaction and mental health. Organizations can focus on improving employee overall job satisfaction which can influence their employees positive mental health.
Photoproduction of charged pions from the deuteron
Kanda Hiroki
EPJ Web of Conferences , 2012, DOI: 10.1051/epjconf/20122002006
Abstract: The photoproduction of the charged pions from the deuteron has been studied with the Neutral Kaon Spectrometer (NKS) and the Neutral Kaon Spectrometer 2 (NKS2) at the Research Center for Electron Photon Science, Tohoku University (ELPH) which was previously known as the Laboratory of Nuclear Science (LNS-Tohoku) using the GeV-region tagged photon beam. The total cross section for the quasi-free (QF) π+π photoproduction from the deuteron was measured with NKS in the energy region from 0.8 to 1.1 GeV. The cross section for the double Δ excitation in the intermediate state was derived in the analysis of the non-quasi-free (NQF) process, in which two nucleons of the deuteron share the energy of the incident photon. The prospect of the measurements of double pion photoproduction with NKS2 and upgraded NKS2 is discussed.
Large diamonds grown at high pressure conditions
Kanda H.
Brazilian Journal of Physics , 2000,
Abstract: A technique has been established to grow large diamonds up to 2 cm. The crystals are bulky polyhedron with yellow, blue, green or brown color as well as colorless, which depend on impurities. The impurities incorporated into the diamond are limited, i.e. nitrogen, boron, nickel, cobalt, silicon and phosphorus.
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